Development of a novel diagnostic tool using microRNA for heart failure

• Project/Area Number: 16K09460
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cardiovascular medicine
• Research Institution: Fujita Health University
• Principal Investigator: Izawa Hideo 藤田医科大学, 医学部, 教授 (80402569)
• Co-Investigator(Kenkyū-buntansha): 尾崎 行男 藤田医科大学, 医学部, 教授 (50298569) ; 成瀬 寛之 藤田医科大学, 医学部, 准教授 (50319266) ; 藤原 稚也 藤田医科大学, 医学部, 講師 (60644870) ; 加藤 靖周 藤田医科大学, 医学部, 講師 (70351012) ; 林 睦晴 藤田医科大学, 医学部, 准教授 (70426500)
• Project Period (FY): 2016-04-01 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2018: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2016: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
• Keywords: 循環器 / 心臓リハビリテーション / マイクロRNA / 心不全 / 心筋症 / 運動療法 / バイオマーカー / サルコイドーシス / 循環器・高血圧 / リハビリテーション / マイクロアレイ

Outline of Final Research Achievements

The purpose of this study is to identify serum microRNAs (miRNAs) that are useful as non-invasive blood biomarkers for diagnosis and therapeutic effects of heart failure and cardiomyopathy. As a result of examining the miRNA expression level in serum samples of cardiac sarcoidosis, we found that two miRNAs were significantly aberrantly expressed in cardiac sarcoidosis cases. In addition, as a result of analysis using serum of heart failure patients who received exercise therapy, it was recognized that many miRNAs were abnormally expressed in serum in heart failure patients. Furthermore, we introduced a low-frequency treatment device, Solius, and created a protocol to perform cardiac rehabilitation for cases where exercise can not be performed. And we evaluated its efficacy and safety in the clinical settings.

Academic Significance and Societal Importance of the Research Achievements

私たちは2次性心筋症の代表的疾患である心臓サルコイドーシスの血液診断バイオマーカーとして2種類のmiRNAの同定に世界で初めて成功し英文誌 (J Cardiol 2018) にて発表した。この論文に対するEditorialでは心サルコイドーシスの診断に革命を来す大きな第一歩となる成果であると高い評価を得た。本研究の結果は、心臓病の診断や治療効果の評価に有用な新規血液バイオマーカーとしてのマイクロRNAの可能性を示す結果であり、今後の開発や将来の産業化も視野に入る等、本研究成果の意義は極めて大きいと思われる。

Research Products

• [Journal Article] Serum microRNA-126 and -223 as new-generation biomarkers for sarcoidosis in patients with heart failure (2018)
  • Author(s): Fujiwara Wakaya、Kato Yasuchika、Hayashi Mutsuharu、Sugishita Yoshinori、Okumura Satoshi、Yoshinaga Masataka、Ishiguro Tomoya、Yamada Ryo、Ueda Sayano、Harada Masahide、Naruse Hiroyuki、Ishii Junnichi、Ozaki Yukio、Izawa Hideo
  • Journal Title: Journal of Cardiology Volume: 72 Issue: 6 Pages: 452-457
  • DOI: 10.1016/j.jjcc.2018.06.004
  • Peer Reviewed
• [Journal Article] A multicenter prospective cohort study to develop frailty-based prognostic criteria in heart failure patients (FLAGSHIP): rationale and design (2018)
  • Author(s): Yamada Sumio、on behalf of the FLAGSHIP collaborators、Adachi Takuji、Izawa Hideo、Murohara Toyoaki、Kondo Takaaki
  • Journal Title: BMC Cardiovascular Disorders Volume: 18 Issue: 1 Pages: 159-159
  • DOI: 10.1186/s12872-018-0897-y
  • Peer Reviewed / Open Access
• [Journal Article] Predicting acute kidney injury using urinary liver-type fatty-acid binding protein and serum N-terminal pro-B-type natriuretic peptide levels in patients treated at medical cardiac intensive care units. (2018)
  • Author(s): Naruse H, Ishii J, Takahashi H, et al.
  • Journal Title: Critical Care Volume: 22 Issue: 1 Pages: 197-197
  • DOI: 10.1186/s13054-018-2120-z
  • Peer Reviewed / Open Access
• [Journal Article] Combination of high-sensitivity troponin I and N-terminal pro-B-type natriuretic peptide predicts future hospital admission for heart failure in high-risk hypertensive patients with preserved left ventricular ejection fraction (2017)
  • Author(s): Ryunosuke Okuyama
  • Journal Title: Heart and Vessels Volume: 印刷中 Issue: 7 Pages: 880-892
  • DOI: 10.1007/s00380-017-0948-9
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Significant association of RNF213 p.R4810K, a moyamoya susceptibility variant, with coronary artery disease (2017)
  • Author(s): Morimoto T, Mineharu Y, Ono K, Nakatochi M, Ichihara S, Kabata R, Takagi Y, Cao Y, Zhao L, Kobayashi H, Harada K. H, Takenaka K, Funaki T, Yokota M, Matsubara T, Yamamoto K, Izawa H, Kimura T, Miyamoto S, Koizumi A
  • Journal Title: PLoS ONE Volume: 12 Issue: 4 Pages: e0175649-e0175649
  • DOI: 10.1371/journal.pone.0175649
  • NAID: 120006534994
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Prognostic Value of Combination of Plasma D-Dimer Concentration and Estimated Glomerular Filtration Rate in Predicting Long-Term Mortality of Patients With Stable Coronary Artery Disease (2017)
  • Author(s): Naruse H, Ishii J, Takahashi H, Kitagawa F, Okuyama R, Kawai H, Muramatsu T, Harada M, Yamada A, Motoyama S, Matsui S, Hayashi M, Sarai M, Watanabe E, Izawa H, Ozaki Y.
  • Journal Title: Circulation Journal Volume: 81 Issue: 10 Pages: 1506-1513
  • DOI: 10.1253/circj.CJ-16-1272
  • NAID: 130006099870
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed / Open Access
• [Journal Article] Antihypertensive efficacy and safety of the angiotensin receptor blocker azilsartan in elderly patients with hypertension. (2017)
  • Author(s): Kamada T, Hayashi M, Fujiwara W, Yoshikawa D, Mukaide D, Sugishita Y, Yoshinaga M, Itoh T, Yokoi H, Ishii J, Watanabe E, Ozaki Y, Izawa H.
  • Journal Title: Drug Chem Toxicol. Volume: 40 Issue: 1 Pages: 110-114
  • DOI: 10.1080/01480545.2016.1188301
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Brain natriuretic peptide as a potential novel marker of salt-sensitivity in chronic kidney disease patients without cardiac dysfunction. (2017)
  • Author(s): Hayashi M, Yasuda Y, Suzuki S, Tagaya M, Ito T, Kamada T, Yoshinaga M, Sugishita Y, Fujiwara W, Yokoi H, Ozaki Y, Izawa H.
  • Journal Title: Heart Vessels. Volume: 32 Issue: 3 Pages: 279-286
  • DOI: 10.1007/s00380-016-0867-1
  • Peer Reviewed
• [Journal Article] Hospitalization Deteriorates Performance of Activities of Daily Living by Super-Elderly Patients With Heart Failure (2017)
  • Author(s): Izawa H, Kohno Y, Fujiwara W, Hayashi M.
  • Journal Title: Circulation Journal Volume: 81 Issue: 1 Pages: 28-29
  • DOI: 10.1253/circj.CJ-16-1171
  • NAID: 130005252725
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed / Open Access
• [Journal Article] Persistent Excessive Electrocardiogram ST-segment Elevation in a Patient with a Takotsubo Syndrome: What Could be the Cause? (2016)
  • Author(s): Hayashi M, Kamada T, Yokoi H, Fujiwara W, Yoshikawa D, Mukaide D, Sugishita Y, Yoshinaga M, Ito T, Ozaki Y, Izawa H.
  • Journal Title: Internal Medicine Volume: 55 Issue: 3 Pages: 323-323
  • DOI: 10.2169/internalmedicine.55.5549
  • NAID: 130005122598
  • ISSN: 0918-2918, 1349-7235
  • Peer Reviewed / Open Access
• [Journal Article] Endomyocardial radial strain rate imaging during dobutamine stress echocardiography for the evaluation of contractile reserve in patients with dilated cardiomyopathy (2016)
  • Author(s): Minoshima M, Noda A, Kobayashi M, Miyata S, Hirashiki A, Okumura T, Izawa H, Ishii H, Kondo T, Murohara T.
  • Journal Title: J Clin Ultrasound Volume: 44 Issue: 9 Pages: 555-560
  • DOI: 10.1002/jcu.22376
  • Peer Reviewed / Open Access
• [Presentation] Urinary Liver-type Fatty Acid-Binding Protein and N-Terminal Pri-B-Type Natriuretic Peptide Predict Acute Kidney Injury in Patients with Acute Coronary Syndrome. (2019)
  • Author(s): Naruse H, Ishii J, Nishimura H, Ohta M, Kawai H, Muramatsu T, Harada M, Yamada A, Motoyama S, Hayashi M, Sarai M, Izawa H, Watanabe E, Ozaki Y.
  • Organizer: 第83回日本循環器学会学術集会
• [Presentation] Prognostic Utility of Plasma Concentration of Presepsin, Soluble CD14 Subtype, for Six-Month Mortality in Patients with Acute Heart Failure. (2019)
  • Author(s): 西村豪人、石井潤一、河合秀樹、村松崇、原田将英、元山貞子、成瀬寛之、渡邉英一、林睦晴、井澤英夫、尾崎行男.
  • Organizer: 第83回日本循環器学会学術集会
• [Presentation] Prognostic Utility of Multimarker Approach Using D-dimer, N-Terminal Pro-B-Type Natriuretic Peptide, and High-Sensitivity C-reactive Protein in Acute Heart Failure. (2019)
  • Author(s): 成瀬寛之、石井潤一、西村豪人、大田将也、河合秀樹、村松崇、原田将英、山田晶、元山貞子、林睦晴、皿井正義、井澤英夫、渡邉英一、尾崎行男.
  • Organizer: 第83回日本循環器学会学術集会
• [Presentation] 高齢心不全患者に対する早期リハビリ介入は退院後再入院予防と関連する (2019)
  • Author(s): 河野裕治、井澤英夫、青柳陽一郎、山田亮、石黒智也、良永真隆、奥村聡、藤原稚也、林睦晴、才藤栄一.
  • Organizer: 第83回日本循環器学会学術集会
• [Presentation] Serum miR-126 and -223 as a new generation biomarkers for cardiac salcoidosis. (2018)
  • Author(s): Fujiwara W, Kato Y, Hayashi M, Sugishita Y, Okumura S, Yoshinaga M, Ishiguro T, Yamada R, Ueda S, Harada M, Naruse H, Ishii J, Ozaki Y, Izawa H.
  • Organizer: Heart Failure2018, Heart Failure Association of the European Society of Cardiology
  • Int'l Joint Research
• [Presentation] Circulating miR-489 as a useful biomarker for DCM (2018)
  • Author(s): Ishiguro T, Hayashi M, Fujiwara W, Okumura S, Sugishita Y, Yoshinaga M, Yamada R, Izawa H.
  • Organizer: Heart Failure2018, Heart Failure Association of the European Society of Cardiology
  • Int'l Joint Research
• [Presentation] Exercise Training Restores Circulating MicroRNAs to Nonpathological Levels in Patients with Heart Failure. (2018)
  • Author(s): Yamada R, Okumura S, Niwa Y, Miyazaki A, Tagaya M, Ueda S, Ishiguro T, Yoshinaga M, Fujiwara W, Kato Y, Hayashi M, Ishii J, Harada M, Ozaki Y, Izawa H.
  • Organizer: Scientific Sessions 2018, American Heart Association.
  • Int'l Joint Research
• [Presentation] The Clinical Impact of heart failure severity on bone mineral density in elderly patients with heart failure. (2018)
  • Author(s): Yuji Kono, Ayako Ishikawa, Yoichiro Aoyagi, Sayano Ueda, Ryo Yamada, Mutsuharu Hayashi, Eiichi Saito, Hideo Izawa.
  • Organizer: 第24回心臓リハビリテーション学会学術集会
• [Presentation] Combination of D-Dimer and N-Terminal Pro-B-Type Natriuretic Peptide on Admission Predicts 30-Day Mortality in Patients Hospitalized for Worsening Heart Failure. (2018)
  • Author(s): Naruse H, Ishii J, Nishimura H, Ohta M, Kawai H, Muramatsu T, Harada M, Yamada A, Motoyama S, Hayashi M, Sarai M, Izawa H, Watanabe E, Ozaki Y.
  • Organizer: 第22回日本心不全学会学術集会
• [Presentation] Urinary Liver-Type Fatty-Acid Binding Protein on Admission Improves Prediction of Acute Kidney Injury in Patients Hospitalized for Worsening Heart Failure. (2018)
  • Author(s): Nishimura H, Ishii J, Muramatsu T, Harada M, Motoyama S, Naruse H, Watanabe E, Izawa H, Ozaki Y.
  • Organizer: 第22回日本心不全学会学術集会
• [Presentation] 心不全の心臓リハビリテーション標準プログラムを理解する (2018)
  • Author(s): 井澤英夫
  • Organizer: 第24回日本心臓リハビリテーション学会学術集会
  • Invited
• [Presentation] 心不全パンデミックにおける心臓リハビリテーションの役割 (2018)
  • Author(s): 井澤英夫、河野裕治、青柳陽一郎、上田清乃、山田亮、石黒智也、良永真隆、奥村聡、藤原稚也、林睦晴
  • Organizer: 第22回日本心不全学会学術集会
  • Invited
• [Presentation] Urinary Neutrophil Gelatinase-Associated Lipocalin and Plasma Glucose Levels Improve Prediction of Acute Kidney Injury in Patients Hospitalized to CCUs. (2018)
  • Author(s): 松井 茂、 石井 潤一、高橋宏、西村 豪人、河合 秀樹、村松 崇、山田 晶、元山 貞子、成瀬 寛之、林 睦晴、井澤 英夫、尾崎 行男
  • Organizer: 第82回日本循環器学会学術集会
• [Presentation] Urinary Liver-Type Fatty-Acid Binding Protein and Serum N-Terminal Pro-B-Type Natriuretic Peptide Predict Acute Kidney Injury in Patients Hospitalized to CCUs (2018)
  • Author(s): 成瀬 寛之、石井 潤一、西村 豪人、大田 将也、河合 秀樹、村松 崇、原田 将英、山田 晶、松井 茂、 元山 貞子、林 睦晴、井澤 英夫、渡邉 英一、尾崎 行男
  • Organizer: 第82回日本循環器学会学術集会
• [Presentation] Urinary Albumin to Creatinine Ratio on Admission Improves Prediction of Acute Kidney Injury in Patients Hospitalized for Acute Coronary Syndrome (2018)
  • Author(s): 西村 豪人、石井 潤一、河合 秀樹、村松 崇、原田 将英、元山 貞子、成瀬 寛之、渡邉 英一、林 睦晴、井澤 英夫、尾崎 行男
  • Organizer: 第82回日本循環器学会学術集会
• [Presentation] 心不全の心臓リハビリテーション (2018)
  • Author(s): 井澤英夫
  • Organizer: 第82回日本循環器学会学術集会
  • Invited
• [Presentation] Circulating MiR-489 could be a New Generation Biomarker for Dilated Cardiomyopathy. (2017)
  • Author(s): Tomoya Ishiguro, Mutsuharu Hayashi, Yoshinori Sugishita, Hiroyuki Naruse, Junichi Ishii, Yasuchika Kato, Yukio Ozaki, Hideo Izawa.
  • Organizer: 第81回日本循環器学会学術集会
  • Place of Presentation: 金沢市（石川県立音楽堂他）
  • Year and Date: 2017-03-17
• [Presentation] Impact of the Early Administration of Vasopressin Type 2 Receptor Antagonist for Improving In-Hospital Mortality of Acute Decompensated Heart Failure Patients. (2017)
  • Author(s): Mutsuharu Hayashi, Manaka Tagaya, Tomoya Ishiguro, Ryo Yamada, Tomohito Kamada, Masataka Yoshinaga, Yoshinori Sugishita, Wakaya Fujiwara, Hideo Izawa.
  • Organizer: 第81回日本循環器学会学術集会
  • Place of Presentation: 金沢市（石川県立音楽堂他）
  • Year and Date: 2017-03-17
• [Presentation] Prognostic Value of Combination of Presepsin, Soluble CD14 Subtype, and NT-proBNP for 6-Month Mortality in Patients Hospitalized for Heart Failure. (2017)
  • Author(s): 奥山龍之介、石井潤一、高橋宏、河合秀樹、村松崇、原田将英、元山貞子、松井茂、成瀬寛之、渡邉英一、林睦晴、井澤英夫、尾崎行男
  • Organizer: 第81回日本循環器学会学術集会
  • Place of Presentation: 金沢市（石川県立音楽堂他）
  • Year and Date: 2017-03-17
• [Presentation] Prognostic Value of Plasma Concentration of Procalcitonin for 6-Month Mortality in Patients Hospitalized for Acute Coronary Syndrome. (2017)
  • Author(s): 高田佳代子、石井潤一、奥山龍之介、高橋宏、河合秀樹、村松崇、原田将英、山田晶、元山貞子、松井茂、成瀬寛之、渡邉英一、林睦晴、井澤英夫、尾崎行男
  • Organizer: 第81回日本循環器学会学術集会
  • Place of Presentation: 金沢市（石川県立音楽堂他）
  • Year and Date: 2017-03-17
• [Presentation] Prognostic Value of Plasma Concentration of Presepsin, Soluble CD14 Subtype, in Patients Hospitalized to Coronary Care Unit. (2017)
  • Author(s): 西村豪人、石井潤一、大田将也、河合秀樹、奥村雅徳、村松崇、原田将英、山田晶、成瀬寛之、松井茂、元山貞子、林睦晴、井澤英夫、尾崎行男
  • Organizer: 第81回日本循環器学会学術集会
  • Place of Presentation: 金沢市（石川県立音楽堂他）
  • Year and Date: 2017-03-17
• [Presentation] Prognostic Value of Plasma Concentration of Procalcitonin for 6-Month Mortality in Patients Hospitalized to Coronary Care Units. (2017)
  • Author(s): 松井茂、石井潤一、高橋宏、西村豪人、奥山龍之介、河合秀樹、村松崇、山田晶、元山貞子、成瀬寛之、林睦晴、井澤英夫、尾崎行男
  • Organizer: 第81回日本循環器学会学術集会
  • Place of Presentation: 金沢市（石川県立音楽堂他）
  • Year and Date: 2017-03-17
• [Presentation] Prognostic Value of Combination of High-Sensitivity Troponin I and NT-proBNP for Future Heart Failure Admission in High-Risk Hypertensive Patients. (2017)
  • Author(s): 奥山龍之介、石井潤一、河合秀樹、村松崇、原田将英、元山貞子、松井茂、成瀬寛之、渡邉英一、林睦晴、井澤英夫、尾崎行男
  • Organizer: 第81回日本循環器学会学術集会
  • Place of Presentation: 金沢市（石川県立音楽堂他）
  • Year and Date: 2017-03-17
• [Presentation] Prognostic Value of Combined Assessment of D-Dimer and High-Sensitivity C-Reactive Protein in Atrial Fibrillation Patients Hospitalized for Worsening Heart Failure. (2017)
  • Author(s): Hiroyuki Naruse, Junichi Ishii, Taketo Nishimura, Ryunosuke Okuyama, Masaya Ohta, Hideki Kawai, Masanori Okumura, Takashi Muramatsu, Masahide Harada, Akira Yamada, Shigeru Matsui, Sadako Motoyama, Mutsuharu Hayashi, Hideo Izawa, Yukio Ozaki.
  • Organizer: 第81回日本循環器学会学術集会
  • Place of Presentation: 金沢市（石川県立音楽堂他）
  • Year and Date: 2017-03-17
• [Presentation] Prognostic Value of Serum Concentration of Oxidized Lipoprotein (a) in Patients with Stable Coronary Artery Disease. (2017)
  • Author(s): 森義久、石井潤一、成瀬寛之、松井茂、渡邉英一、林睦晴、井澤英夫、尾崎行男
  • Organizer: 第81回日本循環器学会学術集会
  • Place of Presentation: 金沢市（石川県立音楽堂他）
  • Year and Date: 2017-03-17
• [Presentation] Combination of High-Sensitivity Troponin T and N-Terminal Pro-B-Type Natriureic Peptide Predicts Heart Failure Admission in Patients with Chronic Kidney Disease. (2017)
  • Author(s): 松井茂、石井潤一、高橋宏、西村豪人、奥山龍之介、河合秀樹、村松崇、山田晶、元山貞子、成瀬寛之、林睦晴、井澤英夫、尾崎行男
  • Organizer: 第81回日本循環器学会学術集会
  • Place of Presentation: 金沢市（石川県立音楽堂他）
  • Year and Date: 2017-03-17
• [Presentation] 急性冠症候群患者におけるCCU入院時血漿プレセプシン（可溶性CD14サブタイプ）濃度と予後との関係. (2017)
  • Author(s): 西村豪人、石井潤一、河合秀樹、村松崇、原田将英、元山貞子、成瀬寛之、渡邉英一、林睦晴、井澤英夫、尾崎行男
  • Organizer: 第65回日本心臓病学会学術集会
• [Presentation] サルコペニアは心肺運動負荷試験の除外基準となる (2017)
  • Author(s): 河野裕治、上田清乃、山田亮、石黒智也、良永真隆、杉下義倫、奥村聡、藤原稚也、林睦晴、井澤英夫
  • Organizer: 第21回日本心不全学会学術集会
• [Presentation] 心臓リハビリテーションを軸とした急性期での再入院予防への取り組み (2017)
  • Author(s): 河野裕治、森悦子、石川綾子、杉浦翼、板野里奈、青柳陽一郎、山田亮、林睦晴、井澤英夫
  • Organizer: 第21回日本心不全学会学術集会
• [Presentation] Combination of D-Dimer and High-Sensitivity C-Reactive Protein Predicts 30-Day Mortality in Atrial Fibrillation Patients Hospitalized for Worsening Heart Failure. (2017)
  • Author(s): Naruse T, Ishii J, Nishimura T, Kawai H, Muramatsu T, Harada M, Yamada A, Matsui S, Izawa H, Ozaki Y
  • Organizer: 第21回日本心不全学会学術集会
• [Presentation] Presepsin, Soluble CD14 Subtype, Is a Novel Marker of Short-Term Mortality in Patients Hospitalized for Worsening Heart Failure (2017)
  • Author(s): Nishimura H, Ishii J, Muramatsu T, Harada M, Motoyama S, Matsui S, Naruse H, Watanabe E, Izawa H
  • Organizer: 第21回日本心不全学会学術集会
• [Presentation] Serum micro-ribonucleic acid-126 and -223 as a new generation biomarker for cardiac sarcoidosis (2017)
  • Author(s): Fujiwara W, Yamada R, Ishiguro T, Okumura S, Yoshinaga M, Sugishita Y, Hayashi M, Kato Y, Ozaki Y, Izawa H
  • Organizer: 第21回日本心不全学会学術集会
• [Presentation] 高齢者心不全の特徴と課題 (2017)
  • Author(s): 井澤英夫
  • Organizer: 第59回日本老年医学会学術集会
  • Invited
• [Presentation] 高齢患者に対する電気刺激療法 (2017)
  • Author(s): 河野裕治、井澤英夫、石川綾子、杉浦翼、森悦子、青柳陽一郎、奥村聡、林睦晴
  • Organizer: 第23回日本心臓リハビリテーション学会学術集会
• [Presentation] Serum Micro RNAs coulg be a New Generation Biomarker for Cardiac Sarcoidosis. (2016)
  • Author(s): Wakaya Fujiwara, Mutsuharu Hayashi, Yoshinori Sugishita, Masataka Yoshinaga, Tomoya Ishiguro, Hiroyuki Naruse, Junichi Ishii, Yasuchika Kato, Yukio Ozaki, Hideo Izawa.
  • Organizer: 第20回日本心不全学会学術集会
  • Place of Presentation: 札幌市（ロイトン札幌）
  • Year and Date: 2016-10-06
• [Presentation] Circulating miR-479 could be a New Generation Biomarker for Dilated Cardiomyopathy. (2016)
  • Author(s): Tomoya Ishiguro, Mutsuharu Hayashi, Yoshinori Sugishita, Wakaya Fujiwara, Tomohito Kamada, Hiroyuki Naruse, Junichi Ishii, Yasuchika Kato, Yukio Ozaki, Hideo Izawa.
  • Organizer: 第20回日本心不全学会学術集会
  • Place of Presentation: 札幌市（ロイトン札幌）
  • Year and Date: 2016-10-06
• [Presentation] 心不全の包括的心臓リハビリテーション実施上の課題：オーバービュー (2016)
  • Author(s): 井澤英夫、河野裕治、林睦晴、藤原稚也、青柳陽一郎
  • Organizer: 第20回日本心不全学会学術集会
  • Place of Presentation: 札幌市（ロイトン札幌）
  • Year and Date: 2016-10-06
• [Presentation] CCU入室患者の予後評価：急性腎障害と入院時D－dimer値の組合せの有用性 (2016)
  • Author(s): 松井茂、石井潤一、高橋宏、奥山龍之介、奥村雅徳、河合秀樹、村松崇、元山貞子、成瀬寛之、渡邉英一、井澤英夫、尾崎行男
  • Organizer: 第64回日本心臓病学会学術集会
  • Place of Presentation: 東京（東京国際フォーラム）
  • Year and Date: 2016-09-23
• [Presentation] 安定冠動脈疾患患者の予後評価：血漿D-ダイマー濃度と推定糸球体濾過量の組み合わせの有用性 (2016)
  • Author(s): 成瀬寛之、石井潤一、奥山龍之介、大田将也、奥村雅徳、村松崇、森義久、松井茂、林睦晴、井澤英夫、尾崎行男
  • Organizer: 第64回日本心臓病学会学術集会
  • Place of Presentation: 東京（東京国際フォーラム）
  • Year and Date: 2016-09-23
• [Presentation] 非ST上昇型心筋梗塞（NSTEMI）の診断におけるSensitiveトロポニンI測定の臨床 (2016)
  • Author(s): 奥山龍之介、石井潤一、西村豪人、大田将也、村松崇、山田晶、奥村雅徳、 元山貞子、成瀬寛之、松井茂、林睦晴、井澤英夫、尾崎行男
  • Organizer: 第64回日本心臓病学会学術集会
  • Place of Presentation: 東京（東京国際フォーラム）
  • Year and Date: 2016-09-23
• [Presentation] Resistance training is a key factor of exercise prescription in heart failure patients with frailty. (2016)
  • Author(s): Yuji Kono, Tomoko Kayukawa, Tomoyasu Hiratsuka, Wataru Kikuchi, Tsubasa Sugiura, Etsuko Mori, Yoichiro Aoyagi, Manaka Tagaya, Yoshinori Sugishita, Tomohito Kamada, Masataka Yoshinaga, Wakaya Fujiwara, Mutsuharu Hayashi, Eiichi Saito, Hideo Izawa.
  • Organizer: 第22回心臓リハビリテーション学会学術集会
  • Place of Presentation: 東京（東京国際フォーラム）
  • Year and Date: 2016-07-16
• [Presentation] 高齢心疾患患者に対するサルコペニアの意義と身体機能評価 (2016)
  • Author(s): 河野裕治、石川綾子、杉浦翼、森悦子、粥川知子、井澤英夫
  • Organizer: 第22回心臓リハビリテーション学会学術集会
  • Place of Presentation: 東京（東京国際フォーラム）
  • Year and Date: 2016-07-16