| Project/Area Number |
16K09461
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cardiovascular medicine
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| Research Institution | Fujita Health University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
元山 貞子 藤田医科大学, 医学部, 教授 (30308902)
夏目 貴弘 藤田医科大学, 保健学研究科, 准教授 (30597604)
尾崎 行男 藤田医科大学, 医学部, 教授 (50298569)
外山 宏 藤田医科大学, 医学部, 教授 (90247643)
市原 隆 藤田医科大学, 医学部, 教授 (90527748)
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| Project Period (FY) |
2016-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2018: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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| Keywords | 心筋血流 / 核医学 / CT / 心筋血流CT / 定量的心筋血流量 / 循環器・高血圧 |
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| Outline of Final Research Achievements |
The purpose of this study is to compare the three calculation methods of MBF quantification by dynamic CT perfusion imaging during ATP infusion. A total of 7 cases were examined including 3 normal, 2 SVD, 1 TVD and 1 OMI. All images were assessed in 17 segments. The MBF (ml/min/g) of each were compared with SPECT data. The relationship between MBF-CT and % uptake-SPECT during stress showed significant correlation in one-shot scan (P<.0001) and clearance phase (P<.0001). The relationship between MBF-CT and % uptake-SPECT at rest showed significant correlation in one-shot scan (P=.0021) and clearance phase (P=.0002). In SVD, the relationship between MBF-CT and % uptake-SPECT during stress showed significant correlation. It is considered that MBF quantification calculated from one-shot scan and clearance phase of TAC are appropriate value by dynamic CT perfusion imaging during ATP infusion.
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| Academic Significance and Societal Importance of the Research Achievements |
臨床では狭心症の評価を相対的な心筋血流評価法で行っているが、重症虚血を見落とす可能性がある。今回、臨床で使用している造影CTで絶対的な心筋血流を評価することが可能となり、より安全で正確な狭心症評価が可能となった。
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