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Intracardiac/extracardiac circulating microRNA profiling in atrial fibrillation -cardiac specific biomarkers for atrial remodeling-

Research Project

Project/Area Number 16K09462
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Cardiovascular medicine
Research InstitutionFujita Health University

Principal Investigator

Harada Masahide  藤田医科大学, 医学部, 准教授 (70514800)

Co-Investigator(Kenkyū-buntansha) 奥崎 大介  大阪大学, 微生物病研究所, 助教 (00346131)
尾崎 行男  藤田医科大学, 医学部, 教授 (50298569)
渡邉 英一  藤田医科大学, 医学部, 教授 (80343656)
Research Collaborator Koshikawa Masayuki  
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
KeywordsマイクロRNA / 心房細動 / 心房リモデリング / バイオマーカー / 循環器・高血圧 / 不整脈
Outline of Final Research Achievements

The blood samples were collected from the coronary sinus (CS, reflecting cardiac phenomena more specifically) and the central venous (CV) in patients with and without atrial fibrillation (AF); the plasma expression of microRNAs (miRNAs) was measured using quantitative PCR and next generation sequencer (NGS). We identified miRNAs that showed significant differences in the plasma expression between patients with and without AF in the CS samples. Among them, we focused on miRNAs that also showed similar expression differences in the CV samples; these were candidates for the clinical biomarkers. We created the novel miRNA-based method to assess AF pathophysiology and prospectively evaluate the efficacy in terms of whether it can predict therapeutic outcomes, disease progression, and adverse event risk.

Academic Significance and Societal Importance of the Research Achievements

血中miRNAによる新たなAFの評価法が確立されれば、病態に基づいた個別化医療が実現できる可能性がある。そして、AFの治療効果、病態の進行、合併症の発症などが正確に予測できるようになれば、治療成績や生命予後を劇的に改善させる可能性がある。また、臨床指標を用いた病態評価法は、基礎研究でのmiRNAの新知見を臨床的に確認するツールとなり、学術的な意義も極めて大きい。AFは実臨床で最も頻度の高い不整脈でり、本研究によってAFの臨床マネージメントが革新的に進歩すれば、社会的、医療経済的な貢献度は計り知れない。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (61 results)

All 2019 2018 2017 2016

All Journal Article (14 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 14 results,  Open Access: 8 results,  Acknowledgement Compliant: 2 results) Presentation (36 results) (of which Int'l Joint Research: 15 results,  Invited: 7 results) Book (11 results)

  • [Journal Article] Impact of serum albumin levels on supratherapeutic PT-INR control and bleeding risk in atrial fibrillation patients on warfarin: A prospective cohort study.2019

    • Author(s)
      Kawai M, Harada M, Motoike Y, Koshikawa M, Ichikawa T, Watanabe E, Ozaki Y.
    • Journal Title

      Int J Cardiol Heart Vasc.

      Volume: 22 Pages: 111-116

    • DOI

      10.1016/j.ijcha.2019.01.002

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Left Atrial Appendage Thrombus Prior to Atrial Fibrillation Ablation in the Era of Direct Oral Anticoagulants2018

    • Author(s)
      Harada Masahide、Koshikawa Masayuki、Motoike Yuji、Ichikawa Tomohide、Sugimoto Kunihiko、Watanabe Eiichi、Ozaki Yukio
    • Journal Title

      Circulation Journal

      Volume: 82 Issue: 11 Pages: 2715-2721

    • DOI

      10.1253/circj.CJ-18-0398

    • NAID

      40021697183

    • ISSN
      1346-9843, 1347-4820
    • Year and Date
      2018-10-25
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Serum microRNA-126 and -223 as new-generation biomarkers for sarcoidosis in patients with heart failure.2018

    • Author(s)
      Fujiwara W, Kato Y, Hayashi M, Sugishita Y, Okumura S, Yoshinaga M, Ishiguro T, Yamada R, Ueda S, Harada M, Naruse H, Ishii J, Ozaki Y, Izawa H.
    • Journal Title

      J Cardiol.

      Volume: 72 Pages: 452-457

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Predicting acute kidney injury using urinary liver-type fatty-acid binding protein and serum N-terminal pro-B-type natriuretic peptide levels in patients treated at medical cardiac intensive care units.2018

    • Author(s)
      Naruse H, Ishii J, Takahashi H, et al.
    • Journal Title

      Critical Care

      Volume: 22 Issue: 1 Pages: 197-197

    • DOI

      10.1186/s13054-018-2120-z

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Thromboembolisms in atrial fibrillation and heart failure patients with a preserved ejection fraction (HFpEF) compared to those with a reduced ejection fraction (HFrEF)2018

    • Author(s)
      Sobue Yoshihiro、Watanabe Eiichi、Lip Gregory Y. H.、Koshikawa Masayuki、Ichikawa Tomohide、Kawai Mayumi、Harada Masahide、Inamasu Joji、Ozaki Yukio
    • Journal Title

      Heart and Vessels

      Volume: 33 Issue: 4 Pages: 403-412

    • DOI

      10.1007/s00380-017-1073-5

    • Related Report
      2018 Annual Research Report 2017 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Midkine Promotes Atherosclerotic Plaque Formation Through Its Pro-Inflammatory, Angiogenic and Anti-Apoptotic Functions in Apolipoprotein E-Knockout Mice2018

    • Author(s)
      Takemoto Y, Horiba M, Harada M, Sakamoto K, Takeshita K, Murohara T, Kadomatsu K, Kamiya K.
    • Journal Title

      Circulation Journal

      Volume: 82 Issue: 1 Pages: 19-27

    • DOI

      10.1253/circj.CJ-17-0043

    • NAID

      130006281926

    • ISSN
      1346-9843, 1347-4820
    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Metabolic Considerations in Atrial Fibrillation ― Mechanistic Insights and Therapeutic Opportunities ―2017

    • Author(s)
      Harada M, Melka J, Sobue Y, Nattel S.
    • Journal Title

      Circulation Journal

      Volume: 81 Issue: 12 Pages: 1749-1757

    • DOI

      10.1253/circj.CJ-17-1058

    • NAID

      130006219238

    • ISSN
      1346-9843, 1347-4820
    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Prognostic Value of Combination of Plasma D-Dimer Concentration and Estimated Glomerular Filtration Rate in Predicting Long-Term Mortality of Patients With Stable Coronary Artery Disease2017

    • Author(s)
      Naruse H, Ishii J, Takahashi H, Kitagawa F, Okuyama R, Kawai H, Muramatsu T, Harada M, Yamada A, Motoyama S, Matsui S, Hayashi M, Sarai M, Watanabe E, Izawa H, Ozaki Y.
    • Journal Title

      Circulation Journal

      Volume: 81 Issue: 10 Pages: 1506-1513

    • DOI

      10.1253/circj.CJ-16-1272

    • NAID

      130006099870

    • ISSN
      1346-9843, 1347-4820
    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Physically triggered Takotsubo cardiomyopathy has a higher in-hospital mortality rate.2017

    • Author(s)
      Sobue Y, Watanabe E, Ichikawa T, Koshikawa M, Yamamoto M, Harada M, Ozaki Y.
    • Journal Title

      International Journal of Cardiology

      Volume: 235 Pages: 87-93

    • DOI

      10.1016/j.ijcard.2017.02.090

    • Related Report
      2017 Research-status Report 2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Combination of high-sensitivity troponin I and N-terminal pro-B-type natriuretic peptide predicts future hospital admission for heart failure in high-risk hypertensive patients with preserved left ventricular ejection fraction2017

    • Author(s)
      Ryunosuke Okuyama
    • Journal Title

      Heart and Vessels

      Volume: 印刷中 Issue: 7 Pages: 880-892

    • DOI

      10.1007/s00380-017-0948-9

    • Related Report
      2017 Research-status Report 2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Assessment of trough rivaroxaban concentrations on markers of coagulation activation in nonvalvular atrial fibrillation population.2017

    • Author(s)
      Kitagawa F, Ishii J, Hiramitsu S, Takahashi H, Okuyama R, Kawai H, Muramatsu T, Harada M, Motoyama S, Naruse H, Matsui S, Sarai M, Hayashi M, Watanabe E, Izawa H, Ozaki Y.
    • Journal Title

      Heart and Vessels

      Volume: 32 Issue: 5 Pages: 609-617

    • DOI

      10.1007/s00380-016-0912-0

    • Related Report
      2017 Research-status Report 2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Prognostic importance of novel oxygen desaturation metrics in patients with heart failure and central sleep apnea.2017

    • Author(s)
      Watanabe, E., Kiyono, K., Matsui, S., Somers, V. K., Sano, K.,Hayano, J., Ichikawa, T., Kawai, M., Harada, M., Ozaki, Y.
    • Journal Title

      J Card Fail

      Volume: 23 Issue: 2 Pages: 131-137

    • DOI

      10.1016/j.cardfail.2016.09.004

    • Related Report
      2017 Research-status Report 2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Intracellular angiotensin-II interacts with nuclear angiotensin receptors in cardiac fibroblasts and regulates RNA synthesis, cell proliferation, and collagen secretion.2017

    • Author(s)
      Tadevosyan A, Xiao J, Surinkaew S, Naud P, Merlen C, Harada M, Qi X, Chatenet D, Fournier A, Allen BG, Nattel S.
    • Journal Title

      Journal of the American Heart Association

      Volume: 印刷中 Issue: 4

    • DOI

      10.1161/jaha.116.004965

    • Related Report
      2017 Research-status Report 2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Prognostic Value of Combination of Plasma D-Dimer Concentration and Estimated Glomerular Filtration Rate in Predicting Long-Term Mortality of Patients with Stable Coronary Artery Disease.2017

    • Author(s)
      Naruse H, Ishii J, Takahashi H, Kitagawa F, Okuyama R, Kawai H, Muramatsu T, Harada M, Yamada A, Motoyama S, Matsui S, Hayashi M, Sarai M, Watanabe E, Izawa H, Ozaki Y.
    • Journal Title

      Circulation Journal

      Volume: 印刷中

    • NAID

      130006099870

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Next Generation Sequencing Reveals Intra‐cardiac/Extra‐cardiac MicroRNA Transcriptomes in Atrial Fibrillation.2018

    • Author(s)
      Masahide Harada, Daisuke Okuzaki, Jun Takeda, Yuji Motoike, Masayuki Koshikawa, Eiichi Watanabe, Yukio Ozaki.
    • Organizer
      American Heart Association Scientific Session 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Pulmonary Vein-dependent Electrophysiological Heterogeneity Underlies Localized Reentry and Atrial Fibrillation Provoked by Single Extra Stimulation: Implications of Anatomical Characteristics in Electrophysiology-.2018

    • Author(s)
      Harada M, Motoike Y, Asami F, Takeda J, Ichikawa T, Koshikawa M, Watanabe E, Ozaki Y.
    • Organizer
      Heart Rhythm 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] MicroRNA in Atrial Fibrillation: from Basic Mechanism to Translational Potential.-.2018

    • Author(s)
      Harada M.
    • Organizer
      The 11th Asian Pacific Heart Rhythm Society.
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Current Status of Molecular Study in AF: From Basic Mechanisms to Translational Potential.2018

    • Author(s)
      Harada M.
    • Organizer
      The 11th Asian Pacific Heart Rhythm Society.
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Metabolic Consideration in Atrial Fibrillation: Mechanistic Insight And Therapeutic Opportunities.2018

    • Author(s)
      Harada M.
    • Organizer
      The 11th Asian Pacific Heart Rhythm Society.
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Left Pulmonary Vein-dependent Electrophysiological Heterogeneity Underlies Localized Reentry and Atrial Fibrillation Provoked by Single Extra Stimulation: Implications of Anatomical Characteristics in Electrophysiology-.2018

    • Author(s)
      Harada M, Motoike Y, Asami F, Takeda J, Ichikawa T, Koshikawa M, Watanabe E, Ozaki Y.
    • Organizer
      Heart Rhythm 2018
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Shortened Refractoriness and Conduction Slowing Associated with Elevated Left-atrial Pressure Confers Atrial Fibrillation Sustainability in Patients with Sleep Apnea Syndrome.2018

    • Author(s)
      Motoike Y, Harada M, Fujiwara A, Makino T, Koshikawa M, Ichikawa T, Kawai M, Watanabe E, Ozaki Y.
    • Organizer
      Heart Rhythm 2018
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Next Generation Sequencing Reveals Intra-cardiac/Extra-cardiac Circulating MicroRNA Transcriptomes in Atrial Fibrillation.2018

    • Author(s)
      Harada M, Okuzaki D, Takeda J, Motoike Y, Koshikawa M, Ichikawa T, Koshikawa M, Watanabe E, Ozaki Y.
    • Organizer
      The 82nd Annual Scientific Meeting of the Japanese Circulation Society
    • Related Report
      2017 Research-status Report
  • [Presentation] Feasibility of Switching to Dabigatran on the Day of Catheter Ablation in Atrial Fibrillation Patients Taking Direct Oral Anticoagulants.2018

    • Author(s)
      Harada M, Motoike Y, Koshikawa M, Ichikawa T, Watanabe E, Ozaki Y.
    • Organizer
      The 82nd Annual Scientific Meeting of the Japanese Circulation Society
    • Related Report
      2017 Research-status Report
  • [Presentation] High-Resolution Electro-anatomical Mapping-guided Procedure Decreases Residual Gap and Acute Reconnection in Pulmonary Vein Isolation for Atrial Fibrillation.2018

    • Author(s)
      Koshikawa M, Harada M, Motoike Y, Ichikawa T, Watanabe E, Ozaki Y.
    • Organizer
      The 82nd Annual Scientific Meeting of the Japanese Circulation Society
    • Related Report
      2017 Research-status Report
  • [Presentation] Obstructive and Central Sleep Apnea Have Different Impacts on Left-Atrial Arrhythmogenic Electrophysiology in Paroxysmal Atrial Fibrillation.2018

    • Author(s)
      Motoike Y, Harada M, Fujiwara A, Takeda J, Ichikawa T, Koshikawa M, Watanabe E, Ozaki Y.
    • Organizer
      The 82nd Annual Scientific Meeting of the Japanese Circulation Society
    • Related Report
      2017 Research-status Report
  • [Presentation] Peripheral Perfusion Reactivity to Sinus Rhythm Restoration after Catheter Ablation in Patients with Persistent Atrial Fibrillation.2018

    • Author(s)
      Motoike Y, Harada M, Koshikawa M, Ichikawa T, Watanabe E, Ozaki Y.
    • Organizer
      The 82nd Annual Scientific Meeting of the Japanese Circulation Society
    • Related Report
      2017 Research-status Report
  • [Presentation] Prognostic Implication of Selvester QRS Scoring in Atrial Fibrillation Patients with HFrEF Undergoing Catheter Ablation.2018

    • Author(s)
      Nomura Y, Harada M, Kitagawa F, Motoike Y, Koshikawa M, Ichikawa T, Watanabe E, Ozaki Y.
    • Organizer
      The 82nd Annual Scientific Meeting of the Japanese Circulation Society
    • Related Report
      2017 Research-status Report
  • [Presentation] Thrombolytic Efficacy of Dabigatran in Patients Undergoing Atrial Fibrillation Ablation -Peri-procedural Left-atrial Thrombus in the Era of Direct Oral Anticoagulants-.2017

    • Author(s)
      Harada M, Koshikawa M, Motoike Y, Makino T, Ichikawa T, Kawai M, Watanabe E, Ozaki Y.
    • Organizer
      The 81st Annual Scientific Meeting of the Japanese Circulation Society
    • Place of Presentation
      石川県立音楽堂 他(石川県 金沢市)
    • Year and Date
      2017-03-17
    • Related Report
      2016 Research-status Report
  • [Presentation] Semi-automatic Selvester QRS Scoring Can Estimate Scar Lesion in Patients with Cardiac Sarcoidosis -Development of Novel ECG Analysis Software-2017

    • Author(s)
      Harada M, Kitagawa F, Sobue Y, Motoike Y, Makino T, Koshikawa M, Ichikawa T, Watanabe E, Ozaki Y.
    • Organizer
      The 81st Annual Scientific Meeting of the Japanese Circulation Society
    • Place of Presentation
      石川県立音楽堂 他(石川県 金沢市)
    • Year and Date
      2017-03-17
    • Related Report
      2016 Research-status Report
  • [Presentation] Shortened Refractoriness and Conduction Slowing Associated with Elevated Left-atrial Pressure Confers Atrial Fibrillation Sustainability in Patients with Sleep Apnea Syndrome.2017

    • Author(s)
      Motoike Y, Harada M, Fujiwara A, Makino T, Koshikawa M, Ichikawa T, Kawai M, Watanabe E, Ozaki Y.
    • Organizer
      The 81st Annual Scientific Meeting of the Japanese Circulation Society
    • Place of Presentation
      石川県立音楽堂 他(石川県 金沢市)
    • Year and Date
      2017-03-17
    • Related Report
      2016 Research-status Report
  • [Presentation] Thrombolytic Efficacy of Dabigatran in Patients Undergoing Atrial Fibrillation Ablation -Peri-procedural Left-atrial Thrombus in the Era of Direct Oral Anticoagulants-.2017

    • Author(s)
      Harada M, Koshikawa M, Motoike Y, Makino T, Ichikawa T, Kawai M, Watanabe E, Ozaki Y.
    • Organizer
      Heart Rhythm 2017
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Shortened Refractoriness and Conduction Slowing Associated with Elevated Left-atrial Pressure Confers Atrial Fibrillation Sustainability in Patients with Sleep Apnea Syndrome.2017

    • Author(s)
      Motoike Y, Harada M, Fujiwara A, Makino T, Koshikawa M, Ichikawa T, Kawai M, Watanabe E, Ozaki Y.
    • Organizer
      Heart Rhythm 2017
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Age- and Obesity-related Epicardial Adipose Tissue Accumulation Remodels Autonomic Balance and Increases Inflammation in Paroxysmal Atrial Fibrillation Patients.2017

    • Author(s)
      Ichikawa T, Harada M, Takeda J, Motoike Y, Makino T, Koshikawa M, Watanabe E, Ozaki Y.
    • Organizer
      Heart Rhythm 2017
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Inappropriate Dose Reduction of Direct Oral Anticoagulants Increases the Risk of Peri-procedural Left-atrial Thrombus in Patients Undergoing Atrial Fibrillation Ablation.2017

    • Author(s)
      Harada M, Koshikawa M, Makino T, Motoike Y, Ichikawa T, Fujiwara A, Watanabe E, Ozaki Y.
    • Organizer
      The 64st Annual Meeting of the Japanese Heart Rhythm Society/The 10th Asia Pacific Heart Rhythm Society Scientific Session.
    • Related Report
      2017 Research-status Report
  • [Presentation] Serum albumin levels predict major bleeding events associated with increased PT-INR in atrial fibrillation patients on warfarin.2017

    • Author(s)
      Yamamoto M, Harada M, Makino T, Motoike Y, Koshikawa M, Ichikawa T, Watanabe E, Ozaki Y.
    • Organizer
      The 64st Annual Meeting of the Japanese Heart Rhythm Society/The 10th Asia Pacific Heart Rhythm Society Scientific Session.
    • Related Report
      2017 Research-status Report
  • [Presentation] Age- and Obesity-related Epicardial Adipose Tissue Accumulation Remodels Autonomic Balance and Increases Inflammation in Paroxysmal Atrial Fibrillation Patients.2017

    • Author(s)
      Ichikawa T, Harada M, Takeda J, Makino T, Motoike Y, Koshikawa M, Watanabe E, Ozaki Y.
    • Organizer
      The 64st Annual Meeting of the Japanese Heart Rhythm Society/The 10th Asia Pacific Heart Rhythm Society Scientific Session.
    • Related Report
      2017 Research-status Report
  • [Presentation] Intracardiac and Extracardiac Expression of Pro-fibrotic MicroRNAs in Atrial Fibrillation -Implication for Cardiac Specific Biomarkers for Atrial Remodeling-.2017

    • Author(s)
      Harada M, Motoike Y, Makino T, Koshikawa M, Ichikawa T, Kawai M, Watanabe E, Ozaki Y.
    • Organizer
      The 81st Annual Scientific Meeting of the Japanese Circulation Society
    • Related Report
      2017 Research-status Report 2016 Research-status Report
  • [Presentation] Thrombolytic Efficacy of Dabigatran in Patients Undergoing Atrial Fibrillation Ablation -Peri-procedural Left-atrial Thrombus in the Era of Direct Oral Anticoagulants-.2017

    • Author(s)
      Harada M, Koshikawa M, Motoike Y, Makino T, Ichikawa T, Kawai M, Watanabe E, Ozaki Y.
    • Organizer
      The 81st Annual Scientific Meeting of the Japanese Circulation Society.
    • Related Report
      2017 Research-status Report
  • [Presentation] Semi-automatic Selvester QRS Scoring Can Estimate Scar Lesion in Patients with Cardiac Sarcoidosis; Development of Novel ECG Analysis Software-.2017

    • Author(s)
      Harada M, Kitagawa F, Sobue Y, Motoike Y, Makino T, Koshikawa M, Ichikawa T, Watanabe E, Ozaki Y.
    • Organizer
      The 81st Annual Scientific Meeting of the Japanese Circulation Society.
    • Related Report
      2017 Research-status Report
  • [Presentation] Human LA and PV Electrophysiology in AF -clinical implication for the pathophysiology-2016

    • Author(s)
      Harada M.
    • Organizer
      Asia Pacific Heart Rhythm Society 2016
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2016-10-12
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] MicroRNA as potential therapeutic target and biomarkers for atrial fibrillation.2016

    • Author(s)
      Harada M.
    • Organizer
      Asia Pacific Heart Rhythm Society 2016
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2016-10-12
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Intracardiac and extracardiac expression of pro-fibrotic microRNAs in atrial fibrillation -implication for cardiac specific biomarkers for atrial remodeling-2016

    • Author(s)
      Harada M, Matsuo C, Motoike Y, Makino T, Koshikawa M, Ichikawa T, Kawai M, Watanabe E, Ozaki Y.
    • Organizer
      European Society of Cardiology Congress 2016
    • Place of Presentation
      Roma, Italy
    • Year and Date
      2016-08-27
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Rate-dependent Shortening of Refractory Period with Conduction Slowing in the Left Pulmonary Vein Increases Atrial Vulnerability in Paroxysmal AF Patients.2016

    • Author(s)
      Harada M, Motoike Y, Fujiwara A, Makino T, Koshikawa M, Ichikawa T, Kawai M, Sawasaki K, Muto M, Murohara T, Watanabe E, Ozaki Y.
    • Organizer
      The 31st Annual Meeting of the Japanese Heart Rhythm Society
    • Place of Presentation
      札幌コンベンションセンター(北海道 札幌市)
    • Year and Date
      2016-07-14
    • Related Report
      2016 Research-status Report
  • [Presentation] Electrophysiological Characteristics of the Left Atrium and Pulmonary Vein Confers Development of Atrial Fibrillation in Patients with Sleep Apnea Syndrome.2016

    • Author(s)
      Motoike Y, Harada M, Fujiwara A, Makino T, Koshikawa M, Ichikawa T, Kawai M, Watanabe E, Ozaki Y.
    • Organizer
      The 31st Annual Meeting of the Japanese Heart Rhythm Society
    • Place of Presentation
      札幌コンベンションセンター(北海道 札幌市)
    • Year and Date
      2016-07-14
    • Related Report
      2016 Research-status Report
  • [Presentation] Passive Oscillation and Its Amplitude of Inter-atrial Septum in Transesophageal Echocardiography is a Novel Non-invasive Parameter for Left Atrial Pressure in Atrial Fibrillation.2016

    • Author(s)
      Makino T, Yamamoto M, Harada M, Motoike Y, Koshikawa M, Ichikawa T, Watanabe E, Ozaki Y.
    • Organizer
      The 31st Annual Meeting of the Japanese Heart Rhythm Society
    • Place of Presentation
      札幌コンベンションセンター(北海道 札幌市)
    • Year and Date
      2016-07-14
    • Related Report
      2016 Research-status Report
  • [Presentation] MicroRNAs as Potential Therapeutic Target and Biomarkers for Atrial Fibrillation.2016

    • Author(s)
      Harada M, Watanabe E, Ozaki Y.
    • Organizer
      The 31st Annual Meeting of the Japanese Heart Rhythm Society
    • Place of Presentation
      札幌コンベンションセンター(北海道 札幌市)
    • Year and Date
      2016-07-14
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] Autonomic Nerve-mediated Atrial Fibrillation: Clinical Characteristics and Mechanistic Implications.2016

    • Author(s)
      Harada M.
    • Organizer
      The 31st Annual Meeting of the Japanese Heart Rhythm Society
    • Place of Presentation
      札幌コンベンションセンター(北海道 札幌市)
    • Year and Date
      2016-07-14
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] Urinary 3-methylhystidine is a Surrogate Maker for Inflammation-related Physical Frailty in Atrial Fibrillation.2016

    • Author(s)
      Koshikawa M, Harada M, Motoike Y, Makino T, Ichikawa T, Kawai M, Watanabe E, Ozaki Y.
    • Organizer
      The 31st Annual Meeting of the Japanese Heart Rhythm Society
    • Place of Presentation
      札幌コンベンションセンター(北海道 札幌市)
    • Year and Date
      2016-07-14
    • Related Report
      2016 Research-status Report
  • [Presentation] Shortening of Effective Refractory Period with Conduction Slowing in Left Pulmonary Vein Increases Vulnerability to Paroxysmal Atrial Fibrillation.2016

    • Author(s)
      Harada M, Motoike Y, Fujiwara A, Makino T, Koshikawa M, Ichikawa T, Kawai M, Sawasaki K, Muto M, Murohara T, Watanabe E, Ozaki Y.
    • Organizer
      Heart Rhythm 2017
    • Place of Presentation
      San Francisco, CA, USA
    • Year and Date
      2016-05-04
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Serum MicroRNA26a Levels Progressively Decrease during AF Development in Coronary Vein Blood Samples.2016

    • Author(s)
      Harada M, Motoike Y, Makino T, Koshikawa M, Ichikawa T, Kawai M, Watanabe E, Ozaki Y.
    • Organizer
      Heart Rhythm 2017
    • Place of Presentation
      San Francisco, CA, USA
    • Year and Date
      2016-05-04
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Book] 心房細動と心房リモデリング-病態機序とマイクロRNAの関与- Bio Clinica2018

    • Author(s)
      原田将英
    • Total Pages
      7
    • Publisher
      北隆館
    • Related Report
      2018 Annual Research Report
  • [Book] 心房細動 (山下 武編) 心房細動における血栓塞栓症予防2018

    • Author(s)
      原田将英、渡邊英一
    • Publisher
      最新医学社
    • Related Report
      2017 Research-status Report
  • [Book] 臨床医のための循環器診療 心臓自律神経と心房細動-病態の理解とアブレーションへの応用-2018

    • Author(s)
      原田将英、渡邊英一
    • Publisher
      学樹書院
    • Related Report
      2017 Research-status Report
  • [Book] 私の治療 2017-2018年度版 Wolf-Parkinson-White (WPW) 症候群2017

    • Author(s)
      原田将英、渡邊英一
    • Publisher
      日本医事新報社
    • Related Report
      2017 Research-status Report
  • [Book] Circulation Up-to Date Books 17 超実践的! 抗凝固薬の使い方 (池田隆徳 編)、 ワルファリン2017

    • Author(s)
      原田将英、渡邊英一
    • Publisher
      メディカ出版
    • Related Report
      2017 Research-status Report
  • [Book] 循環器ジャーナル 心電図スキルアップ2017

    • Author(s)
      原田将英、渡邊英一
    • Publisher
      医学書院
    • Related Report
      2017 Research-status Report
  • [Book] Circulation Up-to Date Books 17 超実践的! 抗凝固薬の使い方2017

    • Author(s)
      原田将英、渡邊英一
    • Publisher
      メディカ出版
    • Related Report
      2016 Research-status Report
  • [Book] 循環器ジャーナル 心電図診断スキルアップ2017

    • Author(s)
      原田将英、渡邊英一
    • Publisher
      医学書院
    • Related Report
      2016 Research-status Report
  • [Book] 心不全x不整脈2016

    • Author(s)
      原田将英、渡邊英一
    • Publisher
      メディカ出版
    • Related Report
      2016 Research-status Report
  • [Book] 薬局/特集 心房細動と抗血栓療法2016

    • Author(s)
      原田将英、渡邊英一
    • Publisher
      南山堂
    • Related Report
      2016 Research-status Report
  • [Book] 循環器内科 心不全と心房細動2016

    • Author(s)
      市川智英、原田将英、渡邉英一
    • Publisher
      科学評論社
    • Related Report
      2016 Research-status Report

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Published: 2016-04-21   Modified: 2020-03-30  

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