| Project/Area Number |
16K09466
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cardiovascular medicine
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| Research Institution | Kawasaki Medical School |
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Principal Investigator |
Imai Koichiro 川崎医科大学, 医学部, 講師 (90388942)
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| Co-Investigator(Kenkyū-buntansha) |
古山 輝將 川崎医科大学, 医学部, 講師 (20434996)
玉田 智子 川崎医科大学, 医学部, 講師 (90435016)
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2018: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
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| Keywords | 内皮機能 / エンドパッド / 心房細動 / アブレーション / 血管内皮機能 / EndPAT / カテーテルアブレーション / 血管内皮機能障害 / 臨床医学 |
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| Outline of Final Research Achievements |
Before ablation, vascular endothelial function was measured using an end pat and also measured at follow-up. In general, vascular endothelial function (RHI) is the observation item and the criteria Values: 2.10 or more Good, 1.68 to 2.09 No problem, 1.67 or less It is judged that it needs attention.
The RHI before ablation was 1.93, and after ablation, it showed a tendency of improvement of 2.2, and there was no statistically significant difference. However, RHI was good before ablation. The number of cases is small, and it is necessary to consider as limitation because it is a test that is often measured at the time of out-patient and susceptible to environmental changes during Follow-up, but it is necessary to consider it as a blood vessel by atrial fibrillation patient Endothelial function improvement effect was not found in this study。
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| Academic Significance and Societal Importance of the Research Achievements |
今回の研究ではアブレーションにおける内皮機能障害の改善は見いだせなかった。
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