Home Blood Pressure and Vascular Endothelial Function in Mothers, Children and the Elderly: A women cohort and general cohort

• Project/Area Number: 16K09472
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cardiovascular medicine
• Research Institution: Teikyo University (2018-2019); Tohoku University (2016-2017)
• Principal Investigator: KIKUYA Masahiro 帝京大学, 医学部, 教授 (80361111)
• Project Period (FY): 2016-04-01 – 2020-03-31
• Project Status: Completed (Fiscal Year 2019)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2018: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2017: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2016: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
• Keywords: 血管内皮機能 / 動脈硬化 / RHI / FMD / 臨床血管学

Outline of Final Research Achievements

Vascular endothelial function was measured in 189 women (age 41.6 ± 4.6 years) with End pads and UNEX FMD with simultaneously measurement procedure. Reactive hyperemia index after natural logarithm conversion (LnRHI), Flow-mediated dilatation (FMD) and their correlation coefficient were 0.86 ± 0.24, 7.60 ± 1.63%, and the 0.047. A multiple regression analysis with LnRHI as the dependent variable and FMD, age, BMI, systolic blood pressure, and pulse as independent variables showed a positive association only with body mass index (standardized regression coefficient = 0.25, P = 0.0006). It was confirmed that RHI and FMD, which are indicators of vascular endothelial function, hoses different implication.

Academic Significance and Societal Importance of the Research Achievements

心疾患、脳卒中は日本人の死因の2位および4位を占めており、その原因である動脈硬化の予防は生活習慣病予防の重要なターゲットである。動脈硬化の危険因子は血圧、高脂血症、糖尿病など確立されているが、そのメカニズムに関しては必ずしも充分には解明されていない。その間に介在するものとして血管内皮機能の障害が示唆されている。しかし、その測定法には複数の方法があり臨床的な意義（危険因子、臓器障害、予後との関連）の確立の為に更にエビデンスを積み上げる必要がある。本研究では2種類の血管内皮機能の測定法を用いて、まだ動脈硬化の無いと考えられる若年女性を対象として両者の測定を検証した。

Research Products

• [Journal Article] Do estimated 24-h pulse pressure components affect outcome? The Ohasama study (2020)
  • Author(s): Bursztyn Michael、Kikuya Masahiro、Asayama Kei、Satoh Michihiro、Gavish Benjamin、Ohkubo Takayoshi
  • Journal Title: Journal of Hypertension Volume: - Issue: 7 Pages: 1-1
  • DOI: 10.1097/hjh.0000000000002366
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Age‐Related Trends in Home Blood Pressure, Home Pulse Rate, and Day‐to‐Day Blood Pressure and Pulse Rate Variability Based on Longitudinal Cohort Data: The Ohasama Study (2019)
  • Author(s): Satoh Michihiro、Metoki Hirohito、Asayama Kei、Murakami Takahisa、Inoue Ryusuke、Tsubota‐Utsugi Megumi、Matsuda Ayako、Hirose Takuo、Hara Azusa、Obara Taku、Kikuya Masahiro、Nomura Kyoko、Hozawa Atsushi、Imai Yutaka、Ohkubo Takayoshi
  • Journal Title: Journal of the American Heart Association Volume: 8 Issue: 15
  • DOI: 10.1161/jaha.119.012121
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Moderate morning rise in blood pressure has lowest risk of stroke but only in women (2019)
  • Author(s): Head Geoffrey A.、Sata Yusuke、Imai Yukata、Kikuya Masahiro、Ohkubo Takayoshi、Reid Christopher M.、McGrath Barry M.、Lukoshkova Elena V.
  • Journal Title: Journal of Hypertension Volume: 37 Issue: 7 Pages: 1437-1447
  • DOI: 10.1097/hjh.0000000000002027
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] N-Terminal Pro-B-Type Natriuretic Peptide Is Not a Significant Predictor of Stroke Incidence After 5 Years ― The Ohasama Study ― (2018)
  • Author(s): Satoh Michihiro、Murakami Takahisa、Asayama Kei、Hirose Takuo、Kikuya Masahiro、Inoue Ryusuke、Tsubota-Utsugi Megumi、Murakami Keiko、Matsuda Ayako、Hara Azusa、Obara Taku、Kawasaki Ryo、Nomura Kyoko、Metoki Hirohito、Node Koichi、Imai Yutaka、Ohkubo Takayoshi
  • Journal Title: Circulation Journal Volume: 82 Issue: 8 Pages: 2055-2062
  • DOI: 10.1253/circj.CJ-17-1227
  • NAID: 130007418933
  • ISSN: 1346-9843, 1347-4820
  • Year and Date: 2018-07-25
  • Peer Reviewed
• [Journal Article] Association between tooth loss and cognitive impairment in community-dwelling older Japanese adults: a 4-year prospective cohort study from the Ohasama study (2018)
  • Author(s): Saito Sho、Ohi Takashi、Murakami Takahisa、Komiyama Takamasa、Miyoshi Yoshitada、Endo Kosei、Satoh Michihiro、Asayama Kei、Inoue Ryusuke、Kikuya Masahiro、Metoki Hirohito、Imai Yutaka、Ohkubo Takayoshi、Hattori Yoshinori
  • Journal Title: BMC Oral Health Volume: 18 Issue: 1 Pages: 1-8
  • DOI: 10.1186/s12903-018-0602-7
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Nocturnal blood pressure decline based on different time intervals and long-term cardiovascular risk: the Ohasama Study. (2018)
  • Author(s): Satoh M, Asayama K, Kikuya M, Inoue R, Tsubota-Utsugi M, Obara T, Murakami K, Matsuda A, Murakami T, Nomura K, Metoki H, Imai Y, Ohkubo T.
  • Journal Title: Clin Exp Hypertens Volume: 40 Issue: 1 Pages: 1-7
  • DOI: 10.1080/10641963.2016.1259324
  • Peer Reviewed
• [Journal Article] Home blood pressure predicts stroke incidence among older adults with impaired physical function: the Ohasama study. (2017)
  • Author(s): Murakami K, Asayama K, Satoh M, Hosaka M, Matsuda A, Inoue R, Tsubota-Utsugi M, Murakami T, Nomura K, Kikuya M, Metoki H, Imai Y, Ohkubo T.
  • Journal Title: J Hypertens. Volume: 35 Issue: 12 Pages: 2395-2401
  • DOI: 10.1097/hjh.0000000000001473
  • Peer Reviewed
• [Journal Article] Lacunar Infarcts Rather than White Matter Hyperintensity as a Predictor of Future Higher Level Functional Decline: The Ohasama Study. (2017)
  • Author(s): Tsubota-Utsugi M, Satoh M, Tomita N, Hara A, Kondo T, Hosaka M, Saito S, Asayama K, Inoue R, Hirano M, Hosokawa A, Murakami K, Murakami T, Metoki H, Kikuya M, Izumi SI, Imai Y, Ohkubo T.
  • Journal Title: J Stroke Cerebrovasc Dis. Volume: 26 Issue: 2 Pages: 376-384
  • DOI: 10.1016/j.jstrokecerebrovasdis.2016.09.036
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Risk Factors for Stroke among Young-Old and Old-Old Community-Dwelling Adults in Japan: The Ohasama Study (2017)
  • Author(s): Murakami K, Asayama K, Satoh M, Inoue R, Tsubota-Utsugi M, Hosaka M, Matsuda A, Nomura K, Murakami T, Kikuya M, Metoki H, Imai Y, Ohkubo T.
  • Journal Title: Journal of Atherosclerosis and Thrombosis Volume: 24 Issue: 3 Pages: 290-300
  • DOI: 10.5551/jat.35766
  • NAID: 130005397989
  • ISSN: 1340-3478, 1880-3873
  • Peer Reviewed / Open Access
• [Journal Article] Menstrual Factors and Stroke Incidence in Japanese Postmenopausal Women: The Ohasama Study. (2016)
  • Author(s): Murakami K, Metoki H, Satoh M, Asayama K, Hosaka M, Matsuda A, Inoue R, Tsubota-Utsugi M, Murakami T, Nomura K, Kikuya M, Imai Y, Ohkubo T.
  • Journal Title: Neuroepidemiology. Volume: 47 Pages: 109-116
  • Peer Reviewed