A novel strategy for detection of hyperetnsive gene analyzed from high risk families in large scale general health check-up

• Project/Area Number: 16K09475
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cardiovascular medicine
• Research Institution: Kagoshima University
• Principal Investigator: Ohishi Mitsuru 鹿児島大学, 医歯学域医学系, 教授 (50335345)
• Co-Investigator(Kenkyū-buntansha): 池田 義之 鹿児島大学, 医歯学域医学系, 講師 (00573023) ; 赤崎 雄一 鹿児島大学, 医歯学域附属病院, 助教 (00631920) ; 吉満 誠 鹿児島大学, 医歯学域医学系, 准教授 (70404530)
• Project Period (FY): 2016-04-01 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2018: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000); Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
• Keywords: 高血圧 / 尿酸 / 心房細動 / 大規模健診データ / 疾患感受性遺伝子 / 家系 / 遺伝子 / 循環器・高血圧

Outline of Final Research Achievements

Although it is quite difficult to extract high risk families from general health check-up database with more than 350,000 people because of personal information protection law, we clarified hyperuricemia is risk for onset and morbidity of atrial fibrillation in women by both cross-sectional and longitudinal researches during data cleaning. We also clarified frequencies and clinical features of hypouricemia and triglyceride should be a risk factor for arterial stiffness in patients with low LDL cholesterol. Moreover, we found out low risk for onset of hypertension in women with body weight reduction.

Academic Significance and Societal Importance of the Research Achievements

高血圧高浸透率家系の抽出はできなかったが、データクリーニング途中で解析をした、高尿酸血症および低尿酸血症の循環器疾患、特に心房細動に対する影響の可能性やLDL低値群における中性脂肪の動脈硬化リスクなどは、今後のリスクファクターコントロールに重要な方向性を与えるものであると考えている。
また、体重が減った女性が高血圧発症リスクが低下することは、減量による高血圧発症抑制の可能性を示すデータであり、生活習慣病予防に極めて有用なデータであるといえる。

Research Products

• [Journal Article] Distribution and Characteristics of Hypouricemia within the Japanese General Population: A Cross-Sectional Study (2019)
  • Author(s): Kawasoe Shin、Ide Kazuki、Usui Tomoko、Kubozono Takuro、Yoshifuku Shiro、Miyahara Hironori、Maenohara Shigeho、Ohishi Mitsuru、Kawakami Koji
  • Journal Title: Medicina Volume: 55 Issue: 3 Pages: 61-61
  • DOI: 10.3390/medicina55030061
  • Peer Reviewed
• [Journal Article] Uric Acid Level and New-Onset Atrial Fibrillation in the Japanese General Population ― Longitudinal Study ― (2018)
  • Author(s): Kawasoe S, Kubozono T, Yoshifuku S, Ojima S, Miyata M, Miyahara H, Maenohara S, Ohishi M
  • Journal Title: Circulation Journal Volume: 83 Issue: 1 Pages: 156-163
  • DOI: 10.1253/circj.CJ-18-0508
  • NAID: 130007550394
  • ISSN: 1346-9843, 1347-4820
  • Year and Date: 2018-12-25
  • Peer Reviewed / Open Access
• [Journal Article] Association of Serum Triglycerides With Arterial Stiffness in Subjects With Low Levels of Low-Density Lipoprotein Cholesterol (2018)
  • Author(s): Kawasoe S, Ide K, Usui T, Kubozono T, Yoshifuku S, Miyahara H, Maenohara S, Ohishi M, Kawakami K.
  • Journal Title: Circulation Journal Volume: 82 Issue: 12 Pages: 3052-3057
  • DOI: 10.1253/circj.CJ-18-0607
  • NAID: 130007521297
  • ISSN: 1346-9843, 1347-4820
  • Year and Date: 2018-11-24
  • Peer Reviewed / Open Access
• [Journal Article] High Pulse Wave Velocity Has a Strong Impact on Early Carotid Atherosclerosis in a Japanese General Male Population (2017)
  • Author(s): Takuro Kubozono, Masaaki Miyata, Shin Kawasoe, Satoko Ojima, Shiro Yoshifuku, Hironori Miyahara, Shigeho Maenohara, Mitsuru Ohishi
  • Journal Title: Circulation Journal Volume: 81 Issue: 3 Pages: 310-315
  • DOI: 10.1253/circj.CJ-16-0687
  • NAID: 130005242976
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed / Open Access
• [Journal Article] Uric Acid Level and Prevalence of Atrial Fibrillation in 285,882 Japanese General Population. (2016)
  • Author(s): 9.Kawasoe S, Kubozono T, Yoshifuku S, Ojima S, Oketani N, Miyata M, Miyahara H, Maenohara S, Ohishi M.
  • Journal Title: Circulation Journal Volume: 80 Pages: 2453-2459
  • Peer Reviewed
• [Presentation] How to achieve optimal blood pressure? (2018)
  • Author(s): Ohishi M
  • Organizer: Korean Clinical Hypertension Society
  • Int'l Joint Research / Invited
• [Presentation] Metabolic Disorders in Blood Pressure Variability (2018)
  • Author(s): Ohishi M
  • Organizer: International Society of Hypertension
  • Int'l Joint Research / Invited
• [Presentation] 高血圧と循環器疾患予防 －Hypertension Paradoxの克服へ－ (2018)
  • Author(s): 大石 充
  • Organizer: 第54回日本循環器病予防学会学術集会
• [Presentation] 相互信頼が生み出す適切な高血圧診療を目指して (2018)
  • Author(s): 大石 充
  • Organizer: 日本高血圧学会 第7回臨床高血圧フォーラム
• [Presentation] Hypertension Paradox克服のために (2018)
  • Author(s): 大石 充
  • Organizer: 第41回日本高血圧学会総会
• [Presentation] 高血圧 (2018)
  • Author(s): 大石 充
  • Organizer: ARIA 2018
• [Presentation] Uric acid level and new onset atrial fibrillation in Japanese general population (2017)
  • Author(s): Kawasoe S, Kubozono T, Ojima S, Yoshikawa A, Yoshifuku S, Miyahara H, Miyata M, Maenohara S, Ohishi M
  • Organizer: The 8th Congress of the International Society for Gender Medicine
  • Int'l Joint Research
• [Book] 循環器疾患最新の治療2018-2019 (2018)
  • Author(s): 大石 充
  • Total Pages: 540
  • Publisher: 南江堂
  • ISBN: 9784524252183
• [Book] 日常診療に活かす診療ガイドラインUP-TO-DATE 2018-2019 (2018)
  • Author(s): 赤﨑雄一，大石 充
  • Total Pages: 2064
  • Publisher: メディカルレビュー社
  • ISBN: 9784779220081
• [Book] 血圧 (2018)
  • Author(s): 佐々木雄一，池田義之，大石 充
  • Total Pages: 70
  • Publisher: 先端医学社
  • ISBN: 9784865503180
• [Book] Medical Practice (2018)
  • Author(s): 大石 充
  • Total Pages: 160
  • Publisher: 文光堂