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Acute treatment and clinical outcome in patients with intracranial arterial dissection

Research Project

Project/Area Number 16K09485
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Cardiovascular medicine
Research InstitutionNational Cardiovascular Center Research Institute

Principal Investigator

Koga Masatoshi  国立研究開発法人国立循環器病研究センター, 病院, 部長 (30512230)

Project Period (FY) 2016-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords頭蓋内動脈解離 / 若年性脳梗塞 / くも膜下出血 / MRI / 超音波検査 / 抗血栓療法 / 脳梗塞 / MRIのT1 SPACE画像 / 頚部血管エコー / 脳血管造影 / クモ膜下出血 / 好中球・リンパ球比 / 頭痛 / 高解像度3D T1 / 椎骨動脈 / 頸部血管エコー / 3T MRI / T1強調画像 / 抗凝固薬 / 抗血小板薬
Outline of Final Research Achievements

Our observational study of intracranial artery dissection (IAD) showed that the identification of intramural hematoma of dissociated intracranial artery by high-resolution 3D T1-weighted imaging was very useful for diagnosing IAD. Follow-up evaluation of blood flow velocity by carotid ultrasound was useful to identify the appearance and progression of intracranial vertebral artery stenosis. In IAD patients with ischemia stroke or headache alone, the clinical course was generally favorable regardless of antithrombotic treatment.
We enrolled 50 patients (500 cases in total) to an international observational study of IAD. We plan to show the pathophysiology and clinical course of IAD, which has been mostly reported by East Asian countries including Japan, and clarify racial differences.

Academic Significance and Societal Importance of the Research Achievements

若年性脳梗塞の重要な原因の一つである頭蓋内動脈解離は、画像診断の進歩により診断される機会が増えたが、診断方法や治療方法は確立していない。これまで脳血管撮影による評価が重視されてきたが、非侵襲的画像診断である高分解能3D T1強調画像による壁内血腫同定が一般的になっていく可能性がある。また非侵襲的画像診断である頚部血管エコーのフォローアップで椎骨動脈狭窄出現や進行を同定できることを明らかにした。頭蓋内動脈解離の一部は解離性動脈瘤からくも膜下出血を来し転帰不良の経過をとるが、虚血発症や頭痛のみの症例の多くは経過が良好であった。国際共同研究で多数例を解析し、さらなる検討を行っていく。

Report

(5 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (25 results)

All 2020 2019 2018 2017 Other

All Int'l Joint Research (8 results) Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (12 results) (of which Int'l Joint Research: 6 results,  Invited: 1 results) Book (1 results) Remarks (1 results)

  • [Int'l Joint Research] ベルン大学/バーゼル大学(スイス)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] ピサ大学(イタリア)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] ヘルシンキ大学(フィンランド)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] ベルン大学/バーゼル大学(スイス)

    • Related Report
      2018 Research-status Report
  • [Int'l Joint Research] ピサ大学(イタリア)

    • Related Report
      2018 Research-status Report
  • [Int'l Joint Research] ヘルシンキ大学(フィンランド)

    • Related Report
      2018 Research-status Report
  • [Int'l Joint Research] ベルン大学/バーゼル大学(スイス)

    • Related Report
      2017 Research-status Report
  • [Int'l Joint Research] ベルン大学/バーゼル大学(スイス)

    • Related Report
      2016 Research-status Report
  • [Journal Article] Clinical and Radiological Characteristics of Intracranial Artery Dissection Using Recently Proposed Diagnostic Criteria2019

    • Author(s)
      Nakamura Y, Yamaguchi Y, Makita N, Morita Y, Ide T, Wada S, Mizoguchi T, Ikenouchi H, Miwa K, Yi K, Irie K, Shimohama S, Ihara M, Toyoda K, Koga M
    • Journal Title

      J Stroke Cerebrovasc Dis

      Volume: Epub Issue: 6 Pages: 30063-1

    • DOI

      10.1016/j.jstrokecerebrovasdis.2019.02.019

    • Related Report
      2019 Annual Research Report 2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Detection of Stenosis Progression in Intracranial Vertebral Artery Dissection Using Carotid Ultrasonography2019

    • Author(s)
      Wada Shinichi、Koga Masatoshi、Makita Naoki、Nakamura Yuki、Miwa Kaori、Ide Toshihiro、Yi Kenichiro、Mizoguchi Tadataka、Yamaguchi Yoshitaka、Ihara Masafumi、Toyoda Kazunori
    • Journal Title

      Journal of Stroke and Cerebrovascular Diseases

      Volume: 28 Issue: 8 Pages: 2201-2206

    • DOI

      10.1016/j.jstrokecerebrovasdis.2019.04.033

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Detection of stenosis progression in intracranial vertebral artery dissection using carotid ultrasonography2019

    • Author(s)
      Wada S, Koga M, Nakamura Y, Makita N, Miwa K, Ide T, Yi K, Mizoguchi T, Yamaguchi Y, Ihara M, Toyoda K
    • Journal Title

      J Stroke Cerebrobasc Dis

      Volume: in press

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Presentation] Angiographic Findings Associated With Ischemic and Hemorrhagic Stroke in Intracranial Artery Dissection.2019

    • Author(s)
      Tadataka Mizoguchi, Kaori Miwa, Kenichiro Yi, Kenichi Irie, Naoki Makita, Hidekazu Chikuie, Tetsu Satow, Jun C Takahashi, Hiroshi Yamagami, Masafumi Ihara, Kazunori Toyoda, Masatoshi Koga.
    • Organizer
      International Stroke Conference 2019, Honolulu, Hawaii, USA
    • Related Report
      2019 Annual Research Report 2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Relationship of Neutrophil-to-Lymphocyte Ratio to Stroke Subtype and Functional Outcome in Intracranial Artery Dissection.2019

    • Author(s)
      Yi K, Miwa K, Mizoguchi T, Irie K, Makita N, Chikuie H, Satow T, Takahashi J, Yamagami H, Ihara M, Toyoda K, Koga M.
    • Organizer
      International Stroke Conference 2019, Honolulu, Hawaii, USA
    • Related Report
      2019 Annual Research Report 2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] 解離性頭蓋内動脈狭窄の診断と急性期抗血栓療法2019

    • Author(s)
      古賀政利、蒔田直輝、中村祐貴、吉村壮平、三輪佳織
    • Organizer
      第38回The Mt Fuji Workshop on CVD
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Medullary infarction due to vertebral artery dissection: infarct topography and functional outcome.2018

    • Author(s)
      Irie K, Miwa K, Mizoguchi T, Yi K, Ihara M, Toyoda K, Koga M.
    • Organizer
      16th Asian Oceanian Congress of Neurology, Seoul, Korea
    • Related Report
      2018 Research-status Report
  • [Presentation] Long- term vascular morphological changes and clinical events in intracranial artery dissection.2018

    • Author(s)
      Makita N, Koga M, Nakamura Y, Ide T, Wada S, Yamaguchi Y, Ihara M, Toyoda K.
    • Organizer
      International Stroke Conference 2018, Los Angeles, USA
    • Related Report
      2018 Research-status Report
  • [Presentation] Clinical and Radiological Characteristics of Intracranial Artery Dissection Using Recently Proposed Diagnostic Criteria.2018

    • Author(s)
      Nakamura Y, Yamaguchi Y, Koga M, Morita Y, Makita N, Ide T, Wada S, Shimohama S, Ihara M, Toyoda K.
    • Organizer
      International Stroke Conference 2018, Los Angeles, USA
    • Related Report
      2018 Research-status Report
  • [Presentation] Arterial velocity on carotid ultrasonography can predict the stenosis progression in patients with vertebro-basillar dissection.2018

    • Author(s)
      Wada S, Koga M, Nakamura Y, Makita N, Ide T, Yamaguchi Y, Ihara M, Toyoda K.
    • Organizer
      International Stroke Conference 2018, Los Angeles, USA
    • Related Report
      2018 Research-status Report
  • [Presentation] Clinical and Radiological Characteristics of Intracranial Artery Dissection Using Recently Proposed Diagnostic Criteria2018

    • Author(s)
      Yuki Nakamura, Yoshitaka Yamaguchi, Masatoshi Koga, Yoshiaki Morita, Naoki Makita, Toshihiro Ide, Shinichi Wada, Shun Shimohama, Masafumi Ihara and Kazunori Toyoda
    • Organizer
      International Stroke Conference 2018
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Arterial Velocity on Carotid Ultrasonography Can Predict the Stenosis Progression in Patients With Vertebro-basillar Dissection2018

    • Author(s)
      Shinichi Wada, Masatoshi Koga, Yuki Nakamura, Naoki Makita, Toshihiro Ide, Yoshitaka Yamaguchi, Masafumi Ihara and Kazunori Toyoda
    • Organizer
      International Stroke Conference 2018
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Long-term Vascular Morphological Changes and Clinical Events in Intracranial Artery Dissection2018

    • Author(s)
      Naoki Makita, Masatoshi Koga, Yuki Nakamura, Toshihiro Ide, Sinichi Wada, Yoshitaka Yamaguchi, Masafumi Ihara and Kazunori Toyoda
    • Organizer
      International Stroke Conference 2018
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Usefulness of high resolusion magnetic resonance imaging with 3D T1 blood black seqence to identify intracranial artery dissection2017

    • Author(s)
      Nakamura Y, Morita Y, Makita N, Koga M, Toyoda K
    • Organizer
      XXIII World Congress of Neurology 2017
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Retrospective case series of intracranial artery dissection in NCVC2017

    • Author(s)
      Masatoshi Koga
    • Organizer
      CADISP-plus meeting at ESOC2017
    • Place of Presentation
      Pragye, Czech Republic
    • Related Report
      2016 Research-status Report
  • [Book] The 38th Meeting of The Mt. Fuji Workshop on CVD2020

    • Author(s)
      古賀政利、蒔田直輝、中村祐貴、吉村壮平、三輪佳織、森田佳明、猪原匡史、 豊田一則
    • Publisher
      株式会社 にゅーろん社
    • Related Report
      2019 Annual Research Report
  • [Remarks] International Intracranial Dissection Study

    • URL

      https://clinicaltrials.gov/ct2/show/NCT02756091

    • Related Report
      2019 Annual Research Report 2017 Research-status Report 2016 Research-status Report

URL: 

Published: 2016-04-21   Modified: 2021-02-19  

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