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Noninvasive imaging and therapy of vascular inflammation with gold nanoparticles

Research Project

Project/Area Number 16K09511
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Cardiovascular medicine
Research InstitutionUniversity of Tsukuba

Principal Investigator

Kosuge Hisanori  筑波大学, 医学医療系, 研究員 (00376774)

Research Collaborator Nakamura Maki  
Oyane Ayako  
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords血管炎症 / ナノ粒子 / 金ナノ粒子 / マクロファージ / 画像診断
Outline of Final Research Achievements

We evaluated gold nanoparticles for noninvasive imaging and therapy of vascular inflammation. Computed tomography (CT) imaging demonstrated gold nanoparticles accumulated in the lesion of vascular inflammation in mouse models after injection of gold nanoparticles. Laser light exposure induced death of cells with gold nanoparticles. Based on these experiments, gold nanoparticles have the potential for CT imaging and laser ablation of vascular inflammation.

Academic Significance and Societal Importance of the Research Achievements

本研究では、金ナノ粒子を用いて血管炎症部位(動脈硬化や腹部大動脈瘤)をCT撮影により非侵襲的に検出することが可能であった。また、金ナノ粒子を取り込んだ細胞に対して近赤外線レーザー光を照射することにより、細胞死が誘導されることが示され、近赤外線レーザー光照射による非侵襲的な治療の可能性が示唆された。金ナノ粒子は診断および治療の双方に有用であり、血管炎症性病変の早期発見に加え、早期治療への応用が期待される。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (11 results)

All 2019 2018 2017

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (10 results) (of which Int'l Joint Research: 4 results)

  • [Journal Article] Facile one-pot fabrication of calcium phosphate-based composite nanoparticles as delivery and MRI contrast agents for macrophages2018

    • Author(s)
      Nakamura Maki、Oyane Ayako、Kuroiwa Kiyoko、Shimizu Yoshiki、Pyatenko Alexander、Misawa Masaki、Numano Tomokazu、Kosuge Hisanori
    • Journal Title

      Colloids and Surfaces B: Biointerfaces

      Volume: 162 Pages: 135-145

    • DOI

      10.1016/j.colsurfb.2017.11.034

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Presentation] Noninvasive imaging of experimental aortic aneurysms using gold nanoparticles2019

    • Author(s)
      Hisanori Kosuge, Maki Nakamura, Ayako Oyane, Kazuko Tajiri, Nobuyuki Murakoshi, Satoshi Sakai, Akira Sato, Masaki Ieda, Kazutaka Aonuma
    • Organizer
      第83回日本循環器学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Gold Nanoparticles Allow CT Imaging of Experimental Atherosclerosis2018

    • Author(s)
      Hisanori Kosuge, Maki Nakamura, Ayako Oyane, Kazuko Tajiri, Nobuyuki Murakoshi, Satoshi Sakai, Akira Sato, Kazutaka Aonuma
    • Organizer
      Vascular Discovery: From Genes to Medicine Scientific Sessions
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Gold Nanoparticles for Detection of Vascular Inflammation in Experimental Carotid Atherosclerosis and Aortic Aneurysms2018

    • Author(s)
      Hisanori Kosuge, Maki Nakamura, Ayako Oyane, Kazuko Tajiri, Nobuyuki Murakoshi, Satoshi Sakai, Akira Sato, Masaki Ieda, Kazutaka Aonuma
    • Organizer
      American Heart Association Scientific Sessions
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Interaction of calcium phosphate with gold nanocrystals coated with polyethylene glycol2018

    • Author(s)
      中村真紀、黒岩輝代子、大矢根綾子、小菅寿徳
    • Organizer
      Bioceramics 30
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] マクロファージイメージングのためのリン酸カルシウム複合ナノ粒子のone-pot合成2018

    • Author(s)
      中村 真紀、大矢根 綾子、黒岩 輝代子、清水禎樹、三澤 雅樹、沼野 智一、小菅 寿徳
    • Organizer
      つくば医工連携フォーラム2018
    • Related Report
      2017 Research-status Report
  • [Presentation] ポリエチレングリコールで被覆された金ナノ粒子を担持したリン酸カルシウム系ナノ粒子の作製2018

    • Author(s)
      中村 真紀・黒岩 輝代子・大矢根 綾子、小菅 寿徳
    • Organizer
      公益社団法人日本セラミックス協会 2018年年会
    • Related Report
      2017 Research-status Report
  • [Presentation] Gold nanoparticles for imaging vascular inflammation2018

    • Author(s)
      Hisanori Kosuge, Maki Nakamura, Ayako Oyane, Kazuko Tajiri, Nobuyuki Murakoshi, Satoshi Sakai, Akira Sato, Kazutaka Aonuma
    • Organizer
      The 82nd Annual Scientific Meeting of the Japanese Circulation Society
    • Related Report
      2017 Research-status Report
  • [Presentation] 医療用注射液を用いた磁性酸化鉄含有リン酸カルシウムナノ粒子の作製2017

    • Author(s)
      中村 真紀・黒岩 輝代子・大矢根 綾子・三澤 雅樹・沼野 智一・小菅 寿徳
    • Organizer
      公益社団法人日本セラミックス協会 2017年年会
    • Place of Presentation
      日本大学 駿河台キャンパス 東京都千代田区
    • Year and Date
      2017-03-17
    • Related Report
      2016 Research-status Report
  • [Presentation] マクロファージ検出のための磁性酸化鉄ナノ粒子含有リン酸カルシウム系粒子の作製2017

    • Author(s)
      中村 真紀、大矢根 綾子、黒岩 輝代子、三澤 雅樹、沼野 智一、小菅 寿徳
    • Organizer
      第39回日本バイオマテリアル学会大会
    • Related Report
      2017 Research-status Report
  • [Presentation] FACILE ONE-POT FABRICATION OF MAGNETIC IRON OXIDE-CALCIUM PHOSPHATE COMPOSITE NANOPARTICLES AS DELIVERY AND IMAGING AGENTS FOR MACROPHAGES2017

    • Author(s)
      Maki Nakamura, Ayako Oyane, Kiyoko Kuroiwa, Masaki Misawa, Tomokazu Numano, Hisanori Kosuge
    • Organizer
      17th Asian BioCeramics Symposium
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research

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Published: 2016-04-21   Modified: 2020-03-30  

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