Noninvasive imaging and therapy of vascular inflammation with gold nanoparticles
| Project/Area Number |
16K09511
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cardiovascular medicine
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| Research Institution | University of Tsukuba |
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Principal Investigator |
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| Research Collaborator |
Nakamura Maki
Oyane Ayako
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 血管炎症 / ナノ粒子 / 金ナノ粒子 / マクロファージ / 画像診断 |
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| Outline of Final Research Achievements |
We evaluated gold nanoparticles for noninvasive imaging and therapy of vascular inflammation. Computed tomography (CT) imaging demonstrated gold nanoparticles accumulated in the lesion of vascular inflammation in mouse models after injection of gold nanoparticles. Laser light exposure induced death of cells with gold nanoparticles. Based on these experiments, gold nanoparticles have the potential for CT imaging and laser ablation of vascular inflammation.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究では、金ナノ粒子を用いて血管炎症部位(動脈硬化や腹部大動脈瘤)をCT撮影により非侵襲的に検出することが可能であった。また、金ナノ粒子を取り込んだ細胞に対して近赤外線レーザー光を照射することにより、細胞死が誘導されることが示され、近赤外線レーザー光照射による非侵襲的な治療の可能性が示唆された。金ナノ粒子は診断および治療の双方に有用であり、血管炎症性病変の早期発見に加え、早期治療への応用が期待される。
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Report
(4 results)
Research Products
(11 results)
