| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
The aim of this study is to investigate alteration in elastic modulus (stiffness) of vascular endothelial cells during inflammation using atomic force microscope, and to clarify the pathophysiological role of cellular stiffness. We found that vascular endothelial cells increased the stiffness during inflammatory stimulation. Here we have demonstrated that gap junction is involved in the regulation of cellular stiffness. Furthermore, we have shown that cellular stiffening induces leukocyte adhesion. Taken together, our results suggested the pathophysiological role of endothelial cellular stiffness.
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