The role of TLR9, a DNA sensor, in the development of vascular inflammation and atherogenesis

• Project/Area Number: 16K09517
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cardiovascular medicine
• Research Institution: The University of Tokushima
• Principal Investigator: FUKUDA Daiju 徳島大学, 大学院医歯薬学研究部(医学域), 特任講師 (40637568)
• Co-Investigator(Kenkyū-buntansha): 佐田 政隆 徳島大学, 大学院医歯薬学研究部(医学域), 教授 (80345214)
• Project Period (FY): 2016-04-01 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 炎症 / 動脈硬化 / 核酸断片 / TLR9 / 核酸受容体 / 慢性炎症 / マクロファージ / 循環器・高血圧

Outline of Final Research Achievements

Genetic deletion or pharmacologic blockade of TLR9 in angiotensin II infused ApoE KO mice attenuated atherogenesis in the aortic arch and decreased macrophage accumulation and inflammatory molecule expression in the aorta with no alteration of metabolic parameters. A TLR9 agonist markedly promoted proinflammatory activation of ApoE KO macrophages but not of TLR9/ApoE dKO macrophages. Furthermore, in humans, circulating ds DNA in the coronary artery positively correlated with inflammatory features of coronary plaques such as lipid arc and macrophage grade determined by OCT in patients with acute myocardial infarction. Our results suggested that TLR9 plays a pivotal role in the development of vascular inflammation and atherogenesis through proinflammatory activation of macrophages. TLR9 may serve as a potential therapeutic target for atherosclerosis.

Academic Significance and Societal Importance of the Research Achievements

世界中で動脈硬化性疾患が増加している。スタチンを用いた脂質低下療法は、動脈硬化に基づく心血管イベントを減少させるが、残余リスクが問題となっており、新規の動脈硬化の治療方法の開発が期待されている。動脈硬化の基盤病態は無菌性慢性炎症であるが、その発症機序は不明であり、慢性炎症を標的とした動脈硬化治療方法の開発もなされていない。本研究は、動脈硬化の基盤病態である慢性炎症の発症に、核酸受容体の1つであるTLR9を介した自然免疫機構が関与することだけでなく、TLR9が治療標的になる可能性を示唆しており、動脈硬化のさらなる病態の理解とともに、新規治療方法の開発につながる可能性が期待される。

Research Products

• [Journal Article] Association of Decreased Docosahexaenoic Acid Level After Statin Therapy and Low Eicosapentaenoic Acid Level with In-Stent Restenosis in Patients with Acute Coronary Syndrome (2019)
  • Author(s): Yagi Shusuke、Kondo Daisuke、Yamaguchi Koji、Wakatsuki Tetsuzo、Kawabata Yutaka、Ito Hiroyuki、Saijo Yoshihito、Seno Hiromitsu、Sutou Kumiko、Ueno Rie、Todoroki Takafumi、Kusunose Kenya、Matsuura Tomomi、Tobiume Takeshi、Yamada Hirotsugu、Soeki Takeshi、Shimabukuro Michio、Aihara Ken-ichi、Akaike Masashi、Sata Masataka
  • Journal Title: Journal of Atherosclerosis and Thrombosis Volume: 26 Issue: 3 Pages: 272-281
  • DOI: 10.5551/jat.44735
  • NAID: 130007606848
  • ISSN: 1340-3478, 1880-3873
  • Year and Date: 2019-03-01
  • Peer Reviewed / Open Access
• [Journal Article] Toll‐Like Receptor 9 Plays a Pivotal Role in Angiotensin II Induced Atherosclerosis (2019)
  • Author(s): Fukuda Daiju、Nishimoto Sachiko、Aini Kunduziayi、Tanaka Atsushi、Nishiguchi Tsuyoshi et al.
  • Journal Title: Journal of the American Heart Association Volume: 8 Issue: 7
  • DOI: 10.1161/jaha.118.010860
  • NAID: 120006602927
  • Peer Reviewed / Open Access
• [Journal Article] Clinical, Electrocardiographic, and Echocardiographic Parameter Combination Predicts the Onset of Atrial Fibrillation (2018)
  • Author(s): Soeki Takeshi、Matsuura Tomomi、Tobiume Takeshi、Bando Sachiko、Matsumoto Kazuhisa、Nagano Hiromi、Uematsu Etsuko、Kusunose Kenya、Ise Takayuki、Yamaguchi Koji、Yagi Shusuke、Fukuda Daiju、Yamada Hirotsugu、Wakatsuki Tetsuzo、Shimabukuro Michio、Sata Masataka
  • Journal Title: Circulation Journal Volume: 82 Issue: 9 Pages: 2253-2258
  • DOI: 10.1253/circj.CJ-17-0758
  • NAID: 130007438979
  • ISSN: 1346-9843, 1347-4820
  • Year and Date: 2018-08-24
  • Peer Reviewed / Open Access
• [Journal Article] Effect of the Epicardial Adipose Tissue Volume on the Prevalence of Paroxysmal and Persistent Atrial Fibrillation (2018)
  • Author(s): Oba Kageyuki、Maeda Minetaka、Maimaituxun Gulinu、Yamaguchi Satoshi、Arasaki Osamu、Fukuda Daiju、Yagi Shusuke、Hirata Yukina、Nishio Susumu、Iwase Takashi、Takao Shoichiro、Kusunose Kenya、Yamada Hirotsugu、Soeki Takeshi、Wakatsuki Tetsuzo、Harada Masafumi、Masuzaki Hiroaki、Sata Masataka、Shimabukuro Michio
  • Journal Title: Circulation Journal Volume: 82 Issue: 7 Pages: 1778-1787
  • DOI: 10.1253/circj.CJ-18-0021
  • NAID: 130007410632
  • ISSN: 1346-9843, 1347-4820
  • Year and Date: 2018-06-25
  • Peer Reviewed / Open Access
• [Journal Article] Ticagrelor, a P2Y12 antagonist, attenuates vascular dysfunction and inhibits atherogenesis in apolipoprotein-E-deficient mice (2018)
  • Author(s): Ganbaatar Byambasuren、Fukuda Daiju、Salim Hotimah Masdan、Nishimoto Sachiko、Tanaka Kimie、Higashikuni Yasutomi、Hirata Yoichiro、Yagi Shusuke、Soeki Takeshi、Sata Masataka
  • Journal Title: Atherosclerosis Volume: 275 Pages: 124-132
  • DOI: 10.1016/j.atherosclerosis.2018.05.053
  • Peer Reviewed
• [Journal Article] Inhibition of activated factor X by rivaroxaban attenuates neointima formation after wire-mediated vascular injury (2018)
  • Author(s): Hara Tomoya、Fukuda Daiju、Tanaka Kimie、Higashikuni Yasutomi、Hirata Yoichiro、Yagi Shusuke、Soeki Takeshi、Shimabukuro Michio、Sata Masataka
  • Journal Title: Euro J Pharmacol Volume: 820 Pages: 222-228
  • DOI: 10.1016/j.ejphar.2017.12.037
  • NAID: 120007097698
  • Peer Reviewed
• [Journal Article] Protease-Activated Receptor-2 Plays a Critical Role in Vascular Inflammation and Atherosclerosis in Apolipoprotein E?Deficient Mice (2018)
  • Author(s): Hara Tomoya、Phuong Pham Tran、Fukuda Daiju、Yamaguchi Koji、Murata Chie、Nishimoto Sachiko、Yagi Shusuke、Kusunose Kenya、Yamada Hirotsugu、Soeki Takeshi、Wakatsuki Tetsuzo、Imoto Issei、Shimabukuro Michio、Sata Masataka
  • Journal Title: Circulation Volume: 138 Issue: 16 Pages: 1706-1719
  • DOI: 10.1161/circulationaha.118.033544
  • NAID: 120006546436
  • Peer Reviewed
• [Journal Article] Left atrial functional response after a marathon in healthy amateur volunteers (2018)
  • Author(s): Hirata Yukina、Kusunose Kenya、Yamada Hirotsugu、Morita Sae、Torii Yuta、Nishio Susumu、Zheng Robert、Saijo Yoshihito、Fukuda Daiju、Yagi Shusuke、Soeki Takeshi、Sata Masataka
  • Journal Title: The International Journal of Cardiovascular Imaging Volume: - Issue: 4 Pages: 633-643
  • DOI: 10.1007/s10554-018-1502-2
  • NAID: 120006844037
  • Peer Reviewed
• [Journal Article] Right Ventricular Function and Beneficial Effects of Cardiac Rehabilitation in Patients With Systolic Chronic Heart Failure (2018)
  • Author(s): Kusunose Kenya、Seno Hiromitsu、Yamada Hirotsugu、Nishio Susumu、Torii Yuta、Hirata Yukina、Saijo Yoshihito、Ise Takayuki、Yamaguchi Koji、Fukuda Daiju、Yagi Shusuke、Soeki Takeshi、Wakatsuki Tetsuzo、Sata Masataka
  • Journal Title: Canadian Journal of Cardiology Volume: 34 Issue: 10 Pages: 1307-1315
  • DOI: 10.1016/j.cjca.2018.06.003
  • NAID: 120006795581
  • Peer Reviewed
• [Journal Article] Local Thickness of Epicardial Adipose Tissue Surrounding the Left Anterior Descending Artery Is a Simple Predictor of Coronary Artery Disease ― New Prediction Model in Combination With Framingham Risk Score ― (2018)
  • Author(s): Maimaituxun Gulinu、Shimabukuro Michio、Fukuda Daiju、Yagi Shusuke、Hirata Yukina、Iwase Takashi、Takao Shoichiro、Matsuura Tomomi、Ise Takayuki、Kusunose Kenya、Tobiume Takeshi、Yamaguchi Koji、Yamada Hirotsugu、Soeki Takeshi、Wakatsuki Tetsuzo、Harada Masafumi、Sata Masataka
  • Journal Title: Circulation Journal Volume: 82 Issue: 5 Pages: 1369-1378
  • DOI: 10.1253/circj.CJ-17-1289
  • NAID: 130006725981
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed / Open Access
• [Journal Article] Activation of Toll-Like Receptor 9 Impairs Blood Flow Recovery After Hind-Limb Ischemia (2018)
  • Author(s): Nishimoto Sachiko、Aini Kunduziayi、Fukuda Daiju、Higashikuni Yasutomi、Tanaka Kimie、Hirata Yoichiro、Yagi Shusuke、Kusunose Kenya、Yamada Hirotsugu、Soeki Takeshi、Shimabukuro Michio、Sata Masataka
  • Journal Title: Frontiers in Cardiovascular Medicine Volume: 5 Pages: 144-144
  • DOI: 10.3389/fcvm.2018.00144
  • NAID: 120006606147
  • Peer Reviewed / Open Access
• [Journal Article] Predictors for the Treatment Effect of Sodium Glucose Co-transporter 2 Inhibitors in Patients with Type 2 Diabetes Mellitus (2018)
  • Author(s): Yagi S、Aihara KI、Kondo T、Kurahashi K、Yoshida S、Endo I、Fukuda D、Nakaya Y、Suwaki K、Takeji T、Wada T、Salim HM、Hama S、Matsuura T、Ise T、Kusunose K、Yamaguchi K、Tobiume T、Yamada H、Soeki T、Wakatsuki T、Matsuhisa M、Shimabukuro M、Akaike M、Sata M
  • Journal Title: Advances in Therapy Volume: 35 Issue: 1 Pages: 124-134
  • DOI: 10.1007/s12325-017-0639-z
  • Peer Reviewed
• [Journal Article] Edoxaban improves acute venous thromboembolism while preserving protein C and protein S levels (2018)
  • Author(s): Yamazaki Hiromu、Yagi Shusuke、Torii Yuta、Amano Rie、Oomichi Yasuyuki、Sangawa Teruaki、Fukuda Daiju、Kadota Muneyuki、Ise Takayuki、Ueno Rie、Hara Tomoya、Kusunose Kenya、Matsuura Tomomi、Tobiume Takeshi、Yamaguchi Koji、Yamada Hirotsugu、Soeki Takeshi、Wakatsuki Tetsuzo、Akaike Masashi、Sata Masataka
  • Journal Title: Journal of Cardiology Volume: 71 Issue: 3 Pages: 305-309
  • DOI: 10.1016/j.jjcc.2017.09.009
  • Peer Reviewed
• [Journal Article] Plasma brain natriuretic peptide levels are elevated in patients with cancer. (2017)
  • Author(s): Bando S, Soeki T, Matsuura T, Tobiume T, Ise T, Kusunose K, Yamaguchi K, Yagi S, Fukuda D, Iwase T, Yamada H, Wakatsuki T, Shimabukuro M, Muguruma N, Takayama T, Kishimoto I, Kangawa K, Sata M.
  • Journal Title: PLoSOne Volume: 12 Issue: 6 Pages: e0178607-e0178607
  • DOI: 10.1371/journal.pone.0178607
  • NAID: 120006534961
  • Peer Reviewed / Open Access
• [Journal Article] Gender-linked impact of epicardial adipose tissue volume in patients who underwent coronary artery bypass graft surgery or non-coronary valve surgery. (2017)
  • Author(s): Maimaituxun G, Shimabukuro M, Salim HM, Tabata M, Yuji D, Morimoto Y, Akasaka T, Matsuura T, Yagi S, Fukuda D, Yamada H, Soeki T, Sugimoto T, Tanaka M, Takanashi S, Sata M.
  • Journal Title: PLoSOne Volume: 12 Issue: 6 Pages: e0177170-e0177170
  • DOI: 10.1371/journal.pone.0177170
  • NAID: 120006534964
  • Peer Reviewed / Open Access
• [Journal Article] A novel lipoprotein (a) lowering drug, D-47, decreases neointima thickening after vascular injury (2017)
  • Author(s): Nakaya Y, Fukuda D, Oyamada T, Ogawa K, Harada N, Nakagami H, Morishita R, Sata M, Sakaue, H.
  • Journal Title: The Journal of Medical Investigation Volume: 64 Issue: 1.2 Pages: 64-67
  • DOI: 10.2152/jmi.64.64
  • NAID: 130005501982
  • ISSN: 1343-1420, 1349-6867
  • Peer Reviewed / Open Access
• [Journal Article] Teneligliptin, a dipeptidyl peptidase-4 inhibitor, attenuated pro-inflammatory phenotype of perivascular adipose tissue and inhibited atherogenesis in normoglycemic apolipoprotein-E-deficient mice. (2017)
  • Author(s): Hotimah Masdan Salim, Daiju Fukuda, Yasutomi Higashikuni, Kimie Tanaka, Yoichiro Hirata, Shusuke Yagi, Takeshi Soeki, Michio Shimabukuro, Masataka Sata.
  • Journal Title: Vascular Pharmacology Volume: 印刷中 Pages: 19-25
  • DOI: 10.1016/j.vph.2017.03.003
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Low Serum Levels of Eicosapentaenoic Acid and Docosahexaenoic Acid are Risk Factors for Cardiogenic Syncope in Patients with Brugada Syndrome (2017)
  • Author(s): Yagi S, Soeki T, Aihara KI, Fukuda D, Ise T, Kadota M, Bando S, Matsuura T, Tobiume T, Yamaguchi K, Kusunose K, Yamada H, Wakatsuki T, Shimabukuro M, Akaike M, Sata M.
  • Journal Title: International Heart Journal Volume: 58 Issue: 5 Pages: 720-723
  • DOI: 10.1536/ihj.16-278
  • NAID: 130006179141
  • ISSN: 1349-2365, 1349-3299
  • Peer Reviewed / Open Access
• [Journal Article] Canagliflozin reduces epicardial fat in patients with type 2 diabetes mellitus. (2017)
  • Author(s): Yagi S, Hirata Y, Ise T, Kusunose K, Yamada H, Fukuda D, Salim HM, Maimaituxun G, Nishio S, Takagawa Y, Hama S, Matsuura T, Yamaguchi K, Tobiume T, Soeki T, Wakatsuki T, Aihara KI, Akaike M, Shimabukuro M, Sata M.
  • Journal Title: Diabetol Metab Syndr. Volume: 9 Issue: 1 Pages: 78-78
  • DOI: 10.1186/s13098-017-0275-4
  • NAID: 120006939620
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] n-3 Polyunsaturated Fatty Acids: Promising Nutrients for Preventing Cardiovascular Disease (2017)
  • Author(s): Yagi S, Fukuda D, Aihara KI, Akaike M, Shimabukuro M, Sata M.
  • Journal Title: Journal of Atherosclerosis and Thrombosis Volume: 24 Issue: 10 Pages: 999-1010
  • DOI: 10.5551/jat.RV17013
  • NAID: 130006110302
  • ISSN: 1340-3478, 1880-3873
• [Journal Article] Improved Exercise Capacity After Cardiac Rehabilitation Is Associated with Reduced Visceral Fat in Patients with Chronic Heart Failure (2017)
  • Author(s): Takagawa Y, Yagi S. Ise T, Ishii A, Nishikawa K, Fukuda D, Kusunose K, Matsuura T, Tobiume T, Yamaguchi K, Yamada H, Soeki T, Wakatsuki T, Shimabukuro M, Katoh S, Aihara KI, Akaike M, Sata M.
  • Journal Title: International Heart Journal Volume: 58 Issue: 5 Pages: 746-751
  • DOI: 10.1536/ihj.16-454
  • NAID: 130006179122
  • ISSN: 1349-2365, 1349-3299
  • Peer Reviewed / Open Access
• [Journal Article] Dipeptidyl Peptidase-4 Inhibitor, Linagliptin, Ameliorates Endothelial Dysfunction and Atherogenesis in Normoglycemic Apolipoprotein-E Deficient Mice. (2016)
  • Author(s): Salim HM, Fukuda D, Higashikuni Y, Tanaka K, Hirata Y, Yagi S, Soeki T, Shimabukuro M, Sata M.
  • Journal Title: Vascul Pharmacol Volume: 79 Pages: 16-23
  • DOI: 10.1016/j.vph.2015.08.011
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Obesity-induced DNA released from adipocytes stimulates chronic adipose tissue (2016)
  • Author(s): Nishimoto S, Fukuda D, Higashikuni Y, Tanaka K, Hirata Y, Murata C, Kim-Kaneyama JR, Sato F, Bando M, Yagi S, Soeki T, Hayashi T, Imoto I, Sakaue H, Shimabukuro M, Sata M.
  • Journal Title: Sci Adv. Volume: 2(3) Issue: 3
  • DOI: 10.1126/sciadv.1501332
  • Peer Reviewed / Open Access
• [Journal Article] Combination of n-3 polyunsaturated fatty acids reduces atherogenesis in apolipoprotein E-deficient mice by inhibiting macrophage activation (2016)
  • Author(s): Takashima A, Fukuda D, Tanaka K, Higashikuni Y, Hirata Y, Nishimoto S, Yagi S, Yamada H, Soeki T, Wakatsuki T, Taketani Y, Shimabukuro M, Sata M
  • Journal Title: Atherosclerosis Volume: 254 Pages: 142-150
  • DOI: 10.1016/j.atherosclerosis.2016.10.002
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Glycemic control with ipragliflozin, a novel selective SGLT2 inhibitor, ameliorated endothelial dysfunction in streptozotocin-induced diabetic mouse (2016)
  • Author(s): Salim HM, Fukuda D, Yagi S, Soeki T, Shimabukuro M, Sata M
  • Journal Title: Front Cardiovasc Med Volume: 3 Pages: 43-43
  • DOI: 10.3389/fcvm.2016.00043
  • NAID: 120006937668
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] PARP9 and PARP14 cross-regulate macrophage activation via STAT1 ADP-ribosylation. (2016)
  • Author(s): Iwata H, Goettsch C, Sharma A, Ricchiuto P, Goh WW, Halu A, Yamada I, Yoshida H, Hara T, Wei M, Inoue N, Fukuda D, Mojcher A, Mattson PC, Barabasi AL, Boothby M, Aikawa E, Singh SA, Aikawa M.
  • Journal Title: Nature Communications Volume: 7 Issue: 1 Pages: 12849-12849
  • DOI: 10.1038/ncomms12849
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Delta-Like Ligand 4-Notch Signaling in Macrophage Activation. (2016)
  • Author(s): Nakano T, Fukuda D, Koga J, Aikawa M
  • Journal Title: Arterioscler Thromb Vasc Biol. Volume: 36(10) Issue: 10 Pages: 2038-2047
  • DOI: 10.1161/atvbaha.116.306926
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] The pathophysiological role of oxidized cholesterols in epicardial fat accumulation and cardiac dysfunction: a study in swine fed a high caloric diet with an inhibitor of intestinal cholesterol absorption, ezetimibe. (2016)
  • Author(s): Shimabukuro M, Okawa C, Yamada H, Yanagi S, Uematsu E, Sugasawa N, Kurobe H, Hirata Y, Kim-Kaneyama JR, Lei XF, Takao S, Tanaka Y, Fukuda D, Yagi S, Soeki T, Kitagawa T, Masuzaki H, Sato M, Sata M.
  • Journal Title: J Nutr Biochem. Volume: 35 Pages: 66-73
  • DOI: 10.1016/j.jnutbio.2016.05.010
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Long-chain monounsaturated fatty acid-rich fish oil attenuates the development of atherosclerosis in mouse models. (2016)
  • Author(s): Yang ZH, Bando M, Sakurai T, Chen Y, Emma-Okon B, Wilhite B, Fukuda D, Pryor BV, Wakabayashi Y, Sampson M, Yu ZX, Sakurai A, Zarzour A, Miyahara H, Takeo J, Sakaue H, Sata M, Remaley AT.
  • Journal Title: Molecular Nutrition & Food Research Volume: 60 Issue: 10 Pages: 2208-2218
  • DOI: 10.1002/mnfr.201600142
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Depot- and gender-specific expression of NLRP3 inflammasome and toll-like receptors in adipose tissue of cancer patients. (2016)
  • Author(s): Shimabukuro M , Sato H, Izaki H, Fukuda D, Uematsu E,Hirata Y, Yagi S, Soeki T, Sakaue H, Kanayama H, Masuzaki H, Sata M
  • Journal Title: Biofactors. Volume: 印刷中 Issue: 4 Pages: 397-406
  • DOI: 10.1002/biof.1287
  • Peer Reviewed
• [Journal Article] Noninvasive quantitative tissue characterization of carotid plaque using color-coded mapping based on ultrasound integrated backscatter. (2016)
  • Author(s): Bando M, Yamada H, Kusunose K, Fukuda D, Amano R, Tamai R, Torii Y, Hirata Y, Nishio S, Satomi J, Nagahiro S, Sata M.
  • Journal Title: JACC Cardiovasc Imaging Volume: 9 Pages: 625-627
  • Peer Reviewed
• [Presentation] Gender disparities of distribution of epicardial adipose tissue and its impact on coronary artery disease. (2018)
  • Author(s): Maimaituxun G, Shimabukuro M, Fukuda D, Yagi S, Hirata Y, Iwase T, Matsuura T, Ise T , Kusunose K, Tobiume T, Yamaguchi K, Yamada H, Soeki T, Wakatsuki T, Sata M.
  • Organizer: European Society of Cardiology Congress 2018
  • Int'l Joint Research
• [Presentation] Atheroprotective effects of ticagrelor, a P2Y12 antagonist, in apolipoprotein-E-deficient mice. (2018)
  • Author(s): Ganbaatar B, Fukuda D, Salim HM, Yagi S, Soeki T, Sata M.
  • Organizer: European Society of Cardiology Congress 2018
  • Int'l Joint Research
• [Presentation] Growth of vasa vasorum is associated with local inflammation around coronary plaque in fresh cadavers. (2018)
  • Author(s): Ito H, Wakatsuki T, Yamaguchi K, Fukuda D, Kawabata Y, Todoroki T, Matsuura T, Ise T, Kusunose K, Tobiume T, Yagi S, Yamada H, Soeki T, Sata M.
  • Organizer: European Society of Cardiology Congress 2018
  • Int'l Joint Research
• [Presentation] C-type natriuretic peptide improves left ventricular diastolic dysfunction and ischemia/reperfusion injury-associated ventricular arrhythmias. (2018)
  • Author(s): Soeki T, Uematsu E, Matsuura T, Tobiume T, Kusunose K, Ise T, Yamaguchi K, Yagi S, Fukuda D, Yamada H, Wakatsuki T, Sata M.
  • Organizer: European Society of Cardiology Congress 2018
  • Int'l Joint Research
• [Presentation] Inhibition of S1P2 receptor ameliorates endothelial dysfunction and prevents atherogenesis in apolipoprotein-E-deficient Mice. (2018)
  • Author(s): Ganbaatar B, Fukuda D, Yagi S, Soeki T, Sata M.
  • Organizer: European Society of Cardiology Congress 2018
  • Int'l Joint Research
• [Presentation] A Deep Learning Approach for Automated Diagnosis of Regional Wall Motion Abnormality on Echocardiography. (2018)
  • Author(s): Kusunose K, Abe T, Haga A, Yamada H, Fukuda D, Harada M, SataM.
  • Organizer: American Heart Association Scientific Sessions 2018
  • Int'l Joint Research
• [Presentation] Inhibition of Thrombin-PARs Signaling by Dabigatran, a Direct Thrombin Inhibitor, Attenuates Endothelial Dysfunction in Diabetic Mice. (2018)
  • Author(s): Fukuda D, Yagi S, Kusunose K, Yamada H, Soeki T, Sata M.
  • Organizer: American Heart Association Scientific Sessions 2018
  • Int'l Joint Research
• [Presentation] Rivaroxaban, a Direct Inhibitor of Factor Xa, Attenuates Endothelial Dysfunction in Streptozotocin-Induced Diabetic Mice Through the Inhibition of Protease-Activated Receptor 2 Signaling. (2018)
  • Author(s): Phuong PT, Fukuda D, Yagi S, Kusunose K, Yamada H, Soeki T, Shimabukuro M, Sata M.
  • Organizer: American Heart Association Scientific Sessions 2018
  • Int'l Joint Research
• [Presentation] 薬物治療が著効したＳＬＥ関連心筋炎の一例 (2018)
  • Author(s): Robert Zheng、數藤久美子、楠瀬賢也、松浦朋美、瀬野弘光、西條良仁、上野理絵、川端豊、坂東美佳、伊藤浩敬、轟貴史、伊勢孝之、飛梅威、山口浩司、八木秀介、福田大受、山田博胤、添木武、若槻哲三、佐田政隆
  • Organizer: 第112回日本循環器学会中国・四国合同地方会
• [Presentation] 活性型血液凝固第X因子が冠動脈硬化に与える影響 (2018)
  • Author(s): 福田大受、山口浩司、楠瀬賢也、八木秀介、山田博胤、若槻哲三、添木武、佐田政隆
  • Organizer: 第66回日本心臓病学会学術集会
• [Presentation] 未固定遺体における冠動脈壁小管腔構造と局所心臓周囲脂肪内炎症との関連 (2018)
  • Author(s): 伊藤浩敬、若槻哲三、山口浩司、福田大受、川端豊、伊勢孝之、楠瀬賢也、松浦朋美、轟貴史、飛梅威、八木秀介、山田博胤、添木武、佐田政隆
  • Organizer: 第66回日本心臓病学会学術集会
• [Presentation] Single coronary 合併重症ASに対してTAVIを施行し救命し得た１例 (2018)
  • Author(s): Robert Zheng、伊勢孝之、川端豊、八木秀介、西條良仁、上野理絵、坂東美佳、伊藤浩敬、轟貴史、松浦朋美、楠瀬賢也、飛梅威、山口浩司、福田大受、山田博胤、添木武、若槻哲三、黒部裕嗣、藤本鋭貴、北川哲也、佐田政隆
  • Organizer: 第113回日本循環器学会四国合同地方会
• [Presentation] 血液凝固因子と動脈硬化‐新規経口抗凝固薬の血管保護効果について‐ (2018)
  • Author(s): 福田大受、佐田政隆
  • Organizer: 第33回日本糖尿病合併症学会
• [Presentation] 未固定遺体において光干渉断層法で観察される冠動脈壁微小管腔構造と局所周囲脂肪炎症との関連 (2018)
  • Author(s): 川端豊、若槻哲三、山口浩司、伊藤浩敬、福田大受、伊勢孝之、楠瀬賢也、松浦朋美、轟貴史、飛梅威、八木秀介、山田博胤、添木武、佐田政隆
  • Organizer: 第66回日本心臓病学会学術集会
• [Presentation] Inhibition of thrombin signaling by dabigatran, a direct thrombin inhibitor, attenuates endothelial dysfunction in diabetic mice. (2018)
  • Author(s): Daiju Fukuda, Shusuke Yagi, Takeshi Soeki, Masataka Sata.
  • Organizer: 第82回日本循環器学会学術集会 （大阪：2018年3月23-25日）
• [Presentation] The mechanism by which lifestyle-related diseases cause atherosclerosis: The role of innate immune system. (2018)
  • Author(s): Daiju Fukuda, Masataka Sata.
  • Organizer: 第82回日本循環器学会学術集会 （大阪：2018年3月23-25日）
• [Presentation] Local Epicardial Adipose Tissue Thickness in Left Anterior Descending Artery Provides a New Prediction Model for Coronary Artery Disease. (2017)
  • Author(s): Gulinu Maimaituxun, Shimabukuro M, Hirata Y, Iwase T, Takao S, Matsuura T, Ise T, Kusunose K, Tobiume T, Yamaguchi K, Yagi S, Fukuda D, Yamada H, Soeki T, Wakatsuki T, Harada M, Sata M.
  • Organizer: American Heart Association Scientific Sessions 2017
  • Int'l Joint Research
• [Presentation] Epicardial Adipose Tissue Produces Proinflammatory Cytokines and Influences the Pathogenesis of Atrial Fibrillation. (2017)
  • Author(s): Soeki T, Matsuura T, Uematsu E, Tobiume T, Kusunose K, Ise T, Yamaguchi K, Yagi S, Fukuda D, Yamada H, Wakatsuki T, Sata M.
  • Organizer: American Heart Association Scientific Sessions 2017
  • Int'l Joint Research
• [Presentation] Activated Factor X Signaling Pathway via Protease-Activated Receptor-2 is a Novel Therapeutic Target to Prevent Atrial Fibrillation. (2017)
  • Author(s): 谷口実佑、添木武、松浦朋美、佐藤裕紀、飛梅威、原知也、楠瀬賢也、伊勢孝之、山口浩司、八木秀介、福田大受、山田博胤、若槻哲三、島袋充生、佐田政隆
  • Organizer: 第81回日本循環器学会学術集会
• [Presentation] The Tissue Characteristics of Coronary Plaque with Microluminal Structures Identified by OCT Associated with Local Inflammatory Response in Fresh Cadavers. (2017)
  • Author(s): 若槻哲三、山口浩司、伊藤浩敬、福田大受、川端豊、轟貴史、松浦朋美、伊勢孝之、楠瀬賢也、飛梅威、八木秀介、山田博胤、添木武、佐田政隆
  • Organizer: 第81回日本循環器学会学術集会
• [Presentation] Lipid-rich Coronary Plaque is Associated with Local Inflammation in Adjacent Epicardial Adipose Tissue in Fresh Cadaveric Models. (2017)
  • Author(s): 伊藤浩敬、若槻哲三、山口浩司、福田大受、川端豊、轟貴史、松浦朋美、楠瀬賢也、伊勢孝之、飛梅威、八木秀介、山田博胤、添木武、佐田政隆
  • Organizer: 第81回日本循環器学会学術集会
• [Presentation] Canagliflozin, a novel selective SGLT2 inhibitor, ameliorated endothelial dysfunction and atherogenesis in diabetic mice. (2017)
  • Author(s): Byambasuren Ganbaatar, Daiju Fukuda, Hotimah Masdan Salim, Shusuke Yagi, Takeshi Soeki, Masataka Sata.
  • Organizer: 第17回日本NO学会学術集会
• [Presentation] Ticagrelor, a P2Y21 inhibitor, attenuated vascular dysfunction and inhibited atherogenesis in apolipoprotein-E-deficient mice. (2017)
  • Author(s): Byambasuren Ganbaatar, Daiju Fukuda, Hotimah Masdan Salim, Shusuke Yagi, Takeshi Soeki, Masataka Sata.
  • Organizer: 第17回日本NO学会学術集会
• [Presentation] Dabigatran, a direct thrombin inhibitor, attenuates endothelial dysfunction in diabetic mice. (2017)
  • Author(s): Daiju Fukuda, Hotimah Masdan Salim, Shusuke Yagi, Takeshi Soeki, Masataka Sata.
  • Organizer: 第17回日本NO学会学術集会
• [Presentation] Dipeptidyl peptidase-4 inhibitor, linagliptin, ameliorates endothelial dysfunction and the development of atherosclerosis in normoglycemic apolipoprotein-E deficient mice. (2017)
  • Author(s): Aini Kunduziayi, Daiju Fukuda, Hotimah Masdan Salim, Shusuke Yagi, Takeshi Soeki, Masataka Sata.
  • Organizer: 第17回日本NO学会学術集会
• [Presentation] picardial Adipose Tissue Thickness in Left Anterior Descending Artery Predictict Coronary Atherosclerosis. (2017)
  • Author(s): マイマイチュクングリヌ、島袋充生、平田有紀奈、山口浩司、八木秀介、福田大受、山田博胤、添木武、原田雅史、佐田政隆
  • Organizer: 第17回日本NO学会学術集会
• [Presentation] 新しい動脈硬化のメカニズムの解明～自己由来核酸断片による自然免疫機構の関与～ (2017)
  • Author(s): 福田大受
  • Organizer: 第38回日本循環制御医学会総会・学術集会
  • Invited
• [Presentation] 多価不飽和脂肪酸と動脈硬化性疾患 (2017)
  • Author(s): 福田大受、佐田政隆
  • Organizer: 第3回Ｊ-ＩＳＣＰ学術集会
  • Invited
• [Presentation] 遊離核酸断片を介した自然免疫機構が脂肪組織の炎症とインスリン抵抗性の発症に与える影響 (2017)
  • Author(s): 福田大受
  • Organizer: 第38回肥満学会
  • Invited
• [Presentation] 心房細動アブレーション後の医原性心房中隔欠損残存により右心不全症状をきたした一例 (2017)
  • Author(s): 矢野哲弘、松浦朋美、數藤久美子、瀬野弘光、西條良仁、上野理絵、川端豊、伊藤浩敬、轟貴史、伊勢孝之、楠瀬賢也、飛梅威、山口浩司、八木秀介、福田大受、山田博胤、添木武、若槻哲三、佐田政隆
  • Organizer: 第111回日本循環器学会四国地方会
• [Presentation] 診断から40年後に治療しえた著明なBroad Kent束を有するWPW症候群の一例 (2017)
  • Author(s): 豊田直人、轟貴史、添木武、瀬野弘光、數藤久美子、西條良仁、上野理絵、川端豊、伊藤浩敬、松浦朋美、伊勢孝之、楠瀬賢也、飛梅威、山口浩司、福田大受、八木秀介、山田博胤、若槻哲三、佐田政隆
  • Organizer: 第111回日本循環器学会四国地方会
• [Presentation] Dabigatran, a direct thrombin inhibitor, attenuates endothelial dysfunction in diabetic mice (2017)
  • Author(s): Daiju Fukuda, Hotimah Masdan Salim, Shusuke Yagi, Takeshi Soeki, Masataka Sata.
  • Organizer: 心血管代謝週間（CVMW）2017
• [Presentation] ω３系不飽和脂肪酸の抗動脈硬化作用 (2017)
  • Author(s): 高島啓, 福田大受, 田中君枝, 東邦康智, 平田陽一郎, 八木秀介, 添木武, 佐田政隆
  • Organizer: 心血管代謝週間（CVMW）2017
• [Presentation] 血管の炎症と動脈硬化症におけるToll様受容体9の役割 (2017)
  • Author(s): 西本幸子、福田大受、佐田政隆
  • Organizer: 心血管代謝週間（CVMW）2017
• [Presentation] DPP-4 inhibitor, linagliptin, ameliorates endothelial dysfunction and the development of atherosclerosis in apolipoprotein-E deficient mice. (2017)
  • Author(s): Kunduziayi Aini, Daiju Fukuda, Hotimah Masdan Salim, Shusuke Yagi, Takeshi Soeki, Masataka Sata.
  • Organizer: 心血管代謝週間（CVMW）2017
• [Presentation] Ticagrelor, a P2Y12 Antagonist, Attenuates Vascular Dysfunction and Inhibits Atherogenesis in Apolipoprotein-E-deficient Mice. (2017)
  • Author(s): Byambasuren Ganbaatar, Daiju Fukuda, Hotimah Masdan Salim, Shusuke Yagi, Takeshi Soeki, Masataka Sata.
  • Organizer: 心血管代謝週間（CVMW）2017
• [Presentation] 自己DNA断片を介した自然免疫機構が心血管代謝性疾患の発症を促進する (2017)
  • Author(s): 福田大受、佐田政隆
  • Organizer: 第38回脳心血管抗加齢研究会
• [Presentation] Atheroprotective effects of Linagliptin, a DPP-4 inhibitor, in normoglycemic ApoE-/- mice. (2017)
  • Author(s): Kunduziayi Aini, Daiju Fukuda, Hotimah Masdan Salim, Shusuke Yagi, Takeshi Soeki, Masataka Sata.
  • Organizer: 第38回脳心血管抗加齢研究会
• [Presentation] Ticagrelor, a P2Y12 antagonist, prevents endothelial dysfunction and the development of atherosclerosis in apolipoprotein-E deficient mice. (2017)
  • Author(s): Byambasuren Ganbaatar, Daiju Fukuda, Hotimah Masdan Salim, Shusuke Yagi, Takeshi Soeki, Masataka Sata.
  • Organizer: 第38回脳心血管抗加齢研究会
• [Presentation] 自然免疫機構が関与する慢性炎症と心血管代謝性疾患 (2017)
  • Author(s): 福田大受
  • Organizer: 第47回心脈管作動物質学会
• [Presentation] Cell free DNA/Toll-like receptor 9 axis plays a pivotal role in chronic inflammation induced by metabolic disorders, leading to atherogenesis and insulin resistance. (2016)
  • Author(s): Fukuda D, Nishimoto S, Higashikuni Y, Tanaka K, Hirata Y, Yagi S, Soeki T, Shimabukuro M, Sata M.
  • Organizer: 19th International Vascular Biology Meeting
  • Place of Presentation: Boston, USA
  • Year and Date: 2016-10-30
  • Int'l Joint Research
• [Presentation] Genetic deletion of TLR9 promotes blood flow recovery in hind limb ischemia. (2016)
  • Author(s): Nishimoto S, Fukuda D, Higashikuni Y, Tanaka K, Hirata Y, Yagi S, Soeki T, Sakaue H, Shimabukuro M, Sata M.
  • Organizer: 19th International Vascular Biology Meeting
  • Place of Presentation: Boston, USA
  • Year and Date: 2016-10-30
  • Int'l Joint Research
• [Presentation] Glycemic control with canagliflozin, a SGLT2 inhibitor, inhibited inflammation in the vascular and adipose tissue, and ameliorated vascular complication in diabetic mice. (2016)
  • Author(s): Salim HM, Fukuda D, Yagi S, Soeki T, Shimabukuro M, Sata M.
  • Organizer: 19th International Vascular Biology Meeting
  • Place of Presentation: Boston, USA
  • Year and Date: 2016-10-30
  • Int'l Joint Research
• [Presentation] Dabigatran, a direct thrombin inhibitor, prevents the development of endothelial dysfunction in diabetic mice. (2016)
  • Author(s): Salim HM, Fukuda D, Yagi S, Soeki T, Shimabukuro M, Sata M.
  • Organizer: 19th International Vascular Biology Meeting
  • Place of Presentation: Boston, USA
  • Year and Date: 2016-10-30
  • Int'l Joint Research
• [Presentation] 遊離核酸断片による血管の炎症と動脈硬化症発症機序の解明 (2016)
  • Author(s): 福田大受、佐田政隆
  • Organizer: 第39回日本高血圧学会総会
  • Place of Presentation: 仙台国際センター （仙台市、宮城県）
  • Year and Date: 2016-09-30
• [Presentation] 動脈硬化発症におけるFXa-PARsシグナルのマクロファージ活性化調節機構の解明 (2016)
  • Author(s): 福田大受
  • Organizer: 第64回日本心臓病学会学術集会
  • Place of Presentation: 東京国際フォーラム （千代田区、東京都）
  • Year and Date: 2016-09-23
• [Presentation] Glycemic Control with Ipragliflozin, a Novel Selective SGLT2 Inhibitor, Ameliorated Endothelial Dysfunction in Obese and Non-Obese Diabetic Mice. (2016)
  • Author(s): Salim HM, Fukuda D, Yagi S, Soeki T, Shimabukuro M, Sata M.
  • Organizer: European Society of Cardiology Congress 2016
  • Place of Presentation: Rome, Italy
  • Year and Date: 2016-08-27
  • Int'l Joint Research
• [Presentation] Oral Direct Factor Xa Inhibitor Prevents Atrial Fibrillation by Inhibiting Inflammation in Rapidly Paced Spontaneously Hypertensive Rats. (2016)
  • Author(s): Matsuura T, Soeki T, Uematsu E, Bando S, Tobiume T, Hara T, Kusunose K, Ise T, Yamaguchi K, Yagi S, Fukuda D, Yamada H, Wakatsuki T, Shimabukuro M, Sata M.
  • Organizer: European Society of Cardiology Congress 2016
  • Place of Presentation: Rome, Italy
  • Year and Date: 2016-08-27
  • Int'l Joint Research
• [Presentation] Adipocyte size distribution and depot-specific modulation of pro- and anti-atherosclerotic adipocytokines and innate immune molecules in human adipose tissue. (2016)
  • Author(s): Shimabukuro M, Sato H, Izaki H, Fukuda D, Uematsu E, Hirata Y, Yagi S, Soeki T, Sakaue H, Kanayama H, Masuzaki H, Sata M.
  • Organizer: European Society of Cardiology Congress 2016
  • Place of Presentation: Rome, Italy
  • Year and Date: 2016-08-27
  • Int'l Joint Research
• [Presentation] Increased local production of C-type natriuretic peptide in patients with vasospastic angina. (2016)
  • Author(s): Soeki T, Matsuura T, Uematsu E, Bando S, Tobiume T, Kusunose K, Ise T, Yamaguchi K, Yagi S, Fukuda D, Yamada H, Wakatsuki T, Shimabukuro M, Sata M.
  • Organizer: European Society of Cardiology Congress 2016
  • Place of Presentation: Rome, Italy
  • Year and Date: 2016-08-27
  • Int'l Joint Research
• [Presentation] ～心不全を予防する～ 遊離核酸断片を介した血管の炎症と動脈硬化症発症機序の解明. (2016)
  • Author(s): 福田大受、佐田政隆
  • Organizer: 第２回J-ISCP学術集会
  • Place of Presentation: 阿波観光ホテル （徳島市、徳島県）
  • Year and Date: 2016-06-25
• [Presentation] Protease-Activated Receptor-2 Plays a Critical Role in Vascular Inflammation and Atherosclerosis in ApoE-Deficient Mice. (2016)
  • Author(s): 福田大受
  • Organizer: 第38回血栓止血学会学術集会
  • Place of Presentation: 奈良春日野国際フォーラム 甍～I・RA・KA～ (奈良市、奈良県)
  • Year and Date: 2016-06-16
• [Presentation] Obesity-induced DNA released from adipocytes stimulates chronic adipose tissue inflammation and insulin resistance. (2016)
  • Author(s): 福田大受
  • Organizer: 第21回アディポサイエンス・シンポジウム
  • Place of Presentation: 千里ライフサイエンスセンター （豊中市、大阪府）