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Regulation of Endothelial Function by mDia1

Research Project

Project/Area Number 16K09523
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Cardiovascular medicine
Research InstitutionFukuoka University (2019)
Jikei University School of Medicine (2016-2018)

Principal Investigator

Kawanami Daiji  福岡大学, 医学部, 教授 (50568889)

Co-Investigator(Kenkyū-buntansha) 宇都宮 一典  東京慈恵会医科大学, 医学部, 教授 (50185047)
Project Period (FY) 2016-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2018: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywords動脈硬化 / 血管内皮機能 / Rho / mDia1 / Rho-kinase / 血管内皮
Outline of Final Research Achievements

Atherosclerosis is known to occur due to vascular endothelial dysfunction. This study focused on mDia1 as a factor that regulates vascular endothelial function. mDia1 is an effector located downstream of small G protein Rho. Rho-kinase is known as an effector of Rho in addition to mDia1. We hypothesized that Rho-kinase and mDia1 interact with each other to regulate vascular endothelial function. We performed experimental studies using mice and cultured cells in which the endothelial ROCK2 isoform of Rho-kinase was deficient. It was revealed that mDia1 does not play a major role in the regulation of vascular endothelial function.

Academic Significance and Societal Importance of the Research Achievements

低分子量GタンパクRhoに関連するシグナルとしては、動脈硬化の治療標的としてmDia1よりもROCK2がふさわしいことが明らかになった。今後はROCK2を標的とした創薬を行うことが動脈硬化治療における新たな戦略となり得る可能性が示された。

Report

(5 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (9 results)

All 2020 2019 2018 2017 2016

All Journal Article (9 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 9 results,  Open Access: 7 results,  Acknowledgement Compliant: 2 results)

  • [Journal Article] SGLT2 inhibitor ipragliflozin attenuates breast cancer cell proliferation2020

    • Author(s)
      Komatsu Shiho、Nomiyama Takashi、Numata Tomohiro、Kawanami Takako、Hamaguchi Yuriko、Iwaya Chikayo、Horikawa Tsuyoshi、Fujimura-Tanaka Yuki、Hamanoue Nobuya、Motonaga Ryoko、Tanabe Makito、Inoue Ryuji、Yanase Toshihiko、Kawanami Daiji
    • Journal Title

      Endocrine Journal

      Volume: 67 Issue: 1 Pages: 99-106

    • DOI

      10.1507/endocrj.EJ19-0428

    • NAID

      130007790952

    • ISSN
      0918-8959, 1348-4540
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] ROCK2 Regulates Monocyte Migration and Cell to Cell Adhesion in Vascular Endothelial Cells.2019

    • Author(s)
      Takeda Y, Matoba K, Kawanami D, Nagai Y, Akamine T, Ishizawa S, Kanazawa Y, Yokota T, Utsunomiya K
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 20 Issue: 6 Pages: 1331-1331

    • DOI

      10.3390/ijms20061331

    • Related Report
      2019 Annual Research Report 2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Unraveling the Role of Inflammation in the Pathogenesis of Diabetic Kidney Disease2019

    • Author(s)
      Unraveling the Role of Inflammation in the Pathogenesis of Diabetic Kidney Disease
    • Journal Title

      10.3390/ijms20143393

      Volume: 20 Issue: 14 Pages: 3393-3393

    • DOI

      10.3390/ijms20143393

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] ROCK2 regulates TGF-β-induced expression of CTGF and profibrotic genes via NF-κB and cytoskeleton dynamics in mesangial cells2019

    • Author(s)
      Yosuke Nagai, Keiichiro Matoba, Daiji Kawanami, Yusuke Takeda, Tomoyo Akamine, Sho Ishizawa, Yasushi Kanazawa, Tamotsu Yokota, Kazunori Utsunomiya, Rimei Nishimura
    • Journal Title

      American Journal of Physiology Renal Physiology

      Volume: 317 Issue: 4 Pages: 839-851

    • DOI

      10.1152/ajprenal.00596.2018

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Establishment of a myelinating co-culture system with a motor neuron-like cell line NSC-34 and an adult rat Schwann cell line IFRS1.2018

    • Author(s)
      Takaku S, Yako H, Niimi N, Akamine T, Kawanami D, Utsunomiya K, Sango K.
    • Journal Title

      Histochem Cell Biol

      Volume: 印刷中 Issue: 5 Pages: 537-543

    • DOI

      10.1007/s00418-018-1649-x

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] SGLT2 Inhibitors as a Therapeutic Option for Diabetic Nephropathy.2017

    • Author(s)
      Kawanami D, Matoba K, Takeda Y, Nagai Y, Akamine T, Yokota T, Sango K, Utsunomiya K.
    • Journal Title

      Int J Mol Sci

      Volume: 18 Issue: 5 Pages: 1083-1083

    • DOI

      10.3390/ijms18051083

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Rho-Kinase Blockade Attenuates Podocyte Apoptosis by Inhibiting the Notch Signaling Pathway in Diabetic Nephropathy.2017

    • Author(s)
      Matoba K, Kawanami D, Nagai Y, Takeda Y, Akamine T, Ishizawa S, Kanazawa Y, Yokota T, Utsunomiya K.
    • Journal Title

      Int J Mol Sci

      Volume: 18 Issue: 8 Pages: 1795-1795

    • DOI

      10.3390/ijms18081795

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Incretin-based Therapies for Diabetic Complications: Basic Mechanisms and Clinical Evidence.2016

    • Author(s)
      Daiji Kawanami, Keiichiro Matoba, Kazunori Sango, Kazunori Utsunomiya
    • Journal Title

      International Journal of Molecular Medicine

      Volume: 17 Issue: 8 Pages: 1223-1223

    • DOI

      10.3390/ijms17081223

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Signaling pathways in diabetic nephropathy2016

    • Author(s)
      Daiji Kawanami, Keiichiro Matoba, Kazunori Utsunomiya
    • Journal Title

      Histology and Histopathology

      Volume: 31 Pages: 1059-1067

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant

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Published: 2016-04-21   Modified: 2021-02-19  

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