Establishment of elucidation and objective assessment of the relationships between mental state and respiratory pattern.

• Project/Area Number: 16K09527
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Respiratory organ internal medicine
• Research Institution: Tohoku University
• Principal Investigator: Kurosawa Hajime 東北大学, 事業支援機構, 教授 (60333788)
• Project Period (FY): 2016-04-01 – 2020-03-31
• Project Status: Completed (Fiscal Year 2019)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 広域オシレーション法 / 心理評価 / コヒーレンス / MostGraph / 安静呼吸 / ポリグラフ / 広域周波オシレーション法 / 心理 / 呼吸 / 感情 / 不安

Outline of Final Research Achievements

The purpose of this study was to explore the possibility of psychological evaluation using a comprehensive respiratory resistance measuring device、MostGraph. In addition to the measurement of the polygraph monitor system, the newly created software was used to build a new evaluation system with the addition of the MostGraph system. The index of breath stability and fluctuation using coherence, etc. is newly recorded, displayed, and made available for output. Standardization for removing measurement noise, training of unconscious breathing, and vocalization method were manualized. Although we tried to process the breathing pattern, we could not find an index that significantly reflects the psychological situation. Coherence also did not change significantly.

Academic Significance and Societal Importance of the Research Achievements

心理的な変化は呼吸の変化によって現れる。本研究の到達点は総合呼吸抵抗測定装置を応用してその評価を可能にすることである。呼吸機能検査を行った時点で心理的評価が同時にできることで、呼吸困難の程度を推計可能となるなど、呼吸の状況を評価するのに役立つのみならず、心理的な評価目的でも簡便な評価法として応用範囲が広いものである。今後、この研究を続けることによって、精度をあげていき、実用化に近づけたい。

Research Products

• [Int'l Joint Research] The University of Sydney/Curtin University/Royal North Shore Hospital(オーストラリア)
• [Int'l Joint Research] University of Vermont/Belleuve Hospital/University of Iowa(米国)
• [Int'l Joint Research] University of Liverpool(英国)
• [Int'l Joint Research] State University of Rio de Janeiro(ブラジル)
• [Int'l Joint Research] Politecnico di Milano University/Meyer Pediatric University Hospital(イタリア)
• [Int'l Joint Research]
• [Journal Article] Technical Standards for Respiratory Oscillometry. (2020)
  • Author(s): King GG, Bates J, Berger KI, Calverley P, de Melo PL, Dellacà RL, Farré R, Hall GL, Ioan I, Irvin CG, Kaczka DW, Kaminsky DA, Kurosawa H, Lombardi E, Maksym GN, Marchal F, Oppenheimer BW, Simpson SJ, Thamrin C, van den Berge M, Oostveen E.
  • Journal Title: Eur Respir J. Volume: 55 Issue: 2 Pages: 1900753-1900753
  • DOI: 10.1183/13993003.00753-2019
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Kobayashi K, Ohkouchi S, Sasahara Y, Ebina M, Nakata K, Saito R, Akiba M, Sado T, Oishi H, Watanabe T, Kurosawa H, Okada Y. Improvement of native pulmonary alveolar proteinosis after contralateral single living-donor lobar lung transplantation: A case report. (2020)
  • Author(s): Kobayashi K, Ohkouchi S, Sasahara Y, Ebina M, Nakata K, Saito R, Akiba M, Sado T, Oishi H, Watanabe T, Kurosawa H, Okada Y.
  • Journal Title: Pediatr Transplant Volume: 24 Issue: 2
  • DOI: 10.1111/petr.13659
  • Peer Reviewed / Open Access
• [Journal Article] Update of occupational lung disease (2019)
  • Author(s): Suganuma N, Natori Y, Kurosawa H, Nakano M, Kasai T, Morimoto Y
  • Journal Title: Journal of Occupational Health Volume: 61 Issue: 1 Pages: 10-18
  • DOI: 10.1002/1348-9585.12031
  • NAID: 130007596523
  • ISSN: 1341-9145, 1348-9585
  • Year and Date: 2019-01-20
• [Journal Article] Novel Respiratory Impedance-Based Phenotypes Reflect Different Pathophysiologies in Chronic Obstructive Pulmonary Disease Patients. (2019)
  • Author(s): Matsuo Y, Ogawa E, Seto-Yukimura R, Ryujin Y, Kinose D, Yamaguchi M, Osawa M, Nagao T, Kurosawa H, Nakano Y.
  • Journal Title: Int J Chron Obstruct Pulmon Dis Volume: 14 Pages: 2971-2977
  • DOI: 10.2147/copd.s224902
  • NAID: 120006777343
  • Peer Reviewed
• [Journal Article] Association between Family History of Cancer and Lung Cancer Risk among Japanese Men and Women (2019)
  • Author(s): Yoshida K, Takizawa Y, Nishino Y, Takahashi S, Kanemura S, Omori J, Kurosawa H, Maemondo M, Minami Y.
  • Journal Title: The Tohoku Journal of Experimental Medicine Volume: 247 Issue: 2 Pages: 99-110
  • DOI: 10.1620/tjem.247.99
  • NAID: 130007601733
  • ISSN: 0040-8727, 1349-3329
  • Peer Reviewed / Open Access
• [Journal Article] Respiratory resistance among adults in a population-based cohort study in Northern Japan. (2019)
  • Author(s): Miura E, Tsuchiya N, Igarashi Y, Arakawa R, Nikkuni E, Tamai T, Tabata M, Ohkouchi S, Irokawa T, Ogawa H, Takai-Igarashi T, Suzuki Y, Kuriyama S, Tamiya G, Hozawa A, Yamamoto M, Kurosawa H.
  • Journal Title: Respiratory Investigation Volume: 印刷中 Issue: 3 Pages: 30226-0
  • DOI: 10.1016/j.resinv.2018.12.008
  • Peer Reviewed
• [Journal Article] Correlation between the native lung volume change and postoperative pulmonary function after single lung transplantation for lymphangioleiomyomatosis: Evaluation of lung volume by three-dimensional computed tomography volumetry. (2019)
  • Author(s): Suzuki H, Oishi H, Noda M, Watanabe T, Matsuda Y, Tominaga J, Sado T, Sakurada A, Kurosawa H, Takase K, Okada Y.
  • Journal Title: PLoS One. Volume: 14 Issue: 2 Pages: 0210975-0210975
  • DOI: 10.1371/journal.pone.0210975
  • Peer Reviewed
• [Journal Article] 青壮年のメンタルヘルス対策～職場での対応を中心に～ (2018)
  • Author(s): 黒澤 一
  • Journal Title: 公衆衛生情報みやぎ Volume: 479 Pages: 1-3
• [Journal Article] Fractional Exhaled Nitric Oxide (FeNO) and Spirometry as INdicators of Inhalation Exposure to Chemical Agents in Pathology Workers (2017)
  • Author(s): Ritsuko Arakawa Suzuki, Toshiya Irokawa, Hiromasa Ogawa, Shinya Ohkouchi, Masao Tabata, Susumu Togashi, Takeshi Nakamura, Noriko Ohisa, Etsuhiro Nikkuni, Emiri Miura, Kaoru Yoshida, Hioshi Inomata and Hajime Kurosawa
  • Journal Title: Journal of Occupational and Environmental Medicine Volume: in press Issue: 5 Pages: 467-473
  • DOI: 10.1097/jom.0000000000000976
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] 胸部食道癌切除再建術前および術後２週の呼吸機能評価～広域周波オシレーション法の意義 (2017)
  • Author(s): 新國 悦弘、荒川 梨津子、三浦 絵美里、吉田 薫、田畑 雅央、大河内 眞也、宮田 剛、色川 俊也、小川 浩正、黒澤 一
  • Journal Title: 日本呼吸ケア・リハビリテーション学会誌 Volume: 27 Pages: 41-47
  • NAID: 130006199727
  • Peer Reviewed
• [Journal Article] 胸部食道癌切除再建術前および術後２週の呼吸機能評価～広域周波オシレーション法の意義． (2017)
  • Author(s): 新國 悦弘、荒川 梨津子、三浦 絵美里、吉田 薫、田畑 雅央、大河内 眞也、宮田 剛、色川 俊也、小川 浩正、黒澤 一．
  • Journal Title: 日本呼吸ケア・リハビリテーション学会誌 Volume: 印刷中
  • NAID: 130006199727
  • Peer Reviewed
• [Journal Article] Clinical Application of the Forced Oscillation Technique (2016)
  • Author(s): Shirai T, Kurosawa H
  • Journal Title: Internal Medicine Volume: 55 Issue: 6 Pages: 559-566
  • DOI: 10.2169/internalmedicine.55.5876
  • NAID: 130005138067
  • ISSN: 0918-2918, 1349-7235
  • Peer Reviewed
• [Journal Article] 慢性閉塞性肺疾患に使用されるドライパウダー吸入器の吸気抵抗 (2016)
  • Author(s): 須田茂明、今野里緒、黒澤 一、田村弦
  • Journal Title: 日本呼吸器学会誌 Volume: 5 Pages: 285-289
  • Peer Reviewed
• [Journal Article] 気管支喘息の長期管理薬として使用されるドライパウダー吸入器の吸気抵抗 (2016)
  • Author(s): 須田茂明、今野里緒、黒澤 一、田村弦
  • Journal Title: アレルギー Volume: 65 Pages: 932-936
  • NAID: 130005405336
  • Peer Reviewed
• [Presentation] The weight loss therapy improved respiratory function and respiratory system impedance in obese subjects. (2018)
  • Author(s): Etsuhiro Nikkuni, Ritsuko Arakawa, Emiri Miura, Yu Igarashi, Tokiwa Tamai, Shinya Ohkouchi,Masaomi Tabata, Toshiya Irokawa, Hiromasa Ogawa, Hajime Kurosawa.
  • Organizer: Asian Pacific Society of Respirology Congress 2018
• [Presentation] Daily Physical Activity Among Patients with Chronic Respiratory Diseases. (2018)
  • Author(s): Miura E, Igarashi Y, Arakawa R, Nikkuni E, Kobayashi D, Tabata M, Ohkouchi S, Irokawa T, Ogawa H, Kurosawa H.
  • Organizer: American Thoracic Society Annual Meeting 2018
• [Presentation] MostGraphの基礎と臨床～結果の活かし方～ (2017)
  • Author(s): 黒澤 一
  • Organizer: 第１４回MostGraph臨床研究会
• [Presentation] Effect of pedometer education on daily physical activities in patients with stable COPD. (2017)
  • Author(s): Sano Y, Matsuoka R, Sato Y, Kimura S, Mihara S, Kurosawa H.
  • Organizer: ERS International Congress 2017.
• [Presentation] Pulmonary function test in small airway diseases (2016)
  • Author(s): Kurosawa H.
  • Organizer: 21th Congress of Asian Pacific Society of Respirology
  • Place of Presentation: タイ、バンコク
  • Year and Date: 2016-11-14
  • Int'l Joint Research / Invited
• [Presentation] Effects of Weight Loss Therapy on Respiratory System Impedance in Obese Subjects. (2016)
  • Author(s): Nikkuni E, Kiuchi K, Arakawa R, Kobayasi D, Miura E, Ohkouchi S, Irokawa T, Ogawa H, Kurosawa H.
  • Organizer: American Thoracic Society International Conference 2016
  • Place of Presentation: 米国、サンフランシスコ
  • Year and Date: 2016-05-15
• [Presentation] Kurosawa H, Ogawa H, Irokawa T, Ohkouchi S, Arakawa R, Miura E, Nikkuni E, Shimizu Y. Machanisms for Decrease in Resistance After Bronchodilator Inhalation Without Change in FEV1 (2016)
  • Author(s): Kurosawa H, Ogawa H, Irokawa T, Ohkouchi S, Arakawa R, Miura E, Nikkuni E, Shimizu Y
  • Organizer: American Thoracic Society International Conference 2016
  • Place of Presentation: 米国、サンフランシスコ
  • Year and Date: 2016-05-15