Significance of sarcopenia in chronic respiratory diseases

• Project/Area Number: 16K09534
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Respiratory organ internal medicine
• Research Institution: Kyoto University
• Principal Investigator: Tanizawa Kiminobu 京都大学, 医学研究科, 病院特定助教 (20639140)
• Co-Investigator(Kenkyū-buntansha): 陳 和夫 京都大学, 医学研究科, 特定教授 (90197640) ; 伊達 洋至 京都大学, 医学研究科, 教授 (60252962) ; 半田 知宏 京都大学, 医学研究科, 助教 (10432395) ; 佐藤 史顕 株式会社関西メディカルネット(関西電力医学研究所), 外科(神経内分泌腫瘍・乳癌)研究部, 上級特別研究員 (20467426)
• Project Period (FY): 2016-04-01 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
• Keywords: サルコペニア / 慢性呼吸不全 / 間質性肺疾患 / 睡眠時無呼吸症候群 / 移植・再生医療 / 内科 / 臨床

Outline of Final Research Achievements

(1)The severity of sleep apnea syndrome was not associated with sarcopenia or adipose accumulation in the skeletal muscles, but with the increase in skeletal muscles. (2)25% of interstitial lung disease patients registered for cadaveric lung transplantation had radiological pleuroparenchymal fibroelastosis (PPFE) pattern, although this pattern was not associated with transplantation-censored survival. (3) Health-related quality of life was marginally associated with five-year worsening of sarcoidosis patients, although corticosteroid/immunosuppressive agent usage and left ventricular dysfunction at baseline were stronger predictors for long-term worsening. (4)Six-month increase in serum KL-6 was an independent predictor for mortality from serum KL-6 at baseline in idiopathic pulmonary fibrosis patients.

Academic Significance and Societal Importance of the Research Achievements

(1)睡眠時無呼吸症候群における骨格筋の意義が、他の慢性呼吸器疾患とは異なることを示した。(2)脳死肺移植待機中の間質性肺疾患患者において、画像的なPPFEパターンと予後の関連を明らかにした。待機患者の優先度を決める基本データとなる可能性がある。(3)サルコイドーシスにおいて、客観的な検査指標だけでなく、患者自身の訴えに耳を傾けることの意義が明らかになった。(4)特発性肺線維症において、KL-6を経時的に評価することの意義を示した。

Research Products

• [Journal Article] Can the Sarcoidosis Health Questionnaire predict the long-term outcomes in Japanese sarcoidosis patients? (2019)
  • Author(s): Tanizawa Kiminobu、Handa Tomohiro、Nagai Sonoko、Oga Toru、Kubo Takeshi、Ito Yutaka、Aihara Kensaku、Ikezoe Kohei、Sokai Akihiko、Nakatsuka Yoshinari、Hirai Toyohiro、Chin Kazuo、Mishima Michiaki、Izumi Takateru
  • Journal Title: Respiratory Medicine Volume: 149 Pages: 1-8
  • DOI: 10.1016/j.rmed.2019.01.001
  • Peer Reviewed
• [Journal Article] Significance of bronchiolocentric fibrosis in patients with histopathological usual interstitial pneumonia (2019)
  • Author(s): Tanizawa Kiminobu、Ley Brett、Vittinghoff Eric、Elicker Brett M、Henry Travis S、Wolters Paul J、Brownell Robert、Liu Shuo、Collard Harold R、Jones Kirk D
  • Journal Title: Histopathology Volume: NA Issue: 7 Pages: 1088-1097
  • DOI: 10.1111/his.13840
  • Peer Reviewed
• [Journal Article] Clinical significance of radiological pleuroparenchymal fibroelastosis pattern in interstitial lung disease patients registered for lung transplantation: a retrospective cohort study (2018)
  • Author(s): Tanizawa Kiminobu、Handa Tomohiro、Kubo Takeshi、Chen-Yoshikawa Toyofumi F.、Aoyama Akihiro、Motoyama Hideki、Hijiya Kyoko、Yoshizawa Akihiko、Oshima Yohei、Ikezoe Kohei、Tokuda Shinsaku、Nakatsuka Yoshinari、Murase Yuko、Nagai Sonoko、Muro Shigeo、Oga Toru、Chin Kazuo、Hirai Toyohiro、Date Hiroshi
  • Journal Title: Respiratory Research Volume: 19 Issue: 1 Pages: 162-162
  • DOI: 10.1186/s12931-018-0860-6
  • Peer Reviewed / Open Access
• [Journal Article] Associations of obstructive sleep apnea with truncal skeletal muscle mass and density (2018)
  • Author(s): Matsumoto Takeshi、Tanizawa Kiminobu、Tachikawa Ryo、Murase Kimihiko、Minami Takuma、Inouchi Morito、Handa Tomohiro、Oga Toru、Hirai Toyohiro、Chin Kazuo
  • Journal Title: Scientific Reports Volume: 8 Issue: 1 Pages: 6550-6557
  • DOI: 10.1038/s41598-018-24750-z
  • NAID: 120006502582
  • Peer Reviewed / Open Access
• [Journal Article] Genetic factors in sleep-disordered breathing (2018)
  • Author(s): Tanizawa Kiminobu、Chin Kazuo
  • Journal Title: Respiratory Investigation Volume: 56 Issue: 2 Pages: 111-119
  • DOI: 10.1016/j.resinv.2017.11.012
  • Peer Reviewed
• [Journal Article] Importance of serial changes in biomarkers in idiopathic pulmonary fibrosis (2017)
  • Author(s): Sokai Akihiko、Tanizawa Kiminobu、Handa Tomohiro、Kanatani Kumiko、Kubo Takeshi、Ikezoe Kohei、Nakatsuka Yoshinari、Tokuda Shinsaku、Oga Toru、Hirai Toyohiro、Nagai Sonoko、Chin Kazuo、Mishima Michiaki
  • Journal Title: ERJ Open Research Volume: 3 Issue: 3 Pages: 00019-2016
  • DOI: 10.1183/23120541.00019-2016
  • Peer Reviewed / Open Access
• [Journal Article] Prognostic factors and outcomes in Japanese lung transplant candidates with interstitial lung disease (2017)
  • Author(s): Ikezoe Kohei、Handa Tomohiro、Tanizawa Kiminobu、Chen-Yoshikawa Toyofumi F.、Kubo Takeshi、Aoyama Akihiro、Motoyama Hideki、Hijiya Kyoko、Tokuda Shinsaku、Nakatsuka Yoshinari、Yamamoto Yuko、Oshima Ayako、Harashima Shin-ichi、Nagai Sonoko、Hirai Toyohiro、Date Hiroshi、Chin Kazuo
  • Journal Title: PLOS ONE Volume: 12 Issue: 8 Pages: e0183171-e0183171
  • DOI: 10.1371/journal.pone.0183171
  • Peer Reviewed / Open Access
• [Journal Article] Chronic Kidney Disease Predicts Survival in Patients with Idiopathic Pulmonary Fibrosis (2017)
  • Author(s): Ikezoe Kohei、Handa Tomohiro、Tanizawa Kiminobu、Yokoi Hideki、Kubo Takeshi、Aihara Kensaku、Sokai Akihiko、Nakatsuka Yoshinari、Hashimoto Seishu、Uemasu Kiyoshi、Sato Susumu、Muro Shigeo、Nagai Sonoko、Yanagita Motoko、Chin Kazuo、Hirai Toyohiro、Taguchi Yoshio、Mishima Michiaki
  • Journal Title: Respiration Volume: 94 Issue: 4 Pages: 346-354
  • DOI: 10.1159/000478787
  • Peer Reviewed
• [Journal Article] Comprehensive evaluation of airway involvement in pulmonary sarcoidosis. (2017)
  • Author(s): Tanizawa K, Handa T, Nagai S, Niimi A, Oguma T, Kubo T, Ito Y, Aihara K, Ikezoe K, Matsumoto H, Hirai T, Chin K, Mishima M.
  • Journal Title: ERJ Open Res. Volume: 3 Issue: 1 Pages: 00105-2016
  • DOI: 10.1183/23120541.00105-2016
  • NAID: 120006360785
  • Peer Reviewed / Open Access
• [Journal Article] The long-term outcome of interstitial lung disease with anti-aminoacyl-tRNA synthetase antibodies (2017)
  • Author(s): Kiminobu Tanizawa, Tomohiro Handa, Ran Nakashima, et al.
  • Journal Title: Respir Med Volume: 印刷中
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Asymmetry in Acute Exacerbation of Idiopathic Pulmonary Fibrosis (2017)
  • Author(s): Akihiko Sokai, Kiminobu Tanizawa, Tomohiro Handa, Takeshi Kubo, Seishu Hashimoto, Kohei Ikezoe, Yoshinari Nakatsuka, Kensaku Aihara, Yoshio Taguchi, Shigeo Muro, Toru Oga, Sonoko Nagai, Takateru Izumi, Toyohiro Hirai, Kazuo Chin and Michiaki Mishima
  • Journal Title: ERJ Open Res Volume: 印刷中
  • Peer Reviewed / Acknowledgement Compliant
• [Presentation] 間質性肺炎をどう理解するか? (2019)
  • Author(s): 谷澤公伸
  • Organizer: 第59回日本呼吸器学会
  • Invited
• [Presentation] Significance of bronchiolocentic fibrosis in patients with histopathological usual interstitial pneumonia (2018)
  • Author(s): Kiminobu Tanizawa
  • Organizer: ICLAF 2018
  • Int'l Joint Research
• [Presentation] Association of radiological pleuroparenchymal fibrobroelastosis with clinical features and outcomes in patients with idiopathic pulmonary fibrosis (2018)
  • Author(s): Kiminobu Tanizawa
  • Organizer: ICLAF 2018
  • Int'l Joint Research
• [Presentation] Radiological pleuroparenchymal fibroelastosis pattern in interstitial lung disease patients registered for lung transplantation: A single-institution experience (2017)
  • Author(s): Kiminobu Tanizawa, Tomohiro Handa, Takeshi Kubo, Toyofumi F. Chen-Yoshikawa, Akihiro Aoyama, Hideki Motoyama, Kyoko Hijiya, Akihiko Yoshizawa, Kohei Ikezoe, Shinsaku Tokuda, Yoshinari Nakatsuka, Yuko Yamamoto, Sonoko Nagai, Shigeo Muro, Toru Oga, Kazuo Chin, Toyohiro Hirai and Hiroshi Date
  • Organizer: American Thoracic Society 2017
  • Place of Presentation: Washington DC
  • Year and Date: 2017-05-18
  • Int'l Joint Research
• [Presentation] Can the Sarcoidosis Health Questionnaire predict the short- and long-term outcomes of patients with chronic sarcoidosis? (2016)
  • Author(s): Kiminobu Tanizawa, Tomohiro Handa, Sonoko Nagai, Toru Oga, Takeshi Kubo, Yutaka Ito, Kensaku Aihara, Kohei Ikezoe, Akihiko Sokai, Yoshinari Nakatsuka, Toyohiro Hirai, Kazuo Chin, Michiaki Mishima and Takateru Izumi
  • Organizer: American Thoracic Society 2016
  • Place of Presentation: San Francisco
  • Year and Date: 2016-05-15
  • Int'l Joint Research
• [Book] Clinical Relevance of Genetic Factors in Pulmonary Diseases (2018)
  • Author(s): Takeshi Kaneko
  • Total Pages: 344
  • Publisher: Springer Singapore