Multifaceted approach to the pathogenesis and novel treatments for acute exacerbation of idiopathic pulmonary fibrosis based on the ethnic difference and neutrophilic transcription factor
Project/Area Number |
16K09541
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Respiratory organ internal medicine
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Research Institution | Hiroshima University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
志馬 伸朗 広島大学, 医歯薬保健学研究科(医), 教授 (00260795)
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Research Collaborator |
HAMADA Hironobu
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Project Period (FY) |
2016-04-01 – 2019-03-31
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Project Status |
Completed (Fiscal Year 2018)
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Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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Keywords | 特発性肺線維症 / 急性呼吸不全 / 人種差 / 救急医療 / 集中治療 / 潜在感染症 / 好中球機能 / 国際研究者交流 / ドイツ / 指定難病 / 予後 / 生存率 / 間質性肺炎 / 肺線維症 / 急性増悪 / 好中球 |
Outline of Final Research Achievements |
Patients with increased serum levels of Helicobacter pylori demonstrated an increased occurrence of acute exacerbation of idiopathic pulmonary fibrosis (IPF). Multiple analyses of 16 oral indigenous bacteria demonstrated that several bacteria promote acute exacerbation of IPF, whereas the others inhibit acute exacerbation. Animal models of interstitial pneumonia (C57BL/6 mice) and the real time PCR demonstrated no significant function of CCAAT/enhancer binding protein(C/EBP) in interstitial pneumonia.
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Academic Significance and Societal Importance of the Research Achievements |
特発性肺線維症の急性増悪発症率には人種差がある可能性が示唆されてきたが,それを科学的に証明した研究はこれまで存在しなかった.本研究は,日本人とドイツ人の特発性肺線維症患者コホートを用いて,同一の研究者が同一の診断基準で評価をした点で,精度・信頼性が高いと考えられる.本研究の成果は,人種差の一因として,潜在感染症の関与があることを初めて明らかにした点で学術的意義が高い.しかもこれらの潜在感染症は日常生活において認識されることが乏しいため,これらの潜在感染症を治療することで,急性増悪発症率を抑えられる可能性を示唆した点で社会的意義も大きい.
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Report
(4 results)
Research Products
(59 results)
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[Journal Article] Gene expression profiling of idiopathic interstitial pneumonias (IIPs): identification of potential diagnostic markers and therapeutic targets.2017
Author(s)
Horimasu Y, Ishikawa N, Taniwaki M, Yamaguchi K, Hamai K, Iwamoto H, Ohshimo S, Hamada H, Hattori N, Okada M, Arihiro K, Ohtsuki Y, Kohno N
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Journal Title
BMC Med Genet
Volume: 18
Issue: 1
Pages: 88-88
DOI
NAID
Related Report
Peer Reviewed / Open Access
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[Journal Article] FAM13A polymorphism as a prognostic factor in patients with idiopathic pulmonary fibrosis2017
Author(s)
Hirano C, Ohshimo S, Horimasu Y, Iwamoto H, Fujitaka K, Hamada H, Hattori N, Shime N, Bonella F, Guzman J, Costabel U, Kohno N
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Journal Title
Respir Med
Volume: 123
Pages: 105-109
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Comparative Study of Circulating MMP-7, CCL18, KL-6, SP-A, and SP-D as Disease Markers of Idiopathic Pulmonary Fibrosis.2016
Author(s)
Hamai K, Iwamoto H, Ishikawa N, Horimasu Y, Masuda T, Miyamoto S, Nakashima T, Ohshimo S, Fujitaka K, Hamada H, Hattori N, Kohno N
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Journal Title
Dis Markers
Volume: なし
Pages: 4759040-4759040
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] Imbalance in the oral bacterial flora as a risk factor for acute exacerbation in idiopathic pulmonary fibrosis2019
Author(s)
Shinichiro Ohshimo, Hiromi Nishi, Koji Hosokawa, Yasushi Horimasu, Shintaro Miyamoto, Hiroshi Iwamoto, Hironobu Hamada, Hiroyuki Kawaguch, Francesco Bonella, Josune Guzman, Ulrich Costabel, Noboru Hattori, Nobuaki Shime
Organizer
European Respiratory Society International Congress 2019
Related Report
Int'l Joint Research
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[Presentation] Clinical utility of CCL15 as a prognostic biomarker for hypersensitivity pneumonitis2019
Author(s)
M. Watanabe, Y. Horimasu, H. Iwamoto, K. Yamaguchi, S. Sakamoto, T. Masuda, T. Nakashima, S. Miyamoto, S. Ohshimo, K. Fujitaka , H. Hamada, N. Kohno, N. Hattori
Organizer
European Respiratory Society International Congress 2019
Related Report
Int'l Joint Research
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[Presentation] Fine crackles quantitative value can help the diagnosis of interstitial lung diseases - Clinical utility of the innovative analyzing system of respiratory sounds2019
Author(s)
Yasushi Horimasu, Shinichiro Ohshimo, Kakuhiro Yamaguchi, Shinjiro Sakamoto, Takeshi Masuda, Taku Nakashima, Shintaro Miyamoto, Hiroshi Iwamoto, Takuma Sadamori, Kazunori Fujitaka, Hironobu Hamada, Nobuaki Shime, Noboru Hattori
Organizer
European Respiratory Society International Congress 2019
Related Report
Int'l Joint Research
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[Presentation] Modified GAP stage as a predictor of acute exacerbation in idiopathic pulmonary fibrosis2018
Author(s)
Shinichiro Ohshimo, Yoshiko Kida, Michihito Kyo, Koji Hosokawa, Yasushi Horimasu, Shintaro Miyamoto, Hiroshi Iwamoto, Hironobu Hamada, Noboru Hattori, Francesco Bonella, Josune Guzman, Ulrich Costabel, Nobuaki Shime
Organizer
European Respiratory Society International Congress 2018
Related Report
Int'l Joint Research
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[Presentation] Extent of the honeycombing area and the presence of traction bronchiectasis are risk factors for a poor prognosis in patients with pleuroparenchymal fibroelastosis2018
Author(s)
Masashi Namba, Takeshi Masuda, Kakuhiro Yamaguchi, Shinjiro Sakamoto, Yasushi Horimasu, Taku Nakashima, Shintarou Miyamoto, Hiroshi Iwamoto, Shinichiro Ohshimo, Kazunori Fujitaka, Hironobu Hamada, Noboru Hattori
Organizer
European Respiratory Society International Congress 2018
Related Report
Int'l Joint Research
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[Presentation] FAM13A polymorphism as a prognostic factor in Japanese patients with idiopathic pulmonary fibrosis2016
Author(s)
Hirano C, Ohshimo S, Horimasu Y, Iwamoto H, Fujitaka K, Hamada H, Hattori N, Bonella F, Guzman J, Costabel U, Kohno N.
Organizer
American Thoracic Society 2017 International Conference
Place of Presentation
San Francisco, California, U.S.A
Year and Date
2016-05-13
Related Report
Int'l Joint Research
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[Presentation] FAM13A polymorphism as a prognostic factor in Japanese patients with idiopathic pulmonary fibrosis.2016
Author(s)
Chihiro Hirano, Shinichiro Ohshimo, Yasushi Horimasu, Hiroshi Iwamoto, Hironobu Hamada, Noboru Hattori, Francesco Bonella, Josune Guzman, Ulrich Costabel, Nobuoki Kohno.
Organizer
The 56th Annual Meeting of the Japanese Respiratory Society
Place of Presentation
Kyoto, Japan
Year and Date
2016-04-08
Related Report
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[Book] 集中治療,ここだけの話2018
Author(s)
田中竜馬・編,大下慎一郎,他・著
Total Pages
448
Publisher
医学書院
ISBN
9784260036719
Related Report
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