• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Development of novel biomarkers for the risk of COPD and prognosis

Research Project

Project/Area Number 16K09547
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Respiratory organ internal medicine
Research InstitutionYokohama City University

Principal Investigator

KANEKO TAKESHI  横浜市立大学, 医学研究科, 教授 (90275066)

Co-Investigator(Kenkyū-buntansha) 新海 正晴  横浜市立大学, 医学研究科, 客員教授 (10535214)
原 悠  横浜市立大学, 医学部, 助教 (70806299)
Research Collaborator USUI Kengo  
TAKAGI Shigeto  
MATSUMOTO Yutaka  
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywordsヘムオキシゲナーゼ-1 / Nrf2 / 一塩基多型 / rs6721961 / 喫煙 / 酸化ストレス / 炎症 / COPD増悪 / 慢性閉塞性肺疾患 / 急性肺障害 / 間質性肺炎 / 急性増悪 / バイオマーカー / COPD / HO-1 / 臨床
Outline of Final Research Achievements

Heme oxygenase-1 (HO-1) is a protein that plays a role in cytoprotection against inflammation and oxidative stress. Here we demonstrated that serum HO-1 tends to be lower in healthy smokers than non-smokers, and is significantly lower in COPD (chronic obstructive pulmonary disease) patients than healthy smokers. In addition, in healthy adults with the SNP (rs6721961) of Nrf2 (nuclear factor E2 related factor 2), a transcription factor of HO-1, there was a tendency for serum HO-1 to decrease. Moreover, COPD patients carried the Nrf2 SNP heterozygous or homozygous allele more frequently. These findings suggest that the combination of the Nrf2 SNP and long-term smoking habits may reduce HO-1 expression and increase the risk of COPD.

Academic Significance and Societal Importance of the Research Achievements

本研究を通じて、COPDの発症リスクやその予後予測のためのバイオマーカーとして血清ヘムオキシゲナーゼ-1(HO-1)が有用である可能性が示唆された。今後のCOPD症例での更なる検討によって、血清HO-1は治療効果の判定や増悪の予測、重症度分類などに応用できる可能性がある。また、Nrf2遺伝子の一塩基多型(rs6721961)の検出も、喫煙によるCOPD発症のリスク診断において有用であり、特に、喫煙歴が浅く血清HO-1の低下を認めない喫煙者に対する禁煙指導の際には、禁煙の重要性について説得力のある情報になると考えられた。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (5 results)

All 2018

All Journal Article (2 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 2 results,  Open Access: 2 results) Presentation (3 results)

  • [Journal Article] Clinical Significance of Serum Hemeoxygenase-1 as a New Biomarker for the Patients with Interstitial Pneumonia.2018

    • Author(s)
      Murohashi K, Hara Y, Shinada K, Nagai K, Shinkai M, Kawana A, Kaneko T.
    • Journal Title

      Canadian Respiratory Journal

      Volume: 2018 Pages: 1-7

    • DOI

      10.1155/2018/7260178

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] ELISA Development for Serum Hemeoxygenase-1 and Its Application to Patients with Acute Respiratory Distress Syndrome2018

    • Author(s)
      Hara Yu、Shinkai Masaharu、Taguri Masataka、Nagai Kenjiro、Hashimoto Satoru、Kaneko Takeshi
    • Journal Title

      Canadian Respiratory Journal

      Volume: 2018 Pages: 1-7

    • DOI

      10.1155/2018/9627420

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] 間質性肺炎(IP)における予後予測マーカーとしての血清ヘムオキシゲナーゼ-1(HO-1)の有用性に関する検討2018

    • Author(s)
      品田佳那子, 原 悠, 長井賢次郎, 室橋光太, 池田美彩子, 佐々木寿, 湯本健太郎, 中島健太郎, 牛尾良太, 木村泰浩, 柴田祐司, 田代 研, 渡邉恵介, 篠田雅宏, 佐藤 隆, 川名明彦, 新海正晴, 金子 猛
    • Organizer
      第58回日本呼吸器学会学術講演会
    • Related Report
      2018 Annual Research Report
  • [Presentation] COPDにおける血清ヘムオキシゲナーゼ-1(HO-1)値に関する検討2018

    • Author(s)
      湯本健太郎, 原 悠, 室橋光太, 品田佳那子, 池田美彩子, 中島健太郎, 木村泰浩, 牛尾良太, 柴田祐司, 田代 研, 長井賢次郎, 渡邉恵介, 篠田雅宏, 小林信明, 山本昌樹, 佐藤 隆, 工藤 誠, 新海正晴, 金子 猛
    • Organizer
      第58回日本呼吸器学会学術講演会
    • Related Report
      2018 Annual Research Report
  • [Presentation] COPDにおける血清ヘムオキシゲナーゼ-1(HO-1)値に関する検討2018

    • Author(s)
      湯本健太郎
    • Organizer
      日本呼吸器学会学術集会
    • Related Report
      2017 Research-status Report

URL: 

Published: 2016-04-21   Modified: 2020-03-30  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi