The role of autophagy on Gut-lung axis in chronic obstructive pulmonary disease
| Project/Area Number |
16K09549
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Nippon Medical School (2017-2019)
Nara Medical University (2016) |
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Principal Investigator |
Kimura Hiroshi 日本医科大学, 大学院医学研究科, 教授 (20195374)
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| Co-Investigator(Kenkyū-buntansha) |
友田 恒一 川崎医科大学, 医学部, 教授 (90364059)
吉川 雅則 奈良県立医科大学, 医学部, 病院教授 (80271203)
山本 佳史 奈良県立医科大学, 医学部, 助教 (00458035)
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| Project Period (FY) |
2016-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | COPD / Gut-lung axis / Autophagy / Mit DNA / Adiponectin / 栄養学 / 慢性閉塞性肺疾患 / 腸内環境 / Gut-lung axis |
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| Outline of Final Research Achievements |
We hypothesized that changes of autophagy (AP) could relate to the alteration in the Gut-lung axis on the development of COPD. We measured plasma levels of mitochondria DNA (mt DNA), which is an index of injury in mitochondria and relates to induction of AP. Moreover, the relationship between these levels and clinical parameters in COPD was investigated to elucidate the role of AP in COPD. The mt DNA levels tended to be higher than those in healthy non-smoker and smoker. However, the levels did not relate to GOLD clinical stage. The levels correlated with BMI while the levels inversely correlated emphysema score in CT. And decline rate in FEV1 before the measurement also correlate with the mt DNA level. There were no significant differences between the survivor and non-survivors 5 years after the measurements. In conclusion, mt DNA partially relates to the clinical findings in COPD and further investigation is needed to elucidate the role of AP.
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| Academic Significance and Societal Importance of the Research Achievements |
COPDは喫煙者の約20％にのみ発症するがなぜ一部の喫煙者のみに発症するかについては明らかではない。発症メカニズムを明らかにすることは、将来的な喫煙対策を含め社会的に重要な課題である。本研究ではautophagyとGut-lung axisが関連しているとの仮説を立て、COPDにおけるAutophagyの役割を検討したものである。本研究にてAutophagyを誘導するとされるミトコンドリアDNA（mitDNA）の血中レベルはCOPDの病態と関連していることが明らかになった。喫煙、COPD発症におけるAutophagyの関与をさらに明らかにすることが求められる。
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Report
(5 results)
Research Products
(66 results)
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[Journal Article] Effectiveness and Outcome of Pulmonary Arterial Hypertension-Specific Therapy in Japanese Patients With Pulmonary Arterial Hypertension2018
Author(s)
Tamura Y, Kumamaru H, Satoh T, Miyata H, Ogawa A, Tanabe N, Hatano M, Yao A, Abe K, Tsujino I, Fukuda K, Kimura H, Kuwana M, Matsubara H, Tatsumi K
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Journal Title
Circulation Journal
Volume: 82
Issue: 1
Pages: 275-282
DOI
NAID
ISSN
1346-9843, 1347-4820
Related Report
Peer Reviewed
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[Journal Article] Effectiveness and Outcome of Pulmonary Arterial Hypertension-Specific Therapy in Japanese Patients2017
Author(s)
Tamura Y, Kumamaru H, Satoh T, Miyata H, Ogawa A, Tanabe N, Hatano M, Yao A, Abe K, Tsujino I, Fukuda K,Kimura H, Kuwana M, Matsubara H, Tatsumi K
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Journal Title
Pulmonary Arterial Hypertension
Volume: 82
Pages: 275-282
Related Report
Peer Reviewed
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[Journal Article] Comparison of clinical and pathological features of lung lesions of systemic IgG4-related disease and idiopathic multicentric Castleman's disease.2017
Author(s)
Terasaki Y, Ikushima S, Matsui S, Hebisawa A, Ichimura Y, Izumi S, Ujita M, Arita M, Tomii K, Komase Y, Owan I, Kawamura T, Matsuzawa Y, Murakami M, Ishimoto H,;Kimura H, Bando M, Nishimoto N, Kawabata Y, Fukuda Y, Ogura T
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Journal Title
Histopathology.
Volume: 70
Pages: 1114-1124
Related Report
Peer Reviewed
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[Journal Article] Up-regulation of selenoprotein P and 160;HIP/PAPmRNAs in hepatocytes by intermittent hypoxia via down-regulation of miR-203.2017
Author(s)
Uchiyama T, Ota H, Itaya-Hironaka A, Shobatake R, Yamauchi A, Sakuramoto-Tsuchida S, Makino M,Kimura H, Takeda M, Ohbayashi C, Takasawa S.
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Journal Title
Biochem Biophys Rep
Volume: 11
Pages: 130-137
Related Report
Peer Reviewed
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[Presentation] 過粘稠性肺炎桿菌による重症肺炎・肺膿瘍の 2 例2018
Author(s)
鏑木翔太, 蛸井浩行, 田中 徹, 渥美健一郎, 林 宏紀, 藤田和恵, 齋藤好信, 阿部信二, 木村 弘, 久保田 馨, 清家正博, 弦間昭彦
Organizer
第228回日本呼吸器学会関東地方会
Related Report
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[Presentation] 肺血管拡張薬の有効性を認めた慢性閉塞性肺疾患に伴う肺高血圧症の一例2018
Author(s)
鈴木彩奈, 渥美健一郎, 戸塚猛大, 二島駿一, 田中 徹, 柏田 健, 林 宏紀, 藤田和恵, 齋藤好信, 清家正博, 弦間昭彦, 木村 弘
Organizer
第232回日本呼吸器学会関東地方会
Related Report
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