Efficacy of sublingual immunotherapy in asthmatic patients with Japanese cedar pollinosis
Project/Area Number |
16K09554
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Respiratory organ internal medicine
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Research Institution | Juntendo University |
Principal Investigator |
Ito Jun 順天堂大学, 医学部, 助教 (80747692)
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Co-Investigator(Kenkyū-buntansha) |
原田 紀宏 順天堂大学, 医学部, 准教授 (10465065)
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Research Collaborator |
SANDHU yuki
TAKESHIGE tomohito
HARADA sonoko
MATSUNO kei
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Project Period (FY) |
2016-04-01 – 2019-03-31
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Project Status |
Completed (Fiscal Year 2018)
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Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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Keywords | スギ花粉症 / 気管支喘息 / アレルギー性鼻炎 / 舌下免疫療法 / 喘息 / スギ花粉舌下免疫療法 / バイオマーカー / CD27 / スギ花粉症合併喘息 / アレルギー・ぜんそく |
Outline of Final Research Achievements |
Allergic rhinitis may increase the risk of developing or worsening asthma, which is the allergic condition most frequently associated with allergic rhinitis. The prevalence of asthma is higher among patients with allergic rhinitis than among patients without allergic rhinitis. In the present study, we investigated whether sublingual immunotherapy for Japanese cedar pollinosis using a single cedar antigen extract reduce the risk of experiencing asthma symptoms. Data from the one-year sublingual immunotherapy in patients with both Japanese cedar pollen allergic rhinitis and asthma demonstrated that a sublingual immunotherapy clinically improved rhinitis symptoms and asthma symptoms with significant reductions in airway resistance.
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Academic Significance and Societal Importance of the Research Achievements |
スギ花粉症患者は日本国内では非常に高率に存在するが、スギが分布していない諸外国ではスギ花粉の飛散が少ないため、スギ花粉症と喘息との関連に関する研究に乏しい。また、スギ花粉舌下免疫療法がアレルギー性鼻炎と喘息を一剤で同時に治療できることが証明され、喘息治療の新たな選択肢として確立されることは、単に治療選択肢が増えるだけでなく医療費の削減にもつながる。このため、スギ花粉症合併喘息患者を対象としたスギ花粉舌下免疫療法に関する本研究の実施は、われわれ日本人にとって重要な研究である。
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Report
(4 results)
Research Products
(63 results)
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[Journal Article] Pulmonary Intravascular Large B-cell Lymphoma (IVLBCL) Disguised as an Asthma Exacerbation in a Patient with Asthma2017
Author(s)
Takeshige T, Harada N, Sekimoto Y, Kanemaru R, Tsutsumi T, Matsuno K, Shiota S, Masuda A, Gotoh A, Asahina M, Uekusa T, Takahashi K.
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Journal Title
Internal Medicine
Volume: 56
Issue: 14
Pages: 1885-1891
DOI
NAID
ISSN
0918-2918, 1349-7235
Related Report
Peer Reviewed / Open Access
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[Journal Article] Circulating activated innate lymphoid cells and mucosal-associated invariant T cells are associated with airflow limitation in patients with asthma2017
Author(s)
Ishimori A, Harada N, Chiba A, Harada S, Matsuno K, Makino F, Ito J, Ohta S, Ono Junya, Atsuta R, Izuhara K, Takahashi K, Miyake S
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Journal Title
Allergology International
Volume: 66
Issue: 2
Pages: 302-309
DOI
NAID
ISSN
1323-8930, 1440-1592
Related Report
Peer Reviewed / Open Access
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[Journal Article] Evaluation of switching low-dose inhaled corticosteroid to pranlukast for step-down therapy in well-controlled patients with mild persistent asthma.2015
Author(s)
Harada, S., N. Harada, Y. Itoigawa, Y. Katsura, F. Kasuga, A. Ishimori, F. Makino, J. Ito, R. Atsuta, and K. Takahashi.
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Journal Title
Journal of Asthma
Volume: 53
Issue: 2
Pages: 207-212
DOI
Related Report
Peer Reviewed
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[Presentation] Innate lymphoid cell subsets in peripheral blood of patients with asthma treated with mepolizumab2018
Author(s)
Hitoshi Sasano, Norihiro Harada, Sonoko Harada Yuki Tanabe Yuuki Sandhu, Tomohito Takeshige, Kei Matsuno, Ayako Ishimori, Fumihiko Makino, Jun Ito, Asako Chiba, Sachiko Miyake, Kazuhisa Takahashi
Organizer
The 3rd International Conference on Innate Lymphoid Cells
Related Report
Int'l Joint Research
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[Presentation] Chitin induced production of prostaglandine E2 in alveolar macrophages and bronchial epithelial cells2018
Author(s)
Tomohito Takeshige, Norihiro Harada, Kei Matsuno, Ayako Ishimori, Yuki Tanabe, Hitoshi Sasano, Ai Nakamura, Sonoko Harada, Yoko Katsura, Fumihiko Makino, Jun Ito, Ryo Atsuta, Hisaya Akiba, Kazuhisa Takahashi
Organizer
The 23nd congress of the Asian Paciffic Society of Respirology
Related Report
Int'l Joint Research
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[Presentation] Chitin Induced Production of Prostaglandin E2 in Alveolar Macrophages and Bronchial Epithelial Cells2018
Author(s)
Tomohito Takeshige, Norihiro Harada, Kei Matsuno, Ayako Ishimori, Yuki Tanabe, Hitoshi Sasano, Sonoko Harada, Yoko Katsura, Fumihiko Makino, Jun Ito, Ryo Atsuta, Hisaya Akiba, Kazuhisa Takahashi
Organizer
XXIV World Congress of Asthma
Related Report
Int'l Joint Research
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[Presentation] Chitin induced production of prostaglandin E2 in alveolar macrophages and bronchial epithelial cells2018
Author(s)
Tomohito Takeshige, Norihiro Harada, Kei Matsuno, Ayako Ishimori, Yuki Tanabe, Hitoshi Sasano, Ai Nakamura, Sonoko Harada, Yoko Katsura, Fumihiko Makino, Jun Ito, Ryo Atsuta, Hisaya Akiba, Kazuhisa Takahashi
Organizer
American Thoracic Society International Conference 2018
Related Report
Int'l Joint Research
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[Presentation] Chitin induced airway inflammation and production of prostaglandin E22018
Author(s)
Tomohito Takeshige, Norihiro Harada1, Kei Matsuno, Ayako Ishimori, Yuki Tanabe, Hitoshi Sasano, Ai Nakamura, Sonoko Harada, Yoko Katsura, Fumihiko Makino, Jun Ito, Ryo Atsuta, Hisaya Akiba, Kazuhisa Takahashi
Organizer
第58回日本呼吸器学会学術講演会
Related Report
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[Presentation] Circulating levels of tenascin-C as type 2 biomarkers in the patients with asthma2018
Author(s)
Mina Asaji, Norihiro Harada, Sonoko Harada, Ayako Ishimori, Yoko Katsura, Yukinari Itoigawa, Kei Matsuno, Fumihiko Makino, Jun Ito, Junya Ono, Kazunori Tobino, Hisaya Akiba, Ryo Atsuta, Kenji Izuhara, and Kazuhisa Takahashi
Organizer
第58回日本呼吸器学会学術講演会
Related Report
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[Presentation] TWEAK induced TSLP expression in human bronchial epithelial cells2018
Author(s)
Kei Matsuno, Norihiro Harada, Tomohito Takeshige, Sonoko Harada, Ayako Ishimori, Yuki Tanabe, Hitoshi Sasano, Ai Nakamura, Yoko Katsura, Fumihiko Makino, Jun Ito, Ryo Atsuta, Kazuhisa Takahashi
Organizer
第58回日本呼吸器学会学術講演会
Related Report
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[Presentation] TWEAK enhances epithelial mesenchymal transition and chemokine production in human bronchial epithelial cells2017
Author(s)
Kei Matsuno, Norihiro Harada, Itoigawa Yukinari, Tomohito Takeshige, Sonoko Harada, Ayako Ishimori, Yuki Tanabe, Yoko Katsura, Fumihiko Makino, Jun Ito, Ryo Atsuta, Hisaya Akiba, Kazuhisa Takahashi
Organizer
第46回日本免疫学会学術集会
Related Report
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[Presentation] TWEAK and TGF-β induced chemokine production in human bronchial epithelial cells during epithelial mesenchymal transition2017
Author(s)
Kei Matsuno, Norihiro Harada, Tomohito Takeshige, Sonoko Harada, Ayako Ishimori, Yuki Tanabe, Hitoshi Sasano, Ai Nakamura, Yoko Katsura, Fumihiko Makino, Jun Ito, Ryo Atsuta, Hisaya Akiba, Kazuhisa Takahashi
Organizer
The 22nd congress of the Asian Paciffic Society of Respirology
Related Report
Int'l Joint Research
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[Presentation] The effect of mepolizumab treatment in patients with severe asthma2017
Author(s)
Yuuki Sandhu, Norihiro Harada, Kei Matsuno, Sonoko Harada, Hitoshi Sasano, Yuki Tanabe, Ai Nakamura, Tomohito Takeshige, Ayako Ishimori, Yoko Katsura, Fumihiko Makino, Jun Ito, Ryo Atsuta, Hisaya Akiba, Kazuhisa Takahashi
Organizer
The 22nd congress of the Asian Paciffic Society of Respirology
Related Report
Int'l Joint Research
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[Presentation] Serum tenascin-C levels in patients with asthma2017
Author(s)
Norihiro Harada, Mina Asaji, Sonoko Harada, Ayako Ishimori, Yoko Katsura, Yukinari Itoigawa, Kei Matsuno, Fumihiko Makino, Jun Ito, Junya Ono, Kazunori Tobino, Hisaya Akiba, Ryo Atsuta, Kenji Izuhara, Kazuhisa Takahashi
Organizer
The 22nd congress of the Asian Paciffic Society of Respirology
Related Report
Int'l Joint Research
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[Presentation] Chitin induced airway inflammation and production of prostaglandin E22017
Author(s)
Tomohito Takeshige, Norihiro Harada, Kei Matsuno, Ayako Ishimori, Yuki Tanabe, Hitoshi Sasano, Ai Nakamura, Sonoko Harada, Yoko Katsura, Fumihiko Makino, Jun Ito, Ryo Atsuta, Hisaya Akiba, Kazuhisa Takahashi
Organizer
The 22nd congress of the Asian Paciffic Society of Respirology
Related Report
Int'l Joint Research
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[Presentation] The differences of values between NOA208i and NIOXvero as a measurement of fractional exhaled nitric oxide2017
Author(s)
Yuki Tanabe, Jun Ito, Hitoshi Sasano, Ai Nakamura, Yuki Sandou, Tomohito Takeshige, Kei Matsuno, Yoko Katsura, Ayako Ishimori, Fumihiko Makino, Ryo Atsuta, Norihiro Harada, Kazuhisa Takahashi
Organizer
American Thoracic Society International Conference 2017
Related Report
Int'l Joint Research
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[Presentation] TWEAK and TGF-β induced chemokine production in human bronchial epithelial cells during EMT2017
Author(s)
Kei Matsuno, Norihiro Harada, Ayako Ishimori, Tomohito Takeshige, Yuki Tanabe, Hitoshi Sasano, Ai Nakamura, Yoko Katsura, Fumihiko Makino, Jun Ito, Ryo Atsuta, Kazuhisa Takahashi
Organizer
第57回日本呼吸器学会学術講演会
Related Report
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