Prostaglandin E- major urinary metabolite (PGE-MUM) as a tumor marker for lung adenocarcinoma
Project/Area Number |
16K09558
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Respiratory organ internal medicine
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Research Institution | Jikei University School of Medicine |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
原 弘道 東京慈恵会医科大学, 医学部, 講師 (70398791)
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Research Collaborator |
HARA HIROMICHI
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Project Period (FY) |
2016-04-01 – 2019-03-31
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Project Status |
Completed (Fiscal Year 2018)
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Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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Keywords | 尿中PGE-MUM / 肺腺癌 / PGE-MUM / 肺癌 |
Outline of Final Research Achievements |
Prostaglandin E- major urinary metabolite (PGE-MUM) levels were significantly elevated in patients with lung adenocarcinoma. PGE-MUM level of 14.9 μg/g・Cr showed 70.4% sensitivity and 67.7% specificity for diagnosis of lung adenocarcinoma. PGE-MUM levels tended to be positively correlated with cancer progression determined by TNM staging system. Advanced stage (stageⅢ, stageⅣ,recurrence) was significantly associated with high PGE-MUM by logistic regression analysis. No apparent correlation was demonstrated between PGE-MUM and CEA levels. PGE-MUM can be a promising biomarker reflecting systemic tumor burden of lung adenocarcinoma.
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Academic Significance and Societal Importance of the Research Achievements |
尿中PGE 代謝産物(prostaglandin E-major urinary metabolite: PGE-MUM)は肺腺癌患者で増加していた。PGE-MUMは14.9 g/g・Crをカットオフとすると肺腺癌の診断感度70.4%、特異度67.7%であった。PGE-MUMは肺癌の進展ともに増加する傾向であった。肺癌が進行期であることは有意にPGE-MUM高値と関連した。PGE-MUMとCEAは相関がみられなかった。PGE-MUMは肺腺癌の腫瘍量を反映する新たなバイオマーカーとなる可能性がある。
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Report
(4 results)
Research Products
(1 results)
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[Journal Article] 2. Increased levels of prostaglandin E-major urinary metabolite (PGE-MUM) in chronic fibrosing interstitial pneumonia.2017
Author(s)
Horikiri T, Hara H, Saito N, Araya J, Takasaka N, Utsumi H, Yanagisawa H, Hashimoto M, Yoshii Y, Wakui H, Minagawa S, Ishikawa T, Shimizu K, Numata T, Arihiro S, Kaneko Y, Nakayama K, Matsuura T, Matsuura M, Fujiwara M, Okayasu I, Ito S, Kuwano K.
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Journal Title
Respir Med.
Volume: 122
Pages: 43-50
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant