|Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
|Outline of Final Research Achievements
In interstitial lung diseases, the importance of endothelial microparticles (EMPs) from circulating peripheral blood has not been understood. We investigated the clinical role of EMPs from patients with idiopathic interstitial pneumonias. We found that the number of PECAM-1-positive EMP at the time of registration was correlated with the decrease of pulmonary function at 6 months later. The total number of EMPs at the time of registration was also correlated with the decrease of pulmonary function at 1 year later. In cases with drug-induced lung injury, a specific kind of EMPs was increased during acute phase and decreased during recovery phase.
We could provide basic knowledge of EMPs as a possible clinical marker in interstitail lung diseases.