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Identification and functional analysis of transmembrane proteins involved in cell adhesion and determines lung cancer prognosis

Research Project

Project/Area Number 16K09574
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Respiratory organ internal medicine
Research InstitutionThe University of Tokyo

Principal Investigator

Kage Hidenori  東京大学, 医学部附属病院, 講師 (80513390)

Research Collaborator Ando Takahiro  
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2018: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywordsインテグリン / ITGA11 / 肺癌 / 術後再発 / 遊走能 / 浸潤能 / 細胞外基質 / 遊走 / 膜タンパク / 膜貫通型タンパク / 細胞接着
Outline of Final Research Achievements

Integrins are a family of transmembrane proteins that bind extracellular matrix. We analyzed the role of integrin alpha 11 (ITGA11) in lung cancer. Analysis revealed that high expression of ITGA11 is associated with higher stage, and also with postoperative recurrence. Overexpression of ITGA11 in lung cancer cells did not result in higher proliferation of cells, but resulted in larger cells, increased cell migration, and increased invasion through extracellular matrix. Our results show that ITGA11 is a potential therapeutic target of lung cancer.

Academic Significance and Societal Importance of the Research Achievements

本研究では、ITGA11の発現量が肺がんのステージや術後再発と関連があることを初めて見出した。肺がんが進行するにつれ、肺がん細胞はITGA11の発現量を高めることにより、遊走能や浸潤能を高め、がんの発生部位における進展や他臓器への転移をおこしやすくしていると推測できる。インテグリン分子は細胞膜の表面に顔を出しているため、本研究でITGA11は肺がんの有力な治療標的になりうることが分かった。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (4 results)

All 2019 2018

All Presentation (4 results) (of which Int'l Joint Research: 1 results)

  • [Presentation] High Expression of Integrin α11 in Non-Small Cell Lung Carcinoma is Associated with Tumor Progression and Postoperative Recurrence2019

    • Author(s)
      Takahiro Ando, Hidenori Kage, Yoko Matsumoto, Kouichi Zokumsu, Takuma Yotsumoto, Keita Maemura, Yosuke Amano, Kousuke Watanabe, Jun Nakajima, Takahide Nagase, Daiya Takai
    • Organizer
      第2回Young Investigator's Respiratory Symposium (YRS)
    • Related Report
      2018 Annual Research Report
  • [Presentation] High expression of ITGA11 in adenocarcinoma is associated with tumor progression and postoperative recurrence2018

    • Author(s)
      Takahiro Ando, Hidenori Kage, Keita Maemura, Noriko Hiyama, Toshio Sakatani, Yosuke Amano, Kousuke Watanabe, Jun Nakajima, Takahide Nagase, Daiya Takai
    • Organizer
      第58回日本呼吸器学会学術講演会
    • Related Report
      2018 Annual Research Report
  • [Presentation] High expression of ITGA11 in adenocarcinoma is associated with tumor progression and postoperative recurrence2018

    • Author(s)
      Takahiro Ando, Hidenori Kage, Keita Maemura, Noriko Hiyama, Toshio Sakatani, Yosuke Amano, Kousuke Watanabe, Jun Nakajima, Takahide Nagase, Daiya Takai
    • Organizer
      American Thoracic Society International Conference 2018
    • Related Report
      2018 Annual Research Report 2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] High expression of ITGA11 in adenocarcinoma is associated with tumor progression and postoperative recurrence2018

    • Author(s)
      Takahiro Ando, Hidenori Kage, Keita Maemura, Noriko Hiyama, Toshio Sakatani, Yosuke Amano, Kousuke Watanabe, Jun Nakajima, Takahide Nagase, Daiya Takai
    • Organizer
      第58回日本呼吸器学会学術講演会
    • Related Report
      2017 Research-status Report

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Published: 2016-04-21   Modified: 2020-03-30  

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