The development of new antibody treatment against immune checkpoint protein PD-1 homolog

• Project/Area Number: 16K09587
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Respiratory organ internal medicine
• Research Institution: Juntendo University
• Principal Investigator: Harada Norihiro 順天堂大学, 医学部, 准教授 (10465065)
• Research Collaborator: AKIBA Hisaya ; ISSIKI takuma ; HARADA sonoko ; MATSUNO kei
• Project Period (FY): 2016-04-01 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 免疫チェックポイント / 抗体 / PD-1H / TIM-3 / 免疫チェックポイント分子 / 補助シグナル / 肺がん / 喘息 / 免疫チェックポイント阻害薬 / 抗PD-1ホモログ抗体 / 免疫チェックポイント阻害 / 補助シグナル分子

Outline of Final Research Achievements

The immune system includes immune checkpoints or inhibitory pathways against excessive immune responses, as well as co-stimulatory molecules, which act to enhance immune responses. New immune checkpoints that are being evaluated in the world includes PD-1homolog (PD-1H) and T cell Ig and mucin domain (TIM)-3. In the present study, we investigated the effects of anti-PD-1H mAb and anti-TIM-3 mAb in a murine model of OVA-induced allergic airway inflammation and in a murine model of bleomycin-induced lung inflammation and fibrosis, respectively. Anti-PD-1H mAb treatment may enhance allergic airway inflammation. Moreover, anti-TIM-3 mAb treatment inhibited the phagocytic ability of alveolar macrophages, resulting in the defective clearance of apoptotic cells in lungs and enhanced bleomycin-induced lung inflammation and fibrosis, suggesting that anti-TIM-3 mAb treatment may enhance cause pneumonitis.

Academic Significance and Societal Importance of the Research Achievements

免疫チェックポイント分子に対する新規抗体の炎症性疾患に対する効果を解析した。がん診療に用いられている免疫チェックポイント阻害療法は、重篤な合併症として間質性肺炎を発症することが知られている。新しい免疫チェックポイント阻害薬として期待される抗TIM-3抗体も同様に、あるいは、それ以上に間質性肺炎の合併症に注意する必要がある。また、同様に抗PD-1H抗体も炎症性疾患を悪化させる可能性が考えられた。

Research Products

• [Journal Article] Cyclooxygenase inhibition in mice heightens adaptive‐ and innate‐type responses against inhaled protease allergen and IL ‐33 (2019)
  • Author(s): Maruyama Natsuko、Takai Toshiro、Kamijo Seiji、Suchiva Punyada、Ohba Mai、Takeshige Tomohito、Suzuki Mayu、Hara Mutsuko、Matsuno Kei、Harada Sonoko、Harada Norihiro、Nakae Susumu、Sudo Katsuko、Okuno Toshiaki、Yokomizo Takehiko、Ogawa Hideoki、Okumura Ko、Ikeda Shigaku
  • Journal Title: Allergy Volume: 印刷中 Issue: 11 Pages: 2237-2240
  • DOI: 10.1111/all.13831
  • Peer Reviewed / Open Access
• [Journal Article] Malignant Pleural Mesothelioma with Bone Marrow Metastases (2018)
  • Author(s): Ihara Hiroaki、Harada Norihiro、Shimada Naoko、Kanamori Koichiro、Hayashi Takuo、Uekusa Toshimasa、Takahashi Kazuhisa
  • Journal Title: Internal Medicine Volume: 57 Issue: 17 Pages: 2541-2545
  • DOI: 10.2169/internalmedicine.9246-17
  • NAID: 130007480073
  • ISSN: 0918-2918, 1349-7235
  • Year and Date: 2018-09-01
  • Peer Reviewed / Open Access
• [Journal Article] Combination of TWEAK and TGF-β1 induces the production of TSLP, RANTES, and TARC in BEAS-2B human bronchial epithelial cells during epithelial-mesenchymal transition (2018)
  • Author(s): Matsuno Kei、Harada Norihiro、Harada Sonoko、Takeshige Tomohito、Ishimori Ayako、Itoigawa Yukinari、Katsura Yoko、Kodama Yuzo、Makino Fumihiko、Ito Jun、Atsuta Ryo、Akiba Hisaya、Takahashi Kazuhisa
  • Journal Title: Experimental Lung Research Volume: 44 Issue: 7 Pages: 332-343
  • DOI: 10.1080/01902148.2018.1522558
  • Peer Reviewed
• [Journal Article] Characterization of tenascin-C as a novel biomarker for asthma: utility of tenascin-C in combination with periostin or immunoglobulin E (2018)
  • Author(s): Yasuda Mina、Harada Norihiro、Harada Sonoko、Ishimori Ayako、Katsura Yoko、Itoigawa Yukinari、Matsuno Kei、Makino Fumihiko、Ito Jun、Ono Junya、Tobino Kazunori、Akiba Hisaya、Atsuta Ryo、Izuhara Kenji、Takahashi Kazuhisa
  • Journal Title: Allergy, Asthma & Clinical Immunology Volume: 14 Issue: 1 Pages: 72-72
  • DOI: 10.1186/s13223-018-0300-7
  • Peer Reviewed / Open Access
• [Journal Article] Difference between two exhaled nitric oxide analyzers, NIOX VERO? electrochemical hand-held analyzer and NOA280i? chemiluminescence stationary analyzer (2018)
  • Author(s): Tanabe Yuki、Harada Norihiro、Ito Jun、Matsuno Kei、Takeshige Tomohito、Harada Sonoko、Takemasa Mirano、Kotajima Masaki、Ishimori Ayako、Katsura Yoko、Makino Fumihiko、Atsuta Ryo、Takahashi Kazuhisa
  • Journal Title: Journal of Asthma Volume: 56 Issue: 2 Pages: 167-172
  • DOI: 10.1080/02770903.2018.1439953
  • Peer Reviewed
• [Journal Article] Dasatinib Suppresses TGFβ-Mediated Epithelial?Mesenchymal Transition in Alveolar Epithelial Cells and Inhibits Pulmonary Fibrosis (2018)
  • Author(s): Kanemaru Ryota、Takahashi Fumiyuki、Kato Motoyasu、Mitsuishi Yoichiro、Tajima Ken、Ihara Hiroaki、Hidayat Moulid、Wirawan Aditya、Koinuma Yoshika、Hayakawa Daisuke、Yagishita Shigehiro、Ko Ryo、Sato Tadashi、Harada Norihiro、Kodama Yuzo、Nurwidya Fariz、Sasaki Shinichi、Niwa Shin-ichiro、Takahashi Kazuhisa
  • Journal Title: Lung Volume: 196 Issue: 5 Pages: 531-541
  • DOI: 10.1007/s00408-018-0134-6
  • Peer Reviewed
• [Journal Article] Anti-TIM-3 Treatment Exacerbates Pulmonary Inflammation and Fibrosis in Mice. (2017)
  • Author(s): Isshiki T, Akiba H, Nakayama M, Harada N, Okumura K, Homma S, Miyake S.
  • Journal Title: J Immunol Volume: 199 Issue: 11 Pages: 3733-3737
  • DOI: 10.4049/jimmunol.1700059
  • Peer Reviewed / Open Access
• [Journal Article] Pulmonary Intravascular Large B-cell Lymphoma (IVLBCL) Disguised as an Asthma Exacerbation in a Patient with Asthma (2017)
  • Author(s): Takeshige T, Harada N, Sekimoto Y, Kanemaru R, Tsutsumi T, Matsuno K, Shiota S, Masuda A, Gotoh A, Asahina M, Uekusa T, Takahashi K.
  • Journal Title: Internal Medicine Volume: 56 Issue: 14 Pages: 1885-1891
  • DOI: 10.2169/internalmedicine.56.7613
  • NAID: 130005773843
  • ISSN: 0918-2918, 1349-7235
  • Peer Reviewed / Open Access
• [Journal Article] Circulating activated innate lymphoid cells and mucosal-associated invariant T cells are associated with airflow limitation in patients with asthma (2017)
  • Author(s): Ishimori A, Harada N, Chiba A, Harada S, Matsuno K, Makino F, Ito J, Ohta S, Ono Junya, Atsuta R, Izuhara K, Takahashi K, Miyake S
  • Journal Title: Allergology International Volume: 66 Issue: 2 Pages: 302-309
  • DOI: 10.1016/j.alit.2016.07.005
  • NAID: 130005628231
  • ISSN: 1323-8930, 1440-1592
  • Peer Reviewed / Open Access
• [Journal Article] Leukotriene B4 receptor type 2 protects against pneumolysin-dependent acute lung injury (2016)
  • Author(s): Shigematsu, M., Koga, T., Ishimori, A., Saeki, K., Ishii, Y., Taketomi, Y., Ohba, M., Jo-Watanabe, A., Okuno, T., Harada, N., Harayama, T., Shindou, H., Li, J. D., Murakami, M., Hoka, S.,Yokomizo, T.
  • Journal Title: Sci Rep Volume: 6 Issue: 1 Pages: 34560-34560
  • DOI: 10.1038/srep34560
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Evaluation of switching low-dose inhaled corticosteroid to pranlukast for step-down therapy in well-controlled patients with mild persistent asthma. (2015)
  • Author(s): Harada, S., N. Harada, Y. Itoigawa, Y. Katsura, F. Kasuga, A. Ishimori, F. Makino, J. Ito, R. Atsuta, and K. Takahashi.
  • Journal Title: Journal of Asthma Volume: 53 Issue: 2 Pages: 207-212
  • DOI: 10.3109/02770903.2015.1087556
  • Peer Reviewed
• [Presentation] 気管支喘息と自然リンパ球 (2018)
  • Author(s): 原田紀宏
  • Organizer: 日本アレルギー学会第１回関東地方会
  • Invited
• [Presentation] Circulating levels of soluble TIM-4 in the patients with asthma (2018)
  • Author(s): Yuki Tanabe, Norihiro Harada, Sonoko Harada, Kei Matsuno, Tomohito Takeshige, Jun Ito, Sachiko Miyake, Kazuhisa Takahashi, Hisaya Akiba
  • Organizer: 第47回日本免疫学会学術集会
• [Presentation] Innate lymphoid cell subsets in peripheral blood of patients with asthma treated with mepolizumab (2018)
  • Author(s): Hitoshi Sasano, Norihiro Harada, Sonoko Harada Yuki Tanabe Yuuki Sandhu, Tomohito Takeshige, Kei Matsuno, Ayako Ishimori, Fumihiko Makino, Jun Ito, Asako Chiba, Sachiko Miyake, Kazuhisa Takahashi
  • Organizer: The 3rd International Conference on Innate Lymphoid Cells
  • Int'l Joint Research
• [Presentation] Chitin induced production of prostaglandine E2 in alveolar macrophages and bronchial epithelial cells (2018)
  • Author(s): Tomohito Takeshige, Norihiro Harada, Kei Matsuno, Ayako Ishimori, Yuki Tanabe, Hitoshi Sasano, Ai Nakamura, Sonoko Harada, Yoko Katsura, Fumihiko Makino, Jun Ito, Ryo Atsuta, Hisaya Akiba, Kazuhisa Takahashi
  • Organizer: The 23nd congress of the Asian Paciffic Society of Respirology
  • Int'l Joint Research
• [Presentation] 気管支喘息と自然リンパ球 (2018)
  • Author(s): 原田紀宏
  • Organizer: XXIV World Congress of Asthma
  • Invited
• [Presentation] Chitin Induced Production of Prostaglandin E2 in Alveolar Macrophages and Bronchial Epithelial Cells (2018)
  • Author(s): Tomohito Takeshige, Norihiro Harada, Kei Matsuno, Ayako Ishimori, Yuki Tanabe, Hitoshi Sasano, Sonoko Harada, Yoko Katsura, Fumihiko Makino, Jun Ito, Ryo Atsuta, Hisaya Akiba, Kazuhisa Takahashi
  • Organizer: XXIV World Congress of Asthma
  • Int'l Joint Research
• [Presentation] ヒト気道上皮細胞におけるキチンによるPGE2産生誘導 (2018)
  • Author(s): 竹重智仁，原田紀宏，石森絢子，松野圭，原田園子，三道ユウキ，上田翔子，安部寿美子，中村愛，笹野仁史，田辺悠記，桂蓉子，牧野文彦，伊藤潤，秋葉久弥，熱田了，高橋和久
  • Organizer: 第67回日本アレルギー学会学術大会
• [Presentation] 気管支喘息のバイオマーカーとしての血清テネイシンC値の可能性 (2018)
  • Author(s): 浅地美奈，原田紀宏，原田園子，石森絢子，桂蓉子，糸魚川幸成，松野圭，牧野文彦，伊藤潤，小野純也，飛野和則，秋葉久弥，熱田了，出原賢治，高橋和久
  • Organizer: 第67回日本アレルギー学会学術大会
• [Presentation] メポリズマブ投与6か月における重症喘息に対する効果 (2018)
  • Author(s): 笹野仁史，原田紀宏，田辺悠記，松野圭，石森絢子，原田園子，安部寿美子，上田翔子，三道ユウキ，中村愛，竹重智仁，桂蓉子，伊藤潤，熱田了，高橋和久
  • Organizer: 第67回日本アレルギー学会学術大会
• [Presentation] 大根の辛み成分のアレルギーと診断した一例 (2018)
  • Author(s): 安部寿美子，伊藤潤，桂蓉子，原田園子，上田翔子，三道ユウキ，中村愛，田辺悠記，笹野仁史，竹重智仁，松野圭，石森絢子，原田紀宏，熱田了，高橋和久
  • Organizer: 第67回日本アレルギー学会学術大会
• [Presentation] 気道上皮細胞におけるTWEAKのTSLP産生誘導について (2018)
  • Author(s): 松野圭，原田紀宏，石森絢子，原田園子，三道ユウキ，上田翔子，安部寿美子，中村愛，笹野仁史，田辺悠記，竹重智仁，桂蓉子，糸魚川幸成，牧野文彦，伊藤潤，熱田了，高橋和久
  • Organizer: 第67回日本アレルギー学会学術大会
• [Presentation] Chitin induced production of prostaglandin E2 in alveolar macrophages and bronchial epithelial cells (2018)
  • Author(s): Tomohito Takeshige, Norihiro Harada, Kei Matsuno, Ayako Ishimori, Yuki Tanabe, Hitoshi Sasano, Ai Nakamura, Sonoko Harada, Yoko Katsura, Fumihiko Makino, Jun Ito, Ryo Atsuta, Hisaya Akiba, Kazuhisa Takahashi
  • Organizer: American Thoracic Society International Conference 2018
  • Int'l Joint Research
• [Presentation] 重症喘息に対するメポリズマブの効果 (2018)
  • Author(s): 田辺悠記，原田紀宏，松野圭，石森絢子，原田園子，上田翔子，三道ユウキ，笹野仁史，中村愛，竹重智仁，桂蓉子，伊藤潤，熱田了，高橋和久
  • Organizer: 第58回日本呼吸器学会学術講演会
• [Presentation] 抗IL-5抗体治療が著効し，治療中止後の経過を追っている好酸球性細気管支炎の一例 (2018)
  • Author(s): 上田翔子，伊藤潤，原口瑞樹，石森絢子，原田園子，山道ユウキ，笹野仁史，田辺悠記，竹重智仁，松野圭，牧野文彦，長島修，原田紀宏，熱田了，高橋和久
  • Organizer: 第58回日本呼吸器学会学術講演会
• [Presentation] Chitin induced airway inflammation and production of prostaglandin E2 (2018)
  • Author(s): Tomohito Takeshige, Norihiro Harada1, Kei Matsuno, Ayako Ishimori, Yuki Tanabe, Hitoshi Sasano, Ai Nakamura, Sonoko Harada, Yoko Katsura, Fumihiko Makino, Jun Ito, Ryo Atsuta, Hisaya Akiba, Kazuhisa Takahashi
  • Organizer: 第58回日本呼吸器学会学術講演会
• [Presentation] Circulating levels of tenascin-C as type 2 biomarkers in the patients with asthma (2018)
  • Author(s): Mina Asaji, Norihiro Harada, Sonoko Harada, Ayako Ishimori, Yoko Katsura, Yukinari Itoigawa, Kei Matsuno, Fumihiko Makino, Jun Ito, Junya Ono, Kazunori Tobino, Hisaya Akiba, Ryo Atsuta, Kenji Izuhara, and Kazuhisa Takahashi
  • Organizer: 第58回日本呼吸器学会学術講演会
• [Presentation] TWEAK induced TSLP expression in human bronchial epithelial cells (2018)
  • Author(s): Kei Matsuno, Norihiro Harada, Tomohito Takeshige, Sonoko Harada, Ayako Ishimori, Yuki Tanabe, Hitoshi Sasano, Ai Nakamura, Yoko Katsura, Fumihiko Makino, Jun Ito, Ryo Atsuta, Kazuhisa Takahashi
  • Organizer: 第58回日本呼吸器学会学術講演会
• [Presentation] 携帯電話アプリ「ぜんそくログ」による喘息実態調査 (2018)
  • Author(s): 原田紀宏，伊藤潤，原田園子，三道ユウキ，上田翔子，浅地美奈，中村愛，笹野仁史，田辺悠記，竹重智仁，松野圭，石森絢子，牧野文彦，熱田了，堀賢，高橋和久
  • Organizer: 第58回日本呼吸器学会学術講演会
• [Presentation] 当院におけるNintedanibの使用経験 (2018)
  • Author(s): 中村貴裕，加藤元康，河野加奈，山田朋子，井原宏彰，金丸良太，佐藤 匡，原田紀宏，十合晋作，長岡鉄太郎，高橋史行，瀬山邦明，高橋和久
  • Organizer: 第58回日本呼吸器学会学術講演会
• [Presentation] TWEAK enhances epithelial mesenchymal transition and chemokine production in human bronchial epithelial cells (2017)
  • Author(s): Kei Matsuno, Norihiro Harada, Itoigawa Yukinari, Tomohito Takeshige, Sonoko Harada, Ayako Ishimori, Yuki Tanabe, Yoko Katsura, Fumihiko Makino, Jun Ito, Ryo Atsuta, Hisaya Akiba, Kazuhisa Takahashi
  • Organizer: 第46回日本免疫学会学術集会
• [Presentation] TIM-3 regulates pulmonary fibrosis through apoptotic cell clearance (2017)
  • Author(s): ISSHIKI Takuma, Hisaya Akiba, Nakayama Masafumi, Norihiro Harada, Ko Okumira, Sachiko Miyake
  • Organizer: 第46回日本免疫学会学術集会
• [Presentation] TWEAK and TGF-β induced chemokine production in human bronchial epithelial cells during epithelial mesenchymal transition (2017)
  • Author(s): Kei Matsuno, Norihiro Harada, Tomohito Takeshige, Sonoko Harada, Ayako Ishimori, Yuki Tanabe, Hitoshi Sasano, Ai Nakamura, Yoko Katsura, Fumihiko Makino, Jun Ito, Ryo Atsuta, Hisaya Akiba, Kazuhisa Takahashi
  • Organizer: The 22nd congress of the Asian Paciffic Society of Respirology
  • Int'l Joint Research
• [Presentation] The effect of mepolizumab treatment in patients with severe asthma (2017)
  • Author(s): Yuuki Sandhu, Norihiro Harada, Kei Matsuno, Sonoko Harada, Hitoshi Sasano, Yuki Tanabe, Ai Nakamura, Tomohito Takeshige, Ayako Ishimori, Yoko Katsura, Fumihiko Makino, Jun Ito, Ryo Atsuta, Hisaya Akiba, Kazuhisa Takahashi
  • Organizer: The 22nd congress of the Asian Paciffic Society of Respirology
  • Int'l Joint Research
• [Presentation] Serum tenascin-C levels in patients with asthma (2017)
  • Author(s): Norihiro Harada, Mina Asaji, Sonoko Harada, Ayako Ishimori, Yoko Katsura, Yukinari Itoigawa, Kei Matsuno, Fumihiko Makino, Jun Ito, Junya Ono, Kazunori Tobino, Hisaya Akiba, Ryo Atsuta, Kenji Izuhara, Kazuhisa Takahashi
  • Organizer: The 22nd congress of the Asian Paciffic Society of Respirology
  • Int'l Joint Research
• [Presentation] Chitin induced airway inflammation and production of prostaglandin E2 (2017)
  • Author(s): Tomohito Takeshige, Norihiro Harada, Kei Matsuno, Ayako Ishimori, Yuki Tanabe, Hitoshi Sasano, Ai Nakamura, Sonoko Harada, Yoko Katsura, Fumihiko Makino, Jun Ito, Ryo Atsuta, Hisaya Akiba, Kazuhisa Takahashi
  • Organizer: The 22nd congress of the Asian Paciffic Society of Respirology
  • Int'l Joint Research
• [Presentation] 上皮間葉転換が誘導された気道上皮細胞におけるケモカイン産生 (2017)
  • Author(s): 松野圭，原田紀宏，石森絢子，竹重智仁，桂蓉子，三道ユウキ，中村愛，笹野仁史，田辺悠記，牧野文彦，伊藤潤，熱田了，秋葉久弥，高橋和久
  • Organizer: 第66回日本アレルギー学会学術大会
• [Presentation] 気管支鏡検査にて好酸球性細気管支炎と診断した一例 (2017)
  • Author(s): 原口瑞樹，渡邊純子，伊藤潤，原田紀宏，高橋和久
  • Organizer: 第66回日本アレルギー学会学術大会
• [Presentation] 好酸球性多発血管炎性肉芽腫症のバイオマーカーとしてのペリオスチン (2017)
  • Author(s): 伊藤潤，谷口正実，福富友馬，渡井健太郎，林浩昭，三井千尋，関谷潔史，粒来崇博，小野純也，原田紀宏，熱田了，出原賢治，高橋和久
  • Organizer: 第66回日本アレルギー学会学術大会
• [Presentation] 携帯電話のアプリを用いた気管支喘息実態調査の試み (2017)
  • Author(s): 原田紀宏，伊藤潤，石森絢子，桂蓉子，原田園子，浅地美奈，中村愛，笹野仁史，田辺悠記，竹重智仁，松野圭，牧野文彦，熱田了，堀賢，高橋和久
  • Organizer: 第66回日本アレルギー学会学術大会
• [Presentation] 気管支喘息に対するメポリズマブの臨床効果の検討 (2017)
  • Author(s): 笹野仁史，原田紀宏，松野圭，石森絢子，原田園子，三道ユウキ，田辺悠記，中村愛，竹重智仁，桂蓉子，伊藤潤，熱田了，高橋和久
  • Organizer: 第66回日本アレルギー学会学術大会
• [Presentation] ASK-20を用いた気管支喘息患者におけるアドヒアランスの検討 (2017)
  • Author(s): 竹重智仁，原田紀宏，桂蓉子，石森絢子，松野圭，三道ユウキ，中村愛，笹野仁史，田辺悠記，原田園子，伊藤潤，熱田了，高橋和久
  • Organizer: 第66回日本アレルギー学会学術大会
• [Presentation] 呼気一酸化窒素濃度(FeNO)の測定機種差(NOA280iとNIOXvero)の比較検討 (2017)
  • Author(s): 田辺悠記，伊藤潤，原田紀宏，武政未来乃，仲條麻美，古田島正樹，笹野仁史，中村愛，三道ユウキ，竹重智仁，松野圭，石森絢子，熱田了，高橋和久
  • Organizer: 第66回日本アレルギー学会学術大会
• [Presentation] The differences of values between NOA208i and NIOXvero as a measurement of fractional exhaled nitric oxide (2017)
  • Author(s): Yuki Tanabe, Jun Ito, Hitoshi Sasano, Ai Nakamura, Yuki Sandou, Tomohito Takeshige, Kei Matsuno, Yoko Katsura, Ayako Ishimori, Fumihiko Makino, Ryo Atsuta, Norihiro Harada, Kazuhisa Takahashi
  • Organizer: American Thoracic Society International Conference 2017
  • Int'l Joint Research
• [Presentation] 気管支喘息症例における末梢血自然リンパ球 (2017)
  • Author(s): 石森絢子，原田紀宏，原田園子，松野圭，浅地美奈，牧野文彦，伊藤潤，熱田了，千葉麻子，出原賢治，三宅幸子，高橋和久
  • Organizer: 第57回日本呼吸器学会学術講演会
• [Presentation] COPD患者および健常成人由来のエクソソームは異なる働きをする (2017)
  • Author(s): 牧野文彦，Hesham Basma，Xiangde Liu，原田紀宏，高橋和久，Stephen I. Rennard
  • Organizer: 第57回日本呼吸器学会学術講演会
• [Presentation] TWEAK and TGF-β induced chemokine production in human bronchial epithelial cells during EMT (2017)
  • Author(s): Kei Matsuno, Norihiro Harada, Ayako Ishimori, Tomohito Takeshige, Yuki Tanabe, Hitoshi Sasano, Ai Nakamura, Yoko Katsura, Fumihiko Makino, Jun Ito, Ryo Atsuta, Kazuhisa Takahashi
  • Organizer: 第57回日本呼吸器学会学術講演会
• [Presentation] 呼気一酸化窒素濃度の機種差検討。NOA208i， NIOXveroの比較 (2017)
  • Author(s): 田辺悠記，伊藤潤，原田紀宏，笹野仁史，中村愛，三道ユウキ，竹重智仁，松野圭，石森絢子，熱田了，高橋和久
  • Organizer: 第57回日本呼吸器学会学術講演会
• [Presentation] ASK-20を用いた気管支喘息患者におけるアドヒアランスの検討 (2017)
  • Author(s): 竹重智仁，原田紀宏，桂蓉子，石森絢子，松野圭，中村愛，田辺悠記，笹野仁史，牧野文彦，伊藤潤，熱田了，高橋和久
  • Organizer: 第57回日本呼吸器学会学術講演会
• [Presentation] TIM-3 regulates pulmonary fibrosis through apoptotic cell clearance. (2016)
  • Author(s): Isshiki Takuma, Hisaya Akiba, Nakayama Masafumi, Norihiro Harada, Ko Okumira, Sachiko Miyake
  • Organizer: 日本免疫学会総会
  • Place of Presentation: 沖縄コンベンションセンター
  • Year and Date: 2016-12-05
• [Presentation] Circulating innate lymphoid cells in patients with asthma (2016)
  • Author(s): 石森絢子，原田紀宏，原田園子，松野圭，浅地美奈，三道ユウキ，中村愛，笹野仁史，田辺悠記，竹重智仁，桂蓉子，糸魚川幸成，牧野文彦，伊藤潤，梶山雄一郎，長島修，熱田了，千葉麻子，出原賢治，三宅幸子，高橋和久
  • Organizer: 国際喘息学会日本・北アジア部会
  • Place of Presentation: 福岡国際会議場
  • Year and Date: 2016-09-17
  • Int'l Joint Research
• [Presentation] キチン誘導性気道炎症モデルマウスにおけるPGE2産生 (2016)
  • Author(s): 石森絢子，原田紀宏，原田園子，松野圭，中村愛，笹野仁史，田辺悠記，竹重智仁，桂蓉子，糸魚川幸成，牧野文彦，伊藤潤，熱田了，高橋和久
  • Organizer: 日本アレルギー学会学術大会
  • Place of Presentation: 東京国際フォーラム
  • Year and Date: 2016-06-17
• [Presentation] TWEAK とTGF-βによる気道上皮細胞の上皮間葉転換 (2016)
  • Author(s): 糸魚川幸成，原田紀宏，石森絢子，原田園子，松野圭，竹重智仁，田辺悠記，笹野仁史，桂蓉子，牧野文彦，伊藤潤，長島修，熱田了，高橋和久
  • Organizer: 日本アレルギー学会学術大会
  • Place of Presentation: 東京国際フォーラム
  • Year and Date: 2016-06-17
• [Presentation] 気道上皮細胞におけるTWEAKによるケモカイン産生誘導 (2016)
  • Author(s): 竹重智仁，原田紀宏，松野圭，石森絢子，原田園子，三道ユウキ，中村愛，笹野仁史，田辺悠記，桂蓉子，糸魚川幸成，牧野文彦，伊藤潤，梶山雄一郎，熱田了，高橋和久
  • Organizer: 日本アレルギー学会学術大会
  • Place of Presentation: 東京国際フォーラム
  • Year and Date: 2016-06-17
• [Presentation] 気管支喘息症例の末梢血中自然リンパ球 (2016)
  • Author(s): 原田紀宏，石森絢子，原田園子，松野圭，中村愛，笹野仁史，田辺悠記，竹重智仁，桂蓉子，糸魚川幸成，牧野文彦，伊藤潤，熱田了，千葉麻子，出原賢治，三宅幸子，高橋和久
  • Organizer: 日本アレルギー学会学術大会
  • Place of Presentation: 東京国際フォーラム
  • Year and Date: 2016-06-17
• [Presentation] 気管支喘息症例の末梢血中MAIT細胞 (2016)
  • Author(s): 石森絢子，原田紀宏，原田園子，松野圭，中村愛，笹野仁史，田辺悠記，竹重智仁，桂蓉子，糸魚川幸成，牧野文彦，伊藤潤，熱田了，千葉麻子，出原賢治，三宅幸子，高橋和久
  • Organizer: 日本アレルギー学会学術大会
  • Place of Presentation: 東京国際フォーラム
  • Year and Date: 2016-06-17
• [Presentation] 気管支喘息症例における血清テネイシンC値 (2016)
  • Author(s): 浅地美奈，原田紀宏，原田園子，石森絢子，松野圭，中村愛，笹野仁史，田辺悠記，竹重智仁，桂蓉子，糸魚川幸成，牧野文彦，伊藤潤，飛野和則，熱田了，出原賢治，高橋和久
  • Organizer: 日本アレルギー学会学術大会
  • Place of Presentation: 東京国際フォーラム
  • Year and Date: 2016-06-17
• [Presentation] 喘息患者における長時間作用型抗コリン薬の長期臨床効果 (2016)
  • Author(s): 伊藤潤，原田紀宏，牧野文彦，桂蓉子，石森絢子，糸魚川幸成，春日文子，松野圭，梶山雄一郎，長島修，熱田了，谷口正実，高橋和久
  • Organizer: 日本アレルギー学会学術大会
  • Place of Presentation: 東京国際フォーラム
  • Year and Date: 2016-06-17
• [Presentation] TWEAK induced chemokine, MCP-1, RANTES and IL-8 production in human bronchial epithelial cells (2016)
  • Author(s): K. Matsuno, N. Harada, A. Ishimori, S. Harada, T. Takeshige, J. Ito, R. Atsuta, K. Takahashi.
  • Organizer: American Thoracic Society International Conference 2016
  • Place of Presentation: San Francisco
  • Year and Date: 2016-05-13
  • Int'l Joint Research
• [Presentation] 気管支喘息症例における末梢血中自然リンパ球MAIT細胞の解析 (2016)
  • Author(s): 石森絢子，原田紀宏，原田園子，松野圭，竹重智仁，中村愛，牧野文彦，伊藤潤，熱田了，千葉麻子，出原賢治，三宅幸子，高橋和久
  • Organizer: 日本呼吸器学会学術講演会
  • Place of Presentation: 国立京都国際会館
  • Year and Date: 2016-04-08
• [Presentation] 気管支喘息症例における血清テネイシンC値 (2016)
  • Author(s): 浅地美奈，原田紀宏，原田園子，石森絢子，松野圭，田辺悠記，笹野仁史，桂蓉子，牧野文彦，伊藤潤，飛野和則，熱田了，出原賢治，高橋和久
  • Organizer: 日本呼吸器学会学術講演会
  • Place of Presentation: 国立京都国際会館
  • Year and Date: 2016-04-08
• [Presentation] 気道上皮細胞におけるTGF-βが誘導するEMTとTWEAKの関連 (2016)
  • Author(s): 糸魚川幸成，原田紀宏，石森絢子，原田園子，桂蓉子，松野圭，竹重智仁，田辺悠記，笹野仁史，牧野文彦，伊藤潤，長島修，熱田了，高橋和久
  • Organizer: 日本呼吸器学会学術講演会
  • Place of Presentation: 国立京都国際会館
  • Year and Date: 2016-04-08
• [Presentation] TWEAK Induced Chemokine, MCP-1, RANTES and IL-8 Production by Human Bronchial Epithelial Cells (2016)
  • Author(s): 松野圭，原田紀宏，石森絢子，原田園子，竹重智仁，田辺悠記，笹野仁史，桂蓉子，糸魚川幸成，牧野文彦，伊藤潤，長島修，熱田了，高橋和久
  • Organizer: 日本呼吸器学会学術講演会
  • Place of Presentation: 国立京都国際会館
  • Year and Date: 2016-04-08
• [Presentation] 喘息外来患者におけるチオトロピウムの長期的な臨床効果 (2016)
  • Author(s): 伊藤潤，原田紀宏，牧野文彦，桂蓉子，石森絢子，糸魚川幸成，春日文子，松野圭，梶山雄一郎，長島修，熱田了，高橋和久
  • Organizer: 日本呼吸器学会学術講演会
  • Place of Presentation: 国立京都国際会館
  • Year and Date: 2016-04-08