Renal injury progression after acute kidney injury

• Project/Area Number: 16K09603
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Kidney internal medicine
• Research Institution: The University of Tokyo
• Principal Investigator: Doi Kent 東京大学, 医学部附属病院, 講師 (80505892)
• Research Collaborator: Matsuura Ryo ; Yamashita Tetsushi
• Project Period (FY): 2016-04-01 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2018: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 急性腎障害 / 慢性腎臓病 / 心腎連関症候群

Outline of Final Research Achievements

This study is aimed to replicate chronic kidney disease (CKD) progression after acute kidney injury (AKI) by using animal models. Combination of Transverse Aortic Constriction (TAC) heart failure model and renal ischemia reperfusion injury model enabled to mimic human cardiorenal syndrome, which is frequently observed in the clinical settings. Evaluating long-term renal fibrotic change after renal ischemia reperfusion injury in heart failure mice suggested the protective role of sympathetic nerve activation against renal injury.

Academic Significance and Societal Importance of the Research Achievements

急性期病態の強い予後規定因子である急性腎障害は、長期的な予後としての慢性腎臓病の発症および進展にも大きく関与していることがヒトにおける多数の疫学的検討から明らかとされている。一方、その病態機序については不明な点が多く、本研究で明らかとされたメカニズムに対する介入が慢性腎臓病進展を抑止しうる可能性がある。

Research Products

• [Presentation] Animal models for progression from acute to chronic kidney injury in mice (2016)
  • Author(s): Kengo Mayumi, Mizuki Yamano, Tetsushi Yamashita, Yoshifumi Hamasaki, Eisei Noiri, Masaomi Nangaku, Kent Doi
  • Organizer: American Society of Nephrology
  • Place of Presentation: Chicago, USA
  • Year and Date: 2016-11-18
  • Int'l Joint Research