Role of renal protein O-GlcNAcylation
| Project/Area Number |
16K09612
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
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| Research Institution | Shiga University of Medical Science |
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Principal Investigator |
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| Research Collaborator |
Kume Shinji
Ono Shinya
Sugahara Sho
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 糖尿病性腎症 / 絶食 / 栄養 / 脂質代謝異常 / 糖鎖修飾 / エネルギー代謝 / 腎臓 / 生理学 / 解糖系 / 医学 / 生物学 / 腎臓病 |
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| Outline of Final Research Achievements |
O-linked β-N-acetylglucosamine modification (O-GlcNAcylation) is a post-translational modification of intracellular proteins, serving as a nutrient sensor. Growing evidence has demonstrated its physiological and pathological importance in various mammalian tissues. This study examined the physiological role of O-GlcNAcylation in function and development in podocyte and proximal tubular cells.
We have first confirmed that O-GlcNAcylation is necessary for maturation of podocyte foot processes, particularly after birth. In addition, we have found that protein O-GlcNAcylation is essential for renal lipolysis during prolonged fasting and offers PTECs significant protection against lipotoxicity in diabetes.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究は糖尿病性腎症に対する新規治療標的の開発を細胞内O-GlcNAc修飾に着目し行うものである。これまで明らかとされてこなかった腎臓におけるO-GlcNAc修飾の生理的役割の解明、更には、腎症進展機構との関連性が示された。本成果は新規腎症治療標的の開発につながるのみならず、腎臓におけるO-GlcNAc修飾に関する網羅的な知見は今後の腎臓領域の研究の発展にも寄与することが期待される。
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Report
(4 results)
Research Products
(10 results)
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[Journal Article] Protein O-GlcNAcylation Is Essential for the Maintenance of Renal Energy Homeostasis and Function via Lipolysis during Fasting and Diabetes2019
Author(s)
Sugahara S, Kume S, Chin-Kanasaki M, Tomita I, Yasuda-Yamahara M, Yamahara K, Takeda N, Osawa N, Yanagita M, Araki SI, Maegawa H.
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Journal Title
Journal of the American Society of Nephrology
Volume: In press
Issue: 6
Pages: 962-978
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] O-linked β-N-acetylglucosamine modification of proteins is essential for foot process maturation and survival in podocytes.2017
Author(s)
Ono S, Kume S, Yasuda-Yamahara M, Yamahara K, Takeda N, Chin-Kanasaki M, Araki H, Sekine O, Yokoi H, Mukoyama M, Uzu T, Araki SI, Maegawa H.
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Journal Title
Nephrol Dial Transplant.
Volume: 未定
Issue: 9
Pages: 000-000
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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