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Development of innovative peritoneal dialysis system employing molecular hydrogen

Research Project

Project/Area Number 16K09622
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Kidney internal medicine
Research InstitutionSt. Luke's International University (2017-2019)
Tohoku University (2016)

Principal Investigator

NAKAYAMA Masaaki  聖路加国際大学, 聖路加国際病院, 部長 (60217940)

Co-Investigator(Kenkyū-buntansha) 寺脇 博之  福島県立医科大学, 医学部, 准教授 (20277057)
渡邉 公雄  福島県立医科大学, 医学部, 助教 (20595607)
林 義満  福島県立医科大学, 医学部, 講師 (70381382)
朱 万君  福島県立医科大学, 医学部, 博士研究員 (10607774)
Project Period (FY) 2016-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2016: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords腹膜透析 / 酸化ストレス / 分子状水素 / 水素ガス / 水素 / 透析液生体適合性 / 腹膜中皮細胞 / a腹膜透析 / 腹膜透析液 / 生体適合性 / 中皮細胞
Outline of Final Research Achievements

Peritoneal damage is the Achilles of peritoneal dialysis (PD) therapy. Oxidative stress is involved with the pathological mechanism.The present study aims to clinical apply dihydrogen molecule (H2) in order to suppress peritoneal damage by PD therapy. In rats with kidney failure, the PD solution with 400ppb H2 could suppress peritoneal damage. In clinical study, single use of PD solution with H2 presented the increased level of reduced albumin ratio in the effuent, indicating the ameliorating effect of H2 containing PD solution for oxidative stress. Based on these results, we developed a special system to deliver H2 containing PD solution at home, which is to use for the preliminary clinical trial in the next step.

Academic Significance and Societal Importance of the Research Achievements

腹膜透析(PD)は末期腎不全患者の在宅治療として家庭・社会復帰に大きく貢献している。しかしながら、治療期間の延長に伴う腹膜障害は本治療法の最大の課題であり、PD中止の主要な原因となっている。これを抑制することができれば、長期にわたる安定したPD治療を提供することができる。本研究はこの課題解決のために、分子状水素(H2)に注目し、その臨床応用の可能性を探った。知見からは臨床的な有用性が期待されたことから、臨床試験を可能とするためのH2含有透析液作成装置を開発した。今後、これを用いて、短期中期的な臨床試験を実施し、腹膜障害抑制の可能性を探る予定である。

Report

(5 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (43 results)

All 2020 2019 2018 2017 2016

All Journal Article (33 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 33 results,  Open Access: 10 results,  Acknowledgement Compliant: 1 results) Presentation (8 results) (of which Int'l Joint Research: 4 results,  Invited: 5 results) Book (2 results)

  • [Journal Article] Serial measurement of electrolyte and citrate concentrations in blood-primed continuous hemodialysis circuits during closed-circuit dialysis.2020

    • Author(s)
      Saito D, Fujimaru T, Inoue Y, Hirayama T, Ezaki I, Kin H, Shuo T, Nakayama M, Komatsu Y.
    • Journal Title

      Pediatr Nephrol.

      Volume: 15 Issue: 1 Pages: 127-133

    • DOI

      10.1007/s00467-019-04318-3

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association between serum ferritin levels and clinical outcomes in maintenance hemodialysis patients: a retrospective single-center cohort study.2019

    • Author(s)
      Raku Son, Takuya Fujimaru,Takeshi Kimura, Fumika Taki, Miyuki Futatsuyama, Masahiko Nagahama, Masaaki Nakayama, Yasuhiro Komatsu.
    • Journal Title

      Renal Replacement Therapy

      Volume: 5 Issue: 1 Pages: 17-17

    • DOI

      10.1186/s41100-019-0212-0

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Randomised clinical trial of ferric citrate hydrate on anaemia management in haemodialysis patients with hyperphosphataemia: ASTRIO study.2019

    • Author(s)
      Yokoyama K, Fukagawa M, Akiba T, Nakayama M, Ito K, Hanaki K, Wolf M, Hirakata H.
    • Journal Title

      Sci Rep.

      Volume: 9 Issue: 1 Pages: 8877-8877

    • DOI

      10.1038/s41598-019-45335-4

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Methylglyoxal as a prognostic factor in patients with chronic kidney disease.2019

    • Author(s)
      Tezuka Y, Nakaya I, Nakayama K, Nakayama M, Yahata M, Soma J.
    • Journal Title

      Nephrology (Carlton)

      Volume: 24 Issue: 9 Pages: 943-950

    • DOI

      10.1111/nep.13526

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Health economic evaluation of peritoneal dialysis based on cost-effectiveness in Japan: a preliminary study.2019

    • Author(s)
      Takura T, Hiramatsu M, Nakamoto H, Kuragano T, Minakuchi J, Ishida H, Nakayama M, Takahashi S, Kawanishi H.
    • Journal Title

      Clinicoecon Outcomes Res

      Volume: 25 Pages: 579-590

    • DOI

      10.2147/ceor.s212911

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 透析療法の問題点・注意点2019

    • Author(s)
      丸山之雄、中山昌明
    • Journal Title

      臨床透析

      Volume: 35 Pages: 13-17

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Q&A“水と腎臓”の質問にお答えします:水素水の効能にはどんなものがありますか?2019

    • Author(s)
      中山昌明
    • Journal Title

      腎臓

      Volume: 41 Pages: 35-37

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Suboptimal initiation predicts short‐term prognosis and vulnerability among very elderly patients who start haemodialysis2018

    • Author(s)
      Kanno Atsuhiro、Nakayama Masaaki、Sanada Satoru、Sato Mitsuhiro、Sato Toshinobu、Taguma Yoshio
    • Journal Title

      Nephrology

      Volume: 24(1) Issue: 1 Pages: 94-101

    • DOI

      10.1111/nep.13194

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Translational Research of Peritoneal Dialysis Solution with Dissolved Molecular Hydrogen2018

    • Author(s)
      Nakayama Masaaki、Watanabe Kimio、Hayashi Yoshimitsu、Terawaki Hiroyuki、Zhu Wan-Jun、Kabayama Shigeru、Ito Sadayoshi
    • Journal Title

      Contrib Nephrol

      Volume: 196 Pages: 162-170

    • DOI

      10.1159/000485717

    • ISBN
      9783318062977, 9783318062984
    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Decline in estimated glomerular filtration rate is associated with risk of end-stage renal disease in type 2 diabetes with macroalbuminuria: an observational study from JDNCS.2018

    • Author(s)
      Shimizu M, Furuichi K, Toyama T, Funamoto T, Kitajima S, Hara A, Ogawa D, Koya D, Ikeda K, Koshino Y, Kurokawa Y, Abe H, Mori K, Nakayama M, Konishi Y, Samejima K, Matsui M, Yamauchi H, Gohda T, Fukami K et al
    • Journal Title

      Clin Exp Nephrol

      Volume: 22 Issue: 2 Pages: 377-387

    • DOI

      10.1007/s10157-017-1467-9

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Diabetes mellitus as a cause or comorbidity of chronic kidney disease and its outcomes: the Gonryo study2018

    • Author(s)
      Iwai Toshiki、Miyazaki Mariko、Yamada Gen、Nakayama Masaaki、Yamamoto Tae、Satoh Michihiro、Sato Hiroshi、Ito Sadayoshi
    • Journal Title

      Clinical and Experimental Nephrology

      Volume: 22(2) Issue: 2 Pages: 328-336

    • DOI

      10.1007/s10157-017-1451-4

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 透析医療と合併症:キュア&ケアガイドブック2018

    • Author(s)
      宮内隆政、中山昌明
    • Journal Title

      臨床透析 6月増刊号

      Volume: 34(7) Pages: 27-30

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] アルカリイオン水、電解水素水の賢い摂り方2018

    • Author(s)
      樺山繁、中山昌明
    • Journal Title

      腎と透析

      Volume: 85(5) Pages: 698-702

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Oral Ferric Citrate Hydrate Associated With Less Oxidative Stress Than Intravenous Saccharated Ferric Oxide.2017

    • Author(s)
      Nakayama M, Tani Y, Zhu WJ, Watanabe K, Yokoyama K, Fukagawa M, Akiba T, Wolf M, Hirakata H.
    • Journal Title

      Kidney Int Rep

      Volume: 3 Issue: 2 Pages: 364-373

    • DOI

      10.1016/j.ekir.2017.10.016

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Dissolved molecular hydrogen (H2) in Peritoneal Dialysis (PD) solutions preserves mesothelial cells and peritoneal membrane integrity.2017

    • Author(s)
      Nakayama M, Zhu WJ, Watanabe K, Gibo A, Sherif AM, Kabayama S, Ito S.
    • Journal Title

      BMC Nephrol

      Volume: 18 Issue: 1 Pages: 327-327

    • DOI

      10.1186/s12882-017-0741-0

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Possible clinical effects of molecular hydrogen (H2) delivery during hemodialysis in chronic dialysis patients: Interim analysis in a 12 month observation.2017

    • Author(s)
      Nakayama M, Itami N, Suzuki H, Hamada H, Osaka N, Yamamoto R, Tsunoda K, Nakano H, Watanabe K, Zhu WJ, Maruyama Y, Terawaki H, Kabayama S, Nakazawa R, Miyazaki M, Ito S.
    • Journal Title

      PLoS One

      Volume: 12 Issue: 9 Pages: e0184535-e0184535

    • DOI

      10.1371/journal.pone.0184535

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 【CKD貧血ガイドライン-二度の改訂を巡って】 鉄投与経路 経口投与か、静注か2017

    • Author(s)
      渡邉 公雄, 中山 昌明
    • Journal Title

      臨床透析

      Volume: 33 Pages: 175-181

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] 【腹膜透析の疑問に答える】 【腹膜透析液のエビデンス】ナトリウム(Na)濃度2017

    • Author(s)
      中山 昌明, 朱 万君, 渡邉 公雄
    • Journal Title

      腎と透析

      Volume: 82 Pages: 75-79

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] 新しい腹膜透析液 重炭酸・乳酸混合中性透析液の臨床的意義2017

    • Author(s)
      中山 昌明
    • Journal Title

      臨床透析

      Volume: 33 Pages: 113-115

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Encapsulating Peritoneal Sclerosis2017

    • Author(s)
      Alston H, Fan S, Nakayama M
    • Journal Title

      Semin Nephrol

      Volume: 37 Issue: 1 Pages: 93-102

    • DOI

      10.1016/j.semnephrol.2016.10.010

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Overlap of Post-obstructive Diuresis and Unmasked Diabetes Insipidus in a Case of IgG4-related Retroperitoneal Fibrosis and Tuberoinfundibular Hypophysitis: A Case Report and Review of the Literature2017

    • Author(s)
      Sasaki Yatabe M, Watanabe K, Hayashi Y, Yatabe J, Morimoto S, Ichihara A,Nakayama M, Watanabe T
    • Journal Title

      Internal Medicine

      Volume: 56 Issue: 1 Pages: 47-53

    • DOI

      10.2169/internalmedicine.56.6648

    • NAID

      130005239493

    • ISSN
      0918-2918, 1349-7235
    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] A new peritoneal dialysis fluid for Japanese patients: a randomized non-inferiority clinical trial of safety and efficacy2016

    • Author(s)
      Nakayama M, Kawaguchi Y, Akiba T, Kim M, Naito H, Hara S, Maeba T, Yorioka N, Sloand JA, Marshall MR
    • Journal Title

      Clin Exp Nephrol

      Volume: 印刷中 Issue: 5 Pages: 895-907

    • DOI

      10.1007/s10157-016-1346-9

    • Related Report
      2017 Research-status Report 2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] 尿毒症物質による認知機能障害の病態解明に関する研究2016

    • Author(s)
      渡邉 公雄, 中山 昌明
    • Journal Title

      日本透析医会雑誌

      Volume: 31 Pages: 620-625

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] 腹膜透析カテーテル抜去に伴い生じた下腹壁動脈損傷に直視下止血術で対応した1例2016

    • Author(s)
      寺脇 博之, 福島 直太郎, 青柳 佳子, 渡邉 公雄, 中島 彩, 田中 健一, 林 義満, 旭 浩一, 中山 昌明
    • Journal Title

      日本透析医学会雑誌

      Volume: 49 Pages: 425-429

    • NAID

      130005160857

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] 【フリーラジカル-腎疾患との新たな関わり】 病態各論:疾病・腎代替療法とフリーラジカル 腹膜透析患者の酸化ストレス2016

    • Author(s)
      中山 昌明, 朱 万君, 渡邉 公雄
    • Journal Title

      腎と透析

      Volume: 81 Pages: 1018-1022

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] 【認知症と透析医療】 認知症患者に対する透析導入・非導入2016

    • Author(s)
      中山 昌明, 渡辺 秀平
    • Journal Title

      臨床透析

      Volume: 32 Pages: 1007-1013

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] 【腎と透析診療指針2016】 (第17章)腎代替療法(腎移植を除く) 腹膜透析導入基準2016

    • Author(s)
      渡邉 公雄, 中山 昌明
    • Journal Title

      腎と透析

      Volume: 80 Pages: 552-554

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] 透析患者に必要な外科的治療】 腹膜透析カテーテル挿入術2016

    • Author(s)
      福島 直太郎, 寺脇 博之, 中山 昌明
    • Journal Title

      腎臓内科・泌尿器科

      Volume: 3 Pages: 457-462

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] 【高齢腎不全患者のバスキュラーアクセスを科学する】 加齢による血管内皮機能障害と薬剤(障害薬、改善薬) スタチン、ACE-i、ARB、CCBなど2016

    • Author(s)
      田中 健一, 木村 浩, 中山 昌明
    • Journal Title

      臨床透析

      Volume: 32 Pages: 786-793

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] High-density Association Mapping and Interaction Analysis of PLA2R1 and HLA Regions with Idiopathic Membranous Nephropathy in Japanese.2016

    • Author(s)
      Thiri M, Honda K, Kashiwase K, Mabuchi A, Suzuki H, Watanabe K, Nakayama M, Watanabe T, Doi K, Tokunaga K, Noiri E.
    • Journal Title

      Sci Rep

      Volume: 6 Issue: 1 Pages: 38189-38189

    • DOI

      10.1038/srep38189

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Epidemiology and clinical significance of nephrosclerosis2016

    • Author(s)
      Nakayama M, Tanaka K, Asahi K
    • Journal Title

      Nihon Jinzo Gakkai Shi

      Volume: 58 Pages: 92-96

    • NAID

      40020813205

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Dialyzer-related Thrombocytopenia due to a Polysulfone Membrane2016

    • Author(s)
      Kobari E, Terawaki H, Takahashi Y, Kusano Y, Sakurai K, Matsunaga K, Fukushima N, Suzuki S, Tanaka K, Hayashi Y, Watanabe T, Nakayama M
    • Journal Title

      Internal Medicine

      Volume: 55 Issue: 8 Pages: 965-968

    • DOI

      10.2169/internalmedicine.55.5636

    • NAID

      130005145441

    • ISSN
      0918-2918, 1349-7235
    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Impact of hemoglobin levels on renal and non-renal clinical outcomes differs by chronic kidney disease stages: the Gonryo study.2016

    • Author(s)
      Yamamoto T, Miyazaki M, Nakayama M, Yamada G, Matsushima M, Sato M, Sato T, Taguma Y, Sato H, Ito S.
    • Journal Title

      Clin Exp Nephrol.

      Volume: 20 Issue: 4 Pages: 595-602

    • DOI

      10.1007/s10157-015-1190-3

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Presentation] New insights in encapsulating peritoneal sclerosis: It’s preventable.2019

    • Author(s)
      Masaaki Nakayama
    • Organizer
      The 39th Annual meeting of the Korean Society of Nephrology.
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Endoscopic approach in the peritoneal cavity. A novel ultrafine endoscope for noninvasive peritoneal examination in patients undergoing peritoneal dialysis.2019

    • Author(s)
      Masaaki Nakayama
    • Organizer
      The 9th Asia Pacific Chapter Meeting of International Society for Peritoneal Dialysis.
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Peritoneal membrane damage and prevention: Basic PD physiology and pathophysiology.2019

    • Author(s)
      Masaaki Nakayama
    • Organizer
      The 9th Asia Pacific Chapter Meeting of International Society for Peritoneal Dialysis.
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 腹膜透析の展開―基礎と臨床から2019

    • Author(s)
      中山昌明
    • Organizer
      第64回日本透析医学会学術集会・総会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Laparoscopic examination of the peritoneal cavity of peritoneal dialysis patients to identify the risk of encapsulating peritoneal sclerosis and development of a non-invasive, ultra-fine laparoscope for peritoneal dialysis.2019

    • Author(s)
      Masaaki Nakayama
    • Organizer
      第64回日本透析医学会学術集会・総会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 新しい透析液の開発:低ナトリウム(Na)透析液・水素(H2)腹膜透析液2018

    • Author(s)
      中山昌明
    • Organizer
      第63回日本透析医学会学術集会・総会
    • Related Report
      2018 Research-status Report
  • [Presentation] 血液透析による末梢白血球の酸化的障害~感染症と心血管病発症の危険因子~2018

    • Author(s)
      福士太郎、山本多恵、宮崎真理子、中山昌明
    • Organizer
      第63回日本透析医学会学術集会・総会
    • Related Report
      2018 Research-status Report
  • [Presentation] Molecular hydrogen (H2) ameliorate peritoneal mesothelium injury induced by commercial peritoneal dialysate(PDS) in CKD rat model2017

    • Author(s)
      Wan-Jun Zhu, Kimio Watanabe, Masaaki Nakayama
    • Organizer
      The 8th Asia Pacific Chapter Meeting of International Society for Peritoneal Dialysis
    • Place of Presentation
      China Guangzhou
    • Year and Date
      2017-03-22
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Book] 臓専門医のためのCKD診療Q&A2018

    • Author(s)
      孫 楽、 中山昌明
    • Total Pages
      232
    • Publisher
      東京医学社
    • Related Report
      2018 Research-status Report
  • [Book] CKD-MBD 3rd Edition2018

    • Author(s)
      種本史明、伊藤雄伍、中山昌明
    • Total Pages
      320
    • Publisher
      日本メディカルセンター
    • Related Report
      2018 Research-status Report

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Published: 2016-04-21   Modified: 2021-02-19  

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