The effect of clock gene DEC1 abnormalities in CKD
| Project/Area Number |
16K09624
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
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| Research Institution | Wakayama Medical University |
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Principal Investigator |
Sato Fuyuki 和歌山県立医科大学, 医学部, 講師 (60400131)
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| Co-Investigator(Kenkyū-buntansha) |
向阪 彰 和歌山県立医科大学, 医学部, 准教授 (00458051)
村垣 泰光 和歌山県立医科大学, 医学部, 教授 (40190904)
藤本 勝巳 広島大学, 医歯薬保健学研究科(歯), 助教 (40294566)
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 時計遺伝子 / DEC1 / CKD / 高リン / 日内リズム / 慢性腎不全 / 線維化 / 概日リズム / 腎臓 / 慢性腎臓病 / 内科 / 老化 |
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| Outline of Final Research Achievements |
We showed that DEC1 expression decreased in CKD mice kidneys compared to control mice. Also, the Per1 expression decreased in CKD mice kidneys. These results suggest that abnormalities of circadian rhythm depends on the disturbance of clock genes expression. In cell culture, DEC1 expression decreased in the high concentration phosphorus treatment. On the other hand, alphaSMA increased. We speculate that clock genes link to renal interstitial fibrosis, suggesting induce severe abnormalities of clock genes expression.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究内容は、現在論文作成中であり、完成次第、投稿する予定である。また関連する学会などで発表し、社会や国民に公表をする予定である。本研究は、慢性腎不全が時計遺伝子に影響を及ぼす現象やメカニズムを示した内容であり、将来的には時計遺伝子の発現異常を制御することで、慢性腎不全の進展抑制に繋げることを期待する。
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Report
(4 results)
Research Products
(21 results)
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[Journal Article] Impact of heart-specific disruption of the circadian clock on systemic glucose metabolism in mice2017
Author(s)
Nakao T, Kohsaka A, Otsuka T, Thein ZL, Le HT, Waki H, Gouraud SS, Ihara H, Nakanishi M, Sato F, Muragaki Y, Maeda M.
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Journal Title
Chronobiol Int
Volume: in press
Issue: 4
Pages: 499-510
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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