Estimation of total nephron number in Japanese subjects and the comparison with other races in relation to kidney and cardiovascular diseases
| Project/Area Number |
16K09631
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
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| Research Institution | Jikei University School of Medicine |
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Principal Investigator |
Tsuboi Nobuo 東京慈恵会医科大学, 医学部, 准教授 (40408422)
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| Project Period (FY) |
2016-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | ネフロン数 / CKD |
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| Outline of Final Research Achievements |
A total of 64 nephron kidneys were used to estimate the total number of nephrons. It was clarified that the total number of nephrons in the Japanese has a large individual difference even in the normal renal function, and is closely related to the function of the kidney. Furthermore, it was found that individuals with a history of hypertension had a lower number of nephrons than normotensive. It was revealed that the total number of nephrons in the Japanese population (600,000 / kidney) was lower as compared to the results of similar studies conducted in other races. This study was the first to be conducted for Asians, and its results were highly evaluated at domestic and overseas academic societies in the field of kidney disease and hypertension.
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| Academic Significance and Societal Importance of the Research Achievements |
総ネフロン数の差異は個人間の腎機能低下に対する感受性の違いのみならず、人種間でのCKDや末期腎不全の罹患率の違いにも影響することが予想される。既報の研究は、対象に多人種が混在しており、単一民族を対象とした検討は少ない。したがって、ほぼ単一民族とみなされる日本人を対象として総ネフロン数を計測する意義は大きい。
さらに、最近ではMRIを用いて腎の微細構造を解析し、総ネフロン数を非侵襲的に推定する試みもされている。このような新たな方法の確立においても、Stereologyを用いた総糸球体数の推算による検証は欠かせない。本研究結果はネフロン数研究における近未来的なアプローチを試みる上でも基礎となる。
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Report
(5 results)
Research Products
(24 results)
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[Journal Article] Estimation of nephron number in living humans by combining unenhanced computed tomography with biopsy-based stereology.2019
Author(s)
Sasaki T, Tsuboi N, Okabayashi Y, Haruhara K, Kanzaki G, Koike K, Kobayashi A, Yamamoto I, Takahashi S, Ninomiya T, Shimizu A, Rule AD, Bertram JF, Yokoo T.
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Journal Title
Sci Rep.
Volume: Oct 7;9(1)
Issue: 1
Pages: 14400-14400
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] New insights on glomerular hyperfiltration: a Japanese autopsy study2017
Author(s)
Kanzaki G, Puelles VG, Cullen-McEwen LA, Hoy WE, Okabayashi Y, Tsuboi N, Shimizu A, Denton KM, Hughson MD, Yokoo T, Bertram JF
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Journal Title
JCI Insight
Volume: 2(19)
Issue: 19
Pages: 94334-94334
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Presentation] Racial Differences in nephron number; Role of body size, kidney weight, and cortical volume in adult subjects among five populations2017
Author(s)
Go Kanzaki1, 5, Victor G. Puelles3, Luise A. Cullen-McEwen1, Wendy E. Hoy4, Yusuke Okabayashi5, Nobuo Tsuboi5, Akira Shimizu2, Takashi Yokoo5, John F. Bertram1
Organizer
ASN
Related Report
Int'l Joint Research
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[Presentation] Low nephron number in Japanese subjects without overt renal disease.2016
Author(s)
Kanzaki G, Puelles VG, Gullen-McEwen LA, Hughson MD, Hoy WE, Okabayashi Y, Tsuboi N, Shimizu A, Yokoo T, Bertram JF.
Organizer
the 2016 Asian pacific congress of nephrology
Place of Presentation
Perth, Australia
Year and Date
2016-09-18
Related Report
