| Project/Area Number |
16K09643
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Kidney internal medicine
|
|---|
| Research Institution | Ehime University |
|---|
Principal Investigator |
Takafumi Okura 愛媛大学, 医学系研究科, 寄附講座教授 (40260385)
|
|---|
| Research Collaborator |
Miyoshi Ken-ichi
Nagao Tomoaki
|
|---|
| Project Period (FY) |
2016-04-01 – 2019-03-31
|
| Project Status |
Completed (Fiscal Year 2018)
|
| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2018: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
|---|
| Keywords | 高血圧 / Interleukin-18 / NaCl-co-transporter / インターロイキン-18 / 血圧調節 / NaCl co-transporter / IL-18 / NaCl cotransport / インターロイキン18 |
|---|
| Outline of Final Research Achievements |
An increase in inflammatory cytokines is observed in hypertensive patients, which results in a further increase in blood pressure. We have reported that in Interleukin (IL)-18 deficient mice, even with induction of hypertension, the rise in blood pressure is mild. It is also reported that NaCl co-transporter (NCC) is one of the receptors for IL-18. Therefore, we considered that IL-18 might be involved in elevated blood pressure by activating NCC. However, in this study, it was not possible to clarify that activation of NCC is involved in blood pressure regulation.
|
| Academic Significance and Societal Importance of the Research Achievements |
高血圧患者では、血圧が高いだけでなく、様々な炎症性サイトカインが増加しており、動脈硬化促進に関与している。また、増加したサイトカインが直接血圧を上昇させることも知られている。本研究では、IL-18がNaCl-co-transporter (NCC) を介して、血圧調節に関与している可能性を考え研究を行った。本研究で、IL-18とNCCとの直接の関連性を明らかにすることはできなかったが、両者の関係が血圧に関連している可能性は極めて高く、今後のさらなる研究の発展が望まれる。
|
