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Development of next-generation module for blood purification that can control antithrombotic properties by nitric oxide releasing material.

Research Project

Project/Area Number 16K09653
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Kidney internal medicine
Research InstitutionKitasato University

Principal Investigator

Kokubo Kenichi  北里大学, 医療衛生学部, 准教授 (20287965)

Co-Investigator(Kenkyū-buntansha) 小林 弘祐  北里大学, 医療衛生学部, 教授 (70153632)
小林 こず恵  北里大学, 医療衛生学部, 助教 (60448975)
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords血液透析膜 / 生体適合性 / 一酸化窒素 / 抗血栓性材料 / 血液浄化器
Outline of Final Research Achievements

The aims of the present study were 1) to examine appropriate NO concentration required to exert anticoagulant ability by a rat extracorporeal model, and 2) to develop nitric oxide (NO) releasing material.
1) Extracorporeal circulation was performed for 4 hours using rat, NO gas of different concentration was added to the dialysate, and the residual blood clots to the filter after extracorporeal circulation was evaluated by the hemoglobin content and lactate dehydrogenase activity in the eluent. Appropriate NO concentration added to the dialysate was determined.
2) We tried to develop an NO-releasing material in which an NO donor was encapsulated. By examining several NO donors and macrocapsule materials to be used, we created microcapsules capable of releasing NO at a concentration required to exert antithrombotic properties.

Academic Significance and Societal Importance of the Research Achievements

本研究により、透析膜と血液が接触する際の抗血栓性を向上させるために必要なNO濃度が明らかとなり、またその濃度のNOを放出可能なマイクロカプセルを作成できた。NOを透析膜表面から放出させることで、透析膜の生体適合性、抗凝固性の向上が期待できる。また、出血性病変を有していて抗凝固剤が使いにくい患者に対しても抗血栓性を発揮でき、将来的には装着型や埋込型の人工腎臓の実現につながるモジュールにもつながる技術と考えられ、臨床的な意義も大きい。また本研究により得られた結果は、長時間血液と接触可能な材料の開発において、新たな材料設計のための指針を与えるものであり、他分野への波及効果も期待できる。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (3 results)

All 2019 2018

All Presentation (3 results)

  • [Presentation] SUPPRESSION OF BLOOD COAGULATION ON THE SURFACE OF A DIALYSIS MEMBRANE USING A NITRIC OXIDE-CONTAINING DIALYSATE2019

    • Author(s)
      Kenichi Kokubo, Kozue Kobayashi, Kenya Kohagura, Yuhei Yoshida, Hirosuke Kobayashi
    • Organizer
      56th Congress of the European Renal Association (ERA) and European Dialysis and Transplant Association (EDTA)
    • Related Report
      2018 Annual Research Report
  • [Presentation] 透析液に付加した一酸化窒素による血液透析膜の表面の抗血栓性の改善2018

    • Author(s)
      古波蔵賢弥, 吉田裕平, 小林こず恵, 小久保謙一, 小林弘祐
    • Organizer
      第45回日本血液浄化技術学会学術大会・総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 私の考えるHPM:長期間使用可能な人工膜という側面から2018

    • Author(s)
      小久保謙一
    • Organizer
      ハイパフォーマンス・メンブレン研究会
    • Related Report
      2017 Research-status Report

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Published: 2016-04-21   Modified: 2022-01-27  

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