| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
Multiple system atrophy (MSA) is characterized by the accumulation of aggregated alpha-synuclein (aS), but the mechanism underlying specific accumulation of pathological aS in oligodendrocyte is largely unknown and effective therapies have not been established yet. Recent studies suggested that brain lysates from MSA brains induced aS propagation in neurons, but not in oligodendrocytes, and thus mechanism of specific accumulation of aS in oligodendrocyte still remained unknown. In this study we showed that aS aggregates existed in exosomes which were derived from MSA brains, and exosomes derived from MSA brains were capable of inducing the oligodendrocytic inclusion of aS in mice. From these data cell-type specific exoxomes are possibly involved in cell-specific transfer of disease-associated pathological proteins, and can be a target of the disease-modifying therapy in a-synucleinopathy.
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