Pathomechanisms of Parkinson disease due to dysfunction of iPLA2G6

• Project/Area Number: 16K09675
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Neurology
• Research Institution: Juntendo University
• Principal Investigator: Hatano Taku 順天堂大学, 医学(系)研究科(研究院), 准教授 (60338390)
• Project Period (FY): 2016-04-01 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: パーキンソン病 / PARK14 / PLA2G6 / α-シヌクレイン / リノール酸 / リン脂質代謝 / レヴィ小体 / リン脂質 / C19orf72 / 脂質代謝異常 / 放出機能 / シナプス終末 / Lewy小体

Outline of Final Research Achievements

PLA2G6 is known as the causative gene of familial Parkinson's disease (PARK14). Pathological studies of PARK14 revealed dopaminergic neuronal degeneration with Lewy bodies (LB). Thus, impairment of PLA2G6 may be associated with the aggregation of alpha-synuclein (AS). To reveal the association between PLA2G6 dysfunction and AS aggregation, PLA2G6 knockout Drosophila was generated and exhibited motor and sleep dysfunction due to dopaminergic neuronal degeneration. Additionally, the fly model had synaptic terminal dysfunction. These phenotypes were rescued by overexpression of wild type human PLA2G6 but not A80T pathogenic mutation. Furthermore, I found an alteration in lipid composition and AS aggregation in the brain of the fly model. Administration of linoleic acid could rescue the phenotypes and AS aggregation. Therefore, lipid composition in the brain may be critical for the mechanisms of LB formation and lipid administration therapy might have an effect on Parkinson's disease.

Academic Significance and Societal Importance of the Research Achievements

α-シヌクレイン(AS)は脂質膜、中でもリン脂質に直接結合する事が知られている。膜への結合能の変化はAS凝集に関連し神経変性の原因となる。本研究でリン脂質代謝障害とAS凝集との関連を明らかにしており、パーキンソン病（PD）の病態解明につながる成果を挙げた。さらに、脂質補充をすることで脂質膜を変化させAS凝集を抑制し、神経変性を改善させる事を明らかにした。これにより適切な脂質を摂取する食事療法による治療への応用、つまりは医食同源を実現できる可能性を示した研究である。神経難病であるPDの病態解明として、脂質酵素に焦点を当て治療への応用を検討しており、学術的および社会的意義が高い研究である。

Research Products

• [Journal Article] Metabolomics‐based identification of metabolic alterations in PARK2 (2019)
  • Author(s): Okuzumi Ayami、Hatano Taku、Ueno Shin‐Ichi、Ogawa Takashi、Saiki Shinji、Mori Akio、Koinuma Takahiro、Oji Yutaka、Ishikawa Kei‐Ichi、Fujimaki Motoki、Sato Shigeto、Ramamoorthy Sivapriya、Mohney Robert P.、Hattori Nobutaka
  • Journal Title: Annals of Clinical and Translational Neurology Volume: 6 Issue: 3 Pages: 525-536
  • DOI: 10.1002/acn3.724
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Clinical heterogeneity of frontotemporal dementia and Parkinsonism linked to chromosome 17 caused by MAPT N279K mutation in relation to tau positron emission tomography features (2019)
  • Author(s): Ikeda Aya、Shimada Hitoshi、Nishioka Kenya、Takanashi Masashi、Hayashida Arisa、Li Yuanzhe、Yoshino Hiroyo、Funayama Manabu、Ueno Yuji、Hatano Taku、Sahara Naruhiko、Suhara Tetsuya、Higuchi Makoto、Hattori Nobutaka
  • Journal Title: Movement Disorders Volume: 34 Issue: 4 Pages: 568-574
  • DOI: 10.1002/mds.27623
  • Peer Reviewed / Open Access
• [Journal Article] A Randomized Crossover Pilot Study of Telemedicine Delivered via iPads in Parkinson’s Disease (2019)
  • Author(s): Sekimoto Satoko、Oyama Genko、Hatano Taku、Sasaki Fuyuko、Nakamura Ryota、Jo Takayuki、Shimo Yasushi、Hattori Nobutaka
  • Journal Title: Parkinson's Disease Volume: 2019 Pages: 1-7
  • DOI: 10.1155/2019/9403295
  • Peer Reviewed / Open Access
• [Journal Article] Zonisamide Administration Improves Fatty Acid β-Oxidation in Parkinson's Disease. (2018)
  • Author(s): Ueno SI, Saiki S, Fujimaki M, Takeshige-Amano H, Hatano T, Oyama G, Ishikawa KI, Yamguchi A, Nojiri S, Akamatsu W, Hattori N.
  • Journal Title: Cells Volume: 8 Issue: 1 Pages: 14-14
  • DOI: 10.3390/cells8010014
  • Peer Reviewed / Open Access
• [Journal Article] Rapid dissemination of alpha-synuclein seeds through neural circuits in an in-vivo prion-like seeding experiment (2018)
  • Author(s): Okuzumi Ayami、Kurosawa Masaru、Hatano Taku、Takanashi Masashi、Nojiri Shuuko、Fukuhara Takeshi、Yamanaka Tomoyuki、Miyazaki Haruko、Yoshinaga Saki、Furukawa Yoshiaki、Shimogori Tomomi、Hattori Nobutaka、Nukina Nobuyuki
  • Journal Title: Acta Neuropathologica Communications Volume: 6 Issue: 1 Pages: 96-96
  • DOI: 10.1186/s40478-018-0587-0
  • Peer Reviewed / Open Access
• [Journal Article] Randomized, double-blind, multicenter trial of hydrogen water for Parkinson's disease (2018)
  • Author(s): Yoritaka Asako、Ohtsuka Chigumi、Maeda Tetsuya、Hirayama Masaaki、Abe Takashi、Watanabe Hirohisa、Saiki Hidemoto、Oyama Genko、Fukae Jiro、Shimo Yasushi、Hatano Taku、Hattori Nobutaka、et al
  • Journal Title: Movement Disorders Volume: 33 Issue: 9 Pages: 1505-1507
  • DOI: 10.1002/mds.27472
  • Peer Reviewed / Open Access
• [Journal Article] GCH1 mutations in dopa-responsive dystonia and Parkinson's disease. (2018)
  • Author(s): Yoshino H, Nishioka K, Li Y, Oji Y, Oyama G, Hatano T, Machida Y, Shimo Y, Hayashida A, Ikeda A, Mogushi K, Shibagaki Y, Hosaka A, Iwanaga H, Fujitake J, Ohi T, Miyazaki D, Sekijima Y, Oki M, Kusaka H, Fujimoto KI Ugawa Y, Funayama M, Hattori N.
  • Journal Title: Journal of Neurology Volume: 265(8) Issue: 8 Pages: 1860-1870
  • DOI: 10.1007/s00415-018-8930-8
  • Peer Reviewed / Open Access
• [Journal Article] Myalgia caused by chronic myositis associated with plasmacytosis: a case report. (2018)
  • Author(s): Hatano T, Takanashi M, Tsuchihashi H, Ueno SI, Hayashida A, Tsukune Y, Kanai K, Shimo Y, Hattori N.
  • Journal Title: BMC Neurol. Volume: 18 Issue: 1 Pages: 112-112
  • DOI: 10.1186/s12883-018-1123-3
  • Peer Reviewed / Open Access
• [Journal Article] Neurite orientation dispersion and density imaging of the nigrostriatal pathway in Parkinson's disease: Retrograde degeneration observed by tract-profile analysis. (2018)
  • Author(s): Andica C, Kamagata K, Hatano T, Okuzumi A, Saito A, Nakazawa M, Ueda R, Motoi Y, Kamiya K, Suzuki M, Hori M, Kumamaru KK, Hattori N, Aoki S.
  • Journal Title: Parkinsonism & Related Disorders Volume: 18 Pages: 30112-30113
  • DOI: 10.1016/j.parkreldis.2018.02.046
  • Peer Reviewed / Open Access
• [Journal Article] Neuromelanin imaging and midbrain volumetry in progressive supranuclear palsy and Parkinson's disease (2018)
  • Author(s): Taniguchi Daisuke、Hatano Taku、Kamagata Koji、Okuzumi Ayami、Oji Yutaka、Mori Akio、Hori Masaaki、Aoki Shigeki、Hattori Nobutaka
  • Journal Title: Movement Disorders Volume: 33 Issue: 9 Pages: 1488-1492
  • DOI: 10.1002/mds.27365
  • Peer Reviewed / Open Access
• [Journal Article] Serum caffeine and metabolites are reliable biomarkers of early Parkinson disease. (2018)
  • Author(s): Fujimaki M, Saiki S, Li Y, Kaga N, Taka H, Hatano T, Ishikawa KI, Oji Y, Mori A, Okuzumi A, Koinuma T, Ueno SI, Imamichi Y, Ueno T, Miura Y, Funayama M, Hattori N.
  • Journal Title: Neurology. Volume: 90 Issue: 5 Pages: 1-8
  • DOI: 10.1212/wnl.0000000000004888
  • Peer Reviewed / Open Access
• [Journal Article] Depressive symptoms in Parkinson's disease are related to decreased left hippocampal volume: correlation with the 15-item shortened version of the Geriatric Depression Scale. (2018)
  • Author(s): Goto M, Kamagata K, Hatano T, Hattori N, Abe O, Aoki S, Hori M, Gomi T.
  • Journal Title: Acta Radiologica Volume: 59 Issue: 3 Pages: 341-345
  • DOI: 10.1177/0284185117719100
  • Peer Reviewed / Open Access
• [Journal Article] Serum uric acid level is linked to the disease progression rate in male patients with multiple system atrophy. (2017)
  • Author(s): Fukae J, Fujioka S, Yanamoto S, Mori A, Nomi T, Hatano T, Fukuhara K, Ouma S, Hattori N, Tsuboi Y.
  • Journal Title: Clinical Neurology Neurosurgery Volume: 158 Pages: 15-19
  • DOI: 10.1016/j.clineuro.2017.04.002
  • Peer Reviewed
• [Journal Article] Dystonia due to bilateral caudate hemorrhage associated with a COL4A1 mutation. (2017)
  • Author(s): Hatano T, Daida K, Hoshino Y, Li Y, Saitsu H, Matsumoto N, Hattori N.
  • Journal Title: Parkinsonism and Related Disorders Volume: 40 Pages: 80-82
  • DOI: 10.1016/j.parkreldis.2017.04.009
  • Peer Reviewed
• [Journal Article] Gray Matter Abnormalities in Idiopathic Parkinson's Disease: Evaluation by Diffusional Kurtosis Imaging and Neurite Orientation Dispersion and Density Imaging. (2017)
  • Author(s): Kamagata K, Zalesky A, Hatano T, Ueda R, Di Biase MA, Okuzumi A, Shimoji K, Hori M, Caeyenberghs K, Pantelis C, Hattori N, Aoki S.
  • Journal Title: Human Brain Mapping Volume: in press Issue: 7 Pages: 3704-3722
  • DOI: 10.1002/hbm.23628
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] The Risk Factors for the Wearing-off Phenomenon in Parkinson's Disease in Japan: A Cross-sectional, Multicenter Study (2017)
  • Author(s): Ouma S, Fukae J, Fujioka S, Yamamoto S, Hatano T, Yoritaka A, Okuma Y, Kashihara K, Hattori N, Tsuboi Y.
  • Journal Title: Internal Medicine Volume: 56 Issue: 15 Pages: 1961-1966
  • DOI: 10.2169/internalmedicine.56.7667
  • NAID: 130005876433
  • ISSN: 0918-2918, 1349-7235
  • Peer Reviewed / Open Access
• [Journal Article] Decreased long-chain acylcarnitines from insufficient β-oxidation as potential early diagnostic markers for Parkinson's disease. (2017)
  • Author(s): Saiki S, Hatano T, Fujimaki M, Ishikawa K, Mori A, Oji Y, Okuzumi A, Fukuhara T, Koinuma T, Nagumo M, Furuya N, Nojiri S, Amo T, Yamashiro K, Hattori N.
  • Journal Title: Scientific Reports Volume: 7 Issue: 1 Pages: 7328-7328
  • DOI: 10.1038/s41598-017-06767-y
  • Peer Reviewed / Open Access
• [Journal Article] Mitochondrial-Associated Membranes in Parkinson's Disease. (2017)
  • Author(s): Hattori N, Arano T, Hatano T, Mori A, Imai Y
  • Journal Title: Advances in Experimental Medical Biology Volume: 997 Pages: 157-169
  • DOI: 10.1007/978-981-10-4567-7_12
  • ISBN: 9789811045660, 9789811045677
  • Peer Reviewed
• [Journal Article] Connectome analysis with diffusion MRI in idiopathic Parkinson's disease: Evaluation using multi-shell, multi-tissue, constrained spherical deconvolution. (2017)
  • Author(s): Kamagata K, Zalesky A, Hatano T, Di Biase MA, El Samad O, Saiki S, Shimoji K, Kumamaru KK, Kamiya K, Hori M, Hattori N, Aoki S, Pantelis C.
  • Journal Title: Neuroimage Clinical Volume: 17 Pages: 518-529
  • DOI: 10.1016/j.nicl.2017.11.007
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Neuropathology of PARK14 is identical to idiopathic Parkinson's disease (2017)
  • Author(s): Miki Y, Yoshizawa T, Morohashi S, Seino Y, Kijima H, Shoji M, Mori A, Yamashita C, Hatano T, Hattori N, Wakabayashi K
  • Journal Title: Mov Disord Volume: - Issue: 5 Pages: 35-35
  • DOI: 10.1002/mds.26952
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Neuromelanin MRI is useful for monitoring motor complications in Parkinson’s and PARK2 disease. (2017)
  • Author(s): Hatano T, Okuzumi A, Kamagata K, Daida K, Taniguchi D, Hori M, Yoshino H, Aoki S, Hattori N.
  • Journal Title: Journal of Neural Transmission Volume: 124 Issue: 4 Pages: 407-415
  • DOI: 10.1007/s00702-017-1688-9
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Anhedonia and its correlation with clinical aspects in Parkinson's disease. (2017)
  • Author(s): Nagayama H, Maeda T, Uchiyama T, Hashimoto M, Nomoto N, Kano O, Takahashi T, Terashi H, Hamada S, Hasegawa T, Hatano T, Takahashi T, Baba Y, Sengoku R, Watanabe H, Inoue M, Kadowaki T, Kaneko K, Hideki Shimura H, Kubo S, The Young Japanese Expert Group for Parkinson's Disease and Movement Disorders: YJ-EXPANDS.
  • Journal Title: Journal of Neurological Science Volume: 372 Pages: 403-407
  • DOI: 10.1016/j.jns.2016.10.051
  • Peer Reviewed
• [Journal Article] Peking university - Juntendo university joint symposium on brain and skin disease. Genetics and Parkinson’s Disease. (2016)
  • Author(s): Hatano T, Hattori N.
  • Journal Title: Juntendo Medical Journal Volume: 62 Pages: 308-310
  • Peer Reviewed / Open Access
• [Journal Article] A randomized double-blind multi-center trial of hydrogen water for Parkinson’s disease: protocol and baseline characteristics (2016)
  • Author(s): Yoritaka, A.,Abe, T.,Ohtsuka, C.,Maeda, T., Hirayama, M. et al
  • Journal Title: BMC Neurology Volume: 16 Issue: 1 Pages: 66-66
  • DOI: 10.1186/s12883-016-0589-0
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] A Japanese multicenter survey characterizing pain in Parkinson's disease (2016)
  • Author(s): Kubo SI, Hamada S, Maeda T, Uchiyama T, Hashimoto M, Nomoto N, Kano O, Takahashi T, Terashi H, Takahashi T, Hatano T, Hasegawa T, Baba Y, Sengoku Rl, Watanabe H, Kadowaki T, Inoue M, Kaneko S, Shimura H, Nagayama H
  • Journal Title: Journal of The Neurological Science Volume: 365 Pages: 162-166
  • DOI: 10.1016/j.jns.2016.04.015
  • Peer Reviewed
• [Presentation] Will mobile health technology improve management? (2019)
  • Author(s): Taku Hatano, Nobutaka Hattori
  • Organizer: “Takamatsu” International Symposium for PD & MD
  • Int'l Joint Research / Invited
• [Presentation] 一般診療で覚えておきたい神経疾患 (2019)
  • Author(s): 波田野琢、服部信孝
  • Organizer: 第6回中央区医師会学術講演会
  • Invited
• [Presentation] 不随意運動にも色々ある ―診断と鑑別について― (2018)
  • Author(s): 波田野琢、服部信孝
  • Organizer: 第36回日本神経治療学会学術集会
  • Invited
• [Presentation] Neuromelanin Imaging and Midbrain Volumetry in Progressive Supranuclear Palsy and Parkinson’s Disease (2018)
  • Author(s): Taku Hatano, Daisuke Taniguchi, Koji Kamagata, Masaaki Hori, Shigeki Aoki, Nobutaka Hattori
  • Organizer: 16th Asia Oceanian Congress of Neurology
  • Int'l Joint Research
• [Presentation] パーキンソニズムの脳循環代謝と脳内ネットワーク 臨床診断と脳循環 (2018)
  • Author(s): 波田野 琢、服部 信孝
  • Organizer: 第61回日本脳循環代謝学会学術集会
  • Invited
• [Presentation] DATイメージングを用いたパーキンソニズムの診断 (2018)
  • Author(s): 波田野琢、服部信孝
  • Organizer: 第37回日本認知症学会学術集会
  • Invited
• [Presentation] パーキンソン病の理解・基礎知識 (2018)
  • Author(s): 波田野琢、服部信孝
  • Organizer: MDSJ第8回PDナース研修会
  • Invited
• [Presentation] 神経化学からみた神経疾患 -ベンチとベットサイドの間- (2018)
  • Author(s): 波田野琢、服部信孝
  • Organizer: 第40回日本生物学的精神医学会・第61回日本神経化学会大会 合同年会
  • Invited
• [Presentation] パーキンソン病の治療（薬物療法と生活のヒント） (2018)
  • Author(s): 波田野琢、服部信孝
  • Organizer: 第9回パーキンソン病市民公開講座（青森）
  • Invited
• [Presentation] 実地に沿ったパーキンソン病診療のノウハウ；エキスパートはどう診療するのか？ (2018)
  • Author(s): 波田野琢、服部信孝
  • Organizer: 第59回日本神経学会総会； 第15回生涯教育セミナー「Hands-on」プログラム
  • Invited
• [Presentation] 非運動症状について (2018)
  • Author(s): 波田野琢、服部信孝
  • Organizer: 会津パーキンソン病市民公開講座
  • Invited
• [Presentation] パーキンソン病の治療と日常生活（薬物治療と生活のヒント） (2018)
  • Author(s): 波田野琢、服部信孝
  • Organizer: パーキンソン病市民公開講座
  • Invited
• [Presentation] シンポジウム「パーキンソン病 : 新規の診療ガイドライン」パーキンソン病の運動症状の治療方針 (2017)
  • Author(s): 波田野琢、下泰司、武田篤、服部信孝
  • Organizer: 第35回 日本神経治療学会総会
  • Invited
• [Presentation] Dystonia due to bilateral caudate hemorrhage associated with a COL4A1 mutation. (2017)
  • Author(s): Hatano T, Daida K, Hoshino Y, Li Y, Saitsu H, Matsumoto N, Hattori N
  • Organizer: International Congress of Parkinson’s Disease and Movement Disorders
  • Int'l Joint Research
• [Presentation] PLA2G6変異により脳脂質構成異常を起こし、α-シヌクレイン凝集を加速させる (2017)
  • Author(s): 森聡生、濃沼崇博、井下強、山下力、波田野琢、今居譲、服部信孝
  • Organizer: 第11回パーキンソン病・運動障害疾患コングレス
• [Presentation] パーキンソン病における早期診断マーカーとしての酸化型・還元型アルブミン測定 (2017)
  • Author(s): 上野真一、波田野琢、王子悠、斉木臣二、奥住文美、池田均、服部信孝
  • Organizer: 第11回パーキンソン病・運動障害疾患コングレス
• [Presentation] マウス脳における脳梁離断を用いた線維状αsynucleinの伝播経路の検討 (2017)
  • Author(s): 奥住文美、波田野琢、黒澤大、山中智行、宮崎晴子、古川良明、服部信孝、貫名信行
  • Organizer: 第11回パーキンソン病・運動障害疾患コングレス
• [Presentation] Comprehensive metabolome analysis of serum of parkin knockout mice. (2017)
  • Author(s): Hatano T, Okuzumi A, Saiki S, Sato S, Hattori N
  • Organizer: 23rd World Congress of Neurology
  • Int'l Joint Research
• [Presentation] Serum non-mercaptoalbumin in patients with Parkinson's disease. (2017)
  • Author(s): Ueno S, Hatano T, Oji Y, Saiki S, Ikeda H, Hattori N
  • Organizer: 23rd World Congress of Neurology
  • Int'l Joint Research
• [Presentation] Comprehensive metabolomic analysis of serum of PARK2 patients. (2017)
  • Author(s): Okuzumi A, Hatano T, Saiki S, Hattori N.
  • Organizer: 23rd World Congress of Neurology
  • Int'l Joint Research
• [Presentation] 201 (2017)
  • Author(s): 2017
  • Organizer: 23rd World Congress of Neurology
  • Int'l Joint Research
• [Presentation] ニューロメラニンイメージングを用いた孤発性パーキンソン病およびPARK2の臨床症状に関する解析 (2016)
  • Author(s): 波田野 琢, 鎌形 康二, 奥住 文美, 吉野 浩代, 堀 正明, 青木 茂樹, 服部 信孝
  • Organizer: 第34回日本神経治療学総会
  • Place of Presentation: 鳥取
  • Year and Date: 2016-11-03
• [Presentation] Symposium; Fission, Fusion, Autophagy-2 Mitochondrial dysfunction and Parkinson’s disease (2016)
  • Author(s): Hatano T
  • Organizer: The 13th Conference of Asian Society for Mitochondrial Research and Medicine [ASMRM] and The 16th Conference of Japanese Society of Mitochondrial Research and Medicine [J-mit]
  • Place of Presentation: 東京
  • Year and Date: 2016-10-30
  • Invited
• [Presentation] Neuromelanin-imagingを用いたパーキンソン病とPARK2の解析 (2016)
  • Author(s): 波田野 琢, 鎌形 康司, 奥住 文美, 代田 健祐, 谷口 大祐, 堀 正明, 吉野 浩代, 青木 茂樹, 服部 信孝
  • Organizer: 第10回 パーキンソン病・運動障害疾患コングレス
  • Place of Presentation: 京都
  • Year and Date: 2016-10-06
• [Presentation] シンポジウム11パーキンソン病の在宅医療と緩和ケア 在宅における薬剤療法の実際 (2016)
  • Author(s): 波田野 琢, 石垣 泰則, 服部 信孝
  • Organizer: 第18回日本在宅医学会大会 第21回日本在宅ケア学会学術集会合同大会
  • Place of Presentation: 東京
  • Year and Date: 2016-07-16
  • Invited
• [Presentation] Neuromelanin imaging is useful for monitoring disease progression in Parkinson’s disease and PARK2 (2016)
  • Author(s): T. Hatano, A. Okuzumi, K. Kamagata, K. Daida, D. Taniguchi, M. Hori, H. Yoshino, S. Aoki, N. Hattori
  • Organizer: 20th International Congress of Parkinson’s disease and Movement Disorders.
  • Place of Presentation: ベルリン
  • Year and Date: 2016-06-19
• [Presentation] Prognostic Factors of Motor Symptoms in Parkinson’s Disease Using Neuroimaging (2016)
  • Author(s): A. Okuzumi, T. Hatano, K. Kamagata, M. Hori, S. Aoki, N. Hattori
  • Organizer: 20th International Congress of Parkinson’s disease and Movement Disorders.
  • Place of Presentation: ベルリン
  • Year and Date: 2016-06-19
• [Presentation] PDとPSPにおけるメラニンイメージングを用いた黒質神経細胞脱落の検討 (2016)
  • Author(s): 谷口 大祐，波田野 琢, 鎌形 康司, 奥住 文美, 堀 正明, 青木 茂樹, 服部 信孝
  • Organizer: 第57回日本神経学会総会
  • Place of Presentation: 神戸
  • Year and Date: 2016-05-18
• [Presentation] Prognostic Factors of Motor Symptoms in Parkinson’s Disease Using Neuroimaging (2016)
  • Author(s): A. Okuzumi, T. Hatano, K. Kamagata, M. Hori, S. Aoki, N. Hattori
  • Organizer: 第57回日本神経学会総会
  • Place of Presentation: 神戸
  • Year and Date: 2016-05-18
• [Presentation] Neuromelanin imaging is useful for monitoring disease progression in Parkinson’s disease and PARK2 (2016)
  • Author(s): Daida, D., T. Hatano, A. Okuzumi, K. Kamagata, K. Taniguchi, M. Hori, H. Yoshino, S. Aoki, N. Hattori
  • Organizer: 第57回日本神経学会総会
  • Place of Presentation: 神戸
  • Year and Date: 2016-05-18
• [Book] 神経内科clinical questions & pearls パーキンソン病 (2019)
  • Author(s): 服部信孝、下泰司、波田野琢
  • Total Pages: 335
  • Publisher: 中外医学社
  • ISBN: 9784498328044
• [Book] 神経内科ハンドブック 鑑別診断と治療 第5版 水野美邦 編 (2016)
  • Author(s): 波田野 琢，水野 美邦
  • Total Pages: 1337
  • Publisher: 医学書院
• [Book] 神経内科外来シリーズ2 パーキンソン病外来 荒木信夫，山元敏正，高橋一司 編 (2016)
  • Author(s): 波田野 琢，服部 信孝
  • Total Pages: 264
  • Publisher: メジカルビュー社
• [Patent(Industrial Property Rights)] パーキンソン病診断薬及びモデル動物 (2018)
  • Inventor(s): 服部 信孝、王子 悠、波田野 琢
  • Industrial Property Rights Holder: 服部 信孝、王子 悠、波田野 琢
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2018-200039
  • Filing Date: 2018
• [Patent(Industrial Property Rights)] α―シヌクレイノパチーの診断 (2018)
  • Inventor(s): 服部 信孝、波田野 琢、奥住 文美、上野 真一
  • Industrial Property Rights Holder: 服部 信孝、波田野 琢、奥住 文美、上野 真一
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2018-159694
  • Filing Date: 2018