| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
To understand the pathogenic mechanism of Parkinson's disease (PD), a neurodegenerative disease, and search for new therapeutic targets, we analyzed the genetic correlation between eight PD-related genes. Our results revealed that the PD causative gene LRRK2 has a central role. We also demonstrated that loss of LRRK2 function and expression of pathogenic mutants cause Arl8 accumulation in synapses associated with axonal transport abnormalities. In addition, accumulation of α-synuclein in Arl8-accumulating synapses and co-localization of Arl8 and α-synuclein in autopsy brain of PD patients were revealed. These findings suggested that LRRK2 regulates axonal transport of Arl8 and α-synuclein and disorder of their axon transport might be involved in PD onset.
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