Significance of dystroglycan processing and its participation in the pathogenesis of neuromuscular disorders
| Project/Area Number |
16K09682
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Neurology
|
|---|
| Research Institution | Teikyo University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
真先 敏弘 帝京科学大学, 医学教育センター, 教授 (00585028)
萩原 宏毅 帝京科学大学, 医療科学部, 教授 (80276732)
|
|---|
| Research Collaborator |
Saito Fumiaki
|
|---|
| Project Period (FY) |
2016-04-01 – 2019-03-31
|
| Project Status |
Completed (Fiscal Year 2018)
|
| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
|---|
| Keywords | 筋ジストロフィー / ジストログリカン / インフルエンザ / A型インフルエンザ / 糖鎖修飾 / 蛋白質プロセッシング / 脳神経疾患 |
|---|
| Outline of Final Research Achievements |
α-Dystroglycanopathy, a type of muscular dystrophy, is caused by abnormal post-translational modifications. Although the N-terminal domain of α-dystroglycan (α-DG-N) is secreted from cells by processing, the function of secreted α-DG-N remains unknown. This study was performed to elucidate the function. α-DG-N was presumed to affect the extension of neurites in central nervous system by the results of a previous report. However, this function was not ascertained in vivo using gene-modified mice. On the other hands, an unexpected function of α-DG-N was revealed. Indeed, α-DG-N inhibits infection of influenza virus. Thus, it is possible that α-DG-N may be applied to the therapy of influenza infection in the future.
|
| Academic Significance and Societal Importance of the Research Achievements |
α-ジストログリカンのN末端ドメイン（α-DG-N）の機能はこれまで不明であった。しかし今回の研究によってインフルエンザウイルスの増殖を抑制するという思いがけない作用を有することが明らかとなった。インフルエンザは全世界で毎年300-500万人が罹患し、その結果25-50万人が死亡していると推定されている。また先進国においてもインフルエンザによる高齢者の死亡が問題となっている。今後α-DG-Nを用いたインフルエンザに対する新たな治療法開発への道が開かれるかもしれない。
|
Report
(4 results)
Research Products
(6 results)
-
[Journal Article] A protective role for the N-terminal domain of α-dystroglycan in Influenza A virus proliferation2019
Author(s)
Jessica C. de Greef, Bram Slutterd, Mary E. Andersona, Rebecca Hamlyn, Raul O’Campo Landaa, Ellison J. McNutta, Yuji Haraa, Lecia L. Pewe, David Venzke, Kiichiro Matsumura, Fumiaki Saito, John T. Hartyd, Kevin P. Campbell
-
Journal Title
Proc Natl Acad Sci USA
Volume: 印刷中
Issue: 23
Pages: 11396-11401
DOI
Related Report
Peer Reviewed / Int'l Joint Research
-
[Journal Article] Role of dystroglycan in limiting contraction-induced injury to the sarcomeric cytoskeleton of mature skeletal muscle.2016
Author(s)
Rader EP, Turk R, Willer T, Beltran D, Inamori K, Peterson TA, Engle J, Prouty S, Matsumura K, Saito F, Anderson ME, Campbell KP
-
Journal Title
Proc Natl Acad Sci USA
Volume: 113
Issue: 39
Pages: 10992-10997
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
-
-
-
[Presentation] Tubular aggregate myopathy caused by a novel mutation in the cytoplasmic domain of STIM1.2016
Author(s)
Saito F, Okuma H, Mitsui J, Hara Y, Hatanaka Y, Ikada M, Shimizu T, Matsumura K, Shimizu J, Tsuji S, Sonoo M
Organizer
21st International congress of the World Muscle Society
Place of Presentation
スペイン・グラナダ
Year and Date
2016-10-04
Related Report
Int'l Joint Research
-
