| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
1.Sustained delivery of neurotrophic factors to mice brain. We developed HAC-MSCs which highly expressed neurotrophic factors. Transplanting this cells as a monolayer sheet structure, we confirmed this method is so far the most promising way to deliver the trophic factors to mice brain. Howerver, the HAC-MSC sheet eliminated from host tissue in a quite short term after the transplantation. We considered controlling this immune-rejection is necessary for further improvement of the efficacy of transplantation.
2.Establishing the method to detect cell survival signals efficiently. We observed that the host microglial cells are numerously infiltrating into transplanted cell sheet structure. We also confirmed these infiltrating microglias are both cytoprotective (M2) and cytotoxic (M1) populations. By selectively eliminate the host microglias, we are examining this procedure improve the survival of the transplanted cell sheet.
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