Creation of the most effective method for induction of synaptic plasticity in human brain: paired-associative quadripulse stimulation (PA-QPS)
Project/Area Number |
16K09724
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Neurology
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Research Institution | Fukushima Medical University |
Principal Investigator |
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Research Collaborator |
Winnugroho Wiratman
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Project Period (FY) |
2016-04-01 – 2019-03-31
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Project Status |
Completed (Fiscal Year 2018)
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Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2018: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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Keywords | PA-QPS / シナプス可塑性 / 長期増強 / 長期抑圧 / PAS / QPS / 経頭蓋磁気刺激法 / 非侵襲的脳刺激法 / 運動学習 / 末梢神経電気刺激 |
Outline of Final Research Achievements |
Non-invasive brain stimulation (NIBS) is known as a useful method in neuroscience and clinical neurology. Here we created a new NIBS protocol, combining four burst magnetic stimulation with four peripheral electrical nerve stimulation (paired-associative quadripulse stimulation: PA-QPS) and examined its potential. PA-QPS could induce facilitatory / inhibitory effects in human brain. Direction of the induced effects was dependent on interburst intervals of the magnetic stimulation. Delivered electrical nerve stimuli also enhanced / abolished the effects. In addition, we investigated the effects of PA-QPS in large number of subjects and found that PA-QPS can lead to more effective and stable inhibitory effects compared to other conventional NIBS protocols. We concluded that PA-QPS has great potential for both understanding pathophysiology of movement disorders and application to therapeutic approach.
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Academic Significance and Societal Importance of the Research Achievements |
非侵襲的脳刺激法は神経科学分野の研究だけでなく、精神精神疾患の病態解明や治療といった臨床的応用としても用いられている。しかし、これまでに確立された刺激法の効果は、個人間でばらつきがあり、効果の再現性や確実性の問題が指摘されている。本研究によって開発された新しい刺激法(PA-QPS)は、その点を克服して従来の刺激法に比べてより効果的にシナプス可塑性変化を誘導できる。この手法を用いることで、パーキンソン病やジストニアといった運動異常疾患の病態の解明や治療的応用が期待できる点に学術的、社会的意義がある。
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Report
(4 results)
Research Products
(53 results)
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[Journal Article] Novel pathogenic XK mutations in McLeod syndrome and interaction between XK protein and chorein.2019
Author(s)
Urata Y., Nakamura M., Sasaki N., Shiokawa N., Nishida Y., Arai K., Hiwatashi H., Yokoyama I., Narumi S., Terayama Y., Murakami T., Ugawa Y., Sakamoto H., Kaneko S., Nakazawa Y., Yamasaki R., Sadashima S., Sakai T., Arai H., Sano A.
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Journal Title
Neurology: Genetics
Volume: -
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] The motor network reduces multisensory illusory perception.2018
Author(s)
Murakami T, Abe M, Wiratman W, Fujiwara J, Okamoto M, Mizuochi-Endo T, Iwabuchi T, Makuuchi M, Yamashita A, Tiksnadi A, Chang F, Kubo H, Matsuda N, Kobayashi S, Eifuku S, Ugawa Y
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Journal Title
Journal of Neuroscience
Volume: 24
Issue: 45
Pages: 3650-17
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] A possible role of low regulatory T cells in anti-acetylcholine receptor antibody positive myasthenia gravis after bone marrow transplantation2017
Author(s)
Fukatsu M, Murakami T, Ohkawara H, Saito S, Ikeda K, Kadowaki S, Sasaki I, Segawa M, Soeda T, Hoshi A, Takahashi H, Shichishima-Nakamura A, Ogawa K, Sugiura Y, Ohto H, Takeishi Y, Ikezoe T, Ugawa Y.
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Journal Title
BMC Neurology
Volume: 17
Issue: 1
Pages: 93-93
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Variability in response to quadripulse stimulation of the motor cortex2016
Author(s)
Nakamura K., Groiss S.J., Hamada M., Enomoto H., Kadowaki S., Abe M., Murakami T., Wiratman W., Chang F., Kobayashi S., Hanajima R., Terao Y., Ugawa Y.
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Journal Title
Brain Stimulation
Volume: 9
Issue: 6
Pages: 859-866
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] A case of lymphomatosis cerebri mimicking inflammatory diseases2016
Author(s)
Murakami T., Yoshida K., Segawa M., Yoshihara A., Hoshi A., Nakamura K., Ichikawa M., Suzuki O., Yokoyama Y., Toyoshima Y., Sugiura Y., Ito H., Saito K., Hashimoto Y., Kakita A., Takahashi H., Ugawa Y.
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Journal Title
BMC Neurology
Volume: 16
Issue: 1
Pages: 128-128
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Presentation] 診断に苦慮した中枢神経原発悪性リンパ腫の1例2019
Author(s)
阿部亜妃子, 吉田健二, 板垣裕也, 阿部暖, 時村瞭, 服部香寿美, 黒見祐美子, 安田恵, 村上丈伸, 小林俊輔, 榎本博之, 金井数明, 宇川義一
Organizer
第216回日本内科学会東北地方会
Related Report
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[Presentation] 下肢の錐体路障害を認めたMcLeod症候群の一例2018
Author(s)
阿部暖, 村上丈伸, 松本英之, 時村瞭, 服部香寿美, 黒見祐美子, 吉田健二, 安田恵, 阿部十也, 小林俊輔, 榎本博之, 中村雅之, 佐野輝, 宇川義一
Organizer
第48回日本臨床神経生理学会学術大会
Related Report
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[Presentation] 重症筋無力症でステロイド治療中に抗ARS抗体陽性多発筋炎を発症した一例2018
Author(s)
阿部亜妃子, 吉田健二, 板垣裕也, 阿部暖, 時村瞭, 服部香寿美, 黒見祐美子, 安田恵, 村上丈伸, 榎本博之, 宇川義一
Organizer
第102回日本神経学会東北地方会
Related Report
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[Presentation] 水疱を伴わない帯状疱疹(zoster sine herpete)に続発して, 無菌性髄膜炎・動眼神経麻痺・脳血管症・脊髄炎を来し, 診断と治療に難渋した一例2018
Author(s)
板垣裕也, 松田希, 田中翔子, 阿部暖, 服部香寿美, 中津秀幸, 安田恵, 村上丈伸, 吉田健二, 榎本博之, 宇川義一
Organizer
第102回日本神経学会東北地方会
Related Report
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[Presentation] McLeod症候群での中枢運動伝導時間と運動野皮質内抑制/促通機能2018
Author(s)
阿部暖, 村上丈伸, 松本英之, 時村瞭, 服部香寿美, 黒見祐美子, 吉田健二, 安田恵, 阿部十也, 中村雅之, 佐野輝, 宇川義一
Organizer
第59回日本神経学会学術大会
Related Report
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[Presentation] Contribution of the motor system to McGurk effect -event-related fMRI and TMS studies-.2016
Author(s)
Murakami T., Fujiwara J., Sakamoto Y., Okamoto M., Mizuochi T., Iwabuchi T., Makuuchi M., Abe M., Kubo H., Matsuda N., Kobayashi S., Ito H., Takenoshita S., Ugawa Y.
Organizer
Neuroscience2016
Place of Presentation
サンディエゴ アメリカ
Year and Date
2016-11-12
Related Report
Int'l Joint Research
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[Presentation] 新しいQPS2016
Author(s)
村上丈伸
Organizer
第46回日本臨床神経生理学会学術大会
Place of Presentation
郡山市 福島県
Year and Date
2016-10-27
Related Report
Invited
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