Abnormality of neural plasticity in Parkinson disease
| Project/Area Number |
16K09725
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | Fukushima Medical University |
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Principal Investigator |
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| Research Collaborator |
UGAWA Yoshikazu
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2018: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 神経可塑性 / パーキンソン病 / ドーパミン / 経頭蓋磁気刺激 / 磁気刺激 / 臨床神経生理学 / 神経内科学 |
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| Outline of Final Research Achievements |
Although the treatment environment for Parkinson's disease has made great progress, unfortunately it has not reached the fundamental treatment. As a result, the antiparkinsonian drug treatment period is prolonged. Involuntary movements called dyskinesias in long-term treatment reduce the patient's quality of life. In this study, we evaluated the relationship between dyskinesia and antiparkinsonian drugs, focusing on the flexibility of the brain called plasticity that is impaired in Parkinson's disease.
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| Academic Significance and Societal Importance of the Research Achievements |
パーキンソン病では可塑性と呼ばれる脳の柔軟性に異常が見られることが知られている。そこで、抗パーキンソン病薬が可塑性とよばれる脳の柔軟性に与える影響を検討した。結果、抗パーキンソン病薬の種類により可塑性に与える影響が異なることが判明した。また、パーキンソン病におけるジスキネジアがこの可塑性の調節が困難なことによることが示唆された。結果、ジスキネジアのおきにくい治療計画の立案に必要な情報が得られた。
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Report
(4 results)
Research Products
(11 results)
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[Journal Article] An Essential Role of the Intraparietal Sulcus in Response Inhibition Predicted by Parcellation-Based Network.2019
Author(s)
Osada T, Ohta S, Ogawa A, Tanaka M, Suda A, Kamagata K, Hori M, Aoki S, Shimo Y, Hattori N, Shimizu T, Enomoto H, Hanajima R, Ugawa Y, Konishi S.
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Journal Title
J Neurosci.
Volume: 39
Issue: 13
Pages: 2509-2521
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] The effect of age on the homotopic motor cortical long-term potentiation-like effect induced by quadripulse stimulation2017
Author(s)
Hanajima R, Tanaka N, Tsutsumi R, Enomoto H, Abe M, Nakamura K, Kobayashi S, Hamada M, Shimizu T, Terao Y, Ugawa Y
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Journal Title
Exp Brain Res
Volume: 印刷中
Issue: 7
Pages: 2103-2108
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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