Establishment of biomarkers by pathological approach to Lewy body disease (Parkinson's disease)
| Project/Area Number |
16K09736
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | Jikei University School of Medicine (2020)
Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology (2016-2019) |
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Principal Investigator |
Sengoku Renpei 東京慈恵会医科大学, 医学部, 准教授 (40385331)
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| Project Period (FY) |
2016-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2020: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2019: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2018: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2017: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
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| Keywords | レビー小体病 / パーキンソン病 / レビー小体 / α-シヌクレイン / 免疫組織化学 / レビー小体型認知症 / 顎下腺 / 食道 / 病理 / MIBG心筋シンチグラフィー / バイオマーカー / 嗅覚路 / 梨状葉 / 扁桃核 / 生検 / 〈髄液〉 / ドパミントランスポーターSPECT / 皮膚 / 直腸 / 髄液 / 脳神経疾患 / 早期診断 / 神経病理 |
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| Outline of Final Research Achievements |
The world is aging. Along with this, the number of patients with Parkinson's disease (PD) is also increasing. It is known that non-motor symptoms appear before the appearance of motor symptoms of PD. The purpose of this study is to investigate the pathological evaluation site for early PD diagnosis. As biopsy sites, each site such as the submandibular gland, skin, and intestinal tract is listed as a candidate. As a result of examination in consecutive autopsy cases, the following was found. Lewy pathology is observed in the sympathetic ganglia from an early stage of the disease. It was clarified that Lewy pathology in the submandibular gland was not observed before clinical symptoms were observed.
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| Academic Significance and Societal Importance of the Research Achievements |
難病等の創薬においては、できるだけ発症早期の段階での介入が重要である。パーキンソン病（PD)では、いわゆる振るえ等の運動症状が出現した病期ではすでに、脳内の変性はある程度進んでいる。運動症状出現前の段階でPDと早期診断できるようなサロゲートマーカーを確立することが逼迫した課題である。病理学的なアプローチとしては生検があり、今回剖検検体から得られた結果は、生検部位探索の一助として還元しうる。
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Report
(6 results)
Research Products
(123 results)
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[Journal Article] Metabolic network topology of Alzheimer’s disease and dementia with Lewy bodies generated using fluorodeoxyglucose positron emission tomography.2020
Author(s)
Imai M, Tanaka M, SakataM, Wagatsuma K, Tago T, Toyohara J, Sengoku R, Nishina Y, Kanemaru K, Ishibashi K, Murayama S, Ishii K.
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Journal Title
J Alzheimers Dis
Volume: 73
Issue: 1
Pages: 197-207
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Peak exercise stroke volume effects on cognitive impairment in community-dwelling people with preserved ejection fraction.2018
Author(s)
Sugie M, Harada K, Takahashi T, Nara M, Kawai H, Fujiwara Y, Ishikawa J, Tanaka J, Koyama T, Kim H, Sengoku R, Fujimoto H, Obuchi S, Kyo S, Ito H.
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Journal Title
ESC Heart Fail
Volume: 5
Issue: 5
Pages: 876883-876883
DOI
Related Report
Peer Reviewed
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[Journal Article] Homovanillic acid and 5-hydroxyindole acetic acid as biomarkers for dementia with Lewy bodies and coincident Alzheimer's disease: An autopsy-confirmed study.2017
Author(s)
Morimoto S, Takao M, Hatsuta H, Nishina Y, Komiya T, Sengoku R, Nakano Y, Uchino A, Sumikura H, Saito Y, Kanemaru K, Murayama S.
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Journal Title
PLoS One
Volume: 12
Issue: 2
Pages: e0171524-e0171524
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Anhedonia and its correlation with clinical aspects in Parkinson's disease.2017
Author(s)
Nagayama H, Maeda T, Uchiyama T, Hashimoto M, Nomoto N, Kano O, Takahashi T, Terashi H, Hamada S, Hasegawa T, Hatano T, Takahashi T, Baba Y, Sengoku R, Watanabe H, Inoue M, Kadowaki T, Kaneko K, Hideki Shimura H, Kubo S, The Young Japanese Expert Group for Parkinson's Disease and Movement Disorders: YJ-EXPANDS.
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Journal Title
Journal of Neurological Science
Volume: 372
Pages: 403-407
DOI
Related Report
Peer Reviewed
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[Journal Article] A Japanese multicenter survey characterizing pain in Parkinson's disease2016
Author(s)
Kubo SI, Hamada S, Maeda T, Uchiyama T, Hashimoto M, Nomoto N, Kano O, Takahashi T, Terashi H, Takahashi T, Hatano T, Hasegawa T, Baba Y, Sengoku Rl, Watanabe H, Kadowaki T, Inoue M, Kaneko S, Shimura H, Nagayama H
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Journal Title
Journal of The Neurological Science
Volume: 365
Pages: 162-166
DOI
Related Report
Peer Reviewed
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[Presentation] Validation study of clinical diagnosis of amyotrophic lateral sclerosis: the Brain Bank for Aging Research (BBAR) Project2019
Author(s)
3)Matsubara T, Izumi Y, Miyamoto R, Oda M, Nodera H, Higashihara M, Sengoku R, Oki R, Fujita K, Kawarai T, Watanabe C, Saito Y, Kaji R
Organizer
30th International Symposium on ALS/MND
Related Report
Int'l Joint Research
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[Presentation] Safety and efficacy of alteplase in the treatment of extremely old patients of acute ischemic stroke.2017
Author(s)
Nishina Y, Komiya T, Motoyama R, Yamazaki M, Hiroyoshi Y, Higashihara M, Shibukawa M, Sunagawa M, Kato T, Takanashi S, Kouda S, Sengoku R, Kanemaru K, Murayama S.
Organizer
23th World Congress of Neurology 2017, Kyoto
Related Report
Int'l Joint Research
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[Presentation] 「ブレインバンク」ドナー登録者の意識－高齢遺族のグリーフケアにかかる予備的研究－．2017
Author(s)
小幡真希, 畠山幸子，松原知康, 坂下泰浩, 小林万希子, 高田忠幸, 東原真奈, 仙石錬平, 仁科裕史, 広吉祐子, 森島真帆，金丸和富, 古田 光, 新井冨生, 村山繁雄
Organizer
第36回日本認知症学会
Related Report
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[Presentation] The Establishment of the Biobank for Aging Research in Liason with the Brain Bank for Aging Research2016
Author(s)
Kaneda D, Sengoku R, Kanemaru K, Morimoto S, Nishina Y, Fujigasaki J, Tokumaru A, Ishii K, SaitoY, Murayama S
Organizer
The Alzheimer's Association International Conference
Place of Presentation
Metro Toronto Convention Centre, Totonto, Canada
Year and Date
2016-07-23
Related Report
Int'l Joint Research
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