| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
Energy-storing white adipocytes show unilocular large lipid droplet formation. We found that FSP27α, one of Cide family proteins that were localized on lipid droplet surface was mainly expressed in white adipocytes and this isoform contributes to the unilocular large lipid droplet formation in white adipocytes. In addition, we clarified that other Cide family proteins, CideA and FSP27β were mainly expressed in brown adipocytes and the heterodimerization of these two isoforms were important for the multilocular small lipid droplet formation in brown adipocytes.
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