| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
The roles of incretin/cAMP signaling and Epac2/Rap1 signaling in the protection of pancreatic β-cells were investigated. In a β-cell line, the activation of cAMP and Epac2 signaling suppressed production of reactive oxygen species (ROS) induced by alloxan and palmitate stimulations, suggesting that the role of cAMP and Epac2 signaling in the reduction of oxidative stress in pancreatic β-cells. From the generation and analyses of Epac2 deficient cell lines, we found a new isoform of Epac2 expressed in pancreatic β-cells, which may be involved in cellular functions other than insulin secretion such as the protection of β-cell against cellular stresses including oxidative stress.
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