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Regulation of human resistin gene expression by SNPs determining epigenetics and environmental factors

Research Project

Project/Area Number 16K09754
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Metabolomics
Research InstitutionEhime University

Principal Investigator

Osawa Haruhiko  愛媛大学, 医学系研究科, 教授 (90294800)

Co-Investigator(Kenkyū-buntansha) 大沼 裕  東京女子医科大学, 医学部, 准教授 (00294794)
高田 康徳  愛媛大学, 医学系研究科, 准教授 (20432792)
川村 良一  愛媛大学, 医学系研究科, 講師 (90533092)
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywordsレジスチン / インスリン抵抗性 / SNP / エピジェネティクス / 遺伝子発現 / 2型糖尿病 / 遺伝子 / 環境因子 / 糖尿病
Outline of Final Research Achievements

To examine the relation between serum resistin and environmental factors, we analyzed ~2000 Japanese subjects in the Toon Genome Study. Dietary nutrients were inferred from Food Frequency Questionnaire. Serum resistin was inversely associated with n-3 poly, unsaturated fatty acids intake. This association was strongest in the SNP-420 G/G genotype, suggesting gene-environment interaction.

Academic Significance and Societal Importance of the Research Achievements

一般住民の検診データベとースを構築し、サンプルを収集した。これにより、遺伝子・環境因子の臨床パラメータ―に対する影響を解析できるようになった。実際、摂取したn-3多価不飽和脂肪酸と血中レジスチンとの負の関連は、SNP-420の遺伝子型がG/G型の場合に最も強く、遺伝子・環境因子相互作用の一つのモデルを示すことができた。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (3 results)

All 2018 2017

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (2 results) (of which Invited: 1 results)

  • [Journal Article] An inverse association between serum resistin levels and n-3 polyunsaturated fatty acids intake was strongest in the SNP-420 G/G genotype in the Japanese cohort: The Toon Genome Study.2018

    • Author(s)
      Noumi Y. Kawamura R. Tabara Y. Maruyama K. Takata Y. Nishida W. Okamoto A. Nishimiya T. Onuma H. Saito I. Tanigawa T. Osawa H.
    • Journal Title

      Clin Endocrinol

      Volume: 88 Issue: 1 Pages: 51-57

    • DOI

      10.1111/cen.13500

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Presentation] SNP-420のメチル化率は、C/C型において血中レジスチン及びインスリン抵抗性と負に関連する「東温ゲノムスタディ」2018

    • Author(s)
      羽立登志美, 川村 良一, 田原 康玄, 高田 康徳, 高門 美沙季, 丸山 広達, 西田 亙, 松下 由実, 大沼 裕, 谷川 武, 斉藤 功, 大澤 春彦
    • Organizer
      第61回日本糖尿病学会年次学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] ヒトにおける血中レジスチン調節機構と体質2017

    • Author(s)
      大澤春彦
    • Organizer
      第67回日本体質医学会総会
    • Related Report
      2017 Research-status Report
    • Invited

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Published: 2016-04-21   Modified: 2020-03-30  

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