| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
When glucagon immunoassays were performed on plasma of proglucagon gene-deficient mice, positive reaction was undetected by sandwich ELISA, whereas detected in two different competitive immunoassay kits. On the other hand, in the gastric extract from proglucagon gene-deficient mice, positive reaction of the immunoassay was detected. Furthermore, by immunohistological analyses using various anti-glucagon antibodies in proglucagon-deficient mice, glucagon-positive cells have been observed in stomach. It is suggested that a glucagon like-molecule underived from proglucagon may be synthesized in the stomach.
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