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Pathophysiological involvement of brain fractalkine-CX3CR1 signal in obesity

Research Project

Project/Area Number 16K09788
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Metabolomics
Research InstitutionKagoshima University

Principal Investigator

Katsuura Goro  鹿児島大学, 医歯学総合研究科, 特任研究員 (20401226)

Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords肥満 / マイクログリア / fractalkine / CX3CR1 / 摂食調節 / 学習記憶 / 食事性肥満マウス / 脳内炎症 / ストレプトゾトシン / 海馬 / 神経科学
Outline of Final Research Achievements

Fractalkine-CX3CR1 signal plays an importatnt role in regulation of activities of the central nervous sytem. In the present study, the effects of fractalkine on food intake in mice were observed. The following results were obtained; (1) The mRNA expressions of fractalkineマイクログリアractalkine and CX3CR1 in the hypothalamus were significantly decreased after 48-hr fasting, and then returned to normal levels. The intracerevrobentricular (icv) administration of fractalkine significantly decreased food intake of refeeding.(2) The icv administration of fractalkine significantly deceased food intake of noctarnal phase. (3) The icv administration of fractalkine significantly deceased food intake induced by ghrelin and neuropeptide Y. These findings suggest that fractalkine-CX3CR1 signal has anorexigenic actions in mice.

Academic Significance and Societal Importance of the Research Achievements

肥満病態での中枢神経系のエネルギー調節機能について、神経細胞とマイクログリアの相互作用を明らかにすることによって、肥満に関連する機能異常のメカニズムを明らかにし、さらに、新規治療薬の開発にとっての基盤的情報を得ることができた。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (6 results)

All 2018 2017 2016

All Journal Article (1 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 1 results) Presentation (5 results)

  • [Journal Article] Brain-specific natriuretic peptide receptor-B deletion attenuates high-fat diet-induced visceral and hepatic lipid deposition in mice.2016

    • Author(s)
      Yamashita Y, Yamada-Goto N, Katsuura G, Ochi Y, Kanai Y, Miyazaki Y, Kuwahara K, Kanamoto N, Miura M, Yasoda A, Ohinata K, Inagaki N, Nakao K.
    • Journal Title

      Peptides

      Volume: 81 Pages: 38-50

    • DOI

      10.1016/j.peptides.2016.03.014

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] マウスの摂食調節に対するfractalkine-CX3CR1シグナルの作用2018

    • Author(s)
      河村菜実子、勝浦五郎、森永明倫、浅川明弘、乾 明夫
    • Organizer
      第91回日本内分泌学会学術総会
    • Related Report
      2017 Research-status Report
  • [Presentation] 脳内fractalkine-CX3CR1シグナル:1型糖尿病モデルマウスの学習記憶障害における病態生理的意義2017

    • Author(s)
      河村菜実子、勝浦五郎、森永明倫、浅川明弘、乾 明夫
    • Organizer
      第90回日本内分泌学会学術総会
    • Related Report
      2017 Research-status Report
  • [Presentation] 食事性肥満による脳内炎症に対するfractalkine-CX3CR1シグナルの作用2016

    • Author(s)
      河村菜実子、勝浦五郎、森永明倫、浅川明弘、乾明夫
    • Organizer
      第13回GPCR研究会
    • Place of Presentation
      日本科学未来館、未来館ホール(東京都江東区)
    • Year and Date
      2016-05-13
    • Related Report
      2016 Research-status Report
  • [Presentation] マイクログリアでのLPSによる炎症官能に対するfractalkine-CX3CR1シグナルの作用2016

    • Author(s)
      河村菜実子、勝浦五郎、森永明倫、浅川明弘、乾明夫
    • Organizer
      第89回日本内分泌学会学術総会
    • Place of Presentation
      国立京都国際会館(京都府京都市)
    • Year and Date
      2016-04-21
    • Related Report
      2016 Research-status Report
  • [Presentation] 高脂肪食摂取および絶食-再摂食による視床下部のfractalkineおよびCX3CR1の発現変化2016

    • Author(s)
      河村菜実子、勝浦五郎、森永明倫、浅川明弘、乾明夫
    • Organizer
      第37回日本肥満学会
    • Place of Presentation
      東京ファッションタウンビル(東京都江東区)
    • Related Report
      2016 Research-status Report

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Published: 2016-04-21   Modified: 2020-03-30  

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