| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Outline of Final Research Achievements |
Fractalkine-CX3CR1 signal plays an importatnt role in regulation of activities of the central nervous sytem. In the present study, the effects of fractalkine on food intake in mice were observed. The following results were obtained; (1) The mRNA expressions of fractalkineマイクログリアractalkine and CX3CR1 in the hypothalamus were significantly decreased after 48-hr fasting, and then returned to normal levels. The intracerevrobentricular (icv) administration of fractalkine significantly decreased food intake of refeeding.(2) The icv administration of fractalkine significantly deceased food intake of noctarnal phase. (3) The icv administration of fractalkine significantly deceased food intake induced by ghrelin and neuropeptide Y. These findings suggest that fractalkine-CX3CR1 signal has anorexigenic actions in mice.
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