Pathophysiological involvement of brain fractalkine-CX3CR1 signal in obesity
| Project/Area Number |
16K09788
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Metabolomics
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| Research Institution | Kagoshima University |
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Principal Investigator |
Katsuura Goro 鹿児島大学, 医歯学総合研究科, 特任研究員 (20401226)
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 肥満 / マイクログリア / fractalkine / CX3CR1 / 摂食調節 / 学習記憶 / 食事性肥満マウス / 脳内炎症 / ストレプトゾトシン / 海馬 / 神経科学 |
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| Outline of Final Research Achievements |
Fractalkine-CX3CR1 signal plays an importatnt role in regulation of activities of the central nervous sytem. In the present study, the effects of fractalkine on food intake in mice were observed. The following results were obtained; (1) The mRNA expressions of fractalkineマイクログリアractalkine and CX3CR1 in the hypothalamus were significantly decreased after 48-hr fasting, and then returned to normal levels. The intracerevrobentricular (icv) administration of fractalkine significantly decreased food intake of refeeding.(2) The icv administration of fractalkine significantly deceased food intake of noctarnal phase. (3) The icv administration of fractalkine significantly deceased food intake induced by ghrelin and neuropeptide Y. These findings suggest that fractalkine-CX3CR1 signal has anorexigenic actions in mice.
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| Academic Significance and Societal Importance of the Research Achievements |
肥満病態での中枢神経系のエネルギー調節機能について、神経細胞とマイクログリアの相互作用を明らかにすることによって、肥満に関連する機能異常のメカニズムを明らかにし、さらに、新規治療薬の開発にとっての基盤的情報を得ることができた。
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Report
(4 results)
Research Products
(6 results)
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[Journal Article] Brain-specific natriuretic peptide receptor-B deletion attenuates high-fat diet-induced visceral and hepatic lipid deposition in mice.2016
Author(s)
Yamashita Y, Yamada-Goto N, Katsuura G, Ochi Y, Kanai Y, Miyazaki Y, Kuwahara K, Kanamoto N, Miura M, Yasoda A, Ohinata K, Inagaki N, Nakao K.
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Journal Title
Peptides
Volume: 81
Pages: 38-50
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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