Abnormal Lipoprotein Metabolism in Sitosterolemia- Approach utilyzing Stable Isotole -

• Project/Area Number: 16K09790
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Metabolomics
• Research Institution: National Defense Medical College
• Principal Investigator: Ikewaki Katsunori 防衛医科大学校(医学教育部医学科進学課程及び専門課程、動物実験施設、共同利用研究施設、病院並びに防衛, 内科学, 教授 (40287199)
• Co-Investigator(Kenkyū-buntansha): 塩谷 一紗 防衛医科大学校(医学教育部医学科進学課程及び専門課程、動物実験施設、共同利用研究施設、病院並びに防衛, 内科学, 助教 (20773641)
• Project Period (FY): 2016-04-01 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2018: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: シトステロール血症 / アポ蛋白B / LDL / 安定同位体 / トレーサー / 異化 / 産生 / シトステロール / 代謝

Outline of Final Research Achievements

In this project, we performed kinetic studies using stable isotope in 3 homozygous patients with sitosterolemia. We found that there were no significant changes in VLDL apoB kinetic parameters, but there were marginally elevated LDL apoB concentration which were due to significantly delayed rates of catabolism. In conclusions, sitosterolemia is associated with impaired LDL apoB catabolism, resulting in elevated LDL apoB concentrations. While VLDL and IDL apoB metabolism are preserved in sitosterolemia.

Academic Significance and Societal Importance of the Research Achievements

シトステロール血症は平成27年難病してされ、国としても病態解明に注力している疾患である。本研究は、世界で初めての試みで、シトステロール血症でLDLの代謝障害があることを見いだした。今後、この知見に基づいた治療への展開が期待される。

Research Products

• [Journal Article] Apolipoprotein C-II Mimetic Peptide Promotes the Plasma Clearance of Triglyceride-Rich Lipid Emulsion and the Incorporation of Fatty Acids into Peripheral Tissues of Mice. (2019)
  • Author(s): Komatsu T, Sakurai T, Wolska A, Amar MJ, Sakurai A, Vaisman BL, Sviridov D, Demosky S, Pryor M, Ikewaki K, Remaley AT.
  • Journal Title: J Nutr Metab Volume: 00
  • Peer Reviewed
• [Journal Article] Dietary Intake during 56 Weeks of a Low-Fat Diet for Lomitapide Treatment in Japanese Patients with Homozygous Familial Hypercholesterolemia (2019)
  • Author(s): Kameyama N, Maruyama C, Kitagawa F, Nishii K, Uenomachi K, Katayama Y, Koga H, Chikamoto N, Kuwata Y, Torigoe J, Arimoto M, Tokumaru T, Ikewaki K, Nohara A, Otsubo Y, Yanagi K, Yoshida M, Harada-Shiba M
  • Journal Title: J Atheroscler Thromb Volume: 26 Pages: 72-83
  • NAID: 130007542027
  • Peer Reviewed
• [Journal Article] Safety and Efficacy of Lomitapide in Japanese Patients with Homozygous Familial Hypercholesterolemia (HoFH): Results from the AEGR-733-301 Long-Term Extension Study (2019)
  • Author(s): Nohara A, Otsubo Y, Yanagi K, Yoshida M, Ikewaki K, Harada-Shiba M, Jurecka A
  • Journal Title: J Atheroscler Thromb Volume: 26 Pages: 368-77
  • NAID: 130007621868
• [Journal Article] Postprandial Hyperlipemia is an Indication for Additional Risk in Sitosterolemia (2018)
  • Author(s): Ito M, Ikewaki K
  • Journal Title: J Atheroscler Thromb Volume: 25 Pages: 1183-4
  • NAID: 130007539349
• [Journal Article] Hepatic Overexpression of Endothelial Lipase Induces a Markedly Low HDL-Cholesterol but Maintains Macrophage Reverse Cholesterol Transport in Mice: Role of SR-BI/ABCA1-dependent pathways (2018)
  • Author(s): Takiguchi S, Ayaori M, Yakushiji E, Nakaya K, Sasaki M, Iizuka M, Uto-Kondo H, Terao Y, Yogo M, Komatsu T, Ogura M, Ikewaki K
  • Journal Title: Arterioscler Thromb Vasc Biol. Volume: 38 Pages: 1454-67
• [Journal Article] Should Measures of High-Density Lipoprotein Function Be Added to the Low-Density Lipoprotein Cholesterol Target Level-Based Guidelines for Prevention of Atherosclerotic Disease? (2018)
  • Author(s): Sakuma I, Ikewaki K
  • Journal Title: Circ J Volume: 82 Pages: 1251-2
  • NAID: 130006726014
• [Journal Article] Vitamin E supplementation improves high-densitiy lipoprotein and endothelial functions in end-stage kidney disease patients undergoing hemodialysis (2018)
  • Author(s): Mune M, Uto-Kondo H, Iteya I, Fujii Y, Ikeda S, Ikewaki K
  • Journal Title: Clin Nephrol Volume: 90 Pages: 212-21
• [Journal Article] Microbiota and HDL metabolism (2018)
  • Author(s): Nakaya K, Ikewaki K.
  • Journal Title: Curr Opin Lipidol. Volume: 29 Issue: 1 Pages: 18-23
  • DOI: 10.1097/mol.0000000000000472
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Vitamin E supplementation improves high-densitiy lipoprotein and endothelial functions in end-stage kidney disease patients undergoing hemodialysis (2018)
  • Author(s): Mune M, Uto-Kondo H, Iteya I, Fujii Y, Ikeda S, Ikewaki K.
  • Journal Title: Clin Nephrol. Volume: 印刷中 Issue: 3 Pages: 212-221
  • DOI: 10.5414/cn109197
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Should Measures of High-Density Lipoprotein Function Be Added to the Low-Density Lipoprotein Cholesterol Target Level-Based Guidelines for Prevention of Atherosclerotic Disease? (2018)
  • Author(s): Sakuma I, Ikewaki K.
  • Journal Title: Circulation Journal Volume: 82 Issue: 5 Pages: 1251-1252
  • DOI: 10.1253/circj.CJ-18-0358
  • NAID: 130006726014
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Hepatic Overexpression of Endothelial Lipase Induces a Markedly Low HDL-Cholesterol but Maintains Macrophage Reverse Cholesterol Transport in Mice: Role of SR-BI/ABCA1-dependent pathways (2018)
  • Author(s): Takiguchi S, Ayaori M, Yakushiji E, Nakaya K, Sasaki M, Iizuka M, Uto-Kondo H, Terao Y, Yogo M, Komatsu T, Ogura M, IkewakiK
  • Journal Title: Arterioscler Thromb Vasc Biol. Volume: 印刷中
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Efficacy and Safety of Lomitapide in Japanese Patients with Homozygous Familial Hypercholesterolemia (2017)
  • Author(s): Harada-Shiba M, Ikewaki K, Nohara A, Otsubo Y, Yanagi K, Yoshida M, Chang Q, Foulds P.
  • Journal Title: Journal of Atherosclerosis and Thrombosis Volume: 24 Issue: 4 Pages: 402-411
  • DOI: 10.5551/jat.38216
  • NAID: 130005529958
  • ISSN: 1340-3478, 1880-3873
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] A New Frontier for Reverse Cholesterol Transport: The Impact of Intestinal Microbiota on Reverse Cholesterol Transport. (2017)
  • Author(s): Nakaya K, Takiguchi S, Ikewaki K.
  • Journal Title: Arterioscler Thromb Vasc Biol. Volume: 37 Issue: 3 Pages: 385-6
  • DOI: 10.1161/atvbaha.117.309006
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Massive Hemoptysis due to Right Inferior Phrenic Artery-to-Right Pulmonary Artery Fistula in the Right Middle Lobe of the Lung (2017)
  • Author(s): Yakushiji E, Ota S, Komatsu T, Ayaori M, Ikewaki K.
  • Journal Title: Internal Medicine Volume: 56 Issue: 6 Pages: 687-689
  • DOI: 10.2169/internalmedicine.56.6783
  • NAID: 130005450388
  • ISSN: 0918-2918, 1349-7235
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Lipid-modifying efficacy and tolerability of anacetrapib added to ongoing statin therapy in Japanese patients with dyslipidemia. (2017)
  • Author(s): Teramoto T, Daida H, Ikewaki K, Arai H, Maeda Y, Nakagomi M, Shirakawa M, Watanabe Y, Kakikawa T, Numaguchi H, Johnson-Levonas AO, Blaustein RO.
  • Journal Title: Atherosclerosis Volume: 261 Pages: 69-77
  • DOI: 10.1016/j.atherosclerosis.2017.03.009
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Xanthohumol, a hop-derived prenylated flavonoid, promotes macrophage reverse cholesterol transport. (2017)
  • Author(s): Hirata H, Uto-Kondo H, Ogura M, Ayaori M, Shiotani K, Ota A, Tsuchiya Y, Ikewaki K.
  • Journal Title: J Nutr Biochem. Volume: 47 Pages: 29-34
  • DOI: 10.1016/j.jnutbio.2017.04.011
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Probucol-Oxidized Products, Spiroquinone and Diphenoquinone, Promote Reverse Cholesterol Transport in Mice (2016)
  • Author(s): Yakushiji E, Ayaori M, Nishida T, Shiotani K, Takiguchi S, Nakaya K, Uto-Kondo H, Ogura M, Sasaki M, Yogo M, Komatsu T, Lu R, Yokoyama S, Ikewaki K
  • Journal Title: Arterioscler Thromb Vasc Biol Volume: 36 Issue: 4 Pages: 591-597
  • DOI: 10.1161/atvbaha.115.306376
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Beneficial Effects of Exercise-Based Cardiac Rehabilitation on High-Density Lipoprotein-Mediated Cholesterol Efflux Capacity in Patients with Acute Coronary Syndrome (2016)
  • Author(s): Koba S, Ayaori M, Uto-Kondo H, Furuyama F, Yokota Y, Tsunoda F, Shoji M, Ikewaki K, Kobayashi Y.
  • Journal Title: Journal of Atherosclerosis and Thrombosis Volume: 23 Issue: 7 Pages: 865-877
  • DOI: 10.5551/jat.34454
  • NAID: 130005160386
  • ISSN: 1340-3478, 1880-3873
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Repeated treatments with rituximab in a patient with amyloid-like IgM deposition neuropathy. (2016)
  • Author(s): Masato Kadoya, Akiko Kadoya, Hiroyuki Onoue, Katsunori Ikewaki, Jun Shimizu, Kenichi Kaida
  • Journal Title: Neurol Neuroimmunol Neuroinflamm Volume: 3 Issue: 3 Pages: 220-220
  • DOI: 10.1212/nxi.0000000000000220
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Efficacy and safety of the cholesteryl ester transfer protein inhibitor anacetrapib in Japanese patients with heterozygous familial hypercholesterolemia. (2016)
  • Author(s): Arai H, Teramoto T, Daida H, Ikewaki K, Maeda Y, Nakagomi M, Shirakawa M, Kakikawa T, Numaguchi H, Johnson-Levonas AO, Vaidya S, Blaustein RO.
  • Journal Title: Atherosclerosis Volume: 249 Pages: 215-23
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] IgG4 anti-neurofascin155 antibodies in chronic inflammatory demyelinating polyradiculoneuropathy: Clinical significance and diagnostic utility of a conventional assay. (2016)
  • Author(s): Kadoya M, Kaida K, Koike H, Takazaki H, Ogata H, Moriguchi K, Shimizu J, Nagata E, Takizawa S, Chiba A, Yamasaki R, Kira JI, Sobue G, Ikewaki K.
  • Journal Title: J Neuroimmunol. Volume: 15 Pages: 16-22
  • DOI: 10.1016/j.jneuroim.2016.10.013
  • Peer Reviewed / Int'l Joint Research
• [Presentation] Impaired High-density Lipoprotein Cholesterol Ef- flux Capacity for Development of Denovo Coro- nary Stenosis under Pharmacological Secondary Prevention for Coronary Artery Disease (2019)
  • Author(s): Ukaji T, Ishikawa T, Koshikawa Y, , Satoh H, Yamada K, Nishiyama N, Kudoh A, Fukuda R, Ogino Y, Hori Y, Hisauchi T, Nakahara S, Kobayashi S, Sakai Y, Taguchi I, Nakajima T, Mutoh M, Ikewaki K
  • Organizer: 第83回日本循環器学会学術集会
• [Presentation] High-density Lipoprotein Cholesterol Efflux Capacity as a Relevant Predictor of Major Adverse Cardiac Events in Patients with Coronary Artery Disease. (2019)
  • Author(s): Nakamura H, Ishikawa T, Koshikawa Y, Ukaji T, Satoh H, Yamada K, Nishiyama N, Kudoh A, Fukuda R, Ogino Y, Hori Y, Hisauchi T, Nakahara S, Kobayashi S, Sakai Y, Taguchi I, Nakajima T, Mutoh M, Ikewaki K
  • Organizer: 第83回日本循環器学会学術集会
• [Presentation] 重度肺高血圧症合併のため治療に難渋した甲状腺機能低下症の1例 (2019)
  • Author(s): 星野賢人 遠藤康弘、川先康太、寺本麻菜美、荒川 純子、佐々木誠、池脇克則
  • Organizer: 第69回日本老年医学会関東甲信越地方会
• [Presentation] 「日本食」摂取の血中カロテノイドとトコフェロール濃度への影響：脂質異常症における検討 (2019)
  • Author(s): 梅澤愛理子、丸山千寿子、四條裕里、亀山詞子、佐藤愛紗、小玉真由香、北山はづき、藤谷桐香、西谷藍、綾織誠人、池脇克則、脇昌子、寺本民生
  • Organizer: 第73回栄養食糧学会
• [Presentation] 脂質異常症患者における「日本食」摂取が血清リン脂質中脂肪酸組成に及ぼす影響―無作為化比較介入試験― (2019)
  • Author(s): 佐藤愛紗、梅澤愛理子、丸山千寿子、四條裕里、亀山詞子、小玉真由香、北山はづき、藤谷桐香、西谷藍、綾織誠人、池脇克則、脇昌子、寺本民生
  • Organizer: 第22回日本病態栄養学会年次学術集会
• [Presentation] 脂質異常症患者における栄養指導前の食品および栄養素等摂取量の実態 (2019)
  • Author(s): 亀山詞子、佐藤愛紗、梅澤愛理子、丸山千寿子、四條裕里、小玉真由香、北山はづき、藤谷桐香、西谷藍、綾織誠人、池脇克則、脇昌子、寺本民生
  • Organizer: 第22回日本病態栄養学会年次学術集会
• [Presentation] キサンチンオキシダーゼ阻害薬Febxostatは高尿酸血症患者の血管内皮機能を改善する (2018)
  • Author(s): 荒川純子、綾織誠人、佐々木誠、末永由美子、遠藤康弘、桜田真巳、池脇克則
  • Organizer: 第22回日本適応医学会学術集会
• [Presentation] Reverse Cholesterol Transport is Maintained Despite Knockdown of CYP27A1 in Mice (2018)
  • Author(s): Arakawa J, Ayaori M, Nishida T, Sasaki M, Suenaga Y, Nita R, Ikewaki K
  • Organizer: American Heart Association Scientific Sessions 2018
  • Int'l Joint Research
• [Presentation] A Xanthine Oxidase Inhibitor Febuxostat Improves Endothelial Function as Evaluated by Flow-Mediated Vasodilatation in Hyperuricemic Patients (2018)
  • Author(s): Arakawa J, Ayaori M, Nishida T, Sasaki M, Komatsu T, Suenaga T, Nita R, Uto-Kondo H, Sakurada M, Ikewaki K
  • Organizer: American Heart Association Scientific Sessions 2018
  • Int'l Joint Research
• [Presentation] 超音波検査に下肢MRIを追加することで診断し得たベーカー嚢腫破裂の1例 (2018)
  • Author(s): 和泉香織、西田尚史、綾織誠人、荒川純子、佐々木誠、池脇克則
  • Organizer: 第68回日本老年医学会関東甲信越地方会
• [Presentation] 脂質異常症患者における食品および栄養素等摂取量の実態 (2018)
  • Author(s): 亀山詞子、丸山千寿子、四條裕里、梅澤愛理子、大鹿碧友、シャスファイ、松本萌、山田 皐文、西谷藍、綾織誠人、池脇克則、脇昌子、寺本民生
  • Organizer: 第50回日本動脈硬化学会総会・学術集会
• [Presentation] 日本食」摂取が体格・脂質代謝指標に及ぼす影響—脂質異常症患者における無作為化比較介入試験中間報告— (2018)
  • Author(s): 四條裕里、丸山千寿子、亀山詞子、梅澤愛理子、佐藤愛紗、中澤真梨子、西形ゆい、寺本藍、綾織誠人、池脇克則、脇昌子、寺本民生
  • Organizer: 第50回日本動脈硬化学会総会・学術集会
• [Presentation] 禁煙による血中CRPおよびS100A12濃度の低下効果―バレニクリンによる禁煙がHDL機能および循環性炎症マーカーに及ぼす影響― (2018)
  • Author(s): 仁田玲子、荒川純子、末永由美子、綾織誠人、池脇克則
  • Organizer: 第50回日本動脈硬化学会総会・学術集会
• [Presentation] Renin-angiotensin system inhibition by olmesartan and imidapril both promote endothelial function and reduce circulating aldosterone levels in hypertensive patients: results of a randomized crossover trial. (2018)
  • Author(s): Ito M,Ayaori M, Takiguchi S, Sasaki M, Ikewaki K
  • Organizer: 第50回日本動脈硬化学会総会・学術集会
• [Presentation] Hepatic LXRs promote reverse cholesterol transport in cholesterol-fed mice (2018)
  • Author(s): Nishida T, Ayaori M, Arakawa J, Suenaga Y, Shiotani K, Kondo H,Sasaki M, Komatsu T, Endo Y, Ito M, Ishizuka M, Ikewaki K
  • Organizer: 第50回日本動脈硬化学会総会・学術集会
• [Presentation] 禁煙による血中CRPおよびS100A12濃度の低下効果 (2018)
  • Author(s): 仁田玲子、荒川純子、末永由美子、綾織誠人、池脇克則
  • Organizer: 第72回日本栄養・食糧学会大会
• [Presentation] Aminolevulinic acid attenuates atherosclerotic plaque progression of LDL receptor deficient mice by an antioxidant action (2017)
  • Author(s): Hagisawa Kohsuke, Morimoto Yuji, Naka jima Masahiro, Ayaori Makoto, Ikewaki Katsunori
  • Organizer: American Heart Asso- ciation Scientific Sessions 2017
  • Int'l Joint Research
• [Presentation] 肝臓 Liver X 受容体シグナルはマウス血中 HDLコステロール濃度およひ&コレステロール逆転送を正に制御する (2017)
  • Author(s): 荒川 純子, 西田尚文, 綾織 誠人, 遠藤康弘, 末永由美子, 池脇 克則
  • Organizer: 第 39 回日本臨床栄養学 会総会
• [Presentation] HDL 機能検査法について 脂質 異常症診療のupdate (2017)
  • Author(s): 佐々木 誠, 西田尚文, 荒川 純子, 末永由美 子, 綾織 誠人, 池脇 克則
  • Organizer: 第 49 回日本動脈硬化学会総会学術集会
  • Invited
• [Presentation] 低脂肪食事療法を継続した家族性高コレステロール血 症ホモ接合体患者の食事摂取状況の検討 (2017)
  • Author(s): 亀山詞子, 丸山千寿子, 近本直子, 桒田裕子, 鳥越純子, 有本正子, 徳丸季聡, 池脇 克則, 野原淳, 大坪義彦, 柳光司, 吉田雅幸, 斯波真理子
  • Organizer: 第 49 回日本動脈硬化学 会総会学術集会
• [Presentation] S100A12の動脈炎症および血清脂質に及ぼす影響についての検討 (2016)
  • Author(s): 小松知広、綾織誠人、西田尚史、佐々木誠、遠藤康弘、荒川純子、末永由美子、塩谷一紗、池脇克則
  • Organizer: 第20回日本適応医学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2016-12-16
• [Presentation] 2型糖尿病患者における血糖コントロール前後のFGF19の変化及びLDL-Cとの関連 (2016)
  • Author(s): 伊藤美沙、鈴木節、池脇克則、伊藤利光
  • Organizer: 第20回日本適応医学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2016-12-16
• [Presentation] SD-LDL濃度に及ぼすADRB3(Trp64Arg)変異と食習慣の関連について (2016)
  • Author(s): 伊藤利光、上野美紀、鈴木節、池脇克則、作田英成
  • Organizer: 第20回日本適応医学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2016-12-16
• [Presentation] HDL-Cの意義を再考する - 量から質へのパラダイムシフト - (2016)
  • Author(s): 池脇克則、佐々木誠、塩谷一紗、綾織誠人
  • Organizer: 第64回日本心臓病学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2016-09-23
  • Invited
• [Presentation] Lomitapide Efficacy and Safety in Japanese Patients with Homozygous Familial Hypercholesterolemia on Concurrent Lipid-Lowering Therapy (2016)
  • Author(s): 223.Mariko Harada-Shiba, Masayuki Yoshida, Katsunori Ikewaki, Atsushi Nohara, Koji Yanagi, Yoshihiko Otsubo, Pamela Foulds
  • Organizer: The 48th Annual Scientific Meeting of the Japan Atherosclerosis Society
  • Place of Presentation: 東京
  • Year and Date: 2016-07-14
• [Presentation] Novel Agents on the Horizon for Dyslipidemia (2016)
  • Author(s): Katsunori Ikewaki, Makoto Sasaki
  • Organizer: The 48th Annual Scientific Meeting of the Japan Atherosclerosis Society
  • Place of Presentation: 東京
  • Year and Date: 2016-07-14
  • Invited
• [Presentation] Probucol oxidized products, spiroquinone and diphenoquinone, promote reverse cholesterol transport in mice. (2016)
  • Author(s): 220.Shiotani K, Yakushiji E, Ayaori M, Nishida T, Takiguchi T, Uto-Kondo H, Sasaki M, Yogo M, Komatsu T, Lu R, Yokoyama S, Ikewaki K
  • Organizer: The 84th Congress of the European Atherosclerosis Society
  • Place of Presentation: インスブルク
  • Year and Date: 2016-05-29
  • Int'l Joint Research
• [Presentation] Beneficial effect of azilsartan and amlodipine on endothelial function in hypertensive patients. (2016)
  • Author(s): 221.Nishida T, Ayaori1 M, Shiotani K, Uto-Kondo H, Sasaki M, Komatsu T, Endo Y, Ito M, Ishizuka M, Sakurada M, Ikewaki K
  • Organizer: The 84th Congress of the European Atherosclerosis Society
  • Place of Presentation: インスブルク
  • Year and Date: 2016-05-29
  • Int'l Joint Research
• [Presentation] Xanthohumol, a prenylated flavonoid in hops, promotes macrophage reverse cholesterol transport in hamster. (2016)
  • Author(s): 222.H Hirata, H Uto-Kondo, M Ogura, M. Ayaori, K Ikewaki
  • Organizer: The 84th Congress of the European Atherosclerosis Society
  • Place of Presentation: インスブルク
  • Year and Date: 2016-05-29
  • Int'l Joint Research
• [Book] 高TG血症 (2018)
  • Author(s): 佐々木誠、池脇克則
  • Total Pages: 200
  • Publisher: 最新医学社
• [Book] 糖尿病治療薬 クリニカルクエスチョン (2016)
  • Author(s): 池脇 克則、遠藤 康弘
  • Total Pages: 249
  • Publisher: 診断と治療社
• [Book] そうだったんだ！脂質異常症 (2016)
  • Author(s): 伊藤美沙、池脇克則
  • Total Pages: 250
  • Publisher: 文光堂
• [Book] そうだったんだ！脂質異常症 (2016)
  • Author(s): 遠藤康弘、池脇克則
  • Total Pages: 250
  • Publisher: 37.遠藤康弘、池脇克則