Related elucidation of the tissue-specific pudding metabolism state and lifestyle-related disease
Project/Area Number |
16K09791
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Metabolomics
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Research Institution | The Institute for Adult Diseases Asahi Life Foundation |
Principal Investigator |
Kushiyama Akifumi 公益財団法人朝日生命成人病研究所, その他部局等, 教授(移行) (30435820)
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Research Collaborator |
SAKODA Hideyuki 宮崎大学, 第三内科, 講師
ASANO Tomoichiro 広島大学, 大学院医歯薬保健学研究院, 教授
KURIHARA Hiroki 東京大学, 大学院・医学系研究科, 教授
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Project Period (FY) |
2016-04-01 – 2019-03-31
|
Project Status |
Completed (Fiscal Year 2018)
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Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
Keywords | 尿酸代謝 / 核酸代謝 / 生活習慣病 / キサンチンオキシダーゼ / プリン体代謝異常 |
Outline of Final Research Achievements |
Five types of tissue-specific XORKO mice were generated and XOR activities in each organ and in plasma were examined. XOR activity was respectively reduced in bone marrow and spleen, in various organs such as vascular endothelium, in liver, in white and brown fat, and in small intestine. The plasma XOR activity was significantly reduced when bone marrow or liver XOR activities were reduced, and tended to be slightly reduced when XOR activity in small intestine was reduced. Mice with decreased XOR activity in bone marrow were excellent in glucose tolerance and showed a decrease in brown fat weight, but this lipid burning was considered to be UCP-1 independent.
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Academic Significance and Societal Importance of the Research Achievements |
キサンチンオキシダーゼ阻害がインスリン抵抗性・慢性炎症・脂肪蓄積に直接的に作用することが示唆される結果となった。尿酸値と臓器障害の関係は長年研究されていて不明とされていた機序の解明の端緒となるであろうし、尿酸値よりも尿酸産生に着目すべきという医療行政上のインパクトがもたらされたと考えられる。
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Report
(4 results)
Research Products
(49 results)
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[Journal Article] Prolyl Isomerase Pin1 Suppresses Thermogenic Programs in Adipocytes by Promoting Degradation of Transcriptional Co-activator PRDM16.2019
Author(s)
Nakatsu Y, Matsunaga Y, Yamamotoya T, Ueda K, Inoue MK, Mizuno Y, Nakanishi M, Sano T, Yamawaki Y, Kushiyama A, Sakoda H, Fujishiro M, Ryo A, Ono H, Minamino T, Takahashi SI, Ohno H, Yoneda M, Takahashi K, Ishihara H, Katagiri H, Nishimura F, Kanematsu T, Yamada T, Asano T.
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Journal Title
Cell Rep.
Volume: 26
Issue: 12
Pages: 3221-3230
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Development of Pin1 inhibitors and their potential as therapeutic agents.2018
Author(s)
Nakatsu Y, Matsunaga Y, Ueda K, Yamamotoya T, Inoue Y, Inoue MK, Mizuno Y, Kushiyama A, Ono H, Fujishiro M, Ito H, Okabe T, Asano T.
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Journal Title
Curr Med Chem
Volume: -
Issue: 20
Pages: 1-1
DOI
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Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Gut microbiota as a therapeutic target for metabolic disorders.2018
Author(s)
Okubo H, Nakatsu Y, Kushiyama A, Yamamotoya T, Matsunaga Y, Inoue MK, Fujishiro M, Sakoda H, Ohno H, Yoneda M, Ono H, Asano T.
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Journal Title
Curr Med Chem.
Volume: 25
Issue: 9
Pages: 984-1001
DOI
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Peer Reviewed / Open Access
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[Journal Article] Trk-fused gene (TFG) regulates pancreatic β cell mass and insulin secretory activity.2017
Author(s)
Yamamotoya T, Nakatsu Y, Kushiyama A, Matsunaga Y, Ueda K, Inoue Y, Inoue MK, Sakoda H, Fujishiro M, Ono H, Kiyonari H, Ishihara H, Asano T.
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Journal Title
Sci Rep.
Volume: 7
Issue: 1
Pages: 1-13
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Glial fibrillary acidic protein (GFAP) is a novel biomarker for the prediction of autoimmune diabetes.2017
Author(s)
Pang Z, Kushiyama A, Sun J, Kikuchi T, Yamazaki H, Iwamoto Y, Koriyama H, Yoshida S, Shimamura M, Higuchi M, Kawano T, Takami Y, Rakugi H, Morishita R, Nakagami H.
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Journal Title
FASEB J.
Volume: 31
Issue: 9
Pages: 4053-4063
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] The SGLT2 Inhibitor Luseogliflozin Rapidly Normalizes Aortic mRNA Levels of Inflammation-Related but Not Lipid-Metabolism-Related Genes and Suppresses Atherosclerosis in Diabetic ApoE KO Mice.2017
Author(s)
Yusuke Nakatsu, Hiroki Kokubo, Batmunkh Bumdelger, Masao Yoshizumi, Takeshi Yamamotoya, Yasuka Matsunaga, Koji Ueda, Yuki Inoue, Masa-Ki Inoue, Midori Fujishiro, Akifumi Kushiyama, Hiraku Ono, Hideyuki Sakoda, and Tomoichiro Asano
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Journal Title
International Journal of Molecular Sciences
Volume: 18(8)
Issue: 8
Pages: 1704-1717
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] The prolyl isomerase Pin1 increases β-cell proliferation and enhances insulin secretion2017
Author(s)
Nakatsu Y, Mori K, Matsunaga Y, Yamamotoya T, Ueda K, Inoue Y, Mitsuzaki-Miyoshi K, Sakoda H, Fujishiro M, Yamaguchi S, Kushiyama A, Ono H, Ishihara H, Asano T.
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Journal Title
J Biol Chem.
Volume: 292
Issue: 28
Pages: 11886-11895
DOI
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Peer Reviewed / Open Access
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[Journal Article] Role of Uric Acid Metabolism-Related Inflammation in the Pathogenesis of Metabolic Syndrome Components Such as Atherosclerosis and Nonalcoholic Steatohepatitis.2016
Author(s)
Kushiyama A, Nakatsu Y, Matsunaga Y, Yamamotoya T, Mori K, Ueda K, Inoue Y, Sakoda H, Fujishiro M, Ono H, Asano T.
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Journal Title
Mediators Inflamm.
Volume: 2016
Pages: 8603164-8603164
DOI
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Peer Reviewed / Open Access
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[Journal Article] C-Peptide Level in Fasting Plasma and Pooled Urine Predicts HbA1c after Hospitalization in Patients with Type 2 Diabetes Mellitus.2016
Author(s)
Sonoda R, Tanaka K, Kikuchi T, Onishi Y, Takao T, Tahara T, Yoshida Y, Suzawa N, Kawazu S, Iwamoto Y, Kushiyama A.
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Journal Title
PLoS One.
Volume: 11
Issue: 2
Pages: e0147303-e0147303
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Involvement of resistin-like molecule β in the development of methionine-choline deficient diet-induced non-alcoholic steatohepatitis in mice.2016
Author(s)
Okubo H, Kushiyama A, Sakoda H, Nakatsu Y, Iizuka M, Taki N, Fujishiro M, Fukushima T, Kamata H, Nagamachi A, Inaba T, Nishimura F, Katagiri H, Asahara T, Yoshida Y, Chonan O, Encinas J, Asano T.
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Journal Title
Sci Rep.
Volume: 6
Issue: 1
Pages: 20157-20157
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Physiological and Pathogenic Roles of Prolyl Isomerase Pin1 in Metabolic Regulations via Multiple Signal Transduction Pathway Modulations.2016
Author(s)
Nakatsu Y, Matsunaga Y, Yamamotoya T, Ueda K, Inoue Y, Mori K, Sakoda H, Fujishiro M, Ono H, Kushiyama A, Asano T.
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Journal Title
Int J Mol Sci.
Volume: 17 (9)
Issue: 9
Pages: 1495-1495
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] Role of xanthine oxidoreductase from mesenchymal cells in retinal inflammation after pericyte breakdown2018
Author(s)
AKIFUMI KUSHIYAMA, TAKAKO KIKUCHI, HIROKI YAMAZAKI, TAKESHI YAMAMOTOYA, HIDEYUKI SAKODA, MIDORI FUJISHIRO, YUSUKE NAKATSU, AKIYOSHI UEMURA, TAKASHI SHIRAKURA, TOMOICHIRO ASANO, YASUHIKO IWAMOTO
Organizer
ADA American Diabetes Association 78th Scientific Sessions
Related Report
Int'l Joint Research
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[Presentation] マクロファージ由来キサンチン酸化還元酵素の代謝・熱産生への関与2018
Author(s)
櫛山 暁史, 菊池 貴子, 藤城 緑, 迫田 秀之, 中村 敬志, 村瀬 貴代, 松永 泰花, 山本屋 武, 中津 祐介, 浅野 知一郎, 岩本 安彦
Organizer
第61回日本糖尿病学会年次学術集会
Related Report
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[Presentation] 糖尿病専門医院における患者背景のデータベース構築2017
Author(s)
米川拓渡, 沖村悠希, 梶山里奈, 小泉聖人,仙石悠紀子,宮下紗季,森田修司,金井紀仁,櫛山暁史,山崎広貴,菊池貴子, 赤沢学
Organizer
日本薬学会第137年会
Related Report
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