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Related elucidation of the tissue-specific pudding metabolism state and lifestyle-related disease

Research Project

Project/Area Number 16K09791
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Metabolomics
Research InstitutionThe Institute for Adult Diseases Asahi Life Foundation

Principal Investigator

Kushiyama Akifumi  公益財団法人朝日生命成人病研究所, その他部局等, 教授(移行) (30435820)

Research Collaborator SAKODA Hideyuki  宮崎大学, 第三内科, 講師
ASANO Tomoichiro  広島大学, 大学院医歯薬保健学研究院, 教授
KURIHARA Hiroki  東京大学, 大学院・医学系研究科, 教授
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords尿酸代謝 / 核酸代謝 / 生活習慣病 / キサンチンオキシダーゼ / プリン体代謝異常
Outline of Final Research Achievements

Five types of tissue-specific XORKO mice were generated and XOR activities in each organ and in plasma were examined. XOR activity was respectively reduced in bone marrow and spleen, in various organs such as vascular endothelium, in liver, in white and brown fat, and in small intestine. The plasma XOR activity was significantly reduced when bone marrow or liver XOR activities were reduced, and tended to be slightly reduced when XOR activity in small intestine was reduced.
Mice with decreased XOR activity in bone marrow were excellent in glucose tolerance and showed a decrease in brown fat weight, but this lipid burning was considered to be UCP-1 independent.

Academic Significance and Societal Importance of the Research Achievements

キサンチンオキシダーゼ阻害がインスリン抵抗性・慢性炎症・脂肪蓄積に直接的に作用することが示唆される結果となった。尿酸値と臓器障害の関係は長年研究されていて不明とされていた機序の解明の端緒となるであろうし、尿酸値よりも尿酸産生に着目すべきという医療行政上のインパクトがもたらされたと考えられる。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (49 results)

All 2019 2018 2017 2016 Other

All Int'l Joint Research (1 results) Journal Article (21 results) (of which Int'l Joint Research: 11 results,  Peer Reviewed: 21 results,  Open Access: 21 results,  Acknowledgement Compliant: 2 results) Presentation (25 results) (of which Int'l Joint Research: 4 results,  Invited: 4 results) Book (1 results) Remarks (1 results)

  • [Int'l Joint Research] コロラド大学(米国)

    • Related Report
      2017 Research-status Report
  • [Journal Article] Prolyl isomerase Pin1 binds to and stabilizes acetyl CoA carboxylase 1 protein, thereby supporting cancer cell proliferation2019

    • Author(s)
      Ueda Koji、Nakatsu Yusuke、Yamamotoya Takeshi、Ono Hiraku、Inoue Yuki、Inoue Masa-Ki、Mizuno Yu、Matsunaga Yasuka、Kushiyama Akifumi、Sakoda Hideyuki、Fujishiro Midori、Takahashi Shin-Ichiro、Matsubara Akio、Asano Tomoichiro
    • Journal Title

      Oncotarget

      Volume: 10 Issue: 17 Pages: 1637-1648

    • DOI

      10.18632/oncotarget.26691

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Prolyl Isomerase Pin1 Suppresses Thermogenic Programs in Adipocytes by Promoting Degradation of Transcriptional Co-activator PRDM16.2019

    • Author(s)
      Nakatsu Y, Matsunaga Y, Yamamotoya T, Ueda K, Inoue MK, Mizuno Y, Nakanishi M, Sano T, Yamawaki Y, Kushiyama A, Sakoda H, Fujishiro M, Ryo A, Ono H, Minamino T, Takahashi SI, Ohno H, Yoneda M, Takahashi K, Ishihara H, Katagiri H, Nishimura F, Kanematsu T, Yamada T, Asano T.
    • Journal Title

      Cell Rep.

      Volume: 26 Issue: 12 Pages: 3221-3230

    • DOI

      10.1016/j.celrep.2019.02.066

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Alpha-Blockers As Colorectal Cancer Chemopreventive: Findings from a Case?Control Study, Human Cell Cultures, and In Vivo Preclinical Testing2019

    • Author(s)
      Suzuki Nobumi、Niikura Ryota、Ihara Sozaburo、Hikiba Yohko、Kinoshita Hiroto、Higashishima Naoko、Hayakawa Yoku、Yamada Atsuo、Hirata Yoshihiro、Nakata Ryo、Okamoto Makoto、Sano Munetaka、Kushiyama Akifumi、Ichinose Mari、Woods Susan L.、Worthley Daniel、Iwamoto Yasuhiko、Koike Kazuhiko
    • Journal Title

      Cancer Prevention Research

      Volume: 12 Issue: 3 Pages: 185-194

    • DOI

      10.1158/1940-6207.capr-18-0288

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Treatment of two mitochondrial disease patients with a combination of febuxostat and inosine that enhances cellular ATP2019

    • Author(s)
      Kamatani Naoyuki、Kushiyama Akifumi、Toyo-oka Licht、Toyo-oka Teruhiko
    • Journal Title

      Journal of Human Genetics

      Volume: 64 Issue: 4 Pages: 351-353

    • DOI

      10.1038/s10038-018-0558-0

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The Xanthine Oxidase Inhibitor Febuxostat Suppresses the Progression of IgA Nephropathy, Possibly via Its Anti-Inflammatory and Anti-Fibrotic Effects in the gddY Mouse Model2018

    • Author(s)
      Inoue Masa-Ki、Yamamotoya Takeshi、Nakatsu Yusuke、Ueda Koji、Inoue Yuki、Matsunaga Yasuka、Sakoda Hideyuki、Fujishiro Midori、Ono Hiraku、Morii Kenichi、Sasaki Kensuke、Masaki Takao、Suzuki Yusuke、Asano Tomoichiro、Kushiyama Akifumi
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 19 Issue: 12 Pages: 3967-3967

    • DOI

      10.3390/ijms19123967

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Development of Pin1 inhibitors and their potential as therapeutic agents.2018

    • Author(s)
      Nakatsu Y, Matsunaga Y, Ueda K, Yamamotoya T, Inoue Y, Inoue MK, Mizuno Y, Kushiyama A, Ono H, Fujishiro M, Ito H, Okabe T, Asano T.
    • Journal Title

      Curr Med Chem

      Volume: - Issue: 20 Pages: 1-1

    • DOI

      10.2174/0929867325666181105120911

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Roles of Gut-Derived Secretory Factors in the Pathogenesis of Non-Alcoholic Fatty Liver Disease and Their Possible Clinical Applications2018

    • Author(s)
      Okubo Hirofumi、Kushiyama Akifumi、Nakatsu Yusuke、Yamamotoya Takeshi、Matsunaga Yasuka、Fujishiro Midori、Sakoda Hideyuki、Ohno Haruya、Yoneda Masayasu、Asano Tomoichiro
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 19 Issue: 10 Pages: 3064-3064

    • DOI

      10.3390/ijms19103064

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Protective Effect of Sex Hormone-Binding Globulin against Metabolic Syndrome: In Vitro Evidence Showing Anti-Inflammatory and Lipolytic Effects on Adipocytes and Macrophages2018

    • Author(s)
      Yamazaki Hiroki、Kushiyama Akifumi、Sakoda Hideyuki、Fujishiro Midori、Yamamotoya Takeshi、Nakatsu Yusuke、Kikuchi Takako、Kaneko Sunao、Tanaka Hirotoshi、Asano Tomoichiro
    • Journal Title

      Mediators of Inflammation

      Volume: 2018 Pages: 1-12

    • DOI

      10.1155/2018/3062319

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Serum uric acid is an independent predictor of new-onset diabetes after living-donor kidney transplantation2018

    • Author(s)
      Tanaka Kentaro、Sakai Ken、Kushiyama Akifumi、Hara Shigeko、Hattori Masakazu、Ohashi Yasushi、Muramatsu Masaki、Kawamura Takeshi、Shishido Seiichiro、Aikawa Atsushi
    • Journal Title

      Renal Replacement Therapy

      Volume: 4 Issue: 1

    • DOI

      10.1186/s41100-018-0169-4

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Gut microbiota as a therapeutic target for metabolic disorders.2018

    • Author(s)
      Okubo H, Nakatsu Y, Kushiyama A, Yamamotoya T, Matsunaga Y, Inoue MK, Fujishiro M, Sakoda H, Ohno H, Yoneda M, Ono H, Asano T.
    • Journal Title

      Curr Med Chem.

      Volume: 25 Issue: 9 Pages: 984-1001

    • DOI

      10.2174/0929867324666171009121702

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Gastrointestinal symptom prevalence depends on disease duration and gastrointestinal region in type 2 diabetes mellitus2017

    • Author(s)
      Fujishiro M, Kushiyama A, Yamazaki H, Kaneko S, Koketsu Y, Yamamotoya T, Kikuchi T, Sakoda H, Suzuki R, Kadowaki T
    • Journal Title

      World J Gastroenterol

      Volume: 23 Issue: 36 Pages: 6694

    • DOI

      10.3748/wjg.v23.i36.6694

    • URL

      https://localhost/en/publications/b59c66b8-7150-4729-93a4-df6431c513be

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Trk-fused gene (TFG) regulates pancreatic β cell mass and insulin secretory activity.2017

    • Author(s)
      Yamamotoya T, Nakatsu Y, Kushiyama A, Matsunaga Y, Ueda K, Inoue Y, Inoue MK, Sakoda H, Fujishiro M, Ono H, Kiyonari H, Ishihara H, Asano T.
    • Journal Title

      Sci Rep.

      Volume: 7 Issue: 1 Pages: 1-13

    • DOI

      10.1038/s41598-017-13432-x

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Glial fibrillary acidic protein (GFAP) is a novel biomarker for the prediction of autoimmune diabetes.2017

    • Author(s)
      Pang Z, Kushiyama A, Sun J, Kikuchi T, Yamazaki H, Iwamoto Y, Koriyama H, Yoshida S, Shimamura M, Higuchi M, Kawano T, Takami Y, Rakugi H, Morishita R, Nakagami H.
    • Journal Title

      FASEB J.

      Volume: 31 Issue: 9 Pages: 4053-4063

    • DOI

      10.1096/fj.201700110r

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] The SGLT2 Inhibitor Luseogliflozin Rapidly Normalizes Aortic mRNA Levels of Inflammation-Related but Not Lipid-Metabolism-Related Genes and Suppresses Atherosclerosis in Diabetic ApoE KO Mice.2017

    • Author(s)
      Yusuke Nakatsu, Hiroki Kokubo, Batmunkh Bumdelger, Masao Yoshizumi, Takeshi Yamamotoya, Yasuka Matsunaga, Koji Ueda, Yuki Inoue, Masa-Ki Inoue, Midori Fujishiro, Akifumi Kushiyama, Hiraku Ono, Hideyuki Sakoda, and Tomoichiro Asano
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 18(8) Issue: 8 Pages: 1704-1717

    • DOI

      10.3390/ijms18081704

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] The prolyl isomerase Pin1 increases β-cell proliferation and enhances insulin secretion2017

    • Author(s)
      Nakatsu Y, Mori K, Matsunaga Y, Yamamotoya T, Ueda K, Inoue Y, Mitsuzaki-Miyoshi K, Sakoda H, Fujishiro M, Yamaguchi S, Kushiyama A, Ono H, Ishihara H, Asano T.
    • Journal Title

      J Biol Chem.

      Volume: 292 Issue: 28 Pages: 11886-11895

    • DOI

      10.1074/jbc.m117.780726

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Epicatechin downregulates adipose tissue CCL19 expression and thereby ameliorates diet-induced obesity and insulin resistance.2017

    • Author(s)
      Sano T et al.
    • Journal Title

      Nutr Metab Cardiovasc Dis

      Volume: 27 Issue: 3 Pages: 249-259

    • DOI

      10.1016/j.numecd.2016.11.008

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Role of Uric Acid Metabolism-Related Inflammation in the Pathogenesis of Metabolic Syndrome Components Such as Atherosclerosis and Nonalcoholic Steatohepatitis.2016

    • Author(s)
      Kushiyama A, Nakatsu Y, Matsunaga Y, Yamamotoya T, Mori K, Ueda K, Inoue Y, Sakoda H, Fujishiro M, Ono H, Asano T.
    • Journal Title

      Mediators Inflamm.

      Volume: 2016 Pages: 8603164-8603164

    • DOI

      10.1155/2016/8603164

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Prediction of the effect on antihyperglycaemic action of sitagliptin by plasma active form glucagon-like peptide-1.2016

    • Author(s)
      Kushiyama A, Kikuchi T, Tanaka K, Tahara T, Takao T, Onishi Y, Yoshida Y, Kawazu S, Iwamoto Y.
    • Journal Title

      World J Diabetes

      Volume: 7 Issue: 11 Pages: 230-238

    • DOI

      10.4239/wjd.v7.i11.230

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] C-Peptide Level in Fasting Plasma and Pooled Urine Predicts HbA1c after Hospitalization in Patients with Type 2 Diabetes Mellitus.2016

    • Author(s)
      Sonoda R, Tanaka K, Kikuchi T, Onishi Y, Takao T, Tahara T, Yoshida Y, Suzawa N, Kawazu S, Iwamoto Y, Kushiyama A.
    • Journal Title

      PLoS One.

      Volume: 11 Issue: 2 Pages: e0147303-e0147303

    • DOI

      10.1371/journal.pone.0147303

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Involvement of resistin-like molecule β in the development of methionine-choline deficient diet-induced non-alcoholic steatohepatitis in mice.2016

    • Author(s)
      Okubo H, Kushiyama A, Sakoda H, Nakatsu Y, Iizuka M, Taki N, Fujishiro M, Fukushima T, Kamata H, Nagamachi A, Inaba T, Nishimura F, Katagiri H, Asahara T, Yoshida Y, Chonan O, Encinas J, Asano T.
    • Journal Title

      Sci Rep.

      Volume: 6 Issue: 1 Pages: 20157-20157

    • DOI

      10.1038/srep20157

    • NAID

      120006796541

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Physiological and Pathogenic Roles of Prolyl Isomerase Pin1 in Metabolic Regulations via Multiple Signal Transduction Pathway Modulations.2016

    • Author(s)
      Nakatsu Y, Matsunaga Y, Yamamotoya T, Ueda K, Inoue Y, Mori K, Sakoda H, Fujishiro M, Ono H, Kushiyama A, Asano T.
    • Journal Title

      Int J Mol Sci.

      Volume: 17 (9) Issue: 9 Pages: 1495-1495

    • DOI

      10.3390/ijms17091495

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 尿酸と尿酸産生の血管疾患マーカーとしての役割2019

    • Author(s)
      櫛山暁史
    • Organizer
      第83回日本循環器学会学術集会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 糖尿病の病態における尿酸代謝の役割2019

    • Author(s)
      櫛山暁史
    • Organizer
      第52回日本痛風・核酸代謝学会総会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Role of xanthine oxidoreductase from mesenchymal cells in retinal inflammation after pericyte breakdown2018

    • Author(s)
      AKIFUMI KUSHIYAMA, TAKAKO KIKUCHI, HIROKI YAMAZAKI, TAKESHI YAMAMOTOYA, HIDEYUKI SAKODA, MIDORI FUJISHIRO, YUSUKE NAKATSU, AKIYOSHI UEMURA, TAKASHI SHIRAKURA, TOMOICHIRO ASANO, YASUHIKO IWAMOTO
    • Organizer
      ADA American Diabetes Association 78th Scientific Sessions
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] マクロファージ由来キサンチン酸化還元酵素の代謝・熱産生への関与2018

    • Author(s)
      櫛山 暁史, 菊池 貴子, 藤城 緑, 迫田 秀之, 中村 敬志, 村瀬 貴代, 松永 泰花, 山本屋 武, 中津 祐介, 浅野 知一郎, 岩本 安彦
    • Organizer
      第61回日本糖尿病学会年次学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 2型糖尿病を対象としたキサンチン酸化還元酵素の血管合併症発症および進展に対する影響に関する探索研究2018

    • Author(s)
      藤城 緑、櫛山 暁史、山口 賢、渡邉 健太郎、江頭 富士子、岡本 真由美、村瀬 貴代、中村 敬志、山本屋 武、中津 祐介、浅野 知一郎 、石原 寿光
    • Organizer
      第61回日本糖尿病学会年次学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Role of uric acid metabolism in pathogenesis of diabetes mellitus2018

    • Author(s)
      AKIFUMI KUSHIYAMA
    • Organizer
      3rd EAGER Meeting
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Xanthine Oxidoreductaseの組織特異的発現による代謝制御2018

    • Author(s)
      櫛山暁史、菊池貴子、村瀬貴代、世良康如、藤城緑、山本屋武、中津祐介、中村敬志、本田浩章、春日雅人、浅野知一郎
    • Organizer
      第41回日本分子生物学会年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] ペリサイト障害モデルにおける血管透過性に対するキサンチンオキシダーゼの役割2018

    • Author(s)
      櫛山暁史、菊池貴子、植村明嘉、福嶋葉子、櫛山櫻、浅野知一郎
    • Organizer
      日本血管生物医学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 妊娠中毒症を伴う妊娠および出産と 2 型糖尿病発症の関連2018

    • Author(s)
      末永 みどり, 櫛山 暁史, 庄野 あい子, 赤沢 学
    • Organizer
      日本薬学会 第138年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] ビグアナイド系薬剤服用患者の アドヒアランスに関する要因2018

    • Author(s)
      谷口洸亮、櫛山暁史、末永みどり、庄野あい子、菊池 貴子、岩本 安彦、赤沢学
    • Organizer
      第61回日本糖尿病学会年次学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 組織特異的キサンチンオキシダーゼによるインスリン感受性と慢性炎 症の制御2017

    • Author(s)
      櫛山 暁史, 菊池 貴子, 植村 明嘉, 福嶋 葉子,櫛山 櫻, 岩本 安彦, 浅野 知一郎
    • Organizer
      第60回日本糖尿病学会年次学術集会
    • Related Report
      2017 Research-status Report
  • [Presentation] Inhibition of diabetic retinopathy by xanthine oxidase inhibitor2017

    • Author(s)
      櫛山 暁史, 菊池 貴子, 植村 明嘉, 福嶋 葉子,櫛山 櫻, 岩本 安彦, 浅野 知一郎
    • Organizer
      Molecular Cardiovascular Metabolic Conference
    • Related Report
      2017 Research-status Report
  • [Presentation] 安全かつ効果的に結果にコミットできる減量方法の確立を目指して2017

    • Author(s)
      櫛山暁史
    • Organizer
      第38回日本肥満学会
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] Molecular mechanism of retinal edema by xanthine oxidase inhibitor2017

    • Author(s)
      櫛山 暁史, 菊池 貴子, 植村 明嘉, 福嶋 葉子,櫛山 櫻, 岩本 安彦, 浅野 知一郎
    • Organizer
      2017年度生命科学系学会合同年次大会(ConBIo2017)
    • Related Report
      2017 Research-status Report
  • [Presentation] ペリサイト障害モデルにおける網膜浮腫に対するキサンチンオキシダーゼ阻害の効果2017

    • Author(s)
      櫛山 暁史, 菊池 貴子, 植村 明嘉, 福嶋 葉子,櫛山 櫻, 岩本 安彦, 浅野 知一郎
    • Organizer
      第25回日本血管生物医学会学術集会(CVMW2017)
    • Related Report
      2017 Research-status Report
  • [Presentation] 糖尿病専門医院における患者背景のデータベース構築2017

    • Author(s)
      米川拓渡, 沖村悠希, 梶山里奈, 小泉聖人,仙石悠紀子,宮下紗季,森田修司,金井紀仁,櫛山暁史,山崎広貴,菊池貴子, 赤沢学
    • Organizer
      日本薬学会第137年会
    • Related Report
      2017 Research-status Report
  • [Presentation] 糖尿病専門医による 2 型糖尿病患者の処方変更の実態2017

    • Author(s)
      仙石 悠紀子, 米川 拓渡, 櫛山 暁史, 山崎 広貴, 菊池 貴子, 庄野 あい子, 金井 紀仁, 赤沢 学
    • Organizer
      日本薬学会第137年会
    • Related Report
      2017 Research-status Report
  • [Presentation] 組織特異的キサンチン酸化還元酵素のインスリン抵抗性に果たす役割2016

    • Author(s)
      櫛山暁史、菊池貴子、山崎広貴、藤田政子、嶋崎喜代子、櫛山櫻、浅野知一郎、西山功一、有馬勇一郎、栗原裕基
    • Organizer
      MCCII
    • Place of Presentation
      東京ドームホテル(東京)
    • Year and Date
      2016-09-02
    • Related Report
      2016 Research-status Report
  • [Presentation] 肝外キサンチンオキシダーゼのインスリン抵抗性への関与2016

    • Author(s)
      櫛山暁史、菊池貴子、迫田秀之、藤城緑、山崎広貴、山本屋武、大久保博史、中津祐介、河津捷二、岩本安彦、浅野知一郎
    • Organizer
      第59回 日本糖尿病学会年次学術集会
    • Place of Presentation
      国立京都国際会館(京都)
    • Related Report
      2016 Research-status Report
  • [Presentation] 医療機関での取り組み -初診時療養指導と受診中断者への働きがけによる受診中断対策2016

    • Author(s)
      吉田洋子  櫛山暁史  岩本安彦
    • Organizer
      第59回 日本糖尿病学会年次学術集会
    • Place of Presentation
      国立京都国際会館(京都)
    • Related Report
      2016 Research-status Report
  • [Presentation] 糖尿病患者に対するMCG解析2016

    • Author(s)
      櫛山暁史
    • Organizer
      第57回 日本人間ドック学会学術大会
    • Place of Presentation
      まつもと市民芸術館(長野)
    • Related Report
      2016 Research-status Report
  • [Presentation] 2型糖尿病患者男女における骨密度及び海綿骨スコアの変化2016

    • Author(s)
      櫛山暁史、山崎広貴、藤田政子、菊池貴子、田原たづ、大西由希子、高尾淑子、吉田洋子、岩本安彦、板橋明
    • Organizer
      第18回 骨粗しょう症学会
    • Place of Presentation
      仙台 勝山館(宮城)
    • Related Report
      2016 Research-status Report
  • [Presentation] Anti-angiogenic effect of xanthine oxidase inhibition on endothelial cells2016

    • Author(s)
      Akifumi Kushiyama, Takako Kikuchi, Hiroki Yamazaki, Yoko Fukushima, Akiyoshi Uemura, Yuichiro Arima, Koichi Nishiyama, Sakura Kushiyama, Yasuhiko Iwamoto, Tomoichiro Asano
    • Organizer
      IVBM2016
    • Place of Presentation
      Sheraton Boston Hotel (USA)
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] 血管新生におけるキサンチンオキシダーゼ阻害の血管内皮細胞への影響 Effect of xanthine oxidase inhibitor on endothelial cells during angiogenesis2016

    • Author(s)
      櫛山暁史、菊池貴子、山崎広貴、福嶋葉子、植村明嘉、 西山功一、有馬勇一郎、櫛山櫻、岩本安彦、浅野知一郎
    • Organizer
      第39回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川)
    • Related Report
      2016 Research-status Report
  • [Presentation] Inhibition of endothelial sprouting by the xanthine oxidase inhibitor2016

    • Author(s)
      Akifumi Kushiyama, Takako Kikuchi, Hiroki Yamazaki, Sakura Kushiyama, Yasuhiko Iwamoto, Tomoichiro Asano
    • Organizer
      第24回日本血管生物医学会学術集会
    • Place of Presentation
      長崎ブリックホール(長崎)
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Book] 糖尿病の療養指導Q&A vol.22019

    • Author(s)
      櫛山暁史他
    • Total Pages
      167
    • Publisher
      医歯薬出版株式会社
    • Related Report
      2018 Annual Research Report
  • [Remarks] 朝日生命成人病研究所 糖尿病代謝科 分子病態学班 研究内容

    • URL

      http://www.asahi-life.or.jp/laboratory/biomolecular.html

    • Related Report
      2017 Research-status Report 2016 Research-status Report

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Published: 2016-04-21   Modified: 2022-02-21  

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