Identification of the factors associated with frailty in the elderly
| Project/Area Number |
16K09796
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Endocrinology
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| Research Institution | International University of Health and Welfare |
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Principal Investigator |
Urano Tomohiko 国際医療福祉大学, 医学部, 主任教授 (20334386)
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| Co-Investigator(Kenkyū-buntansha) |
井上 聡 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 研究部長 (40251251)
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| Project Period (FY) |
2016-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | フレイル / 骨粗鬆症 / 糖尿病 / 高齢者診療 / 骨代謝マーカー / 骨折 / サルコペニア / 変形性関節症 |
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| Outline of Final Research Achievements |
Decline of body weight with aging is a major risk factor for frailty, osteoporosis and fracture. Recently, we have shown that treatments with selective estrogen receptor modulator and bisphosphonate prevented age-related weight loss. Our results suggest that selective estrogen receptor modulator and bisphosphonate treatments not only reduces the risk for incident osteoporotic fractures but also for frailty in the elderly. We also investigated whether serum osteocalcin levels are associated with the risk of incident type 2 diabetes mellitus. The group with baseline osteocalcin levels <6.1 ng/mL showed a significantly higher risk for developing diabetes mellitus than the group with baseline osteocalcin levels >6.1 ng/mL during the mean observation period. Our results indicate that a decrease in serum osteocalcin levels is associated with future development of type 2 diabetes mellitus independent of conventional risk factors.
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| Academic Significance and Societal Importance of the Research Achievements |
近年、要介護の前段階で高齢者の活動性が低下することをフレイルと呼ぶようになり、注目されている。早期にフレイルを見出し、介入することは我が国における高齢者医療費や介護負担が軽減すると期待されている。しかしながら、高齢者の活動性低下に関与するメカニズムは十分明らかにされていない。その中で今回の研究成果はフレイル予防に骨粗鬆症治療薬が有効である可能性を示した。骨代謝マーカーであるオステオカルシンの血中濃度測定が糖尿病さらにはフレイルを予期するバイオマーカーとしての可能性を見出している。これら研究成果は超高齢社会を迎えている我が国における高齢者の介護負担の軽減につながる可能性がある。
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Report
(5 results)
Research Products
(32 results)
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[Journal Article] Case of a 78-year-old woman with a neuronal intranuclear inclusion disease.2017
Author(s)
Takumida H, Yakabe M, Mori H, Shibasaki K, Umeda-Kameyama Y, Urano T, Mano T, Hayashi A, Ikemura M, Ogawa S, Akishita M.
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Journal Title
Geriatr Gerontol Int
Volume: 17
Issue: 12
Pages: 2623-2625
DOI
Related Report
Peer Reviewed
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[Journal Article] A novel prognostic factor TRIM44 promotes cell proliferation and migration, and inhibits apoptosis in testicular germ cell tumor.2017
Author(s)
Yamada Y, Takayama KI, Fujimura T, Ashikari D, Obinata D, Takahashi S, Ikeda K, Kakutani S, Urano T, Fukuhara H, Homma Y, Inoue S.
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Journal Title
Cancer Sci.
Volume: 108
Issue: 1
Pages: 32-41
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Prognostic value of CD66b positive tumor-infiltrating neutrophils in testicular germ cell tumor.2016
Author(s)
Yamada Y, Nakagawa T, Sugihara T, Horiuchi T, Yoshizaki U, Fujimura T, Fukuhara H, Urano T, Takayama K, Inoue S, Kume H, Homma Y.
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Journal Title
BMC Cancer
Volume: 6
Pages: 898-898
Related Report
Peer Reviewed
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[Journal Article] Targeting Oct1 genomic function inhibits androgen receptor signaling and castration-resistant prostate cancer growth2016
Author(s)
Obinata D, Takayama K, Fujiwara K, Suzuki T, Tsutsumi S, Fukuda N, Nagase H, Fujimura T, Urano T, Homma Y, Aburatani H, Takahashi S and Inoue S.
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Journal Title
Oncogene
Volume: ３５
Issue: 49
Pages: 6350-6358
DOI
Related Report
Peer Reviewed
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