Mechanism of exosome regulation by adiponectin
| Project/Area Number |
16K09802
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Endocrinology
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| Research Institution | Osaka University |
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Principal Investigator |
Kita Shunbun 大阪大学, 医学系研究科, 寄附講座講師 (10746572)
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| Co-Investigator(Kenkyū-buntansha) |
前田 法一 大阪大学, 医学系研究科, 寄附講座准教授 (30506308)
西澤 均 大阪大学, 医学系研究科, 講師 (20379259)
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | アディポネクチン / T－カドヘリン / エクソソーム / セラミド / 骨格筋再生 / カドヘリン / プロドメイン / T-カドヘリン / 細胞外微粒子 / GPI-アンカー / GPIアンカー / 内分泌学 |
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| Outline of Final Research Achievements |
Adiponectin is known to be a beneficial secreting protein. We revealed that adiponectin accumulates in heart, vessel, and muscle through a unique high-affinity interaction with a cell-surface protein called T-cadherin. Furthermore, adiponectin stimulates exosome biogenesis and secretion, thereby contributes organ protections and regenerations.
Exosome is known to be a machinery to dispose unnecessary materials to keep cellular homeostasis and a packet-signaling machinery to enhance intercellular communications. The long mystery of functional mechanism of this beneficial protein can now be clearly explained by our findings, stimulation of exosome biogenesis. We are going to apply such fundamental mechanism of adiponectin function to novel medications.
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| Academic Significance and Societal Importance of the Research Achievements |
テレビなどでも時折紹介されます脂肪が出すアディポネクチンというタンパクが、どうして体に良いのかを初めてはっきりと説明できるようになりました。アディポネクチンはエクソソームという小さな粒子を細胞から出させることを見つけました。
エクソソームは細胞のゴミを出すゴミ袋のようなもので、アディポネクチンはゴミ袋を増やすことで細胞をきれいに保ちます。またエクソソームは細胞同士のやり取りにも使われますが、このやり取りを活発にすることで病気から守ることも分りました。このような新しい理解は、将来の新しい治療薬に応用されます。
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Report
(4 results)
Research Products
(34 results)
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[Journal Article] Adiponectin promotes muscle regeneration through binding to T-cadherin.2019
Author(s)
Tanaka Y, Kita S, Nishizawa H, Fukuda S, Fujishima Y, Obata Y, Nagao H, Masuda S, Nakamura Y, Shimizu Y, Mineo R, Natsukawa T, Funahashi T, Ranscht B, Fukada SI, Maeda N, Shimomura I.
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Journal Title
Sci. Rep.
Volume: 9
Issue: 1
Pages: 1-12
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Adiponectin/T-cadherin system enhances exosome biogenesis and decreases cellular ceramides by exosomal release.2018
Author(s)
Obata Y, Kita S, Koyama Y, Fukuda S, Takeda H, Takahashi M, Fujishima Y, Nagao H, Masuda S, Tanaka Y, Nakamura Y, Nishizawa H, Funahashi T, Ranscht B, Izumi Y, Bamba T, Fukusaki E, Hanayama R, Shimada S, Maeda N, Shimomura I.
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Journal Title
JCI Insight
Volume: 3(8)
Issue: 8
Pages: 1-18
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Adiponectin/T-cadherin system enhances exosome biogenesis and decreases cellular ceramides by exosomal release2018
Author(s)
Obata Y, Kita S, Koyama Y, Fukuda S, Takeda H, Takahashi M, Fujishima Y, Nagao H, Masuda S, Tanaka Y, Nakamura Y, Nishizawa H, Funahashi T, Ranscht B, Izumi Y, Bamba T, Fukusaki E, Hanayama R, Shimada S, Maeda N, Shimomura I.
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Journal Title
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] The unique prodomain of T-cadherin plays a key role in adiponectin binding with the essential extracellular cadherin repeats 1 and 2.2017
Author(s)
Fukuda S, Kita S, Obata Y, Fujishima Y, Nagao H, Masuda S, Tanaka Y, Nishizawa H, Funahashi T, Takagi J, Maeda N, and Shimomura I.
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Journal Title
J Biol Chem.
Volume: 292
Issue: 19
Pages: 7840-7849
DOI
Related Report
Peer Reviewed
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