| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
G protein-coupled receptors (GPCRs) and their crosstalks may play an important role in fine-tuning of many signals in our body, and their signal unbalance may underlie many disease states. In this study, 1) we have screened and analyzed molecular defects of GPCRs in diseases and tried to rescue them using small molecules targeting GPCRs in vitro and also in patients. 2) We have also designed analogues of small molecules that nitrosyl ate and thereby inactivate GRK2 (G protein-coupled receptor kinase 2 that plays an essential role in many GPCR desensitization) and analyzed their effects on lipolysis of adipocytes. 3)We have also analyzed molecular action of GPCRs by combining accumulated data based on G protein/GPCR disease analysis and structural information.
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