Fibrinolytic factors control MSC expansion thereby enhancing hematopoiesis
| Project/Area Number |
16K09821
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Hematology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
Heissig Beate 東京大学, 医科学研究所, 准教授 (30372931)
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| Research Collaborator |
Hattori Koichi
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 間葉系幹細胞 / stem cells / mesenchymal stem cells / fibrinolytic factors / hematopoiesis / 幹細胞 |
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| Outline of Final Research Achievements |
Tissue plasminogen activator (tPA) is an enzyme used for the treatment of stroke patients. Mesenchymal stem cells can expand stem cells in various tissues, including the tumor bed. We show that tPA can expand mesenchymal stem cells within the bone marrow and the tumor cell bed. We propose that controlling tPA levels can regulate hematopoietic stem cell expansion and tumor cell growth.
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| Academic Significance and Societal Importance of the Research Achievements |
骨髄および腫瘍細胞ニッチにおけるＭＳＣの動員または拡大を調節することにおける線維素溶解因子の重要な役割を強調している。造血幹細胞ならびに癌幹細胞の増殖におけるＭＳＣの役割を実証する研究と一緒に、我々は、線維素溶解因子が臨床現場での造血幹細胞の増殖に有用であり得ることを提案する。 ＭＳＣを動員するそれらの能力のために癌患者に与えられる線維素溶解因子は、腫瘍細胞増殖を支持するかもしれない。
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Report
(4 results)
Research Products
(12 results)
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[Journal Article] Pharmacological targeting of plasmin prevents lethality and tissue damage in a murine model of macrophage activation syndrome2017
Author(s)
1.Shimazu H, Munakata S, Tashiro Y, Salama Y, Eiamboonser S, Ohta Y, Onoda H, Tsuda Y, Okada Y, Nakauchi H, Heissig B and Hattori K
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Journal Title
Blood
Volume: 印刷中
Issue: 1
Pages: 59-72
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Plasminogen activator inhibitor-1 regulates macrophage-dependent postoperative adhesion by enhancing EGF-HER1 signaling in mice.2017
Author(s)
Honjo K, Shinya Munakata S, Tashiro Y, Salama Y, Shimazu H, Eiamboonsert S, Dhahri D, Ichimura A, Dan T, Miyata T, Takeda K, Sakamoto K, Hattori K, Heissig B.
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Journal Title
FASEB J
Volume: 31
Pages: 2625-2637
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Plasminogen activator inhibitor-1 regulates macrophage-dependent postoperative adhesion by enhancing EGF-HER1 signaling in mice.2017
Author(s)
Honjo K, Munakata S, Tashiro Y, Salama Y, Shimazu H, Eiamboonsert S, Dhahri D, Ichimura A, Dan T, Miyata T, Takeda K, Sakamoto K, Hattori K, Heissig B.
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Journal Title
FASEB Journal
Volume: -
Issue: 6
Pages: 2625-2637
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Fibrinolytic crosstalk with endothelial cells expands murine mesenchymal stromal cells2016
Author(s)
Dhahri D, Sato-Kusubata K, Ohki-Koizumi M, Nishida C, Tashiro Y, Munakata S, Shimazu H, Salama Y, Eiamboonsert S, Nakauchi H, Hattori K and Heissig B
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Journal Title
Blood
Volume: 128
Pages: 1063-75
Related Report
Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
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