| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
Interactions between tissue-specific stem cells and their microenvironment known as niche play important roles in the stem cell fate determination such as the maintenance, proliferation, and differentiation. In this study, we aim to elucidate the regulatory mechanisms of hematopoietic stem cell self-renewal mediated by the control of actin polymerization. In particular, we focused on the roles of Spred1, which is a negative regulator of ROCK and ERK signaling pathways, in hematopoietic stem cell (HSC) function. We have clearly shown that the control of actin polymerization mediated by Spred1-ROCK signaling pathway regulates the self-renewal capacity of HSCs. Furthermore, we have elucidated that Spred1 prevents high fat diet-induced tumorigenesis of HSCs through the regulation of ERK signaling pathway.
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