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Epigenetic changes in the development of adult T cell leukemia

Research Project

Project/Area Number 16K09850
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Hematology
Research InstitutionSaga University

Principal Investigator

Sueoka Eisaburo  佐賀大学, 医学部, 教授 (00270603)

Co-Investigator(Kenkyū-buntansha) 小島 研介  佐賀大学, 医学部, 准教授 (10332793)
荒金 尚子  佐賀大学, 医学部, 准教授 (20321846)
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords成人T細胞白血病 / HTLV-1 / DNAメチル化 / エピジェネティック変化 / 分子標的治療 / フローサイトメトリー法 / ゲノム異常 / メチル化 / 多段階発がん / 癌 / 成人T細胞白血病・リンパ腫 / フローサイトメトリー
Outline of Final Research Achievements

HTLV-1 virus-infected cell-specific epigenetic changes for each stage of adult T cell leukemia were analyzed. About 180 cases who visited our hospital were analyzed by Has-Flow method and HTLV-1-infected fractions were separated from the expression pattern of CADM1 / TSLCl and CD7. DNA methylation was analyzed comprehensively by DNA methylation array. Methylation of the TSS 200 region, which is important for gene expression, was enhanced in relation to the progression of the stage. In addition, we found 22 types of gene groups were coincided with the genes which expression were down regulated. Our results suggested that the genes thought to be candidates for diagnostic markers for disease progression and for therapeutic targets.

Academic Significance and Societal Importance of the Research Achievements

いったん発症すると治癒の困難な、成人T細胞白血病(ATL)における遺伝子変化について、キャリアからくすぶり、慢性型と病期の比較的早期から生じるメチル化異常のパターンを明らかにした。これらの遺伝子の中には、がん化や細胞増殖の進展に関与することが知られている遺伝子群が含まれており、ATLの発症のリスク評価や治療法の開発の標的分子も含まれていることが示唆される。現在、それぞれの遺伝子の機能解析とともに、HTLV-1キャリアのおける病期進展のマーカーとしての有用性の検討を進めている。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (55 results)

All 2019 2018 2017 2016

All Journal Article (22 results) (of which Int'l Joint Research: 8 results,  Peer Reviewed: 20 results,  Open Access: 9 results,  Acknowledgement Compliant: 1 results) Presentation (32 results) (of which Int'l Joint Research: 7 results,  Invited: 1 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Primary Chest Wall MYC/BCL6 Double-hit Lymphoma with t (3;7) (q27;p12) and t (8;14) (q24;q32) Translocations2019

    • Author(s)
      Kamachi K, Kubota Y, Nagaie T, Yamaguchi K, Ogusu S, Kidoguchi K, Kusaba K, Kizuka-Sano H, Nishioka A, Yoshimura M, Yokoo M, Ando T, Kai K, Kojima K, Ohshima K, Sueoka E, Kimura S.
    • Journal Title

      Internal Medicine

      Volume: 58 Issue: 14 Pages: 2073-2077

    • DOI

      10.2169/internalmedicine.2532-18

    • NAID

      130007679517

    • ISSN
      0918-2918, 1349-7235
    • Year and Date
      2019-07-15
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Community-acquired Disseminated <i>Exophiala dermatitidis</i> Mycosis with Necrotizing Fasciitis in Chronic Graft-versus-host Disease2019

    • Author(s)
      Sato Eiichi、Togawa Atsushi、Masaki Michio、Shirahashi Akihiko、Kumagawa Midori、Kawano Yasumasa、Ishikura Hiroyasu、Yamashiro Yuri、Takagi Satoshi、To Hiromi、Kobata Katsumi、Takeshita Morishige、Kusaba Koji、Sueoka Eisaburo、Tamura Kazuo、Takamatsu Yasushi、Takata Tohru
    • Journal Title

      Internal Medicine

      Volume: 58 Issue: 6 Pages: 877-882

    • DOI

      10.2169/internalmedicine.1706-18

    • NAID

      130007615020

    • ISSN
      0918-2918, 1349-7235
    • Year and Date
      2019-03-15
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Meeting report of the 14th Japan Korea joint symposium on cancer and aging research: current status of translational research and approaches to precision medicine2019

    • Author(s)
      Sueoka Eisaburo、Watanabe Tatsuro、Mashima Tetsuo、Shirakami Yohei、Komori Atsumasa、Matsuo Keitaro、Yoshikawa Hiroshi Y.、Cho Kyung A、Park Tae Jun、Seimiya Hiroyuki、Kim Eung-Gook、Suganuma Masami、Chung Junho
    • Journal Title

      Journal of Cancer Research and Clinical Oncology

      Volume: 印刷中 Issue: 5 Pages: 1263-1271

    • DOI

      10.1007/s00432-019-02887-2

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The utilization and challenges of Japan's MID‐NET medical information database network in postmarketing drug safety assessments: A summary of pilot pharmacoepidemiological studies2019

    • Author(s)
      Yamada Kaori、Itoh Maori、Fujimura Yoshiaki、Kimura Michio、Murata Koichiro、Nakashima Naoki、Nakayama Masaharu、Ohe Kazuhiko、Orii Takao、Sueoka Eizaburo、Suzuki Takahiro、Yokoi Hideto、Ishiguro Chieko、Uyama Yoshiaki、on behalf of MID‐NET project group
    • Journal Title

      Pharmacoepidemiology and Drug Safety

      Volume: 印刷中 Issue: 5 Pages: 601-608

    • DOI

      10.1002/pds.4777

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clinical impact of the CONUT score and mogamulizumab in adult T cell leukemia/lymphoma.2019

    • Author(s)
      Ureshino H, Kusaba K, Kidoguchi K, Sano H, Nishioka A, Itamura H, Yoshimura M, Yokoo M, Shindo T, Kubota Y, Ando T, Kojima K, Sueoka E, Kimura S.
    • Journal Title

      Annals of Hematology

      Volume: 98 Issue: 2 Pages: 465-471

    • DOI

      10.1007/s00277-018-3502-7

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Acute myeloid leukemia with t(19;21)(q13;q22) and marked eosinophilia.2019

    • Author(s)
      Kubota Y, Kamachi K, Wakayama K, Kitamura H, Yoshihara M, Hisatomi T, Fukushima N, Ichinohe T, Sueoka E, Kimura S.
    • Journal Title

      Annals of Hematology

      Volume: 98 Issue: 1 Pages: 221-222

    • DOI

      10.1007/s00277-018-3408-4

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The concept of the okadaic acid class of tumor promoters is revived in endogenous protein inhibitors of protein phosphatase 2A, SET and CIP2A, in human cancers2018

    • Author(s)
      Fujiki Hirota、Sueoka Eisaburo、Watanabe Tatsuro、Suganuma Masami
    • Journal Title

      Journal of Cancer Research and Clinical Oncology

      Volume: 144 Issue: 12 Pages: 2339-2349

    • DOI

      10.1007/s00432-018-2765-7

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Investigation of appropriate pre-analytical procedure for circulating free DNA from liquid biopsy2018

    • Author(s)
      3.Sato A, Nakashima C, Abe T, Kato J, Hirai M, Nakamura T, Komiya K, Kimura S, Sueoka E, Sueoka-Aragane N
    • Journal Title

      Oncotarget

      Volume: 9 Issue: 61 Pages: 31904-31914

    • DOI

      10.18632/oncotarget.25881

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Incidence of aspiration pneumonia during hospitalization in Japanese hospitalized cases did not increase whereas concern factors were exacerbated in a time-dependent manner: analysis of Diagnosis Procedure Combination (DPC) data2018

    • Author(s)
      Nonaka Sayuri、Fujii Susumu、Hara Megumi、Morita Shigeki、Sueoka Eisaburo、Node Koichi、Fujimoto Kazuma
    • Journal Title

      Journal of Clinical Biochemistry and Nutrition

      Volume: 63 Issue: 1 Pages: 66-69

    • DOI

      10.3164/jcbn.17-119

    • NAID

      130007387137

    • ISSN
      0912-0009, 1880-5086
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of the BRAF V600E mutation in Japanese patients with hairy cell leukemia and related diseases using a quenching probe method2018

    • Author(s)
      Itamura Hidekazu、Ide Masaru、Sato Akemi、Sueoka-Aragane Naoko、Sueoka Eisaburo、Nishida Aya、Masunari Taro、Aoki Sadao、Takizawa Jun、Suzumiya Junji、Kimura Shinya
    • Journal Title

      International Journal of Hematology

      Volume: 108 Issue: 4 Pages: 416-422

    • DOI

      10.1007/s12185-018-2506-3

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Automated DNA extraction using cellulose magnetic beads can improve EGFR point mutation detection with liquid biopsy by efficiently recovering short and long DNA fragments2018

    • Author(s)
      4.Nakashima C, Sato A, Abe T, Kato J, Hirai M, Nakamura T, Komiya K, Sueoka E, Kimura S, Sueoka-Aragane N
    • Journal Title

      Oncotarget

      Volume: 9 Issue: 38 Pages: 25181-25192

    • DOI

      10.18632/oncotarget.25388

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Synchronous mantle cell lymphoma and lung adenocarcinoma presenting in a pleural effusion: A rare tumour combination and a potential pitfall of cytodiagnosis.2018

    • Author(s)
      5.Kai K, Ryu Y, Kamochi K, Nishioka A, Kubota Y, Nakamura M, Kimura S, Sueoka E, Aishima S
    • Journal Title

      Cytopathology

      Volume: 印刷中 Issue: 4 Pages: 400-402

    • DOI

      10.1111/cyt.12532

    • Related Report
      2018 Annual Research Report 2017 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Differentiated embryo chondrocyte plays a crucial role in DNA damage response via transcriptional regulation under hypoxic conditions2018

    • Author(s)
      Nakamura Hideaki、Bono Hidemasa、Hiyama Keiko、Kawamoto Takeshi、Kato Yukio、Nakanishi Takeshi、Nishiyama Masahiko、Hiyama Eiso、Hirohashi Nobuyuki、Sueoka Eisaburo、Poellinger Lorenz、Tanimoto Keiji
    • Journal Title

      PLOS ONE

      Volume: 13 Issue: 2 Pages: e0192136-e0192136

    • DOI

      10.1371/journal.pone.0192136

    • Related Report
      2018 Annual Research Report 2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Cancer Prevention with Green Tea and Its Principal Constituent, EGCG: from Early Investigations to Current Focus on Human Cancer Stem Cells.2018

    • Author(s)
      Fujiki H, Watanabe T, Sueoka E, Rawangkan A, Suganuma M
    • Journal Title

      Mol Cells

      Volume: 41 Pages: 73-82

    • Related Report
      2018 Annual Research Report 2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Deep sequencing of the T cell receptor visualizes reconstitution of T cell immunity in mogamulizumab-treated adult T cell leukemia. Oncoimmunology2017

    • Author(s)
      3.Shindo T, Kitaura K, Ureshino H, Kamachi K, Miyahara M, Doi K, Watanabe T, Sueoka E, Shin-I T, Suzuki R, Kimura S
    • Journal Title

      Oncoimmunology

      Volume: 7 Issue: 3 Pages: e1405204-e1405204

    • DOI

      10.1080/2162402x.2017.1405204

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Prognostic index for chronic- and smoldering-type adult T-cell leukemia-lymphoma2017

    • Author(s)
      Katsuya Hiroo、Shimokawa Mototsugu、Ishitsuka Kenji、Kawai Kazuhiro、Amano Masahiro、Utsunomiya Atae、Hino Ryosuke、Hanada Shuichi、Jo Tatsuro、Tsukasaki Kunihiro、Moriuchi Yukiyoshi、Sueoka Eisaburo、Yoshida Shinichiro、Suzushima Hitoshi、Miyahara Masaharu、Yamashita Kiyoshi、Eto Tetsuya、Suzumiya Junji、Tamura Kazuo
    • Journal Title

      Blood

      Volume: 130 Issue: 1 Pages: 39-47

    • DOI

      10.1182/blood-2017-01-757542

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Human cancer stem cells are a target for cancer prevention using (?)-epigallocatechin gallate2017

    • Author(s)
      Fujiki Hirota、Sueoka Eisaburo、Rawangkan Anchalee、Suganuma Masami
    • Journal Title

      J Cancer Res Clin Oncol

      Volume: 143 Issue: 12 Pages: 2401-2412

    • DOI

      10.1007/s00432-017-2515-2

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Functional analysis of Discoidin domain receptor 2 mutation and expression in squamous cell lung cancer2017

    • Author(s)
      Kobayashi-Watanabe Naomi、Sato Akemi、Watanabe Tatsuro、Abe Tomonori、Nakashima Chiho、Sueoka Eisaburo、Kimura Shinya、Sueoka-Aragane Naoko
    • Journal Title

      Lung Cancer

      Volume: 110 Pages: 35-41

    • DOI

      10.1016/j.lungcan.2017.05.017

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Plasma T790M and HGF as potential predictive markers for EGFR-TKI re-challenge2017

    • Author(s)
      Nakamura Tomomi、Watanabe Naomi、Sato Akemi、Komiya Kazutoshi、Umeguchi Hitomi、Hosomi Toshiya、Hirai Mitsuharu、Sueoka Eisaburo、Kimura Shinya、Sueoka-Aragane Naoko
    • Journal Title

      Oncol Lett

      Volume: 13 Issue: 6 Pages: 4939-4946

    • DOI

      10.3892/ol.2017.6085

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] HTLV-1キャリア相談支援体制の現状2017

    • Author(s)
      末岡 榮三朗, 柘植 薫
    • Journal Title

      日本内科学会雑誌

      Volume: 106 Pages: 1383-1390

    • Related Report
      2017 Research-status Report
  • [Journal Article] iPSバンクを含む国内のバイオバンクの現状と課題 日本のバイオバンク 現状と問題点、そして次世代バイオバンクの構築に向けて2017

    • Author(s)
      末岡榮三朗
    • Journal Title

      臨床病理

      Volume: 65 Pages: 190-198

    • Related Report
      2017 Research-status Report
  • [Journal Article] Torin2 potentiates anti-cancer effects for adult T-cell leukemia/lymphoma by inhibiting mammalian target of rapamycin.2016

    • Author(s)
      3.Watanabe T, Sato A, Kobayashi-Watanabe N, Sueoka-Aragane N, Kimura S, Sueoka E
    • Journal Title

      Anticancer Res

      Volume: 36 Pages: 95-102

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] Investigation of origin of circulating free DNA: Is exosomal DNA the carrier?2018

    • Author(s)
      Nakashima C, Abe T, Sato A, Nakamura T, Komiya K, Sueoka E, Kimura K, Sueoka-Aragan
    • Organizer
      American Association for Cancer Research Annual Meeting
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Characteristics of circulating tumor DNA in lung cancer patients.2018

    • Author(s)
      Abe T, Nakashima C, Sato A, Sueoka E, Kimura K, Sueoka-Aragane N.
    • Organizer
      American Association for Cancer Research Annual Meeting
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Comprehensive approach for eradication of Adult T-cell Leukemia- Lymphoma in Japan - prevention, translational research and clinical approach-2018

    • Author(s)
      Sueoka E, Nakamura H, Watanabe T, Sato A, Kimura S, Yamashita S, Ushijima T
    • Organizer
      The 14th Japan-Korea joint Symposium on Cancer and Ageing Reaearch.
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] DEC plays a crucial role in DNA damage response via transcriptional regulation under hypoxic conditions2018

    • Author(s)
      Tanimoto K, Nakamura H, Hirohashi N, Poellinger L, Sueoka E
    • Organizer
      The 14th Japan-Korea joint Symposium on Cancer and Ageing Reaearch.
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Investigation of origin of circulating free DNA: Is EV the carrier?2018

    • Author(s)
      Nakashima C, Sato A, Abe T, Nakamura T, Komiya K, Sueoka E, Kimura S, Sueoka-Aragane N.
    • Organizer
      The 14th Japan-Korea Joint Symposium on Cancer and Ageing Research,
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Characteristics of circulating tumor DNA in lung cancer patients.2018

    • Author(s)
      Tomonori Abe, Chiho Nakashima, Yohei Harada, Akemi Sato, Eisaburo Sueoka, Shinya Kimura, Naoko Aragane.
    • Organizer
      The 14th Japan-Korea Joint Symposium on Cancer and Ageing Research,
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 他院での造血幹細胞移植情報が 提供されず、緊急輸血を必要とした症例2018

    • Author(s)
      山田麻里江,山田尚友,中尾真実,川崎誠司,末岡榮三朗
    • Organizer
      第67回日本医学検査学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Circulating free DNAとExosomal DNAの関係についての検討.2018

    • Author(s)
      中島千穂,安部友範,佐藤明美,末岡榮三朗,木村 晋也,荒金尚子
    • Organizer
      第22回 日本がん分子標的治療学会 学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 情報共有ツールを活用した輸血医療の質向上 様々な輸血現場における情報共有ツールの作成とチーム医療への応用2018

    • Author(s)
      末岡榮三朗
    • Organizer
      第66回日本輸血細胞治療学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 輸血療法と遠隔医療 在宅輸血と遠隔医療を考える2018

    • Author(s)
      末岡榮三朗
    • Organizer
      第66回日本輸血細胞治療学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 【医療情報が紡ぐ『いのち・ヒト・夢』】(いのち)医療情報が救ういのち-リアルワールドデータからプレシジョンメディシンへ- ビッグデータと個人を繋ぐ基盤整備2018

    • Author(s)
      末岡榮三朗,佐藤明美,中村秀明,藤井 進
    • Organizer
      第22回日本医療情報学会春季学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] フローサイトメトリーにより治療経過を追跡しえた単一性上皮親和性腸症型T細胞リンパ腫の1例2018

    • Author(s)
      海野晃久,草場香那,本田美穂,岡崎智満,吉原由利重,若山一夫,川崎誠司,久保田寧,木村晋也,末岡榮三朗
    • Organizer
      第19回日本検査血液学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Terminal deoxynucleotidyl transferase(TdT)陰性のTリンパ芽球性リンパ腫(T-Lymphoblastic Lymphoma;T-LBL)の一例2018

    • Author(s)
      本田美穂,西眞範,岡崎智満,海野晃久,吉原由利重,若山一夫,川崎誠司,末岡榮三朗
    • Organizer
      第19回日本検査血液学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 骨髄浸潤を認めたランゲルハンス細胞組織球症(Langerhans cell histiocytosis;LCH)の一例2018

    • Author(s)
      吉原由利重,井上卓也,本田美穂,海野晃久,岡崎智満,若山一夫,川崎誠司,末岡榮三朗
    • Organizer
      第19回日本検査血液学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Liquid biopsyのためのプレアナリシス段階の検体品質管理に関する検討2018

    • Author(s)
      佐藤明美,中島千穂,安部友範,中村秀明,荒金尚子,木村晋也,末岡榮三朗
    • Organizer
      第58回日本臨床化学会年次学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 多項目自動血球分析装置XN-9000を用いたHTLV-1感染者の細胞解析法についての検討2018

    • Author(s)
      中村秀明,佐藤明美,渡邉達郎,末岡榮三朗
    • Organizer
      第5回日本 HTLV‐1学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 妊婦健診におけるHTLV1抗体検査陽性者相談体制の検討 当院外来受診妊婦に対する質問紙調査より2018

    • Author(s)
      柘植薫、豊田梨紗、末岡榮三朗
    • Organizer
      第5回日本 HTLV‐1学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Characteristics of circulating free DNA in lung cancer patients.2018

    • Author(s)
      Tomonori Abe, Chiho Nakashima, Akemi Sato, Yohei Harada, Eisaburo Sueoka, Shinya Kimura, Naoko Aragane.
    • Organizer
      77th Annual Meeting of the Japanese Cancer Association
    • Related Report
      2018 Annual Research Report
  • [Presentation] Investigation of origin of circulating free DNA: Are extracellular vesicles the carrier?2018

    • Author(s)
      Chiho Nakashima, Tomonori Abe, Yohei Harada, Akemi Sato, Tomomi Nakamura, Kazutoshi Komiya, Eisaburo Sueoka, Shinya Kimura, Naoko Sueoka-Aragane.
    • Organizer
      77th Annual Meeting of the Japanese Cancer Association
    • Related Report
      2018 Annual Research Report
  • [Presentation] Analysis of a novel mutation of ERBB2 in cancer of unknown primary2018

    • Author(s)
      Yohei Harada, Tomomi Kashiwada, Akemi Sato, Tomonori Abe, Chiho nakashima, Eisaburo Sueoka, Shinya Kimura, Naoko Sueoka-Aragane.
    • Organizer
      77th Annual Meeting of the Japanese Cancer Association
    • Related Report
      2018 Annual Research Report
  • [Presentation] Abnormal CpG methylation around the transcription start sites as therapeutic target in adult-T cell leukemia-lymphoma2018

    • Author(s)
      Tatsuro Watanabe, Hiroshi Uresino, Satoru Yamashita, Toshikazu Ushijima, Eisaburo Sueoka, Shinya Kimura
    • Organizer
      77th Annual Meeting of the Japanese Cancer Association
    • Related Report
      2018 Annual Research Report
  • [Presentation] CSCs in mouse skin carcinogenesis and inhibitory effects of EGCG on expression of stemness markers in human CSCs2018

    • Author(s)
      Hirota Fujiki, Tatsuro Watanabe, Eisaburo Sueoka, Anchalee Rawangkan, Masami Suganuma
    • Organizer
      77th Annual Meeting of the Japanese Cancer Association
    • Related Report
      2018 Annual Research Report
  • [Presentation] 伝子検査におけるcirculating free DNAの保存条件に関する検討2018

    • Author(s)
      佐藤明美,中島千穂,安部友範,中村秀明,荒金尚子,木村晋也,末岡榮三朗
    • Organizer
      日本臨床検査自動化学会 第50回大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 検体管理の自動化を志向した次世代型バイオバンクの構築2018

    • Author(s)
      末岡榮三朗,中村秀明,佐藤明美
    • Organizer
      日本臨床検査自動化学会 第50回大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] DNAメチル化異常を標的とした成人T細胞白血病/リンパ腫の新規治療法の可能性(Novel treatment strategy based on DNA methylation abnormalities for adult-T cell leukemia-lymphoma)2018

    • Author(s)
      渡邉達郎,嬉野博志,倉橋祐樹,山下 聡,牛島俊和,末岡榮三朗,木村晋也
    • Organizer
      第80回日本血液学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] グローバルデータシェアリング対応型次世代型バイオバンクの構築2018

    • Author(s)
      末岡榮三朗,中村秀明,佐藤明美
    • Organizer
      第65回臨床検査医学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Circulating free DNAとExtracellular vesicle associated DNAの関係についての検討2018

    • Author(s)
      中島千穂,安部友範,佐藤明美,中村朝美,小宮一利,末岡榮三朗,木村晋也,荒金 尚子
    • Organizer
      第59会日本肺癌学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 肺がん患者における血漿遊離DNAの特性2018

    • Author(s)
      安部友範,中島千穂,木村晋也,荒金尚子,佐藤明美,末岡榮三朗
    • Organizer
      第59会日本肺癌学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Demands of Counseling Supports for HTLV-1 Infected Pregnant Women in Japan2017

    • Author(s)
      Kaoru Tsuge, Eisaburo Sueoka
    • Organizer
      18th International Conference on Human Retrovirology HTLV and Related Viruses
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] HTLV-1感染者の臨床経過モニタリングにおけるHAS-Flow法の有用性の検討2017

    • Author(s)
      中村 秀明、佐藤 明美、渡邉 達郎、板村 英和、末岡 榮三朗
    • Organizer
      第4回日本 HTLV‐1学会学術集会
    • Related Report
      2017 Research-status Report
  • [Presentation] TCR Repertoire, Effector Regulatory T-cells and KIR Genotyping Uncover Immunological Dynamics in Mogamulizumab-treated ATL.2017

    • Author(s)
      Takero Shindo, Yasushi Kusunoki, Kazutaka Kitaura, Hiroyoshi Nishikawa, Nobukazu Watanabe, Hiroshi Ureshino, Masaharu Miyahara, Tatsuro Watanabe, Eizaburo Sueoka, Luis J Espinoza, Akiyoshi Takami, Tatsuo Ichinohe, Ryuji Suzuki, Hidenori Tanaka, Hiroh Saji, Shinya Kimura
    • Organizer
      18th International Conference on Human Retrovirology HTLV and Related Viruses
    • Related Report
      2017 Research-status Report
  • [Presentation] Epigenetic regulation of the genes in indolent types of adult T-cell leukemia/lymphoma analyzed by comprehensive DNA methylation array2017

    • Author(s)
      Nakamura H, Watanabe T, Sato A, Yamashita S, Ushijima T, Sueoka E
    • Organizer
      18th International Conference on Human Retrovirology HTLV and Related Viruses
    • Related Report
      2017 Research-status Report
  • [Patent(Industrial Property Rights)] 成人T細胞白血病/リンパ腫の検出方法2018

    • Inventor(s)
      渡邉達郎、末岡栄三朗、木村晋也、嬉野博志
    • Industrial Property Rights Holder
      渡邉達郎、末岡栄三朗、木村晋也、嬉野博志
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2019-037246
    • Filing Date
      2018
    • Related Report
      2018 Annual Research Report

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Published: 2016-04-21   Modified: 2020-03-30  

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