Epigenetic changes in the development of adult T cell leukemia
| Project/Area Number |
16K09850
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Hematology
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| Research Institution | Saga University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
小島 研介 佐賀大学, 医学部, 准教授 (10332793)
荒金 尚子 佐賀大学, 医学部, 准教授 (20321846)
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 成人T細胞白血病 / HTLV-1 / DNAメチル化 / エピジェネティック変化 / 分子標的治療 / フローサイトメトリー法 / ゲノム異常 / メチル化 / 多段階発がん / 癌 / 成人T細胞白血病・リンパ腫 / フローサイトメトリー |
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| Outline of Final Research Achievements |
HTLV-1 virus-infected cell-specific epigenetic changes for each stage of adult T cell leukemia were analyzed. About 180 cases who visited our hospital were analyzed by Has-Flow method and HTLV-1-infected fractions were separated from the expression pattern of CADM1 / TSLCl and CD7. DNA methylation was analyzed comprehensively by DNA methylation array. Methylation of the TSS 200 region, which is important for gene expression, was enhanced in relation to the progression of the stage. In addition, we found 22 types of gene groups were coincided with the genes which expression were down regulated. Our results suggested that the genes thought to be candidates for diagnostic markers for disease progression and for therapeutic targets.
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| Academic Significance and Societal Importance of the Research Achievements |
いったん発症すると治癒の困難な、成人T細胞白血病（ATL）における遺伝子変化について、キャリアからくすぶり、慢性型と病期の比較的早期から生じるメチル化異常のパターンを明らかにした。これらの遺伝子の中には、がん化や細胞増殖の進展に関与することが知られている遺伝子群が含まれており、ATLの発症のリスク評価や治療法の開発の標的分子も含まれていることが示唆される。現在、それぞれの遺伝子の機能解析とともに、HTLV-1キャリアのおける病期進展のマーカーとしての有用性の検討を進めている。
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Report
(4 results)
Research Products
(55 results)
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[Journal Article] Primary Chest Wall MYC/BCL6 Double-hit Lymphoma with t (3;7) (q27;p12) and t (8;14) (q24;q32) Translocations2019
Author(s)
Kamachi K, Kubota Y, Nagaie T, Yamaguchi K, Ogusu S, Kidoguchi K, Kusaba K, Kizuka-Sano H, Nishioka A, Yoshimura M, Yokoo M, Ando T, Kai K, Kojima K, Ohshima K, Sueoka E, Kimura S.
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Journal Title
Internal Medicine
Volume: 58
Issue: 14
Pages: 2073-2077
DOI
NAID
ISSN
0918-2918, 1349-7235
Year and Date
2019-07-15
Related Report
Peer Reviewed / Open Access
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[Journal Article] Clinical impact of the CONUT score and mogamulizumab in adult T cell leukemia/lymphoma.2019
Author(s)
Ureshino H, Kusaba K, Kidoguchi K, Sano H, Nishioka A, Itamura H, Yoshimura M, Yokoo M, Shindo T, Kubota Y, Ando T, Kojima K, Sueoka E, Kimura S.
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Journal Title
Annals of Hematology
Volume: 98
Issue: 2
Pages: 465-471
DOI
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Peer Reviewed / Open Access
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[Journal Article] Deep sequencing of the T cell receptor visualizes reconstitution of T cell immunity in mogamulizumab-treated adult T cell leukemia. Oncoimmunology2017
Author(s)
3.Shindo T, Kitaura K, Ureshino H, Kamachi K, Miyahara M, Doi K, Watanabe T, Sueoka E, Shin-I T, Suzuki R, Kimura S
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Journal Title
Oncoimmunology
Volume: 7
Issue: 3
Pages: e1405204-e1405204
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Prognostic index for chronic- and smoldering-type adult T-cell leukemia-lymphoma2017
Author(s)
Katsuya Hiroo、Shimokawa Mototsugu、Ishitsuka Kenji、Kawai Kazuhiro、Amano Masahiro、Utsunomiya Atae、Hino Ryosuke、Hanada Shuichi、Jo Tatsuro、Tsukasaki Kunihiro、Moriuchi Yukiyoshi、Sueoka Eisaburo、Yoshida Shinichiro、Suzushima Hitoshi、Miyahara Masaharu、Yamashita Kiyoshi、Eto Tetsuya、Suzumiya Junji、Tamura Kazuo
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Journal Title
Blood
Volume: 130
Issue: 1
Pages: 39-47
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Presentation] TCR Repertoire, Effector Regulatory T-cells and KIR Genotyping Uncover Immunological Dynamics in Mogamulizumab-treated ATL.2017
Author(s)
Takero Shindo, Yasushi Kusunoki, Kazutaka Kitaura, Hiroyoshi Nishikawa, Nobukazu Watanabe, Hiroshi Ureshino, Masaharu Miyahara, Tatsuro Watanabe, Eizaburo Sueoka, Luis J Espinoza, Akiyoshi Takami, Tatsuo Ichinohe, Ryuji Suzuki, Hidenori Tanaka, Hiroh Saji, Shinya Kimura
Organizer
18th International Conference on Human Retrovirology HTLV and Related Viruses
Related Report
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