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Development of a novel therapy targeting intracellular cholesterol for leukemia

Research Project

Project/Area Number 16K09851
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Hematology
Research InstitutionSaga University

Principal Investigator

Kubota Yasushi  佐賀大学, 医学部, 講師 (60570413)

Project Period (FY) 2016-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywordsシクロデキストリン / コレステロール / 白血病 / アポトーシス / 葉酸受容体 / 葉酸修飾シクロデキストリン / 慢性骨髄性白血病 / 急性骨髄性白血病 / 細胞増殖抑制 / 細胞周期停止 / 葉酸修飾 / 白血病細胞 / 脂質ラフト / 抗腫瘍作用
Outline of Final Research Achievements

2-Hydroxypropyl-β-cyclodextrin (HP-β-CyD) extracts cholesterol from chronic myelogenous leukemia (CML) cells and may have antitumor effects not only on CML cells but also on CML stem cells. In the present study, we investigated the effects of HP-β-CyD on acute myeloid leukemia (AML). Anti-leukemic effect of folate-appended HP-β-CyD was also examined.
AML cell line showed similar effect. In addition, folate-appended HP-β-CyD showed 10 to 20 times the antitumor activity of HP-β-CyD. Moreover, these actions are specific to folate receptor-expressing cells, and are considered to be promising as leukemia cell-targeted therapeutic agents.

Academic Significance and Societal Importance of the Research Achievements

白血病は医療の進歩により予後は改善されてきたものの依然難治である。そこで、腫瘍細胞の生存や治療抵抗性に関わるとされている細胞内コレステロールを標的とする治療法は、従来の薬剤と作用機序も異なり、新規治療として期待できる。さらに、正常細胞と比較して腫瘍細胞でより高発現している葉酸受容体を標的とする葉酸修飾シクロデキストリンは、無修飾のシクロデキストリンの10-20倍の抗腫瘍活性を示すことがわかり、より有効な白血病治療の開発につながる成果と考えられる。

Report

(5 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (63 results)

All 2020 2019 2018 2017 2016 Other

All Journal Article (30 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 29 results,  Open Access: 18 results,  Acknowledgement Compliant: 1 results) Presentation (32 results) (of which Int'l Joint Research: 1 results) Remarks (1 results)

  • [Journal Article] Reconstitution of NK Cells Expressing KIR3DL1 Is Associated With Reduced NK Cell Activity and Relapse of CML After Allogeneic Hematopoietic Stem Cell Transplantation2020

    • Author(s)
      Ureshino H, Shindo T, Sano H, Kubota Y, Ando T, Kidoguchi K, Kusaba K, Itamura H, Kojima H, Kusunoki Y, Miyazaki Y, Kojima K, Tanaka H, Saji H, Oshima K, Kimura S
    • Journal Title

      International Journal of Hematology

      Volume: 111 Issue: 5 Pages: 733-738

    • DOI

      10.1007/s12185-019-02809-5

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Epstein-Barr virus-positive diffuse large B cell lymphoma, not otherwise specified, carrying a t(19;22)(q13;q11) translocation.2020

    • Author(s)
      Yamaguchi K, Kubota Y, Kishimori C, Ohno H, Kidoguchi K, Kizuka-Sano H, Nishioka A, Katsuya H, Ando T, Kimura S.
    • Journal Title

      Ann Hematol

      Volume: 99 Issue: 2 Pages: 389-390

    • DOI

      10.1007/s00277-019-03898-2

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clinical impact of the CONUT score in patients with multiple myeloma2020

    • Author(s)
      Okamoto S, Ureshino H*, Kidoguchi K, Kusaba K, Kizuka-Sano H, Sano H, Nishioka A, Yamaguchi K, Kamachi K, Itamura H, Yoshimura M, Yokoo M, Shindo T, Kubota Y, Ando T, Kojima K, Kawaguchi A, Sueoka E, Kimura S.
    • Journal Title

      Ann Hematol

      Volume: 99 Issue: 1 Pages: 113-119

    • DOI

      10.1007/s00277-019-03844-2

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Severe infusion reaction, anti-rituximab antibodies and lymphoma.2020

    • Author(s)
      Kidoguchi K, Kubota Y, Kusaba K, Kizuka-Sano H, Yamaguchi K, Nishioka A, Yokoo M, Ando T, Kojima K, Kimura S.
    • Journal Title

      QJM

      Volume: 113 Issue: 4 Pages: 273-274

    • DOI

      10.1093/qjmed/hcz296

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Primary Chest Wall MYC/BCL6 Double-hit Lymphoma with t (3;7) (q27;p12) and t (8;14) (q24;q32) Translocations2019

    • Author(s)
      Kamachi K, Kubota Y, Nagaie T, Yamaguchi K, Ogusu S, Kidoguchi K, Kusaba K, Kizuka-Sano H, Nishioka A, Yoshimura M, Yokoo M, Ando T, Kai K, Kojima K, Ohshima K, Sueoka E, Kimura S.
    • Journal Title

      Internal Medicine

      Volume: 58 Issue: 14 Pages: 2073-2077

    • DOI

      10.2169/internalmedicine.2532-18

    • NAID

      130007679517

    • ISSN
      0918-2918, 1349-7235
    • Year and Date
      2019-07-15
    • Related Report
      2019 Annual Research Report 2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Naked antisense double-stranded DNA oligonucleotide efficiently suppresses BCR-ABL positive leukemic cells.2019

    • Author(s)
      Hoshiko T, Kubota Y, Akisawa T, Watanabe T, Tanigawara K, Yano J, Kimura S.
    • Journal Title

      Invest New Drugs

      Volume: - Issue: 4 Pages: 1012-1019

    • DOI

      10.1007/s10637-019-00862-9

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Significance of FLT3-tyrosine kinase domain mutation as a prognostic factor for acute myeloid leukemia.2019

    • Author(s)
      Sakaguchi M, Yamaguchi H, Kuboyama M, Najima Y, Usuki K, Ueki T, Oh I, Mori S, Kawata E, Uoshima N, Kobayashi Y, Kako S, Tajika K, Shono K, Kayamori K, Hagihara M, Kanda J, Uchiyama H, Kuroda J, Uchida N, Kubota Y, Kimura S, Kurosawa S, et al
    • Journal Title

      Int J Hematol

      Volume: 110 Issue: 5 Pages: 566-574

    • DOI

      10.1007/s12185-019-02720-z

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Deficiency of stress-associated gene Nupr1 increases bone volume by attenuating differentiation of osteoclasts and enhancing differentiation of osteoblasts.2019

    • Author(s)
      Shiraki M, Xu X, Iovanna JL, Kukita T, Hirata H, Kamohara A, Kubota Y, Miyamoto H, Mawatari M, Kukita A.
    • Journal Title

      FASEB J.

      Volume: 33 Issue: 8 Pages: 8836-8852

    • DOI

      10.1096/fj.201802322rr

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Clinical impact of the CONUT score and mogamulizumab in adult T cell leukemia/lymphoma.2019

    • Author(s)
      Ureshino H, Kusaba K, Kidoguchi K, Sano H, Nishioka A, Itamura H, Yoshimura M, Yokoo M, Shindo T, Kubota Y, Ando T, Kojima K, Sueoka E, Kimura S.
    • Journal Title

      Annals of Hematology

      Volume: 98 Issue: 2 Pages: 465-471

    • DOI

      10.1007/s00277-018-3502-7

    • Related Report
      2019 Annual Research Report 2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Acute myeloid leukemia with t(19;21)(q13;q22) and marked eosinophilia.2019

    • Author(s)
      Kubota Y, Kamachi K, Wakayama K, Kitamura H, Yoshihara M, Hisatomi T, Fukushima N, Ichinohe T, Sueoka E, Kimura S.
    • Journal Title

      Annals of Hematology

      Volume: 98 Issue: 1 Pages: 221-222

    • DOI

      10.1007/s00277-018-3408-4

    • Related Report
      2019 Annual Research Report 2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Prognostic impact of low allelic ratio FLT3-ITD and NPM1 mutation in acute myeloid leukemia.2018

    • Author(s)
      Sakaguchi M, Yamaguchi H, Najima Y, Usuki K, Ueki T, Oh I, Mori S, Kawata E, Uoshima N, Kobayashi Y, Kako S, Tajika K, Gomi S, Shono K, Kayamori K, Hagihara M, Kanda J, Uchiyama H, Kuroda J, Uchida N, Kubota Y, Kimura S, et al.
    • Journal Title

      Blood Advances

      Volume: 2 Issue: 20 Pages: 2744-2754

    • DOI

      10.1182/bloodadvances.2018020305

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Monomorphic epitheliotropic intestinal T-cell lymphoma involving the central nervous system2018

    • Author(s)
      Kubota Yasushi、Kusaba Kana
    • Journal Title

      Blood

      Volume: 131 Issue: 15 Pages: 1765-1765

    • DOI

      10.1182/blood-2017-11-819136

    • Related Report
      2018 Research-status Report 2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Successful treatment of post-transplant relapsed adult T cell leukemia after cord blood transplantation with low-dose, short-term lenalidomide2018

    • Author(s)
      Ando Toshihiko、Kojima Kensuke、Sano Haruhiko、Kidoguchi Keisuke、Kusaba Kana、Yoshimura Mariko、Yokoo Masako、Kubota Yasushi、Nakamura Hideaki、Takase Yukari、Aishima Shinichi、Kimura Shinya
    • Journal Title

      Leukemia & Lymphoma

      Volume: in press Issue: 10 Pages: 1-4

    • DOI

      10.1080/10428194.2018.1427859

    • Related Report
      2018 Research-status Report 2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Successful Autologous Hematopoietic Stem Cell Transplantation Followed by Bortezomib Maintenance in a Patient with Relapsed CD138-low Multiple Solitary Plasmacytomas Harboring a 17p Deletion2018

    • Author(s)
      Kitamura H, Kubota Y, Yamaguchi K, Kamachi K, Nishioka A, Yokoo M, Shindo T, Ando T, Kojima K, Kimura S.
    • Journal Title

      Internal Medicine

      Volume: 57 Issue: 6 Pages: 855-860

    • DOI

      10.2169/internalmedicine.9446-17

    • NAID

      130006507378

    • ISSN
      0918-2918, 1349-7235
    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Synchronous mantle cell lymphoma and lung adenocarcinoma presenting in a pleural effusion: A rare tumour combination and a potential pitfall of cytodiagnosis.2018

    • Author(s)
      5.Kai K, Ryu Y, Kamochi K, Nishioka A, Kubota Y, Nakamura M, Kimura S, Sueoka E, Aishima S
    • Journal Title

      Cytopathology

      Volume: 印刷中 Issue: 4 Pages: 400-402

    • DOI

      10.1111/cyt.12532

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Three coexisting lymphomas in a single patient: composite lymphoma derived from a common germinal center B-cell precursor and unrelated discordant lymphoma2017

    • Author(s)
      Nishioka Atsujiro、Ureshino Hiroshi、Ando Toshihiko、Kizuka Haruna、Kusaba Kana、Sano Haruhiko、Itamura Hidekazu、Kubota Yasushi、Kojima Kensuke、Ohshima Koichi、Kimura Shinya
    • Journal Title

      International Journal of Hematology

      Volume: in press Issue: 6 Pages: 703-708

    • DOI

      10.1007/s12185-017-2370-6

    • Related Report
      2018 Research-status Report 2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Tocilizumab for severe cytokine-release syndrome after haploidentical donor transplantation in a patient with refractory Epstein-Barr virus-positive diffuse large B-cell lymphoma2017

    • Author(s)
      Ureshino Hiroshi、Ando Toshihiko、Kizuka Haruna、Kusaba Kana、Sano Haruhiko、Nishioka Atsujiro、Itamura Hidekazu、Shindo Takero、Kubota Yasushi、Kojima Kensuke、Kimura Shinya
    • Journal Title

      Hematological Oncology

      Volume: 36 Issue: 1 Pages: 324-327

    • DOI

      10.1002/hon.2481

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Peculiar cold-induced leukoagglutination in Mycoplasma pneumoniae pneumonia2017

    • Author(s)
      Kubota Yasushi、Hirakawa Yuka、Wakayama Kazuo、Kimura Shinya
    • Journal Title

      Turkish Journal of Hematology

      Volume: 34 Pages: 354-355

    • DOI

      10.4274/tjh.2017.0203

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Elderly patients with chronic myeloid leukemia benefit from a dasatinib dose as low as 20 mg.2017

    • Author(s)
      Itamura H, Kubota Y, Shindo T, Ando T, Kojima K, Kimura S
    • Journal Title

      Clin Lymph Myeloma Leuk

      Volume: 印刷中 Issue: 6 Pages: 370-374

    • DOI

      10.1016/j.clml.2017.02.023

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] 5q? syndrome-like features as the first manifestation of myelodysplastic syndrome in a patient with an unbalanced whole-arm translocation der(5;19)(p10;q10)2017

    • Author(s)
      Ureshino Hiroshi、Kizuka Haruna、Kusaba Kana、Sano Haruhiko、Nishioka Atsujiro、Shindo Takero、Kubota Yasushi、Ando Toshihiko、Kojima Kensuke、Kimura Shinya
    • Journal Title

      International Journal of Hematology

      Volume: 105 Issue: 5 Pages: 692-696

    • DOI

      10.1007/s12185-016-2160-6

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] The novel BMI-1 inhibitor PTC596 downregulates MCL-1 and induces p53-independent mitochondrial apoptosis in acute myeloid leukemia progenitor cells.2017

    • Author(s)
      Nishida Y, Maeda A, Kim MJ, Cao L, Kubota Y, Ishizawa J, AlRawi A, Kato Y, Iwama A, Fujisawa M, Matsue K, Weetall M, Dumble M, Andreeff M, Davis TW, Branstrom A, Kimura S, Kojima K.
    • Journal Title

      Blood Cancer J

      Volume: 17 Issue: 2 Pages: e527-e527

    • DOI

      10.1038/bcj.2017.8

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] The MEK inhibitor trametinib separates murine graft-versus-host disease from graft-versus-tumor effects.2016

    • Author(s)
      Itamura H, Shindo T, Tawara I, Kubota Y, Kariya R, Okada S, Komanduri KV, Kimura S.
    • Journal Title

      JCI insight

      Volume: 1

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Subdural Hematoma Associated with Dasatinib and Intrathecal Methotrexate Treatment in Philadelphia Chromosome-positive Acute Lymphoblastic Leukemia2016

    • Author(s)
      Ureshino H, Nishioka A, Kojima K, Kizuka H, Sano H, Shindo T, Kubota Y, Ando T, Kimura S
    • Journal Title

      Internal Medicine

      Volume: 55 Issue: 18 Pages: 2703-2706

    • DOI

      10.2169/internalmedicine.55.6966

    • NAID

      130005414849

    • ISSN
      0918-2918, 1349-7235
    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Famotidine-induced reactive plasmacytosis and generalized lymphadenopathy: a case report and review of the literature.2016

    • Author(s)
      Hiroaki Kitamura, Yasushi Kubota, Noriyasu Fukushima, Tatsuo Ichinohe, Daisuke Hayasaka, Kazuharu Kamachi, Mari Yoshihara, Hidekazu Itamura, Takashi Hisatomi, Kazuo Wakayama, Eisaburo Sueoka, Shinya Kimura
    • Journal Title

      Int J Clin Exp Pathol

      Volume: 9 Pages: 7680-7685

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Rituximab-induced Acute Thrombocytopenia in High Tumor Burden Follicular Lymphoma2016

    • Author(s)
      Ureshino H, Nishioka A, Kojima K, Suzuki M, Kizuka H, Sano H, Shindo T, Kubota Y, Ando T, Kimura S
    • Journal Title

      Internal Medicine

      Volume: 55 Issue: 15 Pages: 2061-2064

    • DOI

      10.2169/internalmedicine.55.6140

    • NAID

      130005254817

    • ISSN
      0918-2918, 1349-7235
    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Reversible Liver Steatosis Induced by Chemotherapy of Mixed-phenotype Acute Leukemia2016

    • Author(s)
      Nishioka A, Kubota Y, Sueoka E, Kimura S.
    • Journal Title

      Internal Medicine

      Volume: 55 Issue: 8 Pages: 1025-1026

    • DOI

      10.2169/internalmedicine.55.5685

    • NAID

      130005145443

    • ISSN
      0918-2918, 1349-7235
    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Domino-Style Cerebral Bleeding in a Patient With Immune Thrombocytopenic Purpura2016

    • Author(s)
      北村浩晃、進藤岳郎、薬師寺祐介、吉原麻里、久保田寧、野口智之、木村晋也
    • Journal Title

      JAMA Neurology

      Volume: 73 Issue: 4 Pages: 474-475

    • DOI

      10.1001/jamaneurol.2015.4508

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Acute myeloid leukemia with t(3;8)(q26;q24) complicated by diabetes insipidus.2016

    • Author(s)
      Kubota Y, Ichinohe T, Yoshimura M, Itamura H, Hisatomi T, Fukushima N, Sueoka E, Kimura S.
    • Journal Title

      Annals of Hematology

      Volume: 95 Issue: 4 Pages: 653-655

    • DOI

      10.1007/s00277-016-2595-0

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] 赤芽球癆と胸腺過形成2016

    • Author(s)
      久保田 寧
    • Journal Title

      Medical Practice

      Volume: 33 Pages: 1822-1822

    • Related Report
      2016 Research-status Report
  • [Journal Article] 移植医療における輸血関連検査 輸血とHLA (human leukocyte antigen) 検査について2016

    • Author(s)
      山田尚友、山田麻里江、中尾真実、久保田寧、末岡榮三朗
    • Journal Title

      日本検査血液学会雑誌

      Volume: 17 Pages: 434-440

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Presentation] 自己末梢血幹細胞採取不良例に対するplerixafor投与例での採取結果の検討2019

    • Author(s)
      久保田寧、山口享祐、末岡榮三朗
    • Organizer
      第66回日本臨床検査医学会学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 佐賀大学におけるdouble-hit lymphoma, double expressor lymphoma症例の診断と治療について2019

    • Author(s)
      蒲池和晴、久保田寧
    • Organizer
      第66回日本臨床検査医学会学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] The Presence of Minimal Residual Disease, As Determined By Highly Sensitive Quantitation of NPM1-Mutatation, Provided Powerful Prognostic Information in Acute Myeloid Leukemia2019

    • Author(s)
      Marumo A, Yamaguchi H,Kubota Y, et al
    • Organizer
      61st ASH Annual Meeting
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 高力価抗リツキシマブ抗体の産生と重症infusion reactionを伴った濾胞性リンパ腫の1例2019

    • Author(s)
      城戸口啓介、久保田寧、草場香那、佐野遥菜、山口享祐、西岡敦二郎、横尾眞子、安藤寿彦、小島研介、木村晋也
    • Organizer
      第327回日本内科学会九州地方会
    • Related Report
      2019 Annual Research Report
  • [Presentation] BCR-ABL1とCBFB-MYH11を認めた骨髄線維化を伴ったCML急性転化期2019

    • Author(s)
      城戸口 啓介, 小島 研介, 横尾 眞子, 草場 香那, 佐野 遥菜, 山口 享祐, 勝屋 弘雄, 久保田 寧, 安藤 寿彦, 木村 晋也
    • Organizer
      第81回日本血液学会学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 2つの異なる免疫表現型を有した初期前駆T細胞性急性リンパ芽球性白血病と考えられた1例2019

    • Author(s)
      海野 晃久, 城戸口 啓介, 本田 美穂, 岡崎 智満, 吉原 由利重, 若山 一夫, 川崎 誠司, 横尾 眞子, 久保田 寧, 木村 晋也, 末岡 榮三朗
    • Organizer
      第81回日本血液学会学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] t(19;22)(q13.1;q11.2)を認めたEBV陽性DLBCLの一例2019

    • Author(s)
      山口 享祐, 久保田 寧, 横尾 眞子, 岸森 千幸, 大野 仁嗣, 城戸口 啓介, 草場 香那, 佐野 遥菜, 西岡 敦二郎, 安藤 寿彦, 小島 研介, 木村 晋也
    • Organizer
      第81回日本血液学会学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 超高齢DLBCL患者における臨床学的特徴についての後方視的研究2019

    • Author(s)
      西岡 敦二郎, 久保田 寧, 草場 香那, 城戸口 啓介, 佐野 遥菜, 山口 享祐, 蒲池 和晴, 嬉野 博志, 横尾 眞子, 安藤 寿彦, 末岡 榮三朗, 小島 研介, 木村 晋也
    • Organizer
      第81回日本血液学会学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] FLT3-ITD陽性急性骨髄性白血病を対象とした13番染色体長腕ヘテロ接合性消失の解析2019

    • Author(s)
      神田 真志, 脇田 知志, 新井 悠, 名島 悠峰, 臼杵 憲祐, 植木 俊充, 翁 家国, 森 慎一郎, 魚嶋 伸彦, 小林 裕, 賀古 真一, 田近 賢二, 鐘野 勝洋, 栢森 健介, 萩原 政夫, 諫田 淳也, 内山 人二, 黒田 純也, 内田 直之, 久保田 寧ら
    • Organizer
      第81回日本血液学会学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 当院におけるABO亜型の検出状況と臨床への結果報告について2019

    • Author(s)
      山田麻里江、中尾真実、山田尚友、中村秀明、久保田寧、木村晋也、末岡榮三朗
    • Organizer
      日本輸血・細胞治療学会九州支部例会 第66回総会・第87回例会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 自己末梢血幹細胞採取1日目の採取不良例に対するplerixafor投与例での採取結果の検討2019

    • Author(s)
      山口享祐、久保田寧、山田尚友、山田麻里江、中尾真実、吉原由利重、岡崎智満、海野晃久、本田美穂、横尾眞子、若山一夫、木村晋也、末岡榮三朗
    • Organizer
      第67回日本輸血・細胞治療学会学術総会
    • Related Report
      2019 Annual Research Report
  • [Presentation] RhD血液型不適合造血幹細胞移植後、移植前の患者血液型となった1例2019

    • Author(s)
      山田麻里江、山田尚友、中尾真実、中村秀明、久保田寧、木村晋也、末岡榮三朗
    • Organizer
      第67回日本輸血・細胞治療学会学術総会
    • Related Report
      2019 Annual Research Report
  • [Presentation] IPEX症候群である生後3か月の児での不規則抗体抗Eの産生を認めた一症例2019

    • Author(s)
      中尾真実、山田麻里江、山田尚友、古賀大介、西眞範、中村秀明、久保田寧、木村晋也、末岡榮三朗
    • Organizer
      第67回日本輸血・細胞治療学会学術総会
    • Related Report
      2019 Annual Research Report
  • [Presentation] t(3;7)(q27;p12)及びt(8;14)(q24;q32)転座を有する胸膜原発MYC/BCL6 double-hit lymphomaの1例2019

    • Author(s)
      長家聡明,蒲池和晴,久保田寧,山口享祐,横尾眞子,安藤寿彦,甲斐敬太,小島研介,大島孝一,木村晋也
    • Organizer
      第325回日本内科学会九州地方会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 単一上皮親和性腸管T細胞リンパ腫に対しタンデム自家・同種移植を施行した一例2018

    • Author(s)
      草場香那、久保田寧、城戸口啓介、佐野晴彦、吉村麻里子、横尾眞子、安藤寿彦、甲斐敬太、小島研介、大島孝一、木村晋也
    • Organizer
      第80回日本血液学会学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] 新たな核酸医薬技術、レナ核酸によるBCR-ABLの抑制効果2018

    • Author(s)
      星子亨幹、久保田寧、中川原慧美、秋澤拓也、渡邉達郎、谷川原万顕、矢野純一、木村晋也
    • Organizer
      第80回日本血液学会学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] 大量化療前導入治療R-CHOP-14とR-CHOP-14/CHASERの比較試験:JCOG09082018

    • Author(s)
      Dai Maruyama, Yoshitoyo Kagami, Taro Shibata, Kensei Tobinai, Kazuhito Yamamoto, Yoshitaka Imaizumi, Toshiki Uchida, Kazuyuki Shimada, Koichiro Minauchi, Noriko Fukuhara, Hirofumi Kobayashi, Nobuhiko Yamauchi, Hedeki Tsujimura, Akira Hangaishi, Ryo Tominaga, Yasushi Kubota, et al.
    • Organizer
      第80回日本血液学会学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] 急性骨髄性白血病におけるFLT3-ITD低アレル比とNPM1の予後因子としての重要性2018

    • Author(s)
      Nana Nakajima, Masahiro Sakaguchi, Yuho Najima, Kensuke Usuki, Toshimitsu Ueki, Iekuni Oh, Sinichiro Mori, Eri Kawata, Nobuhiko Uoshima, Yutaka Kobayashi, Shinichi Kako, Kenji Tajika, Katsuhiro Shono, Kensuke Kayamori, Masao Hagihara, Junya Kanda, Hitoji Uchiyama, Junya Kuroda, Naoyuki Uchida, Yasushi Kubota, et al.
    • Organizer
      第80回日本血液学会学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] 造血器疾患における中心静脈カテーテル関連血流感染症のサーベイランスと中心静脈カテーテル挿入時の環境リスク因子の検討2018

    • Author(s)
      北村浩晃、久保田寧
    • Organizer
      第88回日本感染症学会西日本地方会学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] 免疫グロブリン大量静注療法により抗Aが移行し、O型赤血球製剤を輸血した1例2018

    • Author(s)
      山田麻里江、山田尚友、中尾真実、久保田寧、木村晋也、末岡榮三朗
    • Organizer
      日本輸血・細胞治療学会九州支部第64回総会・第86回例会
    • Related Report
      2018 Research-status Report
  • [Presentation] Randomized Phase II Study of R-CHOP-14 Versus R-CHOP-14 Followed By Chaser As Induction Therapy for High-Dose Chemotherapy (HDT), LEED, and Autologous Stem-Cell Transplantation (ASCT) in Poor-Risk Diffuse Large B-Cell Lymphoma (DLBCL): Japan Clinical Oncology Group (JCOG) Study (JCOG0908)2017

    • Author(s)
      Yoshitoyo Kagami, Yasushi Kubota et al
    • Organizer
      59th Annual Meeting of the American Society of Hematology (59th ASH Annual Meeting)
    • Related Report
      2017 Research-status Report
  • [Presentation] Ponatinib for relapsed Ph+ leukemia with T315I mutation after allogeneic stem cell transplantation2017

    • Author(s)
      Kana Kusaba, Yasushi Kubota, Haruhiko Sano, Haruna Kizuka, Hidekazu Itamura, Toshihiko Ando, Kensuke Kojima, Masatomo Miura, Naoto Takahashi, Koichi Ohshima, Shinya Kimura
    • Organizer
      第79回日本血液学会学術集会
    • Related Report
      2017 Research-status Report
  • [Presentation] 劇症型心筋症として発症した骨髄移植後のcGVHDの1例2017

    • Author(s)
      木塚遥菜、安藤寿彦、七田茂輝、草場香那、佐野晴彦、板村英和、下村光洋、進藤岳郎、久保田寧、小島研介、野出孝一、木村晋也
    • Organizer
      第7回日本血液学会九州地方会
    • Related Report
      2017 Research-status Report
  • [Presentation] B+O血液型キメラにおいて不規則抗Bが疑われた一症例2017

    • Author(s)
      中尾真実、山田麻里江、山田尚友、久保田寧、木村晋也、末岡榮三朗
    • Organizer
      日本輸血・細胞治療学会九州支部会 第64回総会・第85回例会
    • Related Report
      2017 Research-status Report
  • [Presentation] 当院で作製した輸血検査DVDを用いた地域への貢献について2017

    • Author(s)
      山田麻里江、山田尚友、中尾真実、久保田寧、木村晋也、末岡榮三朗
    • Organizer
      日本輸血・細胞治療学会九州支部会 第64回総会・第85回例会
    • Related Report
      2017 Research-status Report
  • [Presentation] The novel BMI-1 inhibitor PTC596 induces p53-independent apoptosis in AML progenitor cells2016

    • Author(s)
      西田有毅, 前田綾, 久保田寧, 木村晋也, 小島研介
    • Organizer
      第78回日本血液学会学術集会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2016-10-13
    • Related Report
      2016 Research-status Report
  • [Presentation] 脾摘後に自然寛解し2年後に再発したCD5陽性びまん性大細胞型B細胞リンパ腫2016

    • Author(s)
      佐野 晴彦, 安藤 寿彦, 久保田 寧, 西岡 敦二郎, 木塚 遥菜, 嬉野 博志, 進藤 岳郎, 小島 研介, 大島 孝一, 木村 晋也
    • Organizer
      第78回日本血液学会学術集会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2016-10-13
    • Related Report
      2016 Research-status Report
  • [Presentation] 広範な皮下血腫と高度の貧血を呈した真性多血症と第XIII/13因子(F13)欠乏症の合併症例2016

    • Author(s)
      嬉野 博志, 木塚 遥菜, 佐野 晴彦, 西岡 敦二郎, 進藤 岳郎, 久保田 寧, 安藤 寿彦, 尾崎 司, 惣宇利 正善, 片山 義雄, 小島 研介, 一瀬 白帝, 木村 晋也
    • Organizer
      第78回日本血液学会学術集会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2016-10-13
    • Related Report
      2016 Research-status Report
  • [Presentation] 輸血とHLA検査について2016

    • Author(s)
      山田 尚友, 山田 麻里江, 中尾 真実, 久保田 寧, 末岡 榮三朗
    • Organizer
      第17回日本検査血液学会学術集会
    • Place of Presentation
      福岡国際会議場
    • Year and Date
      2016-08-06
    • Related Report
      2016 Research-status Report
  • [Presentation] The novel BMI-1 inhibitor PTC596 induces apoptosis in a p53-independent manner and targets immature AML cells2016

    • Author(s)
      西田有毅, 前田綾, 久保田寧, 木村晋也, 小島研介
    • Organizer
      日本がん分子標的治療学会
    • Place of Presentation
      別府国際コンベンションセンター
    • Year and Date
      2016-05-30
    • Related Report
      2016 Research-status Report
  • [Presentation] 同種血輸血における免疫担当細胞の動態に関する解析2016

    • Author(s)
      山田 麻里江, 山田 尚友, 中尾 真実, 東谷 孝徳, 久保田 寧, 木村 晋也, 末岡 榮三朗
    • Organizer
      第64回日本輸血・細胞治療学会総会
    • Place of Presentation
      京都国際会館
    • Year and Date
      2016-04-28
    • Related Report
      2016 Research-status Report
  • [Presentation] 少量リバビリン経口投与により軽快した臍帯血移植後播種性アデノウイルス感染症 -末梢血リンパ球数と治療効果の関連-2016

    • Author(s)
      佐野 晴彦, 久保田 寧, 北村 浩晃, 嬉野 博志
    • Organizer
      第90回日本感染症学会総会
    • Place of Presentation
      仙台
    • Year and Date
      2016-04-15
    • Related Report
      2016 Research-status Report
  • [Remarks] 佐賀大学医学部 血液・呼吸器・腫瘍内科

    • URL

      http://www.saga-hor.jp/main/1.html

    • Related Report
      2016 Research-status Report

URL: 

Published: 2016-04-21   Modified: 2021-02-19  

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